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FGFR3 Gene Translocation

MedGen UID:
1663033
•Concept ID:
C4725875
•
Cell or Molecular Dysfunction
Synonyms: CD333 Gene Translocation; FGFR-3 Gene Translocation; Fibroblast Growth Factor Receptor 3 Gene Translocation; JKT4 Gene Translocation

Definition

A cytogenetic abnormality that refers to any translocation involving the FGFR3 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFGFR3 Gene Translocation

Professional guidelines

PubMed

The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma.
Szudy-Szczyrek A, Mlak R, Mazurek M, Krajka T, Chocholska S, Bitkowska P, Jutrzenka M, Szczyrek M, Homa-Mlak I, Krajka A, Małecka-Massalska T, Hus M
Cells 2023 Mar 28;12(7) doi: 10.3390/cells12071029. PMID: 37048102Free PMC Article
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ; Fusion Analysis Working Group; Cancer Genome Atlas Research Network, Chen K, Lazar AJ, Fields RC, Wendl MC, Van Tine BA, Vij R, Chen F, Nykter M, Shmulevich I, Ding L
Cell Rep 2018 Apr 3;23(1):227-238.e3. doi: 10.1016/j.celrep.2018.03.050. PMID: 29617662Free PMC Article

Recent clinical studies

Etiology

Targetable gene fusions and aberrations in genitourinary oncology.
Pederzoli F, Bandini M, Marandino L, Ali SM, Madison R, Chung J, Ross JS, Necchi A
Nat Rev Urol 2020 Nov;17(11):613-625. Epub 2020 Oct 12 doi: 10.1038/s41585-020-00379-4. PMID: 33046892
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ; Fusion Analysis Working Group; Cancer Genome Atlas Research Network, Chen K, Lazar AJ, Fields RC, Wendl MC, Van Tine BA, Vij R, Chen F, Nykter M, Shmulevich I, Ding L
Cell Rep 2018 Apr 3;23(1):227-238.e3. doi: 10.1016/j.celrep.2018.03.050. PMID: 29617662Free PMC Article
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Walker BA, Boyle EM, Wardell CP, Murison A, Begum DB, Dahir NM, Proszek PZ, Johnson DC, Kaiser MF, Melchor L, Aronson LI, Scales M, Pawlyn C, Mirabella F, Jones JR, Brioli A, Mikulasova A, Cairns DA, Gregory WM, Quartilho A, Drayson MT, Russell N, Cook G, Jackson GH, Leleu X, Davies FE, Morgan GJ
J Clin Oncol 2015 Nov 20;33(33):3911-20. Epub 2015 Aug 17 doi: 10.1200/JCO.2014.59.1503. PMID: 26282654Free PMC Article
Advances in the pathogenesis and diagnosis of multiple myeloma.
Chesi M, Bergsagel PL
Int J Lab Hematol 2015 May;37 Suppl 1:108-14. doi: 10.1111/ijlh.12360. PMID: 25976968
Many multiple myelomas: making more of the molecular mayhem.
Chesi M, Bergsagel PL
Hematology Am Soc Hematol Educ Program 2011;2011:344-53. doi: 10.1182/asheducation-2011.1.344. PMID: 22160056Free PMC Article

Diagnosis

Molecular basis of multiple myeloma.
Nižňanská D, Vlachová M, Gregorová J, Kotašková J, Jarošová M, Ševčíková S
Klin Onkol 2024;38(1):27-33. doi: 10.48095/ccko202427. PMID: 39183548
Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.
Walker BA, Mavrommatis K, Wardell CP, Ashby TC, Bauer M, Davies FE, Rosenthal A, Wang H, Qu P, Hoering A, Samur M, Towfic F, Ortiz M, Flynt E, Yu Z, Yang Z, Rozelle D, Obenauer J, Trotter M, Auclair D, Keats J, Bolli N, Fulciniti M, Szalat R, Moreau P, Durie B, Stewart AK, Goldschmidt H, Raab MS, Einsele H, Sonneveld P, San Miguel J, Lonial S, Jackson GH, Anderson KC, Avet-Loiseau H, Munshi N, Thakurta A, Morgan GJ
Blood 2018 Aug 9;132(6):587-597. Epub 2018 Jun 8 doi: 10.1182/blood-2018-03-840132. PMID: 29884741Free PMC Article
The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing.
Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R
Clin Cancer Res 2016 Jan 1;22(1):259-67. Epub 2015 Sep 15 doi: 10.1158/1078-0432.CCR-14-3212. PMID: 26373574
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Walker BA, Boyle EM, Wardell CP, Murison A, Begum DB, Dahir NM, Proszek PZ, Johnson DC, Kaiser MF, Melchor L, Aronson LI, Scales M, Pawlyn C, Mirabella F, Jones JR, Brioli A, Mikulasova A, Cairns DA, Gregory WM, Quartilho A, Drayson MT, Russell N, Cook G, Jackson GH, Leleu X, Davies FE, Morgan GJ
J Clin Oncol 2015 Nov 20;33(33):3911-20. Epub 2015 Aug 17 doi: 10.1200/JCO.2014.59.1503. PMID: 26282654Free PMC Article
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246

