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Metastatic Urethral Urothelial Carcinoma

MedGen UID:
1667204
•Concept ID:
C4725792
•
Neoplastic Process

Definition

Urethral urothelial carcinoma that has spread to another anatomical site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Urethral Urothelial Carcinoma

Professional guidelines

PubMed

Bladder Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology.
Flaig TW, Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Chang S, Downs TM, Efstathiou JA, Friedlander T, Greenberg RE, Guru KA, Guzzo T, Herr HW, Hoffman-Censits J, Hoimes C, Inman BA, Jimbo M, Kader AK, Lele SM, Michalski J, Montgomery JS, Nandagopal L, Pagliaro LC, Pal SK, Patterson A, Plimack ER, Pohar KS, Preston MA, Sexton WJ, Siefker-Radtke AO, Tward J, Wright JL, Gurski LA, Johnson-Chilla A
J Natl Compr Canc Netw 2020 Mar;18(3):329-354. doi: 10.6004/jnccn.2020.0011. PMID: 32135513
Urethral recurrence after cystectomy: current preventative measures, diagnosis and management.
Chan Y, Fisher P, Tilki D, Evans CP
BJU Int 2016 Apr;117(4):563-9. Epub 2015 Dec 12 doi: 10.1111/bju.13370. PMID: 26556525
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415

Recent clinical studies

Etiology

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
Female urethral carcinoma: a contemporary review of the clinicopathologic features, with emphasis on the histoanatomic landmarks and potential staging issues.
Lagarde-Lenon MS, Aron M
Hum Pathol 2022 Nov;129:71-80. Epub 2022 Aug 28 doi: 10.1016/j.humpath.2022.08.003. PMID: 36037997
Radiotherapy in Metastatic Urothelial Carcinoma: Rationale and Clinical Applications.
Vassiliou V, Katsila T, Sodergren SC, Kardamakis D
Anticancer Res 2022 Aug;42(8):3767-3778. doi: 10.21873/anticanres.15867. PMID: 35896266
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415

Diagnosis

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
NCCN Guidelines® Insights: Bladder Cancer, Version 2.2022.
Flaig TW, Spiess PE, Abern M, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Chan K, Chang S, Friedlander T, Greenberg RE, Guru KA, Herr HW, Hoffman-Censits J, Kishan A, Kundu S, Lele SM, Mamtani R, Margulis V, Mian OY, Michalski J, Montgomery JS, Nandagopal L, Pagliaro LC, Parikh M, Patterson A, Plimack ER, Pohar KS, Preston MA, Richards K, Sexton WJ, Siefker-Radtke AO, Tollefson M, Tward J, Wright JL, Dwyer MA, Cassara CJ, Gurski LA
J Natl Compr Canc Netw 2022 Aug;20(8):866-878. doi: 10.6004/jnccn.2022.0041. PMID: 35948037
Radiotherapy in Metastatic Urothelial Carcinoma: Rationale and Clinical Applications.
Vassiliou V, Katsila T, Sodergren SC, Kardamakis D
Anticancer Res 2022 Aug;42(8):3767-3778. doi: 10.21873/anticanres.15867. PMID: 35896266
Follow-up Management of Cystectomy Patients.
Reddy M, Kader K
Urol Clin North Am 2018 May;45(2):241-247. doi: 10.1016/j.ucl.2018.01.001. PMID: 29650139
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415

Therapy

Evaluating Real-World Characteristics of Patients With Advanced Urothelial Carcinoma Eligible for Avelumab Maintenance Therapy: A Multicountry Retrospective Medical Chart Review.
Bellmunt J, Chang J, Pavilack-Kirker M, Cappelleri JC, Costa N, Esterberg E, Kearney M, Hitchens A, Candrilli SD, Ajmera M
Clin Genitourin Cancer 2023 Aug;21(4):459-466. Epub 2023 Mar 31 doi: 10.1016/j.clgc.2023.03.011. PMID: 37149458
Bladder cancer: shedding light on the most promising investigational drugs in clinical trials.
Bin Riaz I, Khan AM, Catto JW, Hussain SA
Expert Opin Investig Drugs 2021 Aug;30(8):837-855. Epub 2021 Jul 14 doi: 10.1080/13543784.2021.1948999. PMID: 34171206
Urethral recurrence after cystectomy: current preventative measures, diagnosis and management.
Chan Y, Fisher P, Tilki D, Evans CP
BJU Int 2016 Apr;117(4):563-9. Epub 2015 Dec 12 doi: 10.1111/bju.13370. PMID: 26556525
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415
Superficial bladder cancer therapy.
Schenkman E, Lamm DL
ScientificWorldJournal 2004 Jun 28;4 Suppl 1:387-99. doi: 10.1100/tsw.2004.81. PMID: 15349563Free PMC Article

