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Bladder Large Cell Neuroendocrine Carcinoma

MedGen UID:
1677587
Concept ID:
C2111710
Neoplastic Process

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the bladder. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Alhalabi O, Wilson N, Xiao L, Lin Y, Khandelwal J, Moussa MJ, Msaouel P, Navai N, Gao J, Kamat AM, Pilie P, Shah AY, Goswami S, Matin S, Kovitz C, Holla V, Guo C, Czerniak B, Logothetis C, Corn PG, Dinney CPN, Campbell MT, Hansel DE, Tannir NM, Siefker-Radtke AO
Eur Urol Oncol 2023 Dec;6(6):611-620. Epub 2023 Oct 11 doi: 10.1016/j.euo.2023.09.004. PMID: 37833193
Mohanty P, Mohapatra AS, Sabat D, Nayak J
J Cancer Res Ther 2023 Apr-Jun;19(3):617-623. doi: 10.4103/jcrt.jcrt_134_21. PMID: 37470584
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522

Recent clinical studies

Etiology

Fan J, Li H, Zhou C, Xiong W, Villamil C, Ionescu D, Oo HZ, Contreras-Sanz A, Black PC, Wang G
Appl Immunohistochem Mol Morphol 2022 Jul 1;30(6):459-468. Epub 2022 May 24 doi: 10.1097/PAI.0000000000001036. PMID: 35603802
Wang G, Yuan R, Zhou C, Guo C, Villamil C, Hayes M, Eigl BJ, Black P
Am J Surg Pathol 2021 Oct 1;45(10):1399-1408. doi: 10.1097/PAS.0000000000001740. PMID: 34074810Free PMC Article
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Kamboj M, Gandhi JS, Gupta G, Sharma A, Pasricha S, Mehta A, Chandragouda D, Sinha R
J Gastrointest Cancer 2015 Dec;46(4):356-64. doi: 10.1007/s12029-015-9745-9. PMID: 26208508

Diagnosis

Fan J, Li H, Zhou C, Xiong W, Villamil C, Ionescu D, Oo HZ, Contreras-Sanz A, Black PC, Wang G
Appl Immunohistochem Mol Morphol 2022 Jul 1;30(6):459-468. Epub 2022 May 24 doi: 10.1097/PAI.0000000000001036. PMID: 35603802
Sanguedolce F, Calò B, Chirico M, Tortorella S, Carrieri G, Cormio L
Anticancer Res 2020 May;40(5):2439-2447. doi: 10.21873/anticanres.14213. PMID: 32366387
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Pompas-Veganzones N, Gonzalez-Peramato P, Sanchez-Carbayo M
Curr Med Chem 2014;21(9):1117-28. doi: 10.2174/0929867321666131201141346. PMID: 24304278
Martín IJ, Vilar DG, Aguado JM, Perelló CG, Aliaga MR, Argente VG, Ferreres LA, Gómez JG
Arch Esp Urol 2011 Mar;64(2):105-13. PMID: 21399243

