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Thoracic Esophagus Squamous Cell Carcinoma

MedGen UID:
1665515
•Concept ID:
C4725595
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the thoracic esophagus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThoracic Esophagus Squamous Cell Carcinoma

Professional guidelines

PubMed

Development and validation of a radiomics signature on differentially expressed features of (18)F-FDG PET to predict treatment response of concurrent chemoradiotherapy in thoracic esophagus squamous cell carcinoma.
Cao Q, Li Y, Li Z, An D, Li B, Lin Q
Radiother Oncol 2020 May;146:9-15. Epub 2020 Feb 14 doi: 10.1016/j.radonc.2020.01.027. PMID: 32065875

Recent clinical studies

Etiology

A fibroblast-associated signature predicts prognosis and immunotherapy in esophageal squamous cell cancer.
Ren Q, Zhang P, Zhang X, Feng Y, Li L, Lin H, Yu Y
Front Immunol 2023;14:1199040. Epub 2023 May 29 doi: 10.3389/fimmu.2023.1199040. PMID: 37313409Free PMC Article
Esophagus cancer and essential trace elements.
Yang X, Tang Z, Li J, Jiang J
Front Public Health 2022;10:1038153. Epub 2022 Nov 16 doi: 10.3389/fpubh.2022.1038153. PMID: 36466456Free PMC Article
Update on Management of Squamous Cell Esophageal Cancer.
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
A multi-omics study delineates new molecular features and therapeutic targets for esophageal squamous cell carcinoma.
Jin X, Liu L, Wu J, Jin X, Yu G, Jia L, Wang F, Shi M, Lu H, Liu J, Liu D, Yang J, Li H, Ni Y, Luo Q, Jia W, Wang W, Chen WL
Clin Transl Med 2021 Sep;11(9):e538. doi: 10.1002/ctm2.538. PMID: 34586744Free PMC Article
How Many Nodes Need to be Removed to Make Esophagectomy an Adequate Cancer Operation, and Does the Number Change When a Patient has Chemoradiotherapy Before Surgery?
Yeung JC, Bains MS, Barbetta A, Nobel T, DeMeester SR, Louie BE, Orringer MB, Martin LW, Reddy RM, Schlottmann F, Molena D
Ann Surg Oncol 2020 Apr;27(4):1227-1232. Epub 2019 Oct 11 doi: 10.1245/s10434-019-07870-2. PMID: 31605332Free PMC Article

Diagnosis

Advances in diagnosis and management of cancer of the esophagus.
Deboever N, Jones CM, Yamashita K, Ajani JA, Hofstetter WL
BMJ 2024 Jun 3;385:e074962. doi: 10.1136/bmj-2023-074962. PMID: 38830686
Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma.
Liu Z, Zhao Y, Kong P, Liu Y, Huang J, Xu E, Wei W, Li G, Cheng X, Xue L, Li Y, Chen H, Wei S, Sun R, Cui H, Meng Y, Liu M, Li Y, Feng R, Yu X, Zhu R, Wu Y, Li L, Yang B, Ma Y, Wang J, Zhu W, Deng D, Xi Y, Wang F, Li H, Guo S, Zhuang X, Wang X, Jiao Y, Cui Y, Zhan Q
Cancer Cell 2023 Jan 9;41(1):181-195.e9. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.004. PMID: 36584672
SYNGR2 serves as a prognostic biomarker and correlates with immune infiltrates in esophageal squamous cell carcinoma.
Li B, Ren MY, Chen YZ, Meng YQ, Song TN, Su ZP, Yang B
J Gene Med 2022 Aug;24(8):e3441. Epub 2022 Aug 1 doi: 10.1002/jgm.3441. PMID: 35840542
Untargeted metabolomics analysis of esophageal squamous cell cancer progression.
Yang T, Hui R, Nouws J, Sauler M, Zeng T, Wu Q
J Transl Med 2022 Mar 14;20(1):127. doi: 10.1186/s12967-022-03311-z. PMID: 35287685Free PMC Article
Update on Management of Squamous Cell Esophageal Cancer.
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974

