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Metastatic Nasopharyngeal Keratinizing Squamous Cell Carcinoma

MedGen UID:
1663213
•Concept ID:
C4744550
•
Neoplastic Process

Definition

A keratinizing squamous cell carcinoma that arises from the nasopharynx and has metastasized to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Nasopharyngeal Keratinizing Squamous Cell Carcinoma

Professional guidelines

PubMed

Biology and treatment of nasopharyngeal cancer.
Fandi A, Cvitkovic E
Curr Opin Oncol 1995 May;7(3):255-63. doi: 10.1097/00001622-199505000-00011. PMID: 7654828
Computed tomographic density of metastatic lymph nodes as a treatment-related prognostic factor in advanced head and neck cancer.
Munck JN, Cvitkovic E, Piekarski JD, Benhamou E, Recondo G, Bachouchi M, Tellez-Bernal E, Luboinski B, Eschwege F, Wibault P
J Natl Cancer Inst 1991 Apr 17;83(8):569-75. doi: 10.1093/jnci/83.8.569. PMID: 1848639
Nasopharyngeal carcinoma. Clinical presentation, diagnosis, treatment, and prognosis.
Neel HB 3rd
Otolaryngol Clin North Am 1985 Aug;18(3):479-90. PMID: 2995899

Recent clinical studies

Etiology

CXCL8, MMP1, MMP2, and FN1 Gene Expression and Tumor Extension in Nasopharyngeal Cancer Patients: A Cross-sectional Study.
Cahyanur R, Irawan C, Lisnawati L, Adham M, Kamal AF, Utomo ARH, Hardianti MS, Mansyur M, Salamah T
Acta Med Indones 2023 Jul;55(3):261-268. PMID: 37915157
Construction of Prognostic Nomogram in Patients with N3-Stage Nasopharyngeal Carcinoma.
Cao W, Li X, Yang J, Xing E, Wu W, Ge Y, Wang B
ORL J Otorhinolaryngol Relat Spec 2023;85(4):195-207. Epub 2023 May 5 doi: 10.1159/000530053. PMID: 37232012
SSTR2a is constantly expressed in lymphoepithelioma-like carcinoma with squamous differentiation other than that with glandular differentiation.
Tao L, Chen Y, Huang Y, Yin W, Yu G
J Clin Pathol 2021 Nov;74(11):704-708. Epub 2020 Nov 1 doi: 10.1136/jclinpath-2020-206903. PMID: 33132215
Lymph Node Status and Outcomes for Nasopharyngeal Carcinoma According to Histological Subtypes: A SEER Population-Based Retrospective Analysis.
Guo R, Wu H, Wang J, Lian CL, He ZY, Zhang WW, Chen YX, Wu SG
Adv Ther 2019 Nov;36(11):3123-3133. Epub 2019 Sep 26 doi: 10.1007/s12325-019-01100-7. PMID: 31559602
Radiotherapy for elderly patients and cetuximab, a monocentric study.
Falk AT, Hébert C, Tran A, Chand ME, Leysalle A, Thariat J, Dassonville O, Poissonnet G, Bozec A, Saada E, Peyrade F, Benezery K
Eur Arch Otorhinolaryngol 2017 Feb;274(2):1061-1065. Epub 2016 Oct 11 doi: 10.1007/s00405-016-4336-3. PMID: 27730326

Diagnosis

SSTR2a is constantly expressed in lymphoepithelioma-like carcinoma with squamous differentiation other than that with glandular differentiation.
Tao L, Chen Y, Huang Y, Yin W, Yu G
J Clin Pathol 2021 Nov;74(11):704-708. Epub 2020 Nov 1 doi: 10.1136/jclinpath-2020-206903. PMID: 33132215
Metastatic Patterns and Prognosis of de novo Metastatic Nasopharyngeal Carcinoma in the United States.
Xu Y, Huang T, Mao M, Zhai J, Chen J
Laryngoscope 2021 Apr;131(4):E1130-E1138. Epub 2020 Aug 24 doi: 10.1002/lary.28983. PMID: 32833262
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223
Undifferentiated nasopharyngeal cancer (UCNT): current diagnostic and therapeutic aspects.
Altun M, Fandi A, Dupuis O, Cvitkovic E, Krajina Z, Eschwege F
Int J Radiat Oncol Biol Phys 1995 Jun 15;32(3):859-77. doi: 10.1016/0360-3016(95)00516-2. PMID: 7790274
Biology and treatment of nasopharyngeal cancer.
Fandi A, Cvitkovic E
Curr Opin Oncol 1995 May;7(3):255-63. doi: 10.1097/00001622-199505000-00011. PMID: 7654828

