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Thoracic Esophagus Squamous Cell Carcinoma

MedGen UID:
1665515
•Concept ID:
C4725595
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the thoracic esophagus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThoracic Esophagus Squamous Cell Carcinoma

Professional guidelines

PubMed

Development and validation of a radiomics signature on differentially expressed features of (18)F-FDG PET to predict treatment response of concurrent chemoradiotherapy in thoracic esophagus squamous cell carcinoma.
Cao Q, Li Y, Li Z, An D, Li B, Lin Q
Radiother Oncol 2020 May;146:9-15. Epub 2020 Feb 14 doi: 10.1016/j.radonc.2020.01.027. PMID: 32065875

Recent clinical studies

Etiology

First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial.
Song Y, Zhang B, Xin D, Kou X, Tan Z, Zhang S, Sun M, Zhou J, Fan M, Zhang M, Song Y, Li S, Yuan Y, Zhuang W, Zhang J, Zhang L, Jiang H, Gu K, Ye H, Ke Y, Li J, Wang Q, Zhu J, Huang J; ASTRUM-007 investigators
Nat Med 2023 Feb;29(2):473-482. Epub 2023 Feb 2 doi: 10.1038/s41591-022-02179-2. PMID: 36732627Free PMC Article
Esophagus cancer and essential trace elements.
Yang X, Tang Z, Li J, Jiang J
Front Public Health 2022;10:1038153. Epub 2022 Nov 16 doi: 10.3389/fpubh.2022.1038153. PMID: 36466456Free PMC Article
Global and national trends in the age-specific sex ratio of esophageal cancer and gastric cancer by subtype.
Wang S, Zheng R, Arnold M, Abnet C, Zeng H, Zhang S, Chen R, Sun K, Li L, An L, Bray F, Wei W, He J
Int J Cancer 2022 Nov 1;151(9):1447-1461. Epub 2022 Jun 22 doi: 10.1002/ijc.34158. PMID: 35678331Free PMC Article
Update on Management of Squamous Cell Esophageal Cancer.
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Preoperative pembrolizumab combined with chemoradiotherapy for oesophageal squamous cell carcinoma (PALACE-1).
Li C, Zhao S, Zheng Y, Han Y, Chen X, Cheng Z, Wu Y, Feng X, Qi W, Chen K, Xiang J, Li J, Lerut T, Li H
Eur J Cancer 2021 Feb;144:232-241. Epub 2020 Dec 26 doi: 10.1016/j.ejca.2020.11.039. PMID: 33373868

Diagnosis

Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma.
Liu Z, Zhao Y, Kong P, Liu Y, Huang J, Xu E, Wei W, Li G, Cheng X, Xue L, Li Y, Chen H, Wei S, Sun R, Cui H, Meng Y, Liu M, Li Y, Feng R, Yu X, Zhu R, Wu Y, Li L, Yang B, Ma Y, Wang J, Zhu W, Deng D, Xi Y, Wang F, Li H, Guo S, Zhuang X, Wang X, Jiao Y, Cui Y, Zhan Q
Cancer Cell 2023 Jan 9;41(1):181-195.e9. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.004. PMID: 36584672
Global and national trends in the age-specific sex ratio of esophageal cancer and gastric cancer by subtype.
Wang S, Zheng R, Arnold M, Abnet C, Zeng H, Zhang S, Chen R, Sun K, Li L, An L, Bray F, Wei W, He J
Int J Cancer 2022 Nov 1;151(9):1447-1461. Epub 2022 Jun 22 doi: 10.1002/ijc.34158. PMID: 35678331Free PMC Article
Untargeted metabolomics analysis of esophageal squamous cell cancer progression.
Yang T, Hui R, Nouws J, Sauler M, Zeng T, Wu Q
J Transl Med 2022 Mar 14;20(1):127. doi: 10.1186/s12967-022-03311-z. PMID: 35287685Free PMC Article
Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis.
Xue ST, Zheng B, Cao SQ, Ding JC, Hu GS, Liu W, Chen C
Mol Cancer 2022 Mar 7;21(1):69. doi: 10.1186/s12943-022-01539-3. PMID: 35255921Free PMC Article
Update on Management of Squamous Cell Esophageal Cancer.
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974