Prognosis

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
Female urethral carcinoma: a contemporary review of the clinicopathologic features, with emphasis on the histoanatomic landmarks and potential staging issues.
Lagarde-Lenon MS, Aron M
Hum Pathol 2022 Nov;129:71-80. Epub 2022 Aug 28 doi: 10.1016/j.humpath.2022.08.003. PMID: 36037997
Radiotherapy in Metastatic Urothelial Carcinoma: Rationale and Clinical Applications.
Vassiliou V, Katsila T, Sodergren SC, Kardamakis D
Anticancer Res 2022 Aug;42(8):3767-3778. doi: 10.21873/anticanres.15867. PMID: 35896266
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article

Clinical prediction guides

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
Tailored immunotherapy approach with nivolumab with or without ipilimumab in patients with advanced transitional cell carcinoma after platinum-based chemotherapy (TITAN-TCC): a multicentre, single-arm, phase 2 trial.
Grimm MO, Grün CB, Niegisch G, Pichler M, Roghmann F, Schmitz-Dräger B, Baretton G, Schmitz M, Bolenz C, Foller S, Leucht K, Schumacher U, Schostak M, Meran J, Loidl W, Zengerling F
Lancet Oncol 2023 Apr;24(4):347-359. Epub 2023 Feb 28 doi: 10.1016/S1470-2045(23)00053-0. PMID: 36868252
Association Between Perioperative Chemotherapy and Survival in Men Undergoing Radical Resection for Primary Urethral Urothelial Carcinoma: An Analysis of the National Cancer Database.
Celtik K, Lim K, Dursun F, Xu J, Klaassen Z, Zhang J, Efstathiou E, Sonpavde G, Wallis C, Satkunasivam R
Clin Genitourin Cancer 2022 Jun;20(3):244-251. Epub 2022 Jan 31 doi: 10.1016/j.clgc.2022.01.011. PMID: 35181268
Prognostic factors for metastatic urothelial carcinoma treated with cisplatin and 5-fluorouracil-based regimens.
Lin CC, Hsu CH, Huang CY, Tsai YC, Huang KH, Cheng AL, Pu YS
Urology 2007 Mar;69(3):479-84. doi: 10.1016/j.urology.2006.12.010. PMID: 17382149
VI--choosing the right reconstruction for your female patients.
Stenzl A, Strasser H, Hobisch A, Bartsch G
Semin Urol Oncol 2001 Feb;19(1):9-17. PMID: 11246739

Recent systematic reviews

Oncologic and Safety Outcomes for Retrograde and Antegrade Endoscopic Surgeries for Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-analysis.
Laukhtina E, Kawada T, Quhal F, Yanagisawa T, Rajwa P, von Deimling M, Pallauf M, Bianchi A, Majdoub M, Enikeev D, Fajkovic H, Teoh JY, Rouprêt M, Gontero P, Shariat SF
Eur Urol Focus 2023 Mar;9(2):258-263. Epub 2022 Nov 22 doi: 10.1016/j.euf.2022.11.014. PMID: 36428210
French AFU Cancer Committee Guidelines - Update 2022-2024: Muscle-Invasive Bladder Cancer (MIBC).
Neuzillet Y, Audenet F, Loriot Y, Allory Y, Masson-Lecomte A, Leon P, Pradère B, Seisen T, Traxer O, Xylinas E, Roumiguié M, Roupret M
Prog Urol 2022 Nov;32(15):1141-1163. doi: 10.1016/j.purol.2022.07.145. PMID: 36400480
Incidence, risk factors and outcomes of urethral recurrence after radical cystectomy for bladder cancer: A systematic review and meta-analysis.
Laukhtina E, Mori K, D Andrea D, Moschini M, Abufaraj M, Soria F, Mari A, Krajewski W, Albisinni S, Teoh JY, Quhal F, Sari Motlagh R, Mostafaei H, Katayama S, Grossmann NС, Rajwa P, Enikeev D, Zimmermann K, Fajkovic H, Glybochko P, Shariat SF, Pradere B; European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)
Urol Oncol 2021 Dec;39(12):806-815. Epub 2021 Jul 13 doi: 10.1016/j.urolonc.2021.06.009. PMID: 34266740
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article
ICUD-EAU International Consultation on Bladder Cancer 2012: Urothelial carcinoma of the prostate.
Palou J, Wood D, Bochner BH, van der Poel H, Al-Ahmadie HA, Yossepowitch O, Soloway MS, Jenkins LC; International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Eur Urol 2013 Jan;63(1):81-7. Epub 2012 Aug 14 doi: 10.1016/j.eururo.2012.08.011. PMID: 22938869

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