Therapy

Alhalabi O, Wilson N, Xiao L, Lin Y, Khandelwal J, Moussa MJ, Msaouel P, Navai N, Gao J, Kamat AM, Pilie P, Shah AY, Goswami S, Matin S, Kovitz C, Holla V, Guo C, Czerniak B, Logothetis C, Corn PG, Dinney CPN, Campbell MT, Hansel DE, Tannir NM, Siefker-Radtke AO
Eur Urol Oncol 2023 Dec;6(6):611-620. Epub 2023 Oct 11 doi: 10.1016/j.euo.2023.09.004. PMID: 37833193
Pini GM, Uccella S, Corinti M, Colecchia M, Pelosi G, Patriarca C
Virchows Arch 2021 Jul;479(1):69-78. Epub 2021 Jan 17 doi: 10.1007/s00428-021-03023-7. PMID: 33454836Free PMC Article
Li W, Su ZZ, Kang JH, Xie XY, Xie XH, Zhuang BW
BMC Med Imaging 2020 May 3;20(1):46. doi: 10.1186/s12880-020-00447-6. PMID: 32362278Free PMC Article
Sroussi M, Elaidi R, Fléchon A, Lorcet M, Borchiellini D, Tardy MP, Gravis G, Guérin M, Laguerre B, Estrade F, Delva R, Barthélémy P, Loriot Y, Lavaud P, Lebret T, Neuzillet Y, Penel N, Houede N, Pouessel D, Rousseau B, Mussat E, Gross-Goupil M, Culine S, Gauthier H, Gobert A, Roupret M, Huillard O, Tartas S, Radulescu C, Allory Y, Oudard S
Clin Genitourin Cancer 2020 Aug;18(4):295-303.e3. Epub 2019 Dec 5 doi: 10.1016/j.clgc.2019.11.014. PMID: 31882335
Colarossi C, Pino P, Giuffrida D, Aiello E, Costanzo R, Martinetti D, Memeo L
Diagn Pathol 2013 Feb 4;8:19. doi: 10.1186/1746-1596-8-19. PMID: 23379295Free PMC Article

Prognosis

Wang G, Yuan R, Zhou C, Guo C, Villamil C, Hayes M, Eigl BJ, Black P
Am J Surg Pathol 2021 Oct 1;45(10):1399-1408. doi: 10.1097/PAS.0000000000001740. PMID: 34074810Free PMC Article
Sanguedolce F, Calò B, Chirico M, Tortorella S, Carrieri G, Cormio L
Anticancer Res 2020 May;40(5):2439-2447. doi: 10.21873/anticanres.14213. PMID: 32366387
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Pompas-Veganzones N, Gonzalez-Peramato P, Sanchez-Carbayo M
Curr Med Chem 2014;21(9):1117-28. doi: 10.2174/0929867321666131201141346. PMID: 24304278
Martín IJ, Vilar DG, Aguado JM, Perelló CG, Aliaga MR, Argente VG, Ferreres LA, Gómez JG
Arch Esp Urol 2011 Mar;64(2):105-13. PMID: 21399243

Clinical prediction guides

Bahlinger V, Branz A, Strissel PL, Strick R, Lange F, Geppert CI, Klümper N, Hölzel M, Wach S, Taubert H, Sikic D, Wullich B, Angeloni M, Ferrazzi F, Diehl L, Kovalenko M, Elboudwarej E, Jürgensmeier JM, Hartmann A, Eckstein M
Histopathology 2024 Apr;84(5):863-876. Epub 2024 Jan 9 doi: 10.1111/his.15130. PMID: 38196202
Sroussi M, Elaidi R, Fléchon A, Lorcet M, Borchiellini D, Tardy MP, Gravis G, Guérin M, Laguerre B, Estrade F, Delva R, Barthélémy P, Loriot Y, Lavaud P, Lebret T, Neuzillet Y, Penel N, Houede N, Pouessel D, Rousseau B, Mussat E, Gross-Goupil M, Culine S, Gauthier H, Gobert A, Roupret M, Huillard O, Tartas S, Radulescu C, Allory Y, Oudard S
Clin Genitourin Cancer 2020 Aug;18(4):295-303.e3. Epub 2019 Dec 5 doi: 10.1016/j.clgc.2019.11.014. PMID: 31882335
Wang H, Ma C, Wu J, Zhao F, Zou Y, Zhang W, Jiang Y
Pathol Res Pract 2020 Feb;216(2):152788. Epub 2019 Dec 13 doi: 10.1016/j.prp.2019.152788. PMID: 31859117
Wang G, Xiao L, Zhang M, Kamat AM, Siefker-Radtke A, Dinney CP, Czerniak B, Guo CC
Hum Pathol 2018 Sep;79:57-65. Epub 2018 May 12 doi: 10.1016/j.humpath.2018.05.005. PMID: 29763719Free PMC Article
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813

Recent systematic reviews

Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328

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