Therapy

Taxane-based Induction Chemotherapy Plus Concurrent Chemoradiotherapy in Nasopharyngeal Carcinoma: Prospective Results from a Non-endemic Cohort.
Ghosh-Laskar S, Pilar A, Prabhash K, Joshi A, Agarwal JP, Gupta T, Budrukkar A, Murthy V, Swain M, Noronha V, Patil VM, Pai P, Nair D, Chaukar DA, Thiagarajan S, Pantvaidya G, Deshmukh A, Chaturvedi P, Nair S, D'Cruz A
Clin Oncol (R Coll Radiol) 2019 Dec;31(12):850-857. Epub 2019 Jul 8 doi: 10.1016/j.clon.2019.06.011. PMID: 31296457
Radiotherapy for elderly patients and cetuximab, a monocentric study.
Falk AT, Hébert C, Tran A, Chand ME, Leysalle A, Thariat J, Dassonville O, Poissonnet G, Bozec A, Saada E, Peyrade F, Benezery K
Eur Arch Otorhinolaryngol 2017 Feb;274(2):1061-1065. Epub 2016 Oct 11 doi: 10.1007/s00405-016-4336-3. PMID: 27730326
The significance of keratinizing squamous cell histology in Chinese patients with nasopharyngeal carcinoma.
Chan AT, Teo ML, Lee WY, Kwan WH, Choi PH, Johnson PJ
Clin Oncol (R Coll Radiol) 1998;10(3):161-4. doi: 10.1016/s0936-6555(98)80057-5. PMID: 9704177
Undifferentiated nasopharyngeal cancer (UCNT): current diagnostic and therapeutic aspects.
Altun M, Fandi A, Dupuis O, Cvitkovic E, Krajina Z, Eschwege F
Int J Radiat Oncol Biol Phys 1995 Jun 15;32(3):859-77. doi: 10.1016/0360-3016(95)00516-2. PMID: 7790274
Nasopharyngeal carcinoma. Clinical presentation, diagnosis, treatment, and prognosis.
Neel HB 3rd
Otolaryngol Clin North Am 1985 Aug;18(3):479-90. PMID: 2995899

Prognosis

Metastatic Patterns and Prognosis of de novo Metastatic Nasopharyngeal Carcinoma in the United States.
Xu Y, Huang T, Mao M, Zhai J, Chen J
Laryngoscope 2021 Apr;131(4):E1130-E1138. Epub 2020 Aug 24 doi: 10.1002/lary.28983. PMID: 32833262
Lymph Node Status and Outcomes for Nasopharyngeal Carcinoma According to Histological Subtypes: A SEER Population-Based Retrospective Analysis.
Guo R, Wu H, Wang J, Lian CL, He ZY, Zhang WW, Chen YX, Wu SG
Adv Ther 2019 Nov;36(11):3123-3133. Epub 2019 Sep 26 doi: 10.1007/s12325-019-01100-7. PMID: 31559602
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223
Undifferentiated nasopharyngeal cancer (UCNT): current diagnostic and therapeutic aspects.
Altun M, Fandi A, Dupuis O, Cvitkovic E, Krajina Z, Eschwege F
Int J Radiat Oncol Biol Phys 1995 Jun 15;32(3):859-77. doi: 10.1016/0360-3016(95)00516-2. PMID: 7790274
Biology and treatment of nasopharyngeal cancer.
Fandi A, Cvitkovic E
Curr Opin Oncol 1995 May;7(3):255-63. doi: 10.1097/00001622-199505000-00011. PMID: 7654828

Clinical prediction guides

Construction of Prognostic Nomogram in Patients with N3-Stage Nasopharyngeal Carcinoma.
Cao W, Li X, Yang J, Xing E, Wu W, Ge Y, Wang B
ORL J Otorhinolaryngol Relat Spec 2023;85(4):195-207. Epub 2023 May 5 doi: 10.1159/000530053. PMID: 37232012
A rare case of intracytoplasmic mucin-rich nasopharyngeal carcinoma.
Yamaguchi Y, Odate T, Nakazawa K, Oishi N, Mochizuki K, Shimizu T, Horiuchi K, Ishii H, Sakurai D, Kondo T
Diagn Cytopathol 2022 Jun;50(6):E151-E155. Epub 2022 Jan 31 doi: 10.1002/dc.24934. PMID: 35100480
Metastatic Patterns and Prognosis of de novo Metastatic Nasopharyngeal Carcinoma in the United States.
Xu Y, Huang T, Mao M, Zhai J, Chen J
Laryngoscope 2021 Apr;131(4):E1130-E1138. Epub 2020 Aug 24 doi: 10.1002/lary.28983. PMID: 32833262
The developmental transcription factor IRF6 attenuates ABCG2 gene expression and distinctively reverses stemness phenotype in nasopharyngeal carcinoma.
Xu L, Huang TJ, Hu H, Wang MY, Shi SM, Yang Q, Lin F, Qiang YY, Mei Y, Lang YH, Li CZ, Peng LX, Zheng LS, Huang JL, Li XJ, Zhang SJ, Qian CN, Huang BJ
Cancer Lett 2018 Sep 1;431:230-243. Epub 2017 Oct 27 doi: 10.1016/j.canlet.2017.10.016. PMID: 29111349
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223

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