Therapy

Neoadjuvant adebrelimab in locally advanced resectable esophageal squamous cell carcinoma: a phase 1b trial.
Yin J, Yuan J, Li Y, Fang Y, Wang R, Jiao H, Tang H, Zhang S, Lin S, Su F, Gu J, Jiang T, Lin D, Huang Z, Du C, Wu K, Tan L, Zhou Q
Nat Med 2023 Aug;29(8):2068-2078. Epub 2023 Jul 24 doi: 10.1038/s41591-023-02469-3. PMID: 37488287Free PMC Article
Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma.
Liu Z, Zhao Y, Kong P, Liu Y, Huang J, Xu E, Wei W, Li G, Cheng X, Xue L, Li Y, Chen H, Wei S, Sun R, Cui H, Meng Y, Liu M, Li Y, Feng R, Yu X, Zhu R, Wu Y, Li L, Yang B, Ma Y, Wang J, Zhu W, Deng D, Xi Y, Wang F, Li H, Guo S, Zhuang X, Wang X, Jiao Y, Cui Y, Zhan Q
Cancer Cell 2023 Jan 9;41(1):181-195.e9. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.004. PMID: 36584672
Optimizing Sarcopenia to Strengthen Patient Outcomes After Lung and Esophageal Surgery.
Tasnim S, Sudarshan M
Ann Surg Oncol 2022 Nov;29(12):7242-7243. Epub 2022 Jul 30 doi: 10.1245/s10434-022-12303-8. PMID: 35907996
Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial.
Lu Z, Wang J, Shu Y, Liu L, Kong L, Yang L, Wang B, Sun G, Ji Y, Cao G, Liu H, Cui T, Li N, Qiu W, Li G, Hou X, Luo H, Xue L, Zhang Y, Yue W, Liu Z, Wang X, Gao S, Pan Y, Galais MP, Zaanan A, Ma Z, Li H, Wang Y, Shen L; ORIENT-15 study group
BMJ 2022 Apr 19;377:e068714. doi: 10.1136/bmj-2021-068714. PMID: 35440464Free PMC Article
Update on Management of Squamous Cell Esophageal Cancer.
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974

Prognosis

Progenitor-like exhausted SPRY1(+)CD8(+) T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma.
Liu Z, Zhang Y, Ma N, Yang Y, Ma Y, Wang F, Wang Y, Wei J, Chen H, Tartarone A, Velotta JB, Dayyani F, Gabriel E, Wakefield CJ, Kidane B, Carbonelli C, Long L, Liu Z, Su J, Li Z
Cancer Cell 2023 Nov 13;41(11):1852-1870.e9. Epub 2023 Oct 12 doi: 10.1016/j.ccell.2023.09.011. PMID: 37832554
A fibroblast-associated signature predicts prognosis and immunotherapy in esophageal squamous cell cancer.
Ren Q, Zhang P, Zhang X, Feng Y, Li L, Lin H, Yu Y
Front Immunol 2023;14:1199040. Epub 2023 May 29 doi: 10.3389/fimmu.2023.1199040. PMID: 37313409Free PMC Article
SYNGR2 serves as a prognostic biomarker and correlates with immune infiltrates in esophageal squamous cell carcinoma.
Li B, Ren MY, Chen YZ, Meng YQ, Song TN, Su ZP, Yang B
J Gene Med 2022 Aug;24(8):e3441. Epub 2022 Aug 1 doi: 10.1002/jgm.3441. PMID: 35840542
Untargeted metabolomics analysis of esophageal squamous cell cancer progression.
Yang T, Hui R, Nouws J, Sauler M, Zeng T, Wu Q
J Transl Med 2022 Mar 14;20(1):127. doi: 10.1186/s12967-022-03311-z. PMID: 35287685Free PMC Article
Update on Management of Squamous Cell Esophageal Cancer.
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974