Therapy

Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma.
Liu Z, Zhao Y, Kong P, Liu Y, Huang J, Xu E, Wei W, Li G, Cheng X, Xue L, Li Y, Chen H, Wei S, Sun R, Cui H, Meng Y, Liu M, Li Y, Feng R, Yu X, Zhu R, Wu Y, Li L, Yang B, Ma Y, Wang J, Zhu W, Deng D, Xi Y, Wang F, Li H, Guo S, Zhuang X, Wang X, Jiao Y, Cui Y, Zhan Q
Cancer Cell 2023 Jan 9;41(1):181-195.e9. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.004. PMID: 36584672
Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial.
Lu Z, Wang J, Shu Y, Liu L, Kong L, Yang L, Wang B, Sun G, Ji Y, Cao G, Liu H, Cui T, Li N, Qiu W, Li G, Hou X, Luo H, Xue L, Zhang Y, Yue W, Liu Z, Wang X, Gao S, Pan Y, Galais MP, Zaanan A, Ma Z, Li H, Wang Y, Shen L; ORIENT-15 study group
BMJ 2022 Apr 19;377:e068714. doi: 10.1136/bmj-2021-068714. PMID: 35440464Free PMC Article
Update on Management of Squamous Cell Esophageal Cancer.
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinoma.
Chen Z, Zhao M, Liang J, Hu Z, Huang Y, Li M, Pang Y, Lu T, Sui Q, Zhan C, Lin M, Guo W, Wang Q, Tan L
EBioMedicine 2021 Jul;69:103459. Epub 2021 Jun 27 doi: 10.1016/j.ebiom.2021.103459. PMID: 34192657Free PMC Article
Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations.
Chang J, Tan W, Ling Z, Xi R, Shao M, Chen M, Luo Y, Zhao Y, Liu Y, Huang X, Xia Y, Hu J, Parker JS, Marron D, Cui Q, Peng L, Chu J, Li H, Du Z, Han Y, Tan W, Liu Z, Zhan Q, Li Y, Mao W, Wu C, Lin D
Nat Commun 2017 May 26;8:15290. doi: 10.1038/ncomms15290. PMID: 28548104Free PMC Article

Prognosis

Progenitor-like exhausted SPRY1(+)CD8(+) T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma.
Liu Z, Zhang Y, Ma N, Yang Y, Ma Y, Wang F, Wang Y, Wei J, Chen H, Tartarone A, Velotta JB, Dayyani F, Gabriel E, Wakefield CJ, Kidane B, Carbonelli C, Long L, Liu Z, Su J, Li Z
Cancer Cell 2023 Nov 13;41(11):1852-1870.e9. Epub 2023 Oct 12 doi: 10.1016/j.ccell.2023.09.011. PMID: 37832554
Global and national trends in the age-specific sex ratio of esophageal cancer and gastric cancer by subtype.
Wang S, Zheng R, Arnold M, Abnet C, Zeng H, Zhang S, Chen R, Sun K, Li L, An L, Bray F, Wei W, He J
Int J Cancer 2022 Nov 1;151(9):1447-1461. Epub 2022 Jun 22 doi: 10.1002/ijc.34158. PMID: 35678331Free PMC Article
Identifying a confused cell identity for esophageal squamous cell carcinoma.
Pan X, Wang J, Guo L, Na F, Du J, Chen X, Zhong A, Zhao L, Zhang L, Zhang M, Wan X, Wang M, Liu H, Dai S, Tan P, Chen J, Liu Y, Hu B, Chen C
Signal Transduct Target Ther 2022 Apr 13;7(1):122. doi: 10.1038/s41392-022-00946-8. PMID: 35418165Free PMC Article
Untargeted metabolomics analysis of esophageal squamous cell cancer progression.
Yang T, Hui R, Nouws J, Sauler M, Zeng T, Wu Q
J Transl Med 2022 Mar 14;20(1):127. doi: 10.1186/s12967-022-03311-z. PMID: 35287685Free PMC Article
Update on Management of Squamous Cell Esophageal Cancer.
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974

