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Suprasellar Germinoma

MedGen UID:
1669877
•Concept ID:
C4744387
•
Neoplastic Process
Synonym: Germinoma of the Suprasellar Region

Definition

A germinoma that arises from the suprasellar region. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSuprasellar Germinoma

Professional guidelines

PubMed

Endocrine manifestations of paediatric intracranial germ cell tumours: from diagnosis to long-term follow-up.
Partenope C, Pozzobon G, Weber G, Arya VB, Carceller F, Albanese A
Endocrine 2022 Sep;77(3):546-555. Epub 2022 Jun 29 doi: 10.1007/s12020-022-03121-9. PMID: 35767181
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns.
Bhimani AD, Barrington NM, Aguilar TM, Arnone GD, Mehta AI
Pituitary 2020 Aug;23(4):381-388. doi: 10.1007/s11102-020-01042-2. PMID: 32388804
Diagnosis and treatment of suprasellar germinoma.
Handa H, Takeuchi J, Nagata I, Yamashita J
Acta Neurochir Suppl (Wien) 1979;28(2):418-9. PMID: 290221

Recent clinical studies

Etiology

Methionine metabolism and endocrine function of the pituitary gland in patients with suprasellar germinoma.
Lee H, Lee JW, Cho HW, Choe YS, Lee KH, Choi JY, Sung KW, Moon SH
PLoS One 2023;18(7):e0288528. Epub 2023 Jul 13 doi: 10.1371/journal.pone.0288528. PMID: 37440573Free PMC Article
Primary suprasellar germinoma: A series of 15 cases.
Xue K, Han G, Wang Z, Zhang X
J Clin Neurosci 2023 May;111:71-77. Epub 2023 Mar 22 doi: 10.1016/j.jocn.2023.03.007. PMID: 36963125
Endocrine manifestations of paediatric intracranial germ cell tumours: from diagnosis to long-term follow-up.
Partenope C, Pozzobon G, Weber G, Arya VB, Carceller F, Albanese A
Endocrine 2022 Sep;77(3):546-555. Epub 2022 Jun 29 doi: 10.1007/s12020-022-03121-9. PMID: 35767181
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns.
Bhimani AD, Barrington NM, Aguilar TM, Arnone GD, Mehta AI
Pituitary 2020 Aug;23(4):381-388. doi: 10.1007/s11102-020-01042-2. PMID: 32388804
Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience.
Yeo KK, Kayser K, Margol AS, Wong KK, Robison N, Finlay J, Dhall G
Pediatr Blood Cancer 2019 Dec;66(12):e27983. Epub 2019 Sep 10 doi: 10.1002/pbc.27983. PMID: 31502379

Diagnosis

Primary suprasellar germinoma: A series of 15 cases.
Xue K, Han G, Wang Z, Zhang X
J Clin Neurosci 2023 May;111:71-77. Epub 2023 Mar 22 doi: 10.1016/j.jocn.2023.03.007. PMID: 36963125
Endocrine manifestations of paediatric intracranial germ cell tumours: from diagnosis to long-term follow-up.
Partenope C, Pozzobon G, Weber G, Arya VB, Carceller F, Albanese A
Endocrine 2022 Sep;77(3):546-555. Epub 2022 Jun 29 doi: 10.1007/s12020-022-03121-9. PMID: 35767181
Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience.
Yeo KK, Kayser K, Margol AS, Wong KK, Robison N, Finlay J, Dhall G
Pediatr Blood Cancer 2019 Dec;66(12):e27983. Epub 2019 Sep 10 doi: 10.1002/pbc.27983. PMID: 31502379
Suprasellar germinoma and late perioptic seeding.
Pereira LS, Green AJ, Hwang TN, McCulley TJ
Eur J Ophthalmol 2008 Jan-Feb;18(1):159-61. doi: 10.1177/112067210801800130. PMID: 18203106
Suprasellar germinoma.
Takeuchi J, Handa H, Nagata I
J Neurosurg 1978 Jul;49(1):41-8. doi: 10.3171/jns.1978.49.1.0041. PMID: 660267

