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Increased vertical cup-to-disc ratio

MedGen UID:
1670941
•Concept ID:
C4732782
•
Finding
HPO: HP:0031973

Definition

An abnormal increase in the ratio of the height of the cup of the optic nerve head to the height of the disk. [from HPO]

Professional guidelines

PubMed

Evaluating the outcome of screening for glaucoma using colour fundus photography-based referral criteria in a teleophthalmology screening programme for diabetic retinopathy.
Tan R, Teo KYC, Husain R, Tan NC, Lee QX, Hamzah H, Wong T, Aung T, Cheng CY, Lamoureux EL, Tan CS, Wong HT, Wong TY, Tan GSW
Br J Ophthalmol 2024 Jun 20;108(7):933-939. doi: 10.1136/bjo-2023-323339. PMID: 37852739Free PMC Article
Detection of Glaucoma and Its Association With Diabetic Retinopathy in a Diabetic Retinopathy Screening Program.
Gangwani RA, McGhee SM, Lai JS, Chan CK, Wong D
J Glaucoma 2016 Jan;25(1):101-5. doi: 10.1097/IJG.0000000000000138. PMID: 25264989
Detection and prognostic significance of optic disc hemorrhages during the Ocular Hypertension Treatment Study.
Budenz DL, Anderson DR, Feuer WJ, Beiser JA, Schiffman J, Parrish RK 2nd, Piltz-Seymour JR, Gordon MO, Kass MA; Ocular Hypertension Treatment Study Group
Ophthalmology 2006 Dec;113(12):2137-43. Epub 2006 Sep 25 doi: 10.1016/j.ophtha.2006.06.022. PMID: 16996592Free PMC Article

Recent clinical studies

Etiology

Causal relationships between Gut microbiota and primary open-angle Glaucoma: A Mendelian randomization and mediation analysis of Glaucoma endophenotypes.
Zhou X, Xu J, Zhang X, Zhao Y, Duan X
Exp Eye Res 2024 Mar;240:109788. Epub 2024 Jan 11 doi: 10.1016/j.exer.2024.109788. PMID: 38218362
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.
Han X, Gharahkhani P, Hamel AR, Ong JS, Rentería ME, Mehta P, Dong X, Pasutto F, Hammond C, Young TL, Hysi P, Lotery AJ, Jorgenson E, Choquet H, Hauser M, Cooke Bailey JN, Nakazawa T, Akiyama M, Shiga Y, Fuller ZL, Wang X, Hewitt AW, Craig JE, Pasquale LR, Mackey DA, Wiggs JL, Khawaja AP, Segrè AV; 23andMe Research Team; International Glaucoma Genetics Consortium, MacGregor S
Nat Genet 2023 Jul;55(7):1116-1125. Epub 2023 Jun 29 doi: 10.1038/s41588-023-01428-5. PMID: 37386247Free PMC Article
Novel Vertical Cup-to-Disc Classification to Identify Normal Eyes That Maintain Non-Glaucoma Status: A 10-Year Longitudinal Study.
Ikeda Y, Mori K, Maruyama Y, Ueno M, Yoshii K, Yamamoto Y, Imai K, Omi N, Sato R, Sato F, Nakano M, Hamuro J, Tashiro K, Sotozono C, Kinoshita S
J Glaucoma 2023 Feb 1;32(2):127-132. Epub 2022 Aug 25 doi: 10.1097/IJG.0000000000002109. PMID: 36001508
Comparison of vertical cup-to-disc ratio estimates using stereoscopic and monoscopic cameras.
Shrestha R, Budenz DL, Mwanza JC, Tulenko SE, Fleischman D, Gower EW
Eye (Lond) 2021 Dec;35(12):3318-3324. Epub 2021 Jan 29 doi: 10.1038/s41433-021-01395-3. PMID: 33514892Free PMC Article
Automatic optic nerve head localization and cup-to-disc ratio detection using state-of-the-art deep-learning architectures.
Park K, Kim J, Lee J
Sci Rep 2020 Mar 19;10(1):5025. doi: 10.1038/s41598-020-62022-x. PMID: 32193499Free PMC Article

