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Metastatic Nasopharyngeal Carcinoma

MedGen UID:
235127
•Concept ID:
C1377919
•
Neoplastic Process

Definition

A carcinoma that arises from the nasopharynx and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Treatment strategy for de novo metastatic nasopharyngeal carcinoma: a literature review.
Liu Q, Li J, Ng WT, Lee AWM
Chin Clin Oncol 2023 Aug;12(4):43. doi: 10.21037/cco-23-32. PMID: 37699604
Recurrent/Metastatic Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Heading?
Juarez-Vignon Whaley JJ, Afkhami M, Onyshchenko M, Massarelli E, Sampath S, Amini A, Bell D, Villaflor VM
Curr Treat Options Oncol 2023 Sep;24(9):1138-1166. Epub 2023 Jun 15 doi: 10.1007/s11864-023-01101-3. PMID: 37318724Free PMC Article
Treatment for metastatic nasopharyngeal carcinoma.
Bensouda Y, Kaikani W, Ahbeddou N, Rahhali R, Jabri M, Mrabti H, Boussen H, Errihani H
Eur Ann Otorhinolaryngol Head Neck Dis 2011 Apr;128(2):79-85. Epub 2010 Dec 21 doi: 10.1016/j.anorl.2010.10.003. PMID: 21177151

Recent clinical studies

Etiology

Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma: The JUPITER-02 Randomized Clinical Trial.
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi Y, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Wang S, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Luo X, Wang X, Tang X, Feng H, Yao S, Keegan P, Xu RH
JAMA 2023 Nov 28;330(20):1961-1970. doi: 10.1001/jama.2023.20181. PMID: 38015220Free PMC Article
Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial.
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi YR, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Liu Z, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Feng H, Yao S, Keegan P, Xu RH
Nat Med 2021 Sep;27(9):1536-1543. Epub 2021 Aug 2 doi: 10.1038/s41591-021-01444-0. PMID: 34341578
Camrelizumab versus placebo in combination with gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (CAPTAIN-1st): a multicentre, randomised, double-blind, phase 3 trial.
Yang Y, Qu S, Li J, Hu C, Xu M, Li W, Zhou T, Shen L, Wu H, Lang J, Hu G, Luo Z, Fu Z, Qu S, Feng W, Chen X, Lin S, Zhang W, Li X, Sun Y, Lin Z, Lin Q, Lei F, Long J, Hong J, Huang X, Zeng L, Wang P, He X, Zhang B, Yang Q, Zhang X, Zou J, Fang W, Zhang L
Lancet Oncol 2021 Aug;22(8):1162-1174. Epub 2021 Jun 23 doi: 10.1016/S1470-2045(21)00302-8. PMID: 34174189
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Gemcitabine plus cisplatin versus fluorouracil plus cisplatin in recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
Zhang L, Huang Y, Hong S, Yang Y, Yu G, Jia J, Peng P, Wu X, Lin Q, Xi X, Peng J, Xu M, Chen D, Lu X, Wang R, Cao X, Chen X, Lin Z, Xiong J, Lin Q, Xie C, Li Z, Pan J, Li J, Wu S, Lian Y, Yang Q, Zhao C
Lancet 2016 Oct 15;388(10054):1883-1892. Epub 2016 Aug 23 doi: 10.1016/S0140-6736(16)31388-5. PMID: 27567279

Diagnosis

Recurrent/Metastatic Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Heading?
Juarez-Vignon Whaley JJ, Afkhami M, Onyshchenko M, Massarelli E, Sampath S, Amini A, Bell D, Villaflor VM
Curr Treat Options Oncol 2023 Sep;24(9):1138-1166. Epub 2023 Jun 15 doi: 10.1007/s11864-023-01101-3. PMID: 37318724Free PMC Article
Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Detection and staging of recurrent or metastatic nasopharyngeal carcinoma in the era of FDG PET/MR.
Piao Y, Cao C, Xu Y, Huang S, Jiang F, Jin T, Jin Q, Hua Y, Hu Q, Chen X
Eur Arch Otorhinolaryngol 2022 Jan;279(1):353-359. Epub 2021 Mar 29 doi: 10.1007/s00405-021-06779-5. PMID: 33782748
Metastatic characteristics associated with survival of synchronous metastatic nasopharyngeal carcinoma in non-epidemic areas.
Lin M, Yang Q, You R, Zou X, Duan CY, Liu YP, Huang PY, Xie YL, Wang ZQ, Liu T, Chen SY, Hua YJ, Chen MY
Oral Oncol 2021 Apr;115:105200. Epub 2021 Feb 19 doi: 10.1016/j.oraloncology.2021.105200. PMID: 33610003
Efficacy and Safety of Locoregional Radiotherapy With Chemotherapy vs Chemotherapy Alone in De Novo Metastatic Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
You R, Liu YP, Huang PY, Zou X, Sun R, He YX, Wu YS, Shen GP, Zhang HD, Duan CY, Tan SH, Cao JY, Li JB, Xie YL, Zhang YN, Wang ZQ, Yang Q, Lin M, Jiang R, Zhang MX, Hua YJ, Tang LQ, Zhuang AH, Chen QY, Guo L, Mo HY, Chen Y, Mai HQ, Ling L, Liu Q, Chua MLK, Chen MY
JAMA Oncol 2020 Sep 1;6(9):1345-1352. doi: 10.1001/jamaoncol.2020.1808. PMID: 32701129Free PMC Article

