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Metastatic Bladder Sarcomatoid Urothelial Carcinoma

MedGen UID:
1675475
•Concept ID:
C4764345
•
Neoplastic Process
Synonyms: Metastatic Infiltrating Bladder Urothelial Carcinoma, Sarcomatoid Variant; Metastatic Invasive Bladder Urothelial Carcinoma, Sarcomatoid Variant; Metastatic Sarcomatoid Bladder Urothelial Carcinoma; Metastatic Sarcomatoid Urothelial Carcinoma of the Bladder

Definition

Bladder sarcomatoid urothelial carcinoma that has spread to another anatomical site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Bladder Sarcomatoid Urothelial Carcinoma

Professional guidelines

PubMed

Unusual histomorphological spectrum of urinary bladder cancers and their treatment modalities revisited: Our experience with series of five cases.
Mohanty P, Mohapatra AS, Sabat D, Nayak J
J Cancer Res Ther 2023 Apr-Jun;19(3):617-623. doi: 10.4103/jcrt.jcrt_134_21. PMID: 37470584
What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522
Best practices recommendations in the application of immunohistochemistry in the prostate: report from the International Society of Urologic Pathology consensus conference.
Epstein JI, Egevad L, Humphrey PA, Montironi R; Members of the ISUP Immunohistochemistry in Diagnostic Urologic Pathology Group
Am J Surg Pathol 2014 Aug;38(8):e6-e19. doi: 10.1097/PAS.0000000000000238. PMID: 25029122

Recent clinical studies

Etiology

Metastatic Tropism in Urothelial Carcinoma With Variant Histology: A Comprehensive NCDB Analysis.
Drouaud A, Xu V, Velasquez A, Antar R, Boyarsky B, Weiss J, Gonzalez D, Silverman R, Whalen MJ
Clin Genitourin Cancer 2024 Oct;22(5):102179. Epub 2024 Jul 26 doi: 10.1016/j.clgc.2024.102179. PMID: 39153901
Adjuvant Chemotherapy and Survival After Radical Cystectomy in Histologic Subtype Bladder Cancer.
Koehne EL, Bakaloudi DR, Ghali F, Nyame Y, Schade GR, Grivas P, Yezefski TA, Hawley JE, Yu EY, Hsieh AC, Montgomery RB, Psutka SP, Gore JL, Wright JL
Clin Genitourin Cancer 2024 Jun;22(3):102100. Epub 2024 Apr 25 doi: 10.1016/j.clgc.2024.102100. PMID: 38763862
Prognostic Impact of Histologic Subtype and Divergent Differentiation in Patients with Metastatic Urothelial Carcinoma Treated with Enfortumab Vedotin: A Multicenter Retrospective Study.
Minato A, Furubayashi N, Nagata Y, Tomoda T, Masaoka H, Song Y, Hori Y, Kiyoshima K, Negishi T, Kuroiwa K, Seki N, Tomisaki I, Harada K, Nakamura M, Fujimoto N
Curr Oncol 2024 Feb 3;31(2):862-871. doi: 10.3390/curroncol31020064. PMID: 38392058Free PMC Article
Radical cystectomy in non-metastatic sarcomatoid bladder cancer: A direct comparison vs urothelial bladder cancer.
Tappero S, Panunzio A, Hohenhorst L, Cano Garcia C, Barletta F, Piccinelli M, Tian Z, Parodi S, Antonelli A, Graefen M, Chun FKH, Briganti A, De Cobelli O, Saad F, Shariat SF, Suardi N, Borghesi M, Terrone C, Karakiewicz PI
Eur J Surg Oncol 2023 Jan;49(1):271-277. Epub 2022 Sep 24 doi: 10.1016/j.ejso.2022.09.013. PMID: 36192262
Urothelial Carcinoma In Situ of the Bladder With Glandular Differentiation: Report of 92 Cases.
Yang Z, Epstein JI
Am J Surg Pathol 2018 Jul;42(7):971-976. doi: 10.1097/PAS.0000000000001073. PMID: 29683821

