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Abnormal urine carboxylic acid level

MedGen UID:
1671015
•Concept ID:
C4732917
•
Finding
HPO: HP:0031980

Definition

Any deviation from the normal concentration of a carboxylic acid in the urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal urine carboxylic acid level

Professional guidelines

PubMed

Clinical characteristics and genotype analysis of five infants with cblX type of methylmalonic acidemia.
Wang F, Liang L, Ling S, Yu Y, Chen T, Xu F, Gong Z, Han L
Zhejiang Da Xue Xue Bao Yi Xue Ban 2022 Jun 25;51(3):298-305. doi: 10.3724/zdxbyxb-2022-0194. PMID: 36207831Free PMC Article
Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review.
Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Clinical and Metabolic Correlates of Calcium Oxalate Stone Subtypes: Implications for Etiology and Management.
Bamberger JN, Blum KA, Kan KM, Parkhomenko E, Gallante B, Gupta M
J Endourol 2019 Sep;33(9):755-760. Epub 2019 Jul 31 doi: 10.1089/end.2019.0245. PMID: 31154910

Recent clinical studies

Etiology

Relationship between psoriasis and urolithiasis.
Oğuz ID, Oğuz U, Usta M, Kulaklı S, Tosun A, Demirelli E, Akşan B, Emecen Ö, Yüzüak E
J Dermatol 2024 Feb;51(2):280-286. Epub 2023 Dec 12 doi: 10.1111/1346-8138.17058. PMID: 38087833
Scurvy.
Krečak I, Babić G, Skelin M
Acta Dermatovenerol Croat 2022 Jul;30(1):59-60. PMID: 36153722
Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility.
Ji J, Song L, Wang J, Yang Z, Yan H, Li T, Yu L, Jian L, Jiang F, Li J, Zheng J, Li K
Environ Int 2021 Aug;153:106524. Epub 2021 Mar 19 doi: 10.1016/j.envint.2021.106524. PMID: 33773143Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates.
El-Mashad AE, El-Mahdy H, El Amrousy D, Elgendy M
Eur J Pediatr 2017 Feb;176(2):233-240. Epub 2016 Dec 21 doi: 10.1007/s00431-016-2830-7. PMID: 28004188

Diagnosis

Laboratory and metabolic investigations.
Morava E, Oglesbee D
Handb Clin Neurol 2023;194:167-172. doi: 10.1016/B978-0-12-821751-1.00012-9. PMID: 36813311
Scurvy.
Krečak I, Babić G, Skelin M
Acta Dermatovenerol Croat 2022 Jul;30(1):59-60. PMID: 36153722
Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review.
Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Diagnostic evaluation of rhabdomyolysis.
Nance JR, Mammen AL
Muscle Nerve 2015 Jun;51(6):793-810. Epub 2015 Mar 14 doi: 10.1002/mus.24606. PMID: 25678154Free PMC Article

Therapy

Scurvy.
Krečak I, Babić G, Skelin M
Acta Dermatovenerol Croat 2022 Jul;30(1):59-60. PMID: 36153722
Evidence for disordered acid-base handling in calcium stone-forming patients.
Worcester EM, Bergsland KJ, Gillen DL, Coe FL
Am J Physiol Renal Physiol 2020 Feb 1;318(2):F363-F374. Epub 2019 Dec 2 doi: 10.1152/ajprenal.00400.2019. PMID: 31790303Free PMC Article
Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates.
El-Mashad AE, El-Mahdy H, El Amrousy D, Elgendy M
Eur J Pediatr 2017 Feb;176(2):233-240. Epub 2016 Dec 21 doi: 10.1007/s00431-016-2830-7. PMID: 28004188
Behavioral and neurochemical effects of proline.
Wyse AT, Netto CA
Metab Brain Dis 2011 Sep;26(3):159-72. Epub 2011 Jun 4 doi: 10.1007/s11011-011-9246-x. PMID: 21643764
Iron chelation therapy.
Hoffbrand AV, Wonke B
J Intern Med Suppl 1997;740:37-41. PMID: 9350180

Prognosis

Preoperative and postoperative urinary NGAL levels in children with bladder exstrophy.
Gupta A, Bajpai M, Anand S, Ali A
J Nephrol 2023 Jun;36(5):1409-1414. Epub 2022 Dec 23 doi: 10.1007/s40620-022-01548-x. PMID: 36562911
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Du X, Yang L, Kong L, Sun Y, Shen K, Cai Y, Sun H, Zhang B, Guo S, Zhang A, Wang X
Front Endocrinol (Lausanne) 2022;13:1037164. Epub 2022 Oct 27 doi: 10.3389/fendo.2022.1037164. PMID: 36387907Free PMC Article
Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review.
Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Type 1 tyrosinemia in Finland: a nationwide study.
Äärelä L, Hiltunen P, Soini T, Vuorela N, Huhtala H, Nevalainen PI, Heikinheimo M, Kivelä L, Kurppa K
Orphanet J Rare Dis 2020 Oct 12;15(1):281. doi: 10.1186/s13023-020-01547-w. PMID: 33046095Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

Clinical prediction guides

Laboratory and metabolic investigations.
Morava E, Oglesbee D
Handb Clin Neurol 2023;194:167-172. doi: 10.1016/B978-0-12-821751-1.00012-9. PMID: 36813311
Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review.
Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Clinical and Metabolic Correlates of Calcium Oxalate Stone Subtypes: Implications for Etiology and Management.
Bamberger JN, Blum KA, Kan KM, Parkhomenko E, Gallante B, Gupta M
J Endourol 2019 Sep;33(9):755-760. Epub 2019 Jul 31 doi: 10.1089/end.2019.0245. PMID: 31154910
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Chemical toxicity of red cells.
Piomelli S
Environ Health Perspect 1981 Jun;39:65-70. doi: 10.1289/ehp.813965. PMID: 7016524Free PMC Article

Recent systematic reviews

Association between prenatal phthalate exposure and gestational metabolic syndrome parameters: a systematic review of epidemiological studies.
Gao H, Zhang C, Tao FB
Environ Sci Pollut Res Int 2021 May;28(17):20921-20938. Epub 2021 Mar 5 doi: 10.1007/s11356-021-13120-4. PMID: 33674970
Comparative efficacy and safety of mycophenolate mofetil and cyclophosphamide in the induction treatment of lupus nephritis: A systematic review and meta-analysis.
Jiang YP, Zhao XX, Chen RR, Xu ZH, Wen CP, Yu J
Medicine (Baltimore) 2020 Sep 18;99(38):e22328. doi: 10.1097/MD.0000000000022328. PMID: 32957400Free PMC Article
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.
Ohlsson A, Shah PS
Cochrane Database Syst Rev 2018 Apr 6;4(4):CD010061. doi: 10.1002/14651858.CD010061.pub3. PMID: 29624206Free PMC Article
Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.
Shah SS, Ohlsson A
Cochrane Database Syst Rev 2006 Jan 25;(1):CD004213. doi: 10.1002/14651858.CD004213.pub2. PMID: 16437478
Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.
Shah SS, Ohlsson A
Cochrane Database Syst Rev 2003;(2):CD004213. doi: 10.1002/14651858.CD004213. PMID: 12804505

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