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Elevated urine glycolate

MedGen UID:
1670965
•Concept ID:
C4732789
•
Finding
HPO: HP:0031981

Definition

An increased concentration of glycolate in the urine. [from HPO]

Professional guidelines

PubMed

Systematic assessment of urinary hydroxy-oxo-glutarate for diagnosis and follow-up of primary hyperoxaluria type III.
Ventzke A, Feldkötter M, Wei A, Becker J, Beck BB, Hoppe B
Pediatr Nephrol 2017 Dec;32(12):2263-2271. Epub 2017 Jul 15 doi: 10.1007/s00467-017-3731-3. PMID: 28711958
The relationship of panic disorder and its treatment outcome to 24-hour urinary MHPG levels.
Garvey M, Noyes R Jr, Cook B, Tollefson G
Psychiatry Res 1989 Oct;30(1):53-61. doi: 10.1016/0165-1781(89)90171-6. PMID: 2594871
Platelet and plasma amine oxidase inhibition and urinary amine excretion changes during phenelzine treatment.
Murphy DL, Brand E, Goldman T, Baker M, Wright C, van Kammen D, Gordon E
J Nerv Ment Dis 1977 Feb;164(2):129-34. doi: 10.1097/00005053-197702000-00008. PMID: 836485

Recent clinical studies

Etiology

Comprehensive metabolic modulations of sphingolipids are promising severity indicators in COVID-19.
Uranbileg B, Isago H, Nakayama H, Jubishi D, Okamoto K, Sakai E, Kubota M, Tsutsumi T, Moriya K, Kurano M
FASEB J 2024 Jul 31;38(14):e23827. doi: 10.1096/fj.202401099R. PMID: 39012295
Glycolate oxidase-1 gene variants influence the risk of hyperoxaluria and renal stone development.
Patel YP, Patel SB, Patel P, Parikh A, Soni S, Srivastava R, Raval C, Ganpule AP, Desai MR, Patel SG, Pandey SN
World J Urol 2024 Jan 12;42(1):28. doi: 10.1007/s00345-023-04718-z. PMID: 38214752
2,4-D exposure and urinary markers of oxidative DNA damage and lipid peroxidation: a longitudinal study.
Lerro CC, Andreotti G, Wong JY, Blair A, Rothman N, Beane Freeman LE
Occup Environ Med 2020 Apr;77(4):276-280. Epub 2020 Jan 29 doi: 10.1136/oemed-2019-106267. PMID: 31996474
Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations.
Kingman A, Hyman J, Masten SA, Jayaram B, Smith C, Eichmiller F, Arnold MC, Wong PA, Schaeffer JM, Solanki S, Dunn WJ
J Am Dent Assoc 2012 Dec;143(12):1292-302. doi: 10.14219/jada.archive.2012.0090. PMID: 23204083
Neuroendocrine and neurochemical measurements in depression.
Davis KL, Hollister LE, Mathé AA, Davis BM, Rothpearl AB, Faull KF, Hsieh JY, Barchas JD, Berger PA
Am J Psychiatry 1981 Dec;138(12):1555-62. doi: 10.1176/ajp.138.12.1555. PMID: 6171169

Diagnosis

Diethylene glycol produces nephrotoxic and neurotoxic effects in female rats.
Jamison CN, Dayton RD, Latimer B, McKinney MP, Mitchell HG, McMartin KE
Clin Toxicol (Phila) 2022 Mar;60(3):324-331. Epub 2021 Jul 19 doi: 10.1080/15563650.2021.1953049. PMID: 34278906Free PMC Article
Rapid liquid chromatography tandem mass-spectrometry screening method for urinary metabolites of primary hyperoxaluria.
Woodward G, Pryke R, Hoppe B, Rumsby G
Ann Clin Biochem 2019 Mar;56(2):232-239. Epub 2018 Nov 14 doi: 10.1177/0004563218811365. PMID: 30373392
Simultaneous analysis of urinary metabolites for preliminary identification of primary hyperoxaluria.
Clifford-Mobley O, Hewitt L, Rumsby G
Ann Clin Biochem 2016 Jul;53(Pt 4):485-94. Epub 2015 Sep 4 doi: 10.1177/0004563215606158. PMID: 26342005
Primary hyperoxaluria.
Tantbirojn P, Kittikowit W, Kingwattanakul P
J Med Assoc Thai 2007 Aug;90(8):1669-72. PMID: 17927001
Catecholamine metabolism in neuroblastoma.
LaBrosse EH, Comoy E, Bohuon C, Zucker JM, Schweisguth O
J Natl Cancer Inst 1976 Sep;57(3):633-8. doi: 10.1093/jnci/57.3.633. PMID: 10450