Diagnosis

Metastatic Tropism in Urothelial Carcinoma With Variant Histology: A Comprehensive NCDB Analysis.
Drouaud A, Xu V, Velasquez A, Antar R, Boyarsky B, Weiss J, Gonzalez D, Silverman R, Whalen MJ
Clin Genitourin Cancer 2024 Oct;22(5):102179. Epub 2024 Jul 26 doi: 10.1016/j.clgc.2024.102179. PMID: 39153901
Radical cystectomy in non-metastatic sarcomatoid bladder cancer: A direct comparison vs urothelial bladder cancer.
Tappero S, Panunzio A, Hohenhorst L, Cano Garcia C, Barletta F, Piccinelli M, Tian Z, Parodi S, Antonelli A, Graefen M, Chun FKH, Briganti A, De Cobelli O, Saad F, Shariat SF, Suardi N, Borghesi M, Terrone C, Karakiewicz PI
Eur J Surg Oncol 2023 Jan;49(1):271-277. Epub 2022 Sep 24 doi: 10.1016/j.ejso.2022.09.013. PMID: 36192262
Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases.
Wang G, Xiao L, Zhang M, Kamat AM, Siefker-Radtke A, Dinney CP, Czerniak B, Guo CC
Hum Pathol 2018 Sep;79:57-65. Epub 2018 May 12 doi: 10.1016/j.humpath.2018.05.005. PMID: 29763719Free PMC Article
Urothelial Carcinoma In Situ of the Bladder With Glandular Differentiation: Report of 92 Cases.
Yang Z, Epstein JI
Am J Surg Pathol 2018 Jul;42(7):971-976. doi: 10.1097/PAS.0000000000001073. PMID: 29683821
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Shanks JH, Iczkowski KA
Histopathology 2009 Jun;54(7):885-900. Epub 2008 Oct 30 doi: 10.1111/j.1365-2559.2008.03167.x. PMID: 19178589

Therapy

Complete response to combination therapy using nivolumab and ipilimumab for metastatic, sarcomatoid collecting duct carcinoma presenting with high expression of programmed death-ligand 1: a case report.
Fuu T, Iijima K, Kusama Y, Otsuki T, Kato H
J Med Case Rep 2022 May 18;16(1):193. doi: 10.1186/s13256-022-03426-3. PMID: 35581611Free PMC Article
Association Between Surgical Volume and Survival Among Patients With Variant Histologies of Bladder Cancer.
Sui W, Hall ME, Barocas DA, Chang SS, Luckenbaugh AN, Moses KA, Penson DF, Wallis CJD, Laviana AA
Urology 2022 Jan;159:100-106. Epub 2021 Oct 1 doi: 10.1016/j.urology.2021.09.009. PMID: 34606878
Clinical and pathological characteristics of bladder cancer in post brachytherapy patients.
Au S, Keyes M, Black P, Villamil CF, Tavassoli P
Pathol Res Pract 2020 Mar;216(3):152822. Epub 2020 Jan 10 doi: 10.1016/j.prp.2020.152822. PMID: 31982182
Impact of adjuvant chemotherapy in patients with adverse features and variant histology at radical cystectomy for muscle-invasive carcinoma of the bladder: Does histologic subtype matter?
Berg S, D'Andrea D, Vetterlein MW, Cole AP, Fletcher SA, Krimphove MJ, Marchese M, Lipsitz SR, Sonpavde G, Noldus J, Shariat SF, Kibel AS, Trinh QD, Mossanen M
Cancer 2019 May 1;125(9):1449-1458. Epub 2019 Jan 8 doi: 10.1002/cncr.31952. PMID: 30620387
Bladder chondrosarcoma plus urothelial carcinoma in recurred transitional cell carcinoma of the upper urinary tract: a case report and literature review.
Cho MH, Kim SH, Park WS, Joung JY, Seo HK, Chung J, Lee KH
World J Surg Oncol 2016 Oct 20;14(1):270. doi: 10.1186/s12957-016-1021-3. PMID: 27765044Free PMC Article

