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Stage IIC Soft Tissue Sarcoma

MedGen UID:
167162
•Concept ID:
C0796622
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IIC Soft Tissue Sarcoma

Professional guidelines

PubMed

Pembrolizumab for the adjuvant treatment of IIB or IIC melanoma.
Rutkowski P, Czarnecka AM
Expert Rev Anticancer Ther 2023 Jul-Dec;23(9):897-902. Epub 2023 Aug 13 doi: 10.1080/14737140.2023.2247565. PMID: 37573515

Recent clinical studies

Etiology

Pembrolizumab for the adjuvant treatment of IIB or IIC melanoma.
Rutkowski P, Czarnecka AM
Expert Rev Anticancer Ther 2023 Jul-Dec;23(9):897-902. Epub 2023 Aug 13 doi: 10.1080/14737140.2023.2247565. PMID: 37573515
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAF(v600) mutation-positive melanoma receiving adjuvant vemurafenib.
Ascierto PA, Lewis KD, Di Giacomo AM, Demidov L, Mandalà M, Bondarenko I, Herbert C, Mackiewicz A, Rutkowski P, Guminski A, Simmons B, Ye C, Hooper G, Wongchenko MJ, Goodman GR, Yan Y, Schadendorf D
Ann Oncol 2020 Jan;31(1):153-159. doi: 10.1016/j.annonc.2019.10.002. PMID: 31912791
Testicular tumors in children.
Ciftci AO, Bingöl-Koloğlu M, Senocak ME, Tanyel FC, Büyükpamukçu M, Büyükpamukçu N
J Pediatr Surg 2001 Dec;36(12):1796-801. doi: 10.1053/jpsu.2001.28841. PMID: 11733909
Radiocurability of microscopic disease in childhood rhabdomyosarcoma with radiation doses less than 4,000 cGy.
Mandell L, Ghavimi F, Peretz T, LaQuaglia M, Exelby P
J Clin Oncol 1990 Sep;8(9):1536-42. doi: 10.1200/JCO.1990.8.9.1536. PMID: 2391558

Diagnosis

Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial.
Schadendorf D, Luke JJ, Ascierto PA, Long GV, Rutkowski P, Khattak A, Del Vecchio M, de la Cruz-Merino L, Mackiewicz J, Sileni VC, Kirkwood JM, Robert C, Grob JJ, Dummer R, Carlino MS, Zhao Y, Kalabis M, Krepler C, Eggermont A, Scolyer RA
J Immunother Cancer 2024 Mar 13;12(3) doi: 10.1136/jitc-2023-007501. PMID: 38485189Free PMC Article
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Multiple carcinosarcomas of the esophagus with adeno-carcinomatous components: A case report.
Okamoto H, Kikuchi H, Naganuma H, Kamei T
World J Gastroenterol 2020 May 7;26(17):2111-2118. doi: 10.3748/wjg.v26.i17.2111. PMID: 32536778Free PMC Article
Testicular tumors in children.
Ciftci AO, Bingöl-Koloğlu M, Senocak ME, Tanyel FC, Büyükpamukçu M, Büyükpamukçu N
J Pediatr Surg 2001 Dec;36(12):1796-801. doi: 10.1053/jpsu.2001.28841. PMID: 11733909
Treatment of ovarian cancer in the Southern Swedish Health Care Region during the five-year period 1974-1978.
Sigurdsson K, Johnsson JE, Möller T
Ann Chir Gynaecol 1983;72(5):260-7. PMID: 6318647