Diagnosis

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study.
Rajasundaram S, Segrè AV, Gill D, Woolf B, Zekavat SM, Burgess S, Khawaja AP, Zebardast N, Wiggs JL
Invest Ophthalmol Vis Sci 2024 Jul 1;65(8):35. doi: 10.1167/iovs.65.8.35. PMID: 39028976Free PMC Article
Novel Vertical Cup-to-Disc Classification to Identify Normal Eyes That Maintain Non-Glaucoma Status: A 10-Year Longitudinal Study.
Ikeda Y, Mori K, Maruyama Y, Ueno M, Yoshii K, Yamamoto Y, Imai K, Omi N, Sato R, Sato F, Nakano M, Hamuro J, Tashiro K, Sotozono C, Kinoshita S
J Glaucoma 2023 Feb 1;32(2):127-132. Epub 2022 Aug 25 doi: 10.1097/IJG.0000000000002109. PMID: 36001508
Significance of the lncRNAs MALAT1 and ANRIL in occurrence and development of glaucoma.
Huang G, Liang D, Luo L, Lan C, Luo C, Xu H, Lai J
J Clin Lab Anal 2022 Feb;36(2):e24215. Epub 2022 Jan 14 doi: 10.1002/jcla.24215. PMID: 35028972Free PMC Article
Comparison of vertical cup-to-disc ratio estimates using stereoscopic and monoscopic cameras.
Shrestha R, Budenz DL, Mwanza JC, Tulenko SE, Fleischman D, Gower EW
Eye (Lond) 2021 Dec;35(12):3318-3324. Epub 2021 Jan 29 doi: 10.1038/s41433-021-01395-3. PMID: 33514892Free PMC Article
Automatic optic nerve head localization and cup-to-disc ratio detection using state-of-the-art deep-learning architectures.
Park K, Kim J, Lee J
Sci Rep 2020 Mar 19;10(1):5025. doi: 10.1038/s41598-020-62022-x. PMID: 32193499Free PMC Article

Therapy

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study.
Rajasundaram S, Segrè AV, Gill D, Woolf B, Zekavat SM, Burgess S, Khawaja AP, Zebardast N, Wiggs JL
Invest Ophthalmol Vis Sci 2024 Jul 1;65(8):35. doi: 10.1167/iovs.65.8.35. PMID: 39028976Free PMC Article
Causal relationships between Gut microbiota and primary open-angle Glaucoma: A Mendelian randomization and mediation analysis of Glaucoma endophenotypes.
Zhou X, Xu J, Zhang X, Zhao Y, Duan X
Exp Eye Res 2024 Mar;240:109788. Epub 2024 Jan 11 doi: 10.1016/j.exer.2024.109788. PMID: 38218362
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.
Han X, Gharahkhani P, Hamel AR, Ong JS, Rentería ME, Mehta P, Dong X, Pasutto F, Hammond C, Young TL, Hysi P, Lotery AJ, Jorgenson E, Choquet H, Hauser M, Cooke Bailey JN, Nakazawa T, Akiyama M, Shiga Y, Fuller ZL, Wang X, Hewitt AW, Craig JE, Pasquale LR, Mackey DA, Wiggs JL, Khawaja AP, Segrè AV; 23andMe Research Team; International Glaucoma Genetics Consortium, MacGregor S
Nat Genet 2023 Jul;55(7):1116-1125. Epub 2023 Jun 29 doi: 10.1038/s41588-023-01428-5. PMID: 37386247Free PMC Article
Eight-Year Incidence of Open-Angle Glaucoma in the Tema Eye Survey.
Mwanza JC, Tulenko SE, Barton K, Herndon LW, Mathenge E, Hall A, Kim HY, Hay-Smith G, Budenz DL
Ophthalmology 2019 Mar;126(3):372-380. Epub 2018 Oct 12 doi: 10.1016/j.ophtha.2018.10.016. PMID: 30316889
Cup-to-disc ratio: agreement between slit-lamp indirect ophthalmoscopic estimation and stratus optical coherence tomography measurement.
Arnalich-Montiel F, Muñoz-Negrete FJ, Rebolleda G, Sales-Sanz M, Cabarga C
Eye (Lond) 2007 Aug;21(8):1041-9. Epub 2006 May 5 doi: 10.1038/sj.eye.6702391. PMID: 16680099