Therapy

Venous thromboembolism in the setting of pediatric central diabetes insipidus: a systematic review of the literature and report of 2 cases.
Lambert WA, Paro M, Pinci E, Bookland MJ, Martin JE, Riba-Wolman R, McKay L, Hersh DS
J Neurosurg Pediatr 2022 May 1;29(5):580-589. Epub 2022 Feb 25 doi: 10.3171/2022.1.PEDS21469. PMID: 35213827
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns.
Bhimani AD, Barrington NM, Aguilar TM, Arnone GD, Mehta AI
Pituitary 2020 Aug;23(4):381-388. doi: 10.1007/s11102-020-01042-2. PMID: 32388804
Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience.
Yeo KK, Kayser K, Margol AS, Wong KK, Robison N, Finlay J, Dhall G
Pediatr Blood Cancer 2019 Dec;66(12):e27983. Epub 2019 Sep 10 doi: 10.1002/pbc.27983. PMID: 31502379
Suprasellar germinoma and late perioptic seeding.
Pereira LS, Green AJ, Hwang TN, McCulley TJ
Eur J Ophthalmol 2008 Jan-Feb;18(1):159-61. doi: 10.1177/112067210801800130. PMID: 18203106
Long-term functional outcome of suprasellar germinomas: usefulness and limitations of radiotherapy.
Oka H, Kawano N, Tanaka T, Utsuki S, Kobayashi I, Maezawa H, Fujii K
J Neurooncol 1998 Nov;40(2):185-90. doi: 10.1023/a:1006184100834. PMID: 9892101

Prognosis

Primary suprasellar germinoma: A series of 15 cases.
Xue K, Han G, Wang Z, Zhang X
J Clin Neurosci 2023 May;111:71-77. Epub 2023 Mar 22 doi: 10.1016/j.jocn.2023.03.007. PMID: 36963125
Endocrine manifestations of paediatric intracranial germ cell tumours: from diagnosis to long-term follow-up.
Partenope C, Pozzobon G, Weber G, Arya VB, Carceller F, Albanese A
Endocrine 2022 Sep;77(3):546-555. Epub 2022 Jun 29 doi: 10.1007/s12020-022-03121-9. PMID: 35767181
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns.
Bhimani AD, Barrington NM, Aguilar TM, Arnone GD, Mehta AI
Pituitary 2020 Aug;23(4):381-388. doi: 10.1007/s11102-020-01042-2. PMID: 32388804
Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience.
Yeo KK, Kayser K, Margol AS, Wong KK, Robison N, Finlay J, Dhall G
Pediatr Blood Cancer 2019 Dec;66(12):e27983. Epub 2019 Sep 10 doi: 10.1002/pbc.27983. PMID: 31502379
Suprasellar germinoma and late perioptic seeding.
Pereira LS, Green AJ, Hwang TN, McCulley TJ
Eur J Ophthalmol 2008 Jan-Feb;18(1):159-61. doi: 10.1177/112067210801800130. PMID: 18203106

Clinical prediction guides

Primary suprasellar germinoma: A series of 15 cases.
Xue K, Han G, Wang Z, Zhang X
J Clin Neurosci 2023 May;111:71-77. Epub 2023 Mar 22 doi: 10.1016/j.jocn.2023.03.007. PMID: 36963125
Suprasellar germinoma with hypopituitarism in an 18-year old man: A case report and review of literature.
Celik O, Ozyurt S, Saglican Y
Clin Neurol Neurosurg 2020 Sep;196:106026. Epub 2020 Jun 15 doi: 10.1016/j.clineuro.2020.106026. PMID: 32580069
Emergency irradiation with 3.4 Gy/2f in sellar/suprasellar germinoma patients with rapid visual acuity decline.
Li B, Li YQ, Li CD, Chen Y, Liu YW, Liu S, Qiu XG, Luo SQ
Chin Med J (Engl) 2019 Sep 5;132(17):2073-2078. doi: 10.1097/CM9.0000000000000315. PMID: 31261204Free PMC Article
Suprasellar germinoma and late perioptic seeding.
Pereira LS, Green AJ, Hwang TN, McCulley TJ
Eur J Ophthalmol 2008 Jan-Feb;18(1):159-61. doi: 10.1177/112067210801800130. PMID: 18203106
Suprasellar germinoma.
Takeuchi J, Handa H, Nagata I
J Neurosurg 1978 Jul;49(1):41-8. doi: 10.3171/jns.1978.49.1.0041. PMID: 660267

Recent systematic reviews

Venous thromboembolism in the setting of pediatric central diabetes insipidus: a systematic review of the literature and report of 2 cases.
Lambert WA, Paro M, Pinci E, Bookland MJ, Martin JE, Riba-Wolman R, McKay L, Hersh DS
J Neurosurg Pediatr 2022 May 1;29(5):580-589. Epub 2022 Feb 25 doi: 10.3171/2022.1.PEDS21469. PMID: 35213827

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