Therapy

Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma: The JUPITER-02 Randomized Clinical Trial.
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi Y, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Wang S, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Luo X, Wang X, Tang X, Feng H, Yao S, Keegan P, Xu RH
JAMA 2023 Nov 28;330(20):1961-1970. doi: 10.1001/jama.2023.20181. PMID: 38015220Free PMC Article
Pembrolizumab monotherapy versus chemotherapy in platinum-pretreated, recurrent or metastatic nasopharyngeal cancer (KEYNOTE-122): an open-label, randomized, phase III trial.
Chan ATC, Lee VHF, Hong RL, Ahn MJ, Chong WQ, Kim SB, Ho GF, Caguioa PB, Ngamphaiboon N, Ho C, Aziz MASA, Ng QS, Yen CJ, Soparattanapaisarn N, Ngan RK, Kho SK, Tiambeng MLA, Yun T, Sriuranpong V, Algazi AP, Cheng A, Massarelli E, Swaby RF, Saraf S, Yuan J, Siu LL
Ann Oncol 2023 Mar;34(3):251-261. Epub 2022 Dec 16 doi: 10.1016/j.annonc.2022.12.007. PMID: 36535566
Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial.
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi YR, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Liu Z, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Feng H, Yao S, Keegan P, Xu RH
Nat Med 2021 Sep;27(9):1536-1543. Epub 2021 Aug 2 doi: 10.1038/s41591-021-01444-0. PMID: 34341578
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).
Ma BBY, Lim WT, Goh BC, Hui EP, Lo KW, Pettinger A, Foster NR, Riess JW, Agulnik M, Chang AYC, Chopra A, Kish JA, Chung CH, Adkins DR, Cullen KJ, Gitlitz BJ, Lim DW, To KF, Chan KCA, Lo YMD, King AD, Erlichman C, Yin J, Costello BA, Chan ATC
J Clin Oncol 2018 May 10;36(14):1412-1418. Epub 2018 Mar 27 doi: 10.1200/JCO.2017.77.0388. PMID: 29584545Free PMC Article

Prognosis

Camrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial.
Yuan L, Jia GD, Lv XF, Xie SY, Guo SS, Lin DF, Liu LT, Luo DH, Li YF, Deng SW, Guo L, Zeng MS, Cai XY, Liu SL, Sun XS, Li XY, Li SC, Chen QY, Tang LQ, Mai HQ
Nat Commun 2023 Aug 14;14(1):4893. doi: 10.1038/s41467-023-40402-x. PMID: 37580352Free PMC Article
Prognostic factors in metastatic nasopharyngeal carcinoma.
Toumi N, Ennouri S, Charfeddine I, Daoud J, Khanfir A
Braz J Otorhinolaryngol 2022 Mar-Apr;88(2):212-219. Epub 2020 Jul 4 doi: 10.1016/j.bjorl.2020.05.022. PMID: 32690385Free PMC Article
Neoantigen landscape in metastatic nasopharyngeal carcinoma.
Lin M, Zhang XL, You R, Yang Q, Zou X, Yu K, Liu YP, Zou RH, Hua YJ, Huang PY, Wang J, Zhao Q, Jiang XB, Tang J, Gu YK, Yu T, He GP, Xie YL, Wang ZQ, Liu T, Chen SY, Zuo ZX, Chen MY
Theranostics 2021;11(13):6427-6444. Epub 2021 Apr 19 doi: 10.7150/thno.53229. PMID: 33995666Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).
Ma BBY, Lim WT, Goh BC, Hui EP, Lo KW, Pettinger A, Foster NR, Riess JW, Agulnik M, Chang AYC, Chopra A, Kish JA, Chung CH, Adkins DR, Cullen KJ, Gitlitz BJ, Lim DW, To KF, Chan KCA, Lo YMD, King AD, Erlichman C, Yin J, Costello BA, Chan ATC
J Clin Oncol 2018 May 10;36(14):1412-1418. Epub 2018 Mar 27 doi: 10.1200/JCO.2017.77.0388. PMID: 29584545Free PMC Article

