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Central Nervous System Embryonal Tumor

MedGen UID:
234214
•Concept ID:
C1333378
•
Neoplastic Process
Synonyms: Central Nervous System Embryonal Neoplasm; CNS Embryonal Neoplasm; CNS Embryonal Tumor; Embryonal Neoplasm of Central Nervous System; Embryonal Neoplasm of CNS; Embryonal Neoplasm of the Central Nervous System; Embryonal Neoplasm of the CNS; Embryonal Tumor of Central Nervous System; Embryonal Tumor of CNS; Embryonal Tumor of the Central Nervous System; Embryonal Tumor of the CNS

Definition

A malignant neoplasm of embryonal origin, arising from the central nervous system. It usually affects children. Representative examples include ependymoblastoma, medulloblastoma, and atypical teratoid/rhabdoid tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Embryonal Tumor

Professional guidelines

PubMed

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood.
Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G, Bendszus M, Balana C, Chinot O, Dirven L, French P, Hegi ME, Jakola AS, Platten M, Roth P, Rudà R, Short S, Smits M, Taphoorn MJB, von Deimling A, Westphal M, Soffietti R, Reifenberger G, Wick W
Nat Rev Clin Oncol 2021 Mar;18(3):170-186. Epub 2020 Dec 8 doi: 10.1038/s41571-020-00447-z. PMID: 33293629Free PMC Article
Immunotherapy for glioma: Current management and future application.
Xu S, Tang L, Li X, Fan F, Liu Z
Cancer Lett 2020 Apr 28;476:1-12. Epub 2020 Feb 7 doi: 10.1016/j.canlet.2020.02.002. PMID: 32044356
The Diagnosis and Management of Neurofibromatosis Type 1.
Ly KI, Blakeley JO
Med Clin North Am 2019 Nov;103(6):1035-1054. doi: 10.1016/j.mcna.2019.07.004. PMID: 31582003

Recent clinical studies

Therapy

Extramedullary Hematopoiesis in the Dura Mater During Treatment of a CNS Embryonal Tumor.
Ganapathi SS, Havard ME, Ferguson M, Cole BL, Millard NE, Vitanza NA
J Pediatr Hematol Oncol 2021 Nov 1;43(8):e1217-e1219. doi: 10.1097/MPH.0000000000001962. PMID: 33031159

Prognosis

Changes in Peripheral Blood Regulatory T Cells and IL-6 and IL-10 Levels Predict Response of Pediatric Medulloblastoma and Germ Cell Tumors With Residual or Disseminated Disease to Craniospinal Irradiation.
Song L, Wang S, Fang T, Qiu X, Wang X, Zhou X, Morse MA, Hobeika A, Wu W, Yang H, Ren J, Lyerly HK
Int J Radiat Oncol Biol Phys 2021 Oct 1;111(2):479-490. Epub 2021 May 8 doi: 10.1016/j.ijrobp.2021.04.041. PMID: 33974888
Extramedullary Hematopoiesis in the Dura Mater During Treatment of a CNS Embryonal Tumor.
Ganapathi SS, Havard ME, Ferguson M, Cole BL, Millard NE, Vitanza NA
J Pediatr Hematol Oncol 2021 Nov 1;43(8):e1217-e1219. doi: 10.1097/MPH.0000000000001962. PMID: 33031159

Clinical prediction guides

Changes in Peripheral Blood Regulatory T Cells and IL-6 and IL-10 Levels Predict Response of Pediatric Medulloblastoma and Germ Cell Tumors With Residual or Disseminated Disease to Craniospinal Irradiation.
Song L, Wang S, Fang T, Qiu X, Wang X, Zhou X, Morse MA, Hobeika A, Wu W, Yang H, Ren J, Lyerly HK
Int J Radiat Oncol Biol Phys 2021 Oct 1;111(2):479-490. Epub 2021 May 8 doi: 10.1016/j.ijrobp.2021.04.041. PMID: 33974888

Supplemental Content

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