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Abnormal conus terminalis morphology

MedGen UID:
1671014
•Concept ID:
C4732765
•
Anatomical Abnormality
Synonym: Abnormal conus medullaris morphology
 
HPO: HP:0031938

Definition

Any structural anomaly of the conus terminalis, which is the distal bulbous part of the spinal cord at the location where the spinal cord tapers and ends (usually between the L1 and L2 lumbar vertebrae). [from HPO]

Professional guidelines

PubMed

Spinal arteriovenous malformations: surgical management.
Xu DS, Sun H, Spetzler RF
Handb Clin Neurol 2017;143:153-160. doi: 10.1016/B978-0-444-63640-9.00015-1. PMID: 28552138
Lipomyelomeningocele: pathology, treatment, and outcomes.
Sarris CE, Tomei KL, Carmel PW, Gandhi CD
Neurosurg Focus 2012 Oct;33(4):E3. doi: 10.3171/2012.7.FOCUS12224. PMID: 23025444
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Recent clinical studies

Etiology

Imaging of Congenital Spine Malformations.
White C, Milla SS, Maloney JA, Neuberger I
Clin Perinatol 2022 Sep;49(3):623-640. doi: 10.1016/j.clp.2022.05.003. PMID: 36113926
Spinal cavernous malformations.
Clark AJ, Wang DD, Lawton MT
Handb Clin Neurol 2017;143:303-308. doi: 10.1016/B978-0-444-63640-9.00030-8. PMID: 28552154
Iatrogenic spinal deformity.
Jagannathan J, Sansur CA, Shaffrey CI
Neurosurgery 2008 Sep;63(3 Suppl):104-16. doi: 10.1227/01.NEU.0000320386.08993.BE. PMID: 18812912
Tethered cord syndrome: an updated review.
Lew SM, Kothbauer KF
Pediatr Neurosurg 2007;43(3):236-48. doi: 10.1159/000098836. PMID: 17409793
Congenital scoliosis.
Arlet V, Odent T, Aebi M
Eur Spine J 2003 Oct;12(5):456-63. Epub 2003 Jun 14 doi: 10.1007/s00586-003-0555-6. PMID: 14618384Free PMC Article

Diagnosis

Spinal Vascular Shunts: A Patterned Approach.
Kona MP, Buch K, Singh J, Rohatgi S
AJNR Am J Neuroradiol 2021 Dec;42(12):2110-2118. Epub 2021 Oct 14 doi: 10.3174/ajnr.A7312. PMID: 34649916Free PMC Article
Spinal arteriovenous fistulae: surgical management.
Day AL, Turkmani AH, Chen PR
Handb Clin Neurol 2017;143:189-198. doi: 10.1016/B978-0-444-63640-9.00018-7. PMID: 28552141
Congenital Chiari malformations.
Vannemreddy P, Nourbakhsh A, Willis B, Guthikonda B
Neurol India 2010 Jan-Feb;58(1):6-14. doi: 10.4103/0028-3886.60387. PMID: 20228456
Tethered cord syndrome: an updated review.
Lew SM, Kothbauer KF
Pediatr Neurosurg 2007;43(3):236-48. doi: 10.1159/000098836. PMID: 17409793
Robinow syndrome.
Patton MA, Afzal AR
J Med Genet 2002 May;39(5):305-10. doi: 10.1136/jmg.39.5.305. PMID: 12011143Free PMC Article

Therapy

White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies.
Swanson MR, Hazlett HC
J Neurodev Disord 2019 Dec 16;11(1):33. doi: 10.1186/s11689-019-9295-8. PMID: 31839003Free PMC Article
Subacute ascending numbness.
Arshi B, Shaw S
Clin Toxicol (Phila) 2014 Sep-Oct;52(8):905-6. doi: 10.3109/15563650.2014.953170. PMID: 25200456
Intramedullary spinal cord hemorrhage (hematomyelia).
Leep Hunderfund AN, Wijdicks EF
Rev Neurol Dis 2009 Spring;6(2):E54-61. PMID: 19587631
Adult acute nonlymphocytic leukemias.
Dabich L
Med Clin North Am 1980 Jul;64(4):683-704. doi: 10.1016/s0025-7125(16)31588-7. PMID: 6995730
Neuropathology.
Kaufman MA, Roizin L, Gold G
Prog Neurol Psychiatry 1968;23:110-33. PMID: 4304824

