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FGFR Gene Translocation

MedGen UID:
856694
Concept ID:
C3897100
Cell or Molecular Dysfunction
Synonyms: FGF Receptor Gene Family Translocation; FGF Receptor Gene Translocation; FGFR Family Gene Translocation; FGFR Family Translocation; Fibroblast Growth Factor Receptor Gene Family Translocation; Fibroblast Growth Factor Receptor Gene Translocation

Definition

A cytogenetic abnormality that refers to the translocation of an FGFR family gene to a new chromosomal location. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Kutkowska-Kaźmierczak A, Gos M, Obersztyn E
J Appl Genet 2018 May;59(2):133-147. Epub 2018 Feb 1 doi: 10.1007/s13353-017-0423-4. PMID: 29392564
Tiseo M, Gelsomino F, Alfieri R, Cavazzoni A, Bozzetti C, De Giorgi AM, Petronini PG, Ardizzoni A
Cancer Treat Rev 2015 Jun;41(6):527-39. Epub 2015 May 1 doi: 10.1016/j.ctrv.2015.04.011. PMID: 25959741

Recent clinical studies

Etiology

Pederzoli F, Bandini M, Marandino L, Ali SM, Madison R, Chung J, Ross JS, Necchi A
Nat Rev Urol 2020 Nov;17(11):613-625. Epub 2020 Oct 12 doi: 10.1038/s41585-020-00379-4. PMID: 33046892
Javle M, Lowery M, Shroff RT, Weiss KH, Springfeld C, Borad MJ, Ramanathan RK, Goyal L, Sadeghi S, Macarulla T, El-Khoueiry A, Kelley RK, Borbath I, Choo SP, Oh DY, Philip PA, Chen LT, Reungwetwattana T, Van Cutsem E, Yeh KH, Ciombor K, Finn RS, Patel A, Sen S, Porter D, Isaacs R, Zhu AX, Abou-Alfa GK, Bekaii-Saab T
J Clin Oncol 2018 Jan 20;36(3):276-282. Epub 2017 Nov 28 doi: 10.1200/JCO.2017.75.5009. PMID: 29182496Free PMC Article
di Martino E, Tomlinson DC, Williams SV, Knowles MA
Future Oncol 2016 Oct;12(19):2243-63. Epub 2016 Jul 6 doi: 10.2217/fon-2016-0042. PMID: 27381494Free PMC Article
Capelletti M, Dodge ME, Ercan D, Hammerman PS, Park SI, Kim J, Sasaki H, Jablons DM, Lipson D, Young L, Stephens PJ, Miller VA, Lindeman NI, Munir KJ, Richards WG, Jänne PA
Clin Cancer Res 2014 Dec 15;20(24):6551-8. Epub 2014 Oct 7 doi: 10.1158/1078-0432.CCR-14-1337. PMID: 25294908
Macdonald D, Cross NC
Pathobiology 2007;74(2):81-8. doi: 10.1159/000101707. PMID: 17587879

Diagnosis

Qiu T, Hou L, Zhao L, Wang X, Zhou Z, Yang C, Zhang H, Jiang D, Jiao B, Chen C
J Biol Chem 2023 Nov;299(11):105351. Epub 2023 Oct 12 doi: 10.1016/j.jbc.2023.105351. PMID: 37838174Free PMC Article
Phan T, Tong J, Krivanek M, Graf N, Dexter M, Tumuluri K
Ophthalmic Plast Reconstr Surg 2023 May-Jun 01;39(3):206-210. Epub 2022 Oct 20 doi: 10.1097/IOP.0000000000002287. PMID: 36356178
Lasorella A, Sanson M, Iavarone A
Neuro Oncol 2017 Apr 1;19(4):475-483. doi: 10.1093/neuonc/now240. PMID: 27852792Free PMC Article
Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R
Clin Cancer Res 2016 Jan 1;22(1):259-67. Epub 2015 Sep 15 doi: 10.1158/1078-0432.CCR-14-3212. PMID: 26373574
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246

Therapy

Pacini L, Jenks AD, Lima NC, Huang PH
Cells 2021 May 10;10(5) doi: 10.3390/cells10051154. PMID: 34068816Free PMC Article
Servetto A, Kollipara R, Formisano L, Lin CC, Lee KM, Sudhan DR, Gonzalez-Ericsson PI, Chatterjee S, Guerrero-Zotano A, Mendiratta S, Akamatsu H, James N, Bianco R, Hanker AB, Kittler R, Arteaga CL
Clin Cancer Res 2021 Aug 1;27(15):4379-4396. Epub 2021 May 19 doi: 10.1158/1078-0432.CCR-20-3905. PMID: 34011560Free PMC Article
Bedussi F, Bottini A, Memo M, Fox SB, Sigala S, Generali D
Expert Opin Ther Targets 2014 Jun;18(6):665-78. Epub 2014 Mar 20 doi: 10.1517/14728222.2014.898064. PMID: 24833241
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246
Wesche J, Haglund K, Haugsten EM
Biochem J 2011 Jul 15;437(2):199-213. doi: 10.1042/BJ20101603. PMID: 21711248

Prognosis

Qiu T, Hou L, Zhao L, Wang X, Zhou Z, Yang C, Zhang H, Jiang D, Jiao B, Chen C
J Biol Chem 2023 Nov;299(11):105351. Epub 2023 Oct 12 doi: 10.1016/j.jbc.2023.105351. PMID: 37838174Free PMC Article
Pacini L, Jenks AD, Lima NC, Huang PH
Cells 2021 May 10;10(5) doi: 10.3390/cells10051154. PMID: 34068816Free PMC Article
Li F, Peiris MN, Donoghue DJ
Cytokine Growth Factor Rev 2020 Apr;52:56-67. Epub 2019 Dec 19 doi: 10.1016/j.cytogfr.2019.12.005. PMID: 31899106
di Martino E, Tomlinson DC, Williams SV, Knowles MA
Future Oncol 2016 Oct;12(19):2243-63. Epub 2016 Jul 6 doi: 10.2217/fon-2016-0042. PMID: 27381494Free PMC Article
Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R
Clin Cancer Res 2016 Jan 1;22(1):259-67. Epub 2015 Sep 15 doi: 10.1158/1078-0432.CCR-14-3212. PMID: 26373574

Clinical prediction guides

Pacini L, Jenks AD, Lima NC, Huang PH
Cells 2021 May 10;10(5) doi: 10.3390/cells10051154. PMID: 34068816Free PMC Article
Chae YK, Ranganath K, Hammerman PS, Vaklavas C, Mohindra N, Kalyan A, Matsangou M, Costa R, Carneiro B, Villaflor VM, Cristofanilli M, Giles FJ
Oncotarget 2017 Feb 28;8(9):16052-16074. doi: 10.18632/oncotarget.14109. PMID: 28030802Free PMC Article
Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R
Clin Cancer Res 2016 Jan 1;22(1):259-67. Epub 2015 Sep 15 doi: 10.1158/1078-0432.CCR-14-3212. PMID: 26373574
Tiseo M, Gelsomino F, Alfieri R, Cavazzoni A, Bozzetti C, De Giorgi AM, Petronini PG, Ardizzoni A
Cancer Treat Rev 2015 Jun;41(6):527-39. Epub 2015 May 1 doi: 10.1016/j.ctrv.2015.04.011. PMID: 25959741
Bedussi F, Bottini A, Memo M, Fox SB, Sigala S, Generali D
Expert Opin Ther Targets 2014 Jun;18(6):665-78. Epub 2014 Mar 20 doi: 10.1517/14728222.2014.898064. PMID: 24833241

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