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Succinate Dehydrogenase-Deficient Renal Cell Carcinoma

MedGen UID:
1662930
Concept ID:
C4744841
Neoplastic Process
Synonyms: SDH Deficient Renal Cell Carcinoma; SDH-Deficient Renal Cell Carcinoma; Succinate Dehydrogenase Renal Cell Carcinoma

Definition

A very rare renal cell carcinoma that usually affects young adults. It is characterized by mutations in one of the four subunits of the SDH complex (SDHA, SDHB, SDHC, or SDHD gene). Most frequently, the mutations occur in the SDHB subunit. It has a relatively good prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSuccinate Dehydrogenase-Deficient Renal Cell Carcinoma

Professional guidelines

PubMed

Kanakaraj J, Chang J, Hampton LJ, Smith SC
Urol Oncol 2024 Jul;42(7):211-219. Epub 2024 Mar 21 doi: 10.1016/j.urolonc.2024.02.003. PMID: 38519377

Recent clinical studies

Etiology

Abdulfatah E, Kennedy JM, Hafez K, Davenport MS, Xiao H, Weizer AZ, Palapattu GS, Morgan TM, Mannan R, Wang XM, Dhanasekaran SM, Kaffenberger SD, Spratt DE, Kunju L, Wu A, Lew M, Udager AM, Chinnaiyan AM, Mehra R
Histopathology 2020 May;76(6):875-887. Epub 2020 Apr 27 doi: 10.1111/his.14051. PMID: 31872452

Diagnosis

Zhang X, Bolck HA, Rupp NJ, Moch H
Virchows Arch 2024 Feb;484(2):323-337. Epub 2023 Nov 24 doi: 10.1007/s00428-023-03700-9. PMID: 37999735Free PMC Article
Rogala J, Zhou M
Semin Diagn Pathol 2024 Jan;41(1):32-41. Epub 2023 Nov 8 doi: 10.1053/j.semdp.2023.11.001. PMID: 37981479
Sanders ML, Thomas DH, Varma M
J Clin Pathol 2020 Sep;73(9):610. Epub 2020 Feb 14 doi: 10.1136/jclinpath-2019-206260. PMID: 32060077
Abdulfatah E, Kennedy JM, Hafez K, Davenport MS, Xiao H, Weizer AZ, Palapattu GS, Morgan TM, Mannan R, Wang XM, Dhanasekaran SM, Kaffenberger SD, Spratt DE, Kunju L, Wu A, Lew M, Udager AM, Chinnaiyan AM, Mehra R
Histopathology 2020 May;76(6):875-887. Epub 2020 Apr 27 doi: 10.1111/his.14051. PMID: 31872452
Tsai TH, Lee WY
Arch Pathol Lab Med 2019 May;143(5):643-647. Epub 2018 Dec 21 doi: 10.5858/arpa.2018-0024-RS. PMID: 31026220

Prognosis

Rogala J, Zhou M
Semin Diagn Pathol 2024 Jan;41(1):32-41. Epub 2023 Nov 8 doi: 10.1053/j.semdp.2023.11.001. PMID: 37981479
Kodare D, Menon S, Prakash G, Desai S
Indian J Cancer 2023 Oct 1;60(4):583-585. Epub 2024 Jan 4 doi: 10.4103/ijc.ijc_801_21. PMID: 38189645
Tsai TH, Lee WY
Arch Pathol Lab Med 2019 May;143(5):643-647. Epub 2018 Dec 21 doi: 10.5858/arpa.2018-0024-RS. PMID: 31026220

Clinical prediction guides

Karatay H, Ozluk Y, Dogan MA, Erdem S, Kilicaslan I
Ann Diagn Pathol 2021 Oct;54:151788. Epub 2021 Jul 2 doi: 10.1016/j.anndiagpath.2021.151788. PMID: 34246177

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