Therapy

Urinary concentrations of GHB and its novel amino acid and carnitine conjugates following controlled GHB administration to humans.
Steuer AE, Bavato F, Schnider LK, Dornbierer DA, Bosch OG, Quednow BB, Seifritz E, Steuer C, Kraemer T
Sci Rep 2023 Jun 2;13(1):8983. doi: 10.1038/s41598-023-36213-1. PMID: 37268859Free PMC Article
A neonate with metabolic acidosis: Intentional ethylene glycol poisoning.
Greenky D, Ball TT, Murray B
Am J Emerg Med 2021 Jun;44:478.e5-478.e6. Epub 2020 Nov 6 doi: 10.1016/j.ajem.2020.10.078. PMID: 33176951
Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples from the Panama DEG mass poisoning.
Schier JG, Hunt DR, Perala A, McMartin KE, Bartels MJ, Lewis LS, McGeehin MA, Flanders WD
Clin Toxicol (Phila) 2013 Dec;51(10):923-9. Epub 2013 Nov 25 doi: 10.3109/15563650.2013.850504. PMID: 24266434Free PMC Article
Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations.
Kingman A, Hyman J, Masten SA, Jayaram B, Smith C, Eichmiller F, Arnold MC, Wong PA, Schaeffer JM, Solanki S, Dunn WJ
J Am Dent Assoc 2012 Dec;143(12):1292-302. doi: 10.14219/jada.archive.2012.0090. PMID: 23204083
Neuroendocrine and neurochemical measurements in depression.
Davis KL, Hollister LE, Mathé AA, Davis BM, Rothpearl AB, Faull KF, Hsieh JY, Barchas JD, Berger PA
Am J Psychiatry 1981 Dec;138(12):1555-62. doi: 10.1176/ajp.138.12.1555. PMID: 6171169

Prognosis

Comprehensive metabolic modulations of sphingolipids are promising severity indicators in COVID-19.
Uranbileg B, Isago H, Nakayama H, Jubishi D, Okamoto K, Sakai E, Kubota M, Tsutsumi T, Moriya K, Kurano M
FASEB J 2024 Jul 31;38(14):e23827. doi: 10.1096/fj.202401099R. PMID: 39012295
MicroRNA-4516 in Urinary Exosomes as a Biomarker of Premature Ovarian Insufficiency.
Umair Z, Baek MO, Song J, An S, Chon SJ, Yoon MS
Cells 2022 Sep 7;11(18) doi: 10.3390/cells11182797. PMID: 36139370Free PMC Article
Systematic assessment of urinary hydroxy-oxo-glutarate for diagnosis and follow-up of primary hyperoxaluria type III.
Ventzke A, Feldkötter M, Wei A, Becker J, Beck BB, Hoppe B
Pediatr Nephrol 2017 Dec;32(12):2263-2271. Epub 2017 Jul 15 doi: 10.1007/s00467-017-3731-3. PMID: 28711958
Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations.
Kingman A, Hyman J, Masten SA, Jayaram B, Smith C, Eichmiller F, Arnold MC, Wong PA, Schaeffer JM, Solanki S, Dunn WJ
J Am Dent Assoc 2012 Dec;143(12):1292-302. doi: 10.14219/jada.archive.2012.0090. PMID: 23204083
Catecholamine metabolism in neuroblastoma.
LaBrosse EH, Comoy E, Bohuon C, Zucker JM, Schweisguth O
J Natl Cancer Inst 1976 Sep;57(3):633-8. doi: 10.1093/jnci/57.3.633. PMID: 10450

Clinical prediction guides

Succinic semialdehyde dehydrogenase deficiency in mice and in humans: An untargeted metabolomics perspective.
Peters TMA, Engelke UFH, de Boer S, Reintjes JTG, Roullet JB, Broekman S, de Vrieze E, van Wijk E, Wamelink MMC, Artuch R, Barić I, Merx J, Boltje TJ, Martens J, Willemsen MAAP, Verbeek MM, Wevers RA, Gibson KM, Coene KLM
J Inherit Metab Dis 2024 May;47(3):417-430. Epub 2023 Jul 29 doi: 10.1002/jimd.12657. PMID: 37455357
Diethylene glycol produces nephrotoxic and neurotoxic effects in female rats.
Jamison CN, Dayton RD, Latimer B, McKinney MP, Mitchell HG, McMartin KE
Clin Toxicol (Phila) 2022 Mar;60(3):324-331. Epub 2021 Jul 19 doi: 10.1080/15563650.2021.1953049. PMID: 34278906Free PMC Article
Neurotoxic effects of nephrotoxic compound diethylene glycol.
Jamison CN, Dayton RD, Latimer B, McKinney MP, Mitchell HG, McMartin KE
Clin Toxicol (Phila) 2021 Sep;59(9):810-821. Epub 2021 Jan 21 doi: 10.1080/15563650.2021.1874403. PMID: 33475432Free PMC Article
Simultaneous analysis of urinary metabolites for preliminary identification of primary hyperoxaluria.
Clifford-Mobley O, Hewitt L, Rumsby G
Ann Clin Biochem 2016 Jul;53(Pt 4):485-94. Epub 2015 Sep 4 doi: 10.1177/0004563215606158. PMID: 26342005
Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations.
Kingman A, Hyman J, Masten SA, Jayaram B, Smith C, Eichmiller F, Arnold MC, Wong PA, Schaeffer JM, Solanki S, Dunn WJ
J Am Dent Assoc 2012 Dec;143(12):1292-302. doi: 10.14219/jada.archive.2012.0090. PMID: 23204083

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