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Central nervous system germinoma

MedGen UID:
232242
Concept ID:
C1333813
Neoplastic Process
Synonyms: Central Nervous System Germinoma; central nervous system germinoma; central nervous system germinoma (disease); Germinoma of central nervous system; Germinoma of Central Nervous System; germinoma of central nervous system; Germinoma of CNS; germinoma of CNS; Germinoma of the Central Nervous System; germinoma of the central nervous system; Germinoma of the CNS; germinoma of the CNS; intracranial germinoma
SNOMED CT: Germinoma of central nervous system (1156833003)
 
Monarch Initiative: MONDO:0002999

Definition

A malignant germ cell tumor arising from the central nervous system. It is composed of uniform cells resembling primitive germ cells. These cells have large, vesicular nuclei, prominent nucleoli and a clear, glycogen-rich cytoplasm. Additional features are lymphoid or lymphoplasmacytic infiltrates and, less frequently, scattered syncytiotrophoblastic giant cells. (Adapted from WHO) [from NCI]

Professional guidelines

PubMed

Abu-Arja MH, Shatara MS, Okcu MF, McGovern SL, Su JM, Abdelbaki MS
Pediatr Blood Cancer 2023 Oct;70(10):e30601. Epub 2023 Jul 27 doi: 10.1002/pbc.30601. PMID: 37501569
Shibamoto Y
Prog Neurol Surg 2009;23:119-129. Epub 2009 Mar 23 doi: 10.1159/000210058. PMID: 19329866
Ogino H, Shibamoto Y, Takanaka T, Suzuki K, Ishihara S, Yamada T, Sugie C, Nomoto Y, Mimura M
Int J Radiat Oncol Biol Phys 2005 Jul 1;62(3):803-8. doi: 10.1016/j.ijrobp.2004.10.026. PMID: 15936563

Recent clinical studies

Etiology

Zeng C, Yang Q, Li Z, Wei Z, Chen T, Deng M, Wang J, Wang J, Sun F, Huang J, Lu S, Zhu J, Sun X, Zhen Z
J Neurooncol 2023 Sep;164(3):643-653. Epub 2023 Sep 28 doi: 10.1007/s11060-023-04453-w. PMID: 37768471
Abu-Arja MH, Shatara MS, Okcu MF, McGovern SL, Su JM, Abdelbaki MS
Pediatr Blood Cancer 2023 Oct;70(10):e30601. Epub 2023 Jul 27 doi: 10.1002/pbc.30601. PMID: 37501569
Tsurubuchi T, Hara K, Takano S, Muroi A, Fukushima H, Mizumoto M, Sakamoto N, Matsuda M, Akutsu H, Sakurai H, Ishikawa E
World Neurosurg 2022 Oct;166:e325-e336. Epub 2022 Jul 13 doi: 10.1016/j.wneu.2022.07.010. PMID: 35842173
Yeo KK, Kayser K, Margol AS, Wong KK, Robison N, Finlay J, Dhall G
Pediatr Blood Cancer 2019 Dec;66(12):e27983. Epub 2019 Sep 10 doi: 10.1002/pbc.27983. PMID: 31502379
Tseng CK, Tsang NM, Jaing TH, Liau CT, Wu CT, Lin KL
J Pediatr Hematol Oncol 2011 May;33(4):e138-42. doi: 10.1097/MPH.0b013e31820d0c69. PMID: 21516012

