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Stage IIC Adult Soft Tissue Sarcoma

MedGen UID:
167141
•Concept ID:
C0796439
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IIC Adult Soft Tissue Sarcoma

Recent clinical studies

Etiology

Adjuvant vemurafenib in resected, BRAF(V600) mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Maio M, Lewis K, Demidov L, Mandalà M, Bondarenko I, Ascierto PA, Herbert C, Mackiewicz A, Rutkowski P, Guminski A, Goodman GR, Simmons B, Ye C, Yan Y, Schadendorf D; BRIM8 Investigators
Lancet Oncol 2018 Apr;19(4):510-520. Epub 2018 Feb 21 doi: 10.1016/S1470-2045(18)30106-2. PMID: 29477665
The natural history and prognosticative factors of adult extremity soft tissue sarcomas: an Asian perspective.
Wang L, Tan MH
Ann Acad Med Singap 2010 Oct;39(10):771-7. PMID: 21063637
Expression and significance of EGFR in malignant peripheral nerve sheath tumor.
Keizman D, Issakov J, Meller I, Maimon N, Ish-Shalom M, Sher O, Merimsky O
J Neurooncol 2009 Sep;94(3):383-8. Epub 2009 Mar 28 doi: 10.1007/s11060-009-9862-z. PMID: 19330289
Radiocurability of microscopic disease in childhood rhabdomyosarcoma with radiation doses less than 4,000 cGy.
Mandell L, Ghavimi F, Peretz T, LaQuaglia M, Exelby P
J Clin Oncol 1990 Sep;8(9):1536-42. doi: 10.1200/JCO.1990.8.9.1536. PMID: 2391558

Diagnosis

Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial.
Schadendorf D, Luke JJ, Ascierto PA, Long GV, Rutkowski P, Khattak A, Del Vecchio M, de la Cruz-Merino L, Mackiewicz J, Sileni VC, Kirkwood JM, Robert C, Grob JJ, Dummer R, Carlino MS, Zhao Y, Kalabis M, Krepler C, Eggermont A, Scolyer RA
J Immunother Cancer 2024 Mar 13;12(3) doi: 10.1136/jitc-2023-007501. PMID: 38485189Free PMC Article
Multiple carcinosarcomas of the esophagus with adeno-carcinomatous components: A case report.
Okamoto H, Kikuchi H, Naganuma H, Kamei T
World J Gastroenterol 2020 May 7;26(17):2111-2118. doi: 10.3748/wjg.v26.i17.2111. PMID: 32536778Free PMC Article
Expression and significance of EGFR in malignant peripheral nerve sheath tumor.
Keizman D, Issakov J, Meller I, Maimon N, Ish-Shalom M, Sher O, Merimsky O
J Neurooncol 2009 Sep;94(3):383-8. Epub 2009 Mar 28 doi: 10.1007/s11060-009-9862-z. PMID: 19330289
Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component.
Clement PB, Young RH, Keh P, Ostör AG, Scully RE
Am J Surg Pathol 1995 Oct;19(10):1158-71. doi: 10.1097/00000478-199510000-00006. PMID: 7573674
Treatment of ovarian cancer in the Southern Swedish Health Care Region during the five-year period 1974-1978.
Sigurdsson K, Johnsson JE, Möller T
Ann Chir Gynaecol 1983;72(5):260-7. PMID: 6318647