Prognosis

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study.
Rajasundaram S, Segrè AV, Gill D, Woolf B, Zekavat SM, Burgess S, Khawaja AP, Zebardast N, Wiggs JL
Invest Ophthalmol Vis Sci 2024 Jul 1;65(8):35. doi: 10.1167/iovs.65.8.35. PMID: 39028976Free PMC Article
Association of progressive optic disc tilt with development of retinal nerve fibre layer defect in children with large cup-to-disc ratio.
Ha A, Baek SU, Kim JS, Jeoung JW, Park KH, Kim YK
Br J Ophthalmol 2023 Jun;107(6):869-875. Epub 2022 Jan 11 doi: 10.1136/bjophthalmol-2021-320029. PMID: 35017160
Comparison of vertical cup-to-disc ratio estimates using stereoscopic and monoscopic cameras.
Shrestha R, Budenz DL, Mwanza JC, Tulenko SE, Fleischman D, Gower EW
Eye (Lond) 2021 Dec;35(12):3318-3324. Epub 2021 Jan 29 doi: 10.1038/s41433-021-01395-3. PMID: 33514892Free PMC Article
Genetic Risk Score Is Associated with Vertical Cup-to-Disc Ratio and Improves Prediction of Primary Open-Angle Glaucoma in Latinos.
Nannini DR, Kim H, Fan F, Gao X
Ophthalmology 2018 Jun;125(6):815-821. Epub 2018 Feb 1 doi: 10.1016/j.ophtha.2017.12.014. PMID: 29361357Free PMC Article
Cup-to-Disc Ratio Asymmetry in U.S. Adults: Prevalence and Association with Glaucoma in the 2005-2008 National Health and Nutrition Examination Survey.
Qiu M, Boland MV, Ramulu PY
Ophthalmology 2017 Aug;124(8):1229-1236. Epub 2017 May 22 doi: 10.1016/j.ophtha.2017.03.049. PMID: 28545734

Clinical prediction guides

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study.
Rajasundaram S, Segrè AV, Gill D, Woolf B, Zekavat SM, Burgess S, Khawaja AP, Zebardast N, Wiggs JL
Invest Ophthalmol Vis Sci 2024 Jul 1;65(8):35. doi: 10.1167/iovs.65.8.35. PMID: 39028976Free PMC Article
Comparison of vertical cup-to-disc ratio estimates using stereoscopic and monoscopic cameras.
Shrestha R, Budenz DL, Mwanza JC, Tulenko SE, Fleischman D, Gower EW
Eye (Lond) 2021 Dec;35(12):3318-3324. Epub 2021 Jan 29 doi: 10.1038/s41433-021-01395-3. PMID: 33514892Free PMC Article
Glaucoma Workup in Congenital Zika Syndrome.
de Oliveira DR, Ventura CV, Esporcatte BLB, Gracitelli CPB, Dias NC, Ventura LO, Belfort R Jr, Rolim-de-Moura C
J Glaucoma 2019 Apr;28(4):313-317. doi: 10.1097/IJG.0000000000001150. PMID: 30531188
Genetic Risk Score Is Associated with Vertical Cup-to-Disc Ratio and Improves Prediction of Primary Open-Angle Glaucoma in Latinos.
Nannini DR, Kim H, Fan F, Gao X
Ophthalmology 2018 Jun;125(6):815-821. Epub 2018 Feb 1 doi: 10.1016/j.ophtha.2017.12.014. PMID: 29361357Free PMC Article
Cup to disc ratio by optical coherence tomography is abnormal in multiple sclerosis.
Syc SB, Warner CV, Saidha S, Farrell SK, Conger A, Bisker ER, Wilson J, Frohman TC, Frohman EM, Balcer LJ, Calabresi PA
J Neurol Sci 2011 Mar 15;302(1-2):19-24. Epub 2011 Jan 11 doi: 10.1016/j.jns.2010.12.011. PMID: 21227470Free PMC Article

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