Diagnosis

Tsurubuchi T, Hara K, Takano S, Muroi A, Fukushima H, Mizumoto M, Sakamoto N, Matsuda M, Akutsu H, Sakurai H, Ishikawa E
World Neurosurg 2022 Oct;166:e325-e336. Epub 2022 Jul 13 doi: 10.1016/j.wneu.2022.07.010. PMID: 35842173
Yeo KK, Kayser K, Margol AS, Wong KK, Robison N, Finlay J, Dhall G
Pediatr Blood Cancer 2019 Dec;66(12):e27983. Epub 2019 Sep 10 doi: 10.1002/pbc.27983. PMID: 31502379
Tseng CK, Tsang NM, Jaing TH, Liau CT, Wu CT, Lin KL
J Pediatr Hematol Oncol 2011 May;33(4):e138-42. doi: 10.1097/MPH.0b013e31820d0c69. PMID: 21516012
Douglas-Akinwande AC, Ying J, Momin Z, Mourad A, Hattab EM
Acad Radiol 2009 Nov;16(11):1356-65. Epub 2009 Jul 29 doi: 10.1016/j.acra.2009.05.004. PMID: 19643635
Shibamoto Y
Prog Neurol Surg 2009;23:119-129. Epub 2009 Mar 23 doi: 10.1159/000210058. PMID: 19329866

Therapy

Abu-Arja MH, Shatara MS, Okcu MF, McGovern SL, Su JM, Abdelbaki MS
Pediatr Blood Cancer 2023 Oct;70(10):e30601. Epub 2023 Jul 27 doi: 10.1002/pbc.30601. PMID: 37501569
Yeo KK, Kayser K, Margol AS, Wong KK, Robison N, Finlay J, Dhall G
Pediatr Blood Cancer 2019 Dec;66(12):e27983. Epub 2019 Sep 10 doi: 10.1002/pbc.27983. PMID: 31502379
Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646
Cheng S, Kilday JP, Laperriere N, Janzen L, Drake J, Bouffet E, Bartels U
J Neurooncol 2016 Mar;127(1):173-80. Epub 2016 Jan 7 doi: 10.1007/s11060-015-2029-1. PMID: 26744133
Tseng CK, Tsang NM, Jaing TH, Liau CT, Wu CT, Lin KL
J Pediatr Hematol Oncol 2011 May;33(4):e138-42. doi: 10.1097/MPH.0b013e31820d0c69. PMID: 21516012

Prognosis

Zeng C, Yang Q, Li Z, Wei Z, Chen T, Deng M, Wang J, Wang J, Sun F, Huang J, Lu S, Zhu J, Sun X, Zhen Z
J Neurooncol 2023 Sep;164(3):643-653. Epub 2023 Sep 28 doi: 10.1007/s11060-023-04453-w. PMID: 37768471
Yeo KK, Kayser K, Margol AS, Wong KK, Robison N, Finlay J, Dhall G
Pediatr Blood Cancer 2019 Dec;66(12):e27983. Epub 2019 Sep 10 doi: 10.1002/pbc.27983. PMID: 31502379
Cheng S, Kilday JP, Laperriere N, Janzen L, Drake J, Bouffet E, Bartels U
J Neurooncol 2016 Mar;127(1):173-80. Epub 2016 Jan 7 doi: 10.1007/s11060-015-2029-1. PMID: 26744133
Takeshima Y, Yamada S, Motoyama Y, Park YS, Nakase H
Childs Nerv Syst 2012 Dec;28(12):2173-6. Epub 2012 Aug 31 doi: 10.1007/s00381-012-1901-y. PMID: 22936081
Tseng CK, Tsang NM, Jaing TH, Liau CT, Wu CT, Lin KL
J Pediatr Hematol Oncol 2011 May;33(4):e138-42. doi: 10.1097/MPH.0b013e31820d0c69. PMID: 21516012

Clinical prediction guides

Takano S, Yamamoto T, Ishikawa E, Akutsu H, Nakai K, Matsuda M, Muroi A, Shibata Y, Mizumoto M, Tsuboi K, Matsumura A
World Neurosurg 2015 Sep;84(3):846-54. Epub 2015 Jun 23 doi: 10.1016/j.wneu.2015.06.029. PMID: 26115804
Felice MS, Zubizarreta PA, Chantada GL, Alfaro E, Cygler AM, Gallego M, Rossi J, Sackmann-Muriel F
Med Pediatr Oncol 1998 Mar;30(3):160-4. doi: 10.1002/(sici)1096-911x(199803)30:3<160::aid-mpo6>3.0.co;2-f. PMID: 9434824

Recent systematic reviews

Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646

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