Prognosis

Incomplete Cord Syndromes: Clinical and Imaging Review.
Kunam VK, Velayudhan V, Chaudhry ZA, Bobinski M, Smoker WRK, Reede DL
Radiographics 2018 Jul-Aug;38(4):1201-1222. doi: 10.1148/rg.2018170178. PMID: 29995620
Epidemiology of cavernous malformations.
Goldstein HE, Solomon RA
Handb Clin Neurol 2017;143:241-247. doi: 10.1016/B978-0-444-63640-9.00023-0. PMID: 28552146
Neonatal surgical emergencies: stabilization and management.
Lockridge T, Caldwell AD, Jason P
J Obstet Gynecol Neonatal Nurs 2002 May-Jun;31(3):328-39. doi: 10.1111/j.1552-6909.2002.tb00055.x. PMID: 12033546
Split cord malformations.
Dias MS, Pang D
Neurosurg Clin N Am 1995 Apr;6(2):339-58. PMID: 7620358
Open myelomeningocele.
Hahn YS
Neurosurg Clin N Am 1995 Apr;6(2):231-41. PMID: 7620350

Clinical prediction guides

On Denny-Brown's 'spastic dystonia' - What is it and what causes it?
Lorentzen J, Pradines M, Gracies JM, Bo Nielsen J
Clin Neurophysiol 2018 Jan;129(1):89-94. Epub 2017 Nov 4 doi: 10.1016/j.clinph.2017.10.023. PMID: 29161622
Chiari Malformations and Syringohydromyelia in Children.
Poretti A, Boltshauser E, Huisman TA
Semin Ultrasound CT MR 2016 Apr;37(2):129-42. Epub 2015 Dec 10 doi: 10.1053/j.sult.2015.12.001. PMID: 27063663
Spinal dural arteriovenous fistulas.
Krings T, Geibprasert S
AJNR Am J Neuroradiol 2009 Apr;30(4):639-48. Epub 2009 Feb 12 doi: 10.3174/ajnr.A1485. PMID: 19213818Free PMC Article
Conventional MR imaging.
Traboulsee A, Li DK
Neuroimaging Clin N Am 2008 Nov;18(4):651-73, x. doi: 10.1016/j.nic.2008.07.001. PMID: 19068407
Congenital scoliosis.
Arlet V, Odent T, Aebi M
Eur Spine J 2003 Oct;12(5):456-63. Epub 2003 Jun 14 doi: 10.1007/s00586-003-0555-6. PMID: 14618384Free PMC Article

Recent systematic reviews

Cervical Split Cord Malformations: A Systematic Review.
Sreenivasan R, Sharma R, Borkar SA, Arumulla S, Garg K, Chandra SP, Kale SS, Mahapatra AK
Neurol India 2020 Sep-Oct;68(5):994-1002. doi: 10.4103/0028-3886.299132. PMID: 33109840
Integrating retrogenesis theory to Alzheimer's disease pathology: insight from DTI-TBSS investigation of the white matter microstructural integrity.
Alves GS, Oertel Knöchel V, Knöchel C, Carvalho AF, Pantel J, Engelhardt E, Laks J
Biomed Res Int 2015;2015:291658. Epub 2015 Jan 20 doi: 10.1155/2015/291658. PMID: 25685779Free PMC Article
The role of white matter abnormalities in treatment-resistant depression: a systematic review.
Serafini G, Pompili M, Borgwardt S, Giuffra E, Howes O, Girardi P, Amore M
Curr Pharm Des 2015;21(10):1337-46. doi: 10.2174/1381612820666140929094531. PMID: 25269562
Instrumentation and fusion for congenital spine deformities.
Hedequist DJ
Spine (Phila Pa 1976) 2009 Aug 1;34(17):1783-90. doi: 10.1097/BRS.0b013e3181ab62b3. PMID: 19644329
Noninvasive measurement and screening techniques for spinal deformities.
Harrop JS, Birknes J, Shaffrey CI
Neurosurgery 2008 Sep;63(3 Suppl):46-53. doi: 10.1227/01.NEU.0000325678.25152.A7. PMID: 18812932

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