Therapy

Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial.
Schadendorf D, Luke JJ, Ascierto PA, Long GV, Rutkowski P, Khattak A, Del Vecchio M, de la Cruz-Merino L, Mackiewicz J, Sileni VC, Kirkwood JM, Robert C, Grob JJ, Dummer R, Carlino MS, Zhao Y, Kalabis M, Krepler C, Eggermont A, Scolyer RA
J Immunother Cancer 2024 Mar 13;12(3) doi: 10.1136/jitc-2023-007501. PMID: 38485189Free PMC Article
Health-related quality of life in patients with fully resected BRAF(V600) mutation-positive melanoma receiving adjuvant vemurafenib.
Schadendorf D, Di Giacomo AM, Demidov L, Merelli B, Bondarenko I, Ascierto PA, Herbert C, Mackiewicz A, Rutkowski P, Guminski A, Goodman GR, Simmons B, Ye C, Hong A, Lewis K; BRIM8 Investigators
Eur J Cancer 2019 Dec;123:155-161. Epub 2019 Nov 5 doi: 10.1016/j.ejca.2019.09.019. PMID: 31704549
Adjuvant vemurafenib in resected, BRAF(V600) mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Maio M, Lewis K, Demidov L, Mandalà M, Bondarenko I, Ascierto PA, Herbert C, Mackiewicz A, Rutkowski P, Guminski A, Goodman GR, Simmons B, Ye C, Yan Y, Schadendorf D; BRIM8 Investigators
Lancet Oncol 2018 Apr;19(4):510-520. Epub 2018 Feb 21 doi: 10.1016/S1470-2045(18)30106-2. PMID: 29477665
Radiocurability of microscopic disease in childhood rhabdomyosarcoma with radiation doses less than 4,000 cGy.
Mandell L, Ghavimi F, Peretz T, LaQuaglia M, Exelby P
J Clin Oncol 1990 Sep;8(9):1536-42. doi: 10.1200/JCO.1990.8.9.1536. PMID: 2391558
Treatment of ovarian cancer in the Southern Swedish Health Care Region during the five-year period 1974-1978.
Sigurdsson K, Johnsson JE, Möller T
Ann Chir Gynaecol 1983;72(5):260-7. PMID: 6318647

Prognosis

The natural history and prognosticative factors of adult extremity soft tissue sarcomas: an Asian perspective.
Wang L, Tan MH
Ann Acad Med Singap 2010 Oct;39(10):771-7. PMID: 21063637
Expression and significance of EGFR in malignant peripheral nerve sheath tumor.
Keizman D, Issakov J, Meller I, Maimon N, Ish-Shalom M, Sher O, Merimsky O
J Neurooncol 2009 Sep;94(3):383-8. Epub 2009 Mar 28 doi: 10.1007/s11060-009-9862-z. PMID: 19330289
Malignant mixed müllerian tumors of the ovary.
Wei CF, Hwang SH, Ho CM, Shih BY, Chien TY
Zhonghua Yi Xue Za Zhi (Taipei) 2000 Apr;63(4):344-8. PMID: 10820916
Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component.
Clement PB, Young RH, Keh P, Ostör AG, Scully RE
Am J Surg Pathol 1995 Oct;19(10):1158-71. doi: 10.1097/00000478-199510000-00006. PMID: 7573674
Treatment of ovarian cancer in the Southern Swedish Health Care Region during the five-year period 1974-1978.
Sigurdsson K, Johnsson JE, Möller T
Ann Chir Gynaecol 1983;72(5):260-7. PMID: 6318647

Clinical prediction guides

Health-related quality of life in patients with fully resected BRAF(V600) mutation-positive melanoma receiving adjuvant vemurafenib.
Schadendorf D, Di Giacomo AM, Demidov L, Merelli B, Bondarenko I, Ascierto PA, Herbert C, Mackiewicz A, Rutkowski P, Guminski A, Goodman GR, Simmons B, Ye C, Hong A, Lewis K; BRIM8 Investigators
Eur J Cancer 2019 Dec;123:155-161. Epub 2019 Nov 5 doi: 10.1016/j.ejca.2019.09.019. PMID: 31704549
The natural history and prognosticative factors of adult extremity soft tissue sarcomas: an Asian perspective.
Wang L, Tan MH
Ann Acad Med Singap 2010 Oct;39(10):771-7. PMID: 21063637
Expression and significance of EGFR in malignant peripheral nerve sheath tumor.
Keizman D, Issakov J, Meller I, Maimon N, Ish-Shalom M, Sher O, Merimsky O
J Neurooncol 2009 Sep;94(3):383-8. Epub 2009 Mar 28 doi: 10.1007/s11060-009-9862-z. PMID: 19330289
Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component.
Clement PB, Young RH, Keh P, Ostör AG, Scully RE
Am J Surg Pathol 1995 Oct;19(10):1158-71. doi: 10.1097/00000478-199510000-00006. PMID: 7573674

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