Clinical prediction guides

Progenitor-like exhausted SPRY1(+)CD8(+) T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma.
Liu Z, Zhang Y, Ma N, Yang Y, Ma Y, Wang F, Wang Y, Wei J, Chen H, Tartarone A, Velotta JB, Dayyani F, Gabriel E, Wakefield CJ, Kidane B, Carbonelli C, Long L, Liu Z, Su J, Li Z
Cancer Cell 2023 Nov 13;41(11):1852-1870.e9. Epub 2023 Oct 12 doi: 10.1016/j.ccell.2023.09.011. PMID: 37832554
A fibroblast-associated signature predicts prognosis and immunotherapy in esophageal squamous cell cancer.
Ren Q, Zhang P, Zhang X, Feng Y, Li L, Lin H, Yu Y
Front Immunol 2023;14:1199040. Epub 2023 May 29 doi: 10.3389/fimmu.2023.1199040. PMID: 37313409Free PMC Article
Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma.
Liu Z, Zhao Y, Kong P, Liu Y, Huang J, Xu E, Wei W, Li G, Cheng X, Xue L, Li Y, Chen H, Wei S, Sun R, Cui H, Meng Y, Liu M, Li Y, Feng R, Yu X, Zhu R, Wu Y, Li L, Yang B, Ma Y, Wang J, Zhu W, Deng D, Xi Y, Wang F, Li H, Guo S, Zhuang X, Wang X, Jiao Y, Cui Y, Zhan Q
Cancer Cell 2023 Jan 9;41(1):181-195.e9. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.004. PMID: 36584672
First-line nivolumab plus ipilimumab or chemotherapy versus chemotherapy alone in advanced esophageal squamous cell carcinoma: a Japanese subgroup analysis of open-label, phase 3 trial (CheckMate 648/ONO-4538-50).
Kato K, Doki Y, Ogata T, Motoyama S, Kawakami H, Ueno M, Kojima T, Shirakawa Y, Okada M, Ishihara R, Kubota Y, Amaya-Chanaga C, Chen T, Matsumura Y, Kitagawa Y
Esophagus 2023 Apr;20(2):291-301. Epub 2022 Nov 19 doi: 10.1007/s10388-022-00970-1. PMID: 36401133Free PMC Article
A multi-omics study delineates new molecular features and therapeutic targets for esophageal squamous cell carcinoma.
Jin X, Liu L, Wu J, Jin X, Yu G, Jia L, Wang F, Shi M, Lu H, Liu J, Liu D, Yang J, Li H, Ni Y, Luo Q, Jia W, Wang W, Chen WL
Clin Transl Med 2021 Sep;11(9):e538. doi: 10.1002/ctm2.538. PMID: 34586744Free PMC Article

Recent systematic reviews

Comparison of efficacy and safety between neoadjuvant chemotherapy and neoadjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis.
Xu J, Cai Y, Hong Z, Duan H, Ke S
Int J Surg 2024 Jan 1;110(1):490-506. doi: 10.1097/JS9.0000000000000816. PMID: 37800587Free PMC Article
The efficacy and safety of neoadjuvant immunotherapy in resectable locally advanced esophageal squamous cell carcinoma: A systematic review and meta-analysis.
He W, Wang C, Li C, Nie X, Li H, Li J, Zhao N, Chen H, Miao X, Han Y, Peng L, Leng X
Front Immunol 2023;14:1118902. Epub 2023 Feb 17 doi: 10.3389/fimmu.2023.1118902. PMID: 36875107Free PMC Article
Evaluation of Clinical and Safety Outcomes of Neoadjuvant Immunotherapy Combined With Chemotherapy for Patients With Resectable Esophageal Cancer: A Systematic Review and Meta-analysis.
Ge F, Huo Z, Cai X, Hu Q, Chen W, Lin G, Zhong R, You Z, Wang R, Lu Y, Wang R, Huang Q, Zhang H, Song A, Li C, Wen Y, Jiang Y, Liang H, He J, Liang W, Liu J
JAMA Netw Open 2022 Nov 1;5(11):e2239778. doi: 10.1001/jamanetworkopen.2022.39778. PMID: 36322089Free PMC Article
Intakes of citrus fruit and risk of esophageal cancer: A meta-analysis.
Zhao W, Liu L, Xu S
Medicine (Baltimore) 2018 Mar;97(13):e0018. doi: 10.1097/MD.0000000000010018. PMID: 29595629Free PMC Article
Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review.
Wang C, Wang J, Chen Z, Gao Y, He J
Chin J Cancer 2017 Aug 17;36(1):65. doi: 10.1186/s40880-017-0232-5. PMID: 28818096Free PMC Article

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