Clinical prediction guides

Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis.
Petit C, Lee A, Ma J, Lacas B, Ng WT, Chan ATC, Hong RL, Chen MY, Chen L, Li WF, Huang PY, Tan T, Ngan RKC, Zhu G, Mai HQ, Hui EP, Fountzilas G, Zhang L, Carmel A, Kwong DLW, Moon J, Bourhis J, Auperin A, Pignon JP, Blanchard P; MAC-NPC Collaborative Group
Lancet Oncol 2023 Jun;24(6):611-623. doi: 10.1016/S1470-2045(23)00163-8. PMID: 37269842
Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial.
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi YR, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Liu Z, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Feng H, Yao S, Keegan P, Xu RH
Nat Med 2021 Sep;27(9):1536-1543. Epub 2021 Aug 2 doi: 10.1038/s41591-021-01444-0. PMID: 34341578
Neoantigen landscape in metastatic nasopharyngeal carcinoma.
Lin M, Zhang XL, You R, Yang Q, Zou X, Yu K, Liu YP, Zou RH, Hua YJ, Huang PY, Wang J, Zhao Q, Jiang XB, Tang J, Gu YK, Yu T, He GP, Xie YL, Wang ZQ, Liu T, Chen SY, Zuo ZX, Chen MY
Theranostics 2021;11(13):6427-6444. Epub 2021 Apr 19 doi: 10.7150/thno.53229. PMID: 33995666Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Efficacy and Safety of Locoregional Radiotherapy With Chemotherapy vs Chemotherapy Alone in De Novo Metastatic Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
You R, Liu YP, Huang PY, Zou X, Sun R, He YX, Wu YS, Shen GP, Zhang HD, Duan CY, Tan SH, Cao JY, Li JB, Xie YL, Zhang YN, Wang ZQ, Yang Q, Lin M, Jiang R, Zhang MX, Hua YJ, Tang LQ, Zhuang AH, Chen QY, Guo L, Mo HY, Chen Y, Mai HQ, Ling L, Liu Q, Chua MLK, Chen MY
JAMA Oncol 2020 Sep 1;6(9):1345-1352. doi: 10.1001/jamaoncol.2020.1808. PMID: 32701129Free PMC Article

Recent systematic reviews

Efficacy and Safety of Cell-based Immunotherapy in The Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma - A Systematic Review and Meta-analysis.
Yeo BSY, Lee RS, Lim NE, Tan E, Jang IJH, Toh HC, Lim CM
Oral Oncol 2024 May;152:106786. Epub 2024 Apr 13 doi: 10.1016/j.oraloncology.2024.106786. PMID: 38615584
Efficacy and Safety of Immune Checkpoint Inhibitors Combined With Chemotherapy as First-line Treatment for Recurrent or Metastatic Nasopharyngeal Carcinoma: A Network Meta-analysis of Randomized Controlled Trials.
Sun H, Bu F, Li L, Zhang X, Xin X, Yan J, Huang T
Ann Pharmacother 2024 Apr;58(4):349-359. Epub 2023 Jul 24 doi: 10.1177/10600280231188171. PMID: 37488978
Efficacy and safety of PD-1 inhibitors in recurrent or metastatic nasopharyngeal carcinoma patients after failure of platinum-containing regimens: a systematic review and meta-analysis.
Luo J, Xiao W, Hua F, Cao Y, Wang D, Wang X
BMC Cancer 2023 Nov 30;23(1):1172. doi: 10.1186/s12885-023-11318-y. PMID: 38037076Free PMC Article
The efficacy and safety of PD-1/PD-L1 inhibitors in patients with recurrent or metastatic nasopharyngeal carcinoma: A systematic review and meta-analysis.
Wang BC, Cao RB, Fu C, Chen WB, Li PD, Lin GH, Qian XJ, Li YT, Liu Q
Oral Oncol 2020 May;104:104640. Epub 2020 Mar 14 doi: 10.1016/j.oraloncology.2020.104640. PMID: 32182550
Systemic therapies for recurrent or metastatic nasopharyngeal carcinoma: a systematic review.
Prawira A, Oosting SF, Chen TW, Delos Santos KA, Saluja R, Wang L, Siu LL, Chan KKW, Hansen AR
Br J Cancer 2017 Dec 5;117(12):1743-1752. Epub 2017 Oct 24 doi: 10.1038/bjc.2017.357. PMID: 29065104Free PMC Article

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