Clinical prediction guides

Progenitor-like exhausted SPRY1(+)CD8(+) T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma.
Liu Z, Zhang Y, Ma N, Yang Y, Ma Y, Wang F, Wang Y, Wei J, Chen H, Tartarone A, Velotta JB, Dayyani F, Gabriel E, Wakefield CJ, Kidane B, Carbonelli C, Long L, Liu Z, Su J, Li Z
Cancer Cell 2023 Nov 13;41(11):1852-1870.e9. Epub 2023 Oct 12 doi: 10.1016/j.ccell.2023.09.011. PMID: 37832554
STC2 activates PRMT5 to induce radioresistance through DNA damage repair and ferroptosis pathways in esophageal squamous cell carcinoma.
Jiang K, Yin X, Zhang Q, Yin J, Tang Q, Xu M, Wu L, Shen Y, Zhou Z, Yu H, Yan S
Redox Biol 2023 Apr;60:102626. Epub 2023 Feb 3 doi: 10.1016/j.redox.2023.102626. PMID: 36764215Free PMC Article
Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma.
Liu Z, Zhao Y, Kong P, Liu Y, Huang J, Xu E, Wei W, Li G, Cheng X, Xue L, Li Y, Chen H, Wei S, Sun R, Cui H, Meng Y, Liu M, Li Y, Feng R, Yu X, Zhu R, Wu Y, Li L, Yang B, Ma Y, Wang J, Zhu W, Deng D, Xi Y, Wang F, Li H, Guo S, Zhuang X, Wang X, Jiao Y, Cui Y, Zhan Q
Cancer Cell 2023 Jan 9;41(1):181-195.e9. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.004. PMID: 36584672
Global and national trends in the age-specific sex ratio of esophageal cancer and gastric cancer by subtype.
Wang S, Zheng R, Arnold M, Abnet C, Zeng H, Zhang S, Chen R, Sun K, Li L, An L, Bray F, Wei W, He J
Int J Cancer 2022 Nov 1;151(9):1447-1461. Epub 2022 Jun 22 doi: 10.1002/ijc.34158. PMID: 35678331Free PMC Article
Preoperative pembrolizumab combined with chemoradiotherapy for oesophageal squamous cell carcinoma (PALACE-1).
Li C, Zhao S, Zheng Y, Han Y, Chen X, Cheng Z, Wu Y, Feng X, Qi W, Chen K, Xiang J, Li J, Lerut T, Li H
Eur J Cancer 2021 Feb;144:232-241. Epub 2020 Dec 26 doi: 10.1016/j.ejca.2020.11.039. PMID: 33373868

Recent systematic reviews

Evaluation of Clinical and Safety Outcomes of Neoadjuvant Immunotherapy Combined With Chemotherapy for Patients With Resectable Esophageal Cancer: A Systematic Review and Meta-analysis.
Ge F, Huo Z, Cai X, Hu Q, Chen W, Lin G, Zhong R, You Z, Wang R, Lu Y, Wang R, Huang Q, Zhang H, Song A, Li C, Wen Y, Jiang Y, Liang H, He J, Liang W, Liu J
JAMA Netw Open 2022 Nov 1;5(11):e2239778. doi: 10.1001/jamanetworkopen.2022.39778. PMID: 36322089Free PMC Article
Intakes of citrus fruit and risk of esophageal cancer: A meta-analysis.
Zhao W, Liu L, Xu S
Medicine (Baltimore) 2018 Mar;97(13):e0018. doi: 10.1097/MD.0000000000010018. PMID: 29595629Free PMC Article
Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer.
Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. PMID: 28829911Free PMC Article
Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review.
Wang C, Wang J, Chen Z, Gao Y, He J
Chin J Cancer 2017 Aug 17;36(1):65. doi: 10.1186/s40880-017-0232-5. PMID: 28818096Free PMC Article
Longitudinal and circumferential resection margin in adenocarcinoma of distal esophagus and cardia.
Migliore M, Rassl D, Criscione A
Future Oncol 2014 Apr;10(5):891-901. doi: 10.2217/fon.13.241. PMID: 24799068

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