Prognosis

Adjuvant Chemotherapy and Survival After Radical Cystectomy in Histologic Subtype Bladder Cancer.
Koehne EL, Bakaloudi DR, Ghali F, Nyame Y, Schade GR, Grivas P, Yezefski TA, Hawley JE, Yu EY, Hsieh AC, Montgomery RB, Psutka SP, Gore JL, Wright JL
Clin Genitourin Cancer 2024 Jun;22(3):102100. Epub 2024 Apr 25 doi: 10.1016/j.clgc.2024.102100. PMID: 38763862
Prognostic Impact of Histologic Subtype and Divergent Differentiation in Patients with Metastatic Urothelial Carcinoma Treated with Enfortumab Vedotin: A Multicenter Retrospective Study.
Minato A, Furubayashi N, Nagata Y, Tomoda T, Masaoka H, Song Y, Hori Y, Kiyoshima K, Negishi T, Kuroiwa K, Seki N, Tomisaki I, Harada K, Nakamura M, Fujimoto N
Curr Oncol 2024 Feb 3;31(2):862-871. doi: 10.3390/curroncol31020064. PMID: 38392058Free PMC Article
Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases.
Wang G, Xiao L, Zhang M, Kamat AM, Siefker-Radtke A, Dinney CP, Czerniak B, Guo CC
Hum Pathol 2018 Sep;79:57-65. Epub 2018 May 12 doi: 10.1016/j.humpath.2018.05.005. PMID: 29763719Free PMC Article
Metastatic renal cell carcinoma to the urinary bladder: a report of 11 cases.
Zhang M, Wah C, Epstein JI
Am J Surg Pathol 2014 Nov;38(11):1516-21. doi: 10.1097/PAS.0000000000000257. PMID: 25140895
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Shanks JH, Iczkowski KA
Histopathology 2009 Jun;54(7):885-900. Epub 2008 Oct 30 doi: 10.1111/j.1365-2559.2008.03167.x. PMID: 19178589

Clinical prediction guides

Prognostic Impact of Histologic Subtype and Divergent Differentiation in Patients with Metastatic Urothelial Carcinoma Treated with Enfortumab Vedotin: A Multicenter Retrospective Study.
Minato A, Furubayashi N, Nagata Y, Tomoda T, Masaoka H, Song Y, Hori Y, Kiyoshima K, Negishi T, Kuroiwa K, Seki N, Tomisaki I, Harada K, Nakamura M, Fujimoto N
Curr Oncol 2024 Feb 3;31(2):862-871. doi: 10.3390/curroncol31020064. PMID: 38392058Free PMC Article
Do Histology and Primary Tumor Location Influence Metastatic Patterns in Bladder Cancer?
Park HK
Curr Oncol 2023 Oct 11;30(10):9078-9089. doi: 10.3390/curroncol30100656. PMID: 37887556Free PMC Article
Radical cystectomy in non-metastatic sarcomatoid bladder cancer: A direct comparison vs urothelial bladder cancer.
Tappero S, Panunzio A, Hohenhorst L, Cano Garcia C, Barletta F, Piccinelli M, Tian Z, Parodi S, Antonelli A, Graefen M, Chun FKH, Briganti A, De Cobelli O, Saad F, Shariat SF, Suardi N, Borghesi M, Terrone C, Karakiewicz PI
Eur J Surg Oncol 2023 Jan;49(1):271-277. Epub 2022 Sep 24 doi: 10.1016/j.ejso.2022.09.013. PMID: 36192262
Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases.
Wang G, Xiao L, Zhang M, Kamat AM, Siefker-Radtke A, Dinney CP, Czerniak B, Guo CC
Hum Pathol 2018 Sep;79:57-65. Epub 2018 May 12 doi: 10.1016/j.humpath.2018.05.005. PMID: 29763719Free PMC Article
Clinical significance of prominent retraction clefts in invasive urothelial carcinoma.
Shah TS, Kaag M, Raman JD, Chan W, Tran T, Kunchala S, Shuman L, DeGraff DJ, Chen G, Warrick JI
Hum Pathol 2017 Mar;61:90-96. Epub 2016 Nov 4 doi: 10.1016/j.humpath.2016.10.021. PMID: 27818288

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