Therapy

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ; Fusion Analysis Working Group; Cancer Genome Atlas Research Network, Chen K, Lazar AJ, Fields RC, Wendl MC, Van Tine BA, Vij R, Chen F, Nykter M, Shmulevich I, Ding L
Cell Rep 2018 Apr 3;23(1):227-238.e3. doi: 10.1016/j.celrep.2018.03.050. PMID: 29617662Free PMC Article
A place for precision medicine in bladder cancer: targeting the FGFRs.
di Martino E, Tomlinson DC, Williams SV, Knowles MA
Future Oncol 2016 Oct;12(19):2243-63. Epub 2016 Jul 6 doi: 10.2217/fon-2016-0042. PMID: 27381494Free PMC Article
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Walker BA, Boyle EM, Wardell CP, Murison A, Begum DB, Dahir NM, Proszek PZ, Johnson DC, Kaiser MF, Melchor L, Aronson LI, Scales M, Pawlyn C, Mirabella F, Jones JR, Brioli A, Mikulasova A, Cairns DA, Gregory WM, Quartilho A, Drayson MT, Russell N, Cook G, Jackson GH, Leleu X, Davies FE, Morgan GJ
J Clin Oncol 2015 Nov 20;33(33):3911-20. Epub 2015 Aug 17 doi: 10.1200/JCO.2014.59.1503. PMID: 26282654Free PMC Article
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246
Molecular therapy for multiple myeloma.
Martinelli G, Tosi P, Ottaviani E, Soverini S, Tura S
Haematologica 2001 Sep;86(9):908-17. PMID: 11532618

Prognosis

FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression.
Huang YC, Chen WC, Yu CL, Chang TK, I-Chin Wei A, Chang TM, Liu JF, Wang SW
Biochem Pharmacol 2023 Dec;218:115853. Epub 2023 Oct 11 doi: 10.1016/j.bcp.2023.115853. PMID: 37832794
Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.
Walker BA, Mavrommatis K, Wardell CP, Ashby TC, Bauer M, Davies FE, Rosenthal A, Wang H, Qu P, Hoering A, Samur M, Towfic F, Ortiz M, Flynt E, Yu Z, Yang Z, Rozelle D, Obenauer J, Trotter M, Auclair D, Keats J, Bolli N, Fulciniti M, Szalat R, Moreau P, Durie B, Stewart AK, Goldschmidt H, Raab MS, Einsele H, Sonneveld P, San Miguel J, Lonial S, Jackson GH, Anderson KC, Avet-Loiseau H, Munshi N, Thakurta A, Morgan GJ
Blood 2018 Aug 9;132(6):587-597. Epub 2018 Jun 8 doi: 10.1182/blood-2018-03-840132. PMID: 29884741Free PMC Article
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ; Fusion Analysis Working Group; Cancer Genome Atlas Research Network, Chen K, Lazar AJ, Fields RC, Wendl MC, Van Tine BA, Vij R, Chen F, Nykter M, Shmulevich I, Ding L
Cell Rep 2018 Apr 3;23(1):227-238.e3. doi: 10.1016/j.celrep.2018.03.050. PMID: 29617662Free PMC Article
The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing.
Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R
Clin Cancer Res 2016 Jan 1;22(1):259-67. Epub 2015 Sep 15 doi: 10.1158/1078-0432.CCR-14-3212. PMID: 26373574
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Walker BA, Boyle EM, Wardell CP, Murison A, Begum DB, Dahir NM, Proszek PZ, Johnson DC, Kaiser MF, Melchor L, Aronson LI, Scales M, Pawlyn C, Mirabella F, Jones JR, Brioli A, Mikulasova A, Cairns DA, Gregory WM, Quartilho A, Drayson MT, Russell N, Cook G, Jackson GH, Leleu X, Davies FE, Morgan GJ
J Clin Oncol 2015 Nov 20;33(33):3911-20. Epub 2015 Aug 17 doi: 10.1200/JCO.2014.59.1503. PMID: 26282654Free PMC Article

Clinical prediction guides

FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression.
Huang YC, Chen WC, Yu CL, Chang TK, I-Chin Wei A, Chang TM, Liu JF, Wang SW
Biochem Pharmacol 2023 Dec;218:115853. Epub 2023 Oct 11 doi: 10.1016/j.bcp.2023.115853. PMID: 37832794
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ; Fusion Analysis Working Group; Cancer Genome Atlas Research Network, Chen K, Lazar AJ, Fields RC, Wendl MC, Van Tine BA, Vij R, Chen F, Nykter M, Shmulevich I, Ding L
Cell Rep 2018 Apr 3;23(1):227-238.e3. doi: 10.1016/j.celrep.2018.03.050. PMID: 29617662Free PMC Article
The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing.
Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R
Clin Cancer Res 2016 Jan 1;22(1):259-67. Epub 2015 Sep 15 doi: 10.1158/1078-0432.CCR-14-3212. PMID: 26373574
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Walker BA, Boyle EM, Wardell CP, Murison A, Begum DB, Dahir NM, Proszek PZ, Johnson DC, Kaiser MF, Melchor L, Aronson LI, Scales M, Pawlyn C, Mirabella F, Jones JR, Brioli A, Mikulasova A, Cairns DA, Gregory WM, Quartilho A, Drayson MT, Russell N, Cook G, Jackson GH, Leleu X, Davies FE, Morgan GJ
J Clin Oncol 2015 Nov 20;33(33):3911-20. Epub 2015 Aug 17 doi: 10.1200/JCO.2014.59.1503. PMID: 26282654Free PMC Article
Molecular aspects of multiple myeloma.
Kastrinakis NG, Gorgoulis VG, Foukas PG, Dimopoulos MA, Kittas C
Ann Oncol 2000 Oct;11(10):1217-28. doi: 10.1023/a:1008331714186. PMID: 11106109

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