Therapy

Pembrolizumab for the adjuvant treatment of IIB or IIC melanoma.
Rutkowski P, Czarnecka AM
Expert Rev Anticancer Ther 2023 Jul-Dec;23(9):897-902. Epub 2023 Aug 13 doi: 10.1080/14737140.2023.2247565. PMID: 37573515
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Long GV, Luke JJ, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Mohr P, Dummer R, Gershenwald JE, Yoon CH, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Ascierto PA; KEYNOTE-716 Investigators
Lancet Oncol 2022 Nov;23(11):1378-1388. Epub 2022 Oct 18 doi: 10.1016/S1470-2045(22)00559-9. PMID: 36265502
Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAF(v600) mutation-positive melanoma receiving adjuvant vemurafenib.
Ascierto PA, Lewis KD, Di Giacomo AM, Demidov L, Mandalà M, Bondarenko I, Herbert C, Mackiewicz A, Rutkowski P, Guminski A, Simmons B, Ye C, Hooper G, Wongchenko MJ, Goodman GR, Yan Y, Schadendorf D
Ann Oncol 2020 Jan;31(1):153-159. doi: 10.1016/j.annonc.2019.10.002. PMID: 31912791
Radiocurability of microscopic disease in childhood rhabdomyosarcoma with radiation doses less than 4,000 cGy.
Mandell L, Ghavimi F, Peretz T, LaQuaglia M, Exelby P
J Clin Oncol 1990 Sep;8(9):1536-42. doi: 10.1200/JCO.1990.8.9.1536. PMID: 2391558
Treatment of ovarian cancer in the Southern Swedish Health Care Region during the five-year period 1974-1978.
Sigurdsson K, Johnsson JE, Möller T
Ann Chir Gynaecol 1983;72(5):260-7. PMID: 6318647

Prognosis

Pembrolizumab for the adjuvant treatment of IIB or IIC melanoma.
Rutkowski P, Czarnecka AM
Expert Rev Anticancer Ther 2023 Jul-Dec;23(9):897-902. Epub 2023 Aug 13 doi: 10.1080/14737140.2023.2247565. PMID: 37573515
Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAF(v600) mutation-positive melanoma receiving adjuvant vemurafenib.
Ascierto PA, Lewis KD, Di Giacomo AM, Demidov L, Mandalà M, Bondarenko I, Herbert C, Mackiewicz A, Rutkowski P, Guminski A, Simmons B, Ye C, Hooper G, Wongchenko MJ, Goodman GR, Yan Y, Schadendorf D
Ann Oncol 2020 Jan;31(1):153-159. doi: 10.1016/j.annonc.2019.10.002. PMID: 31912791
The natural history and prognosticative factors of adult extremity soft tissue sarcomas: an Asian perspective.
Wang L, Tan MH
Ann Acad Med Singap 2010 Oct;39(10):771-7. PMID: 21063637
Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component.
Clement PB, Young RH, Keh P, Ostör AG, Scully RE
Am J Surg Pathol 1995 Oct;19(10):1158-71. doi: 10.1097/00000478-199510000-00006. PMID: 7573674
Treatment of ovarian cancer in the Southern Swedish Health Care Region during the five-year period 1974-1978.
Sigurdsson K, Johnsson JE, Möller T
Ann Chir Gynaecol 1983;72(5):260-7. PMID: 6318647

Clinical prediction guides

Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAF(v600) mutation-positive melanoma receiving adjuvant vemurafenib.
Ascierto PA, Lewis KD, Di Giacomo AM, Demidov L, Mandalà M, Bondarenko I, Herbert C, Mackiewicz A, Rutkowski P, Guminski A, Simmons B, Ye C, Hooper G, Wongchenko MJ, Goodman GR, Yan Y, Schadendorf D
Ann Oncol 2020 Jan;31(1):153-159. doi: 10.1016/j.annonc.2019.10.002. PMID: 31912791
Health-related quality of life in patients with fully resected BRAF(V600) mutation-positive melanoma receiving adjuvant vemurafenib.
Schadendorf D, Di Giacomo AM, Demidov L, Merelli B, Bondarenko I, Ascierto PA, Herbert C, Mackiewicz A, Rutkowski P, Guminski A, Goodman GR, Simmons B, Ye C, Hong A, Lewis K; BRIM8 Investigators
Eur J Cancer 2019 Dec;123:155-161. Epub 2019 Nov 5 doi: 10.1016/j.ejca.2019.09.019. PMID: 31704549
The natural history and prognosticative factors of adult extremity soft tissue sarcomas: an Asian perspective.
Wang L, Tan MH
Ann Acad Med Singap 2010 Oct;39(10):771-7. PMID: 21063637
Expression and significance of EGFR in malignant peripheral nerve sheath tumor.
Keizman D, Issakov J, Meller I, Maimon N, Ish-Shalom M, Sher O, Merimsky O
J Neurooncol 2009 Sep;94(3):383-8. Epub 2009 Mar 28 doi: 10.1007/s11060-009-9862-z. PMID: 19330289
Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component.
Clement PB, Young RH, Keh P, Ostör AG, Scully RE
Am J Surg Pathol 1995 Oct;19(10):1158-71. doi: 10.1097/00000478-199510000-00006. PMID: 7573674

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