U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bladder Large Cell Neuroendocrine Carcinoma

MedGen UID:
1677587
•Concept ID:
C2111710
•
Neoplastic Process

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the bladder. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Unusual histomorphological spectrum of urinary bladder cancers and their treatment modalities revisited: Our experience with series of five cases.
Mohanty P, Mohapatra AS, Sabat D, Nayak J
J Cancer Res Ther 2023 Apr-Jun;19(3):617-623. doi: 10.4103/jcrt.jcrt_134_21. PMID: 37470584
What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522

Recent clinical studies

Etiology

Classifying Pulmonary and Urinary High-grade Neuroendocrine Carcinoma by CK7 Immunohistochemistry.
Fan J, Li H, Zhou C, Xiong W, Villamil C, Ionescu D, Oo HZ, Contreras-Sanz A, Black PC, Wang G
Appl Immunohistochem Mol Morphol 2022 Jul 1;30(6):459-468. Epub 2022 May 24 doi: 10.1097/PAI.0000000000001036. PMID: 35603802
Urinary Large Cell Neuroendocrine Carcinoma: A Clinicopathologic Analysis of 22 Cases.
Wang G, Yuan R, Zhou C, Guo C, Villamil C, Hayes M, Eigl BJ, Black P
Am J Surg Pathol 2021 Oct 1;45(10):1399-1408. doi: 10.1097/PAS.0000000000001740. PMID: 34074810Free PMC Article
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Neuroendocrine Carcinoma of Gall Bladder: A Series of 19 Cases with Review of Literature.
Kamboj M, Gandhi JS, Gupta G, Sharma A, Pasricha S, Mehta A, Chandragouda D, Sinha R
J Gastrointest Cancer 2015 Dec;46(4):356-64. doi: 10.1007/s12029-015-9745-9. PMID: 26208508

Diagnosis

Classifying Pulmonary and Urinary High-grade Neuroendocrine Carcinoma by CK7 Immunohistochemistry.
Fan J, Li H, Zhou C, Xiong W, Villamil C, Ionescu D, Oo HZ, Contreras-Sanz A, Black PC, Wang G
Appl Immunohistochem Mol Morphol 2022 Jul 1;30(6):459-468. Epub 2022 May 24 doi: 10.1097/PAI.0000000000001036. PMID: 35603802
Urinary Tract Large Cell Neuroendocrine Carcinoma: Diagnostic, Prognostic and Therapeutic Issues.
Sanguedolce F, Calò B, Chirico M, Tortorella S, Carrieri G, Cormio L
Anticancer Res 2020 May;40(5):2439-2447. doi: 10.21873/anticanres.14213. PMID: 32366387
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
The neuroendocrine component in bladder tumors.
Pompas-Veganzones N, Gonzalez-Peramato P, Sanchez-Carbayo M
Curr Med Chem 2014;21(9):1117-28. doi: 10.2174/0929867321666131201141346. PMID: 24304278
Large cell neuroendocrine carcinoma of the urinary bladder. Bibliographic review.
Martín IJ, Vilar DG, Aguado JM, Perelló CG, Aliaga MR, Argente VG, Ferreres LA, Gómez JG
Arch Esp Urol 2011 Mar;64(2):105-13. PMID: 21399243

Therapy

Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior : Description of a case and review of the pertinent literature.
Pini GM, Uccella S, Corinti M, Colecchia M, Pelosi G, Patriarca C
Virchows Arch 2021 Jul;479(1):69-78. Epub 2021 Jan 17 doi: 10.1007/s00428-021-03023-7. PMID: 33454836Free PMC Article
Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report.
Li W, Su ZZ, Kang JH, Xie XY, Xie XH, Zhuang BW
BMC Med Imaging 2020 May 3;20(1):46. doi: 10.1186/s12880-020-00447-6. PMID: 32362278Free PMC Article
Neuroendocrine Carcinoma of the Urinary Bladder: A Large, Retrospective Study From the French Genito-Urinary Tumor Group.
Sroussi M, Elaidi R, Fléchon A, Lorcet M, Borchiellini D, Tardy MP, Gravis G, Guérin M, Laguerre B, Estrade F, Delva R, Barthélémy P, Loriot Y, Lavaud P, Lebret T, Neuzillet Y, Penel N, Houede N, Pouessel D, Rousseau B, Mussat E, Gross-Goupil M, Culine S, Gauthier H, Gobert A, Roupret M, Huillard O, Tartas S, Radulescu C, Allory Y, Oudard S
Clin Genitourin Cancer 2020 Aug;18(4):295-303.e3. Epub 2019 Dec 5 doi: 10.1016/j.clgc.2019.11.014. PMID: 31882335
What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522
Argininosuccinate Synthetase-1 (ASS1) Loss in High-Grade Neuroendocrine Carcinomas of the Urinary Bladder: Implications for Targeted Therapy with ADI-PEG 20.
Gupta S, Sahu D, Bomalaski JS, Frank I, Boorjian SA, Thapa P, Cheville JC, Hansel DE
Endocr Pathol 2018 Sep;29(3):236-241. doi: 10.1007/s12022-018-9516-9. PMID: 29453600

Prognosis

Urinary Large Cell Neuroendocrine Carcinoma: A Clinicopathologic Analysis of 22 Cases.
Wang G, Yuan R, Zhou C, Guo C, Villamil C, Hayes M, Eigl BJ, Black P
Am J Surg Pathol 2021 Oct 1;45(10):1399-1408. doi: 10.1097/PAS.0000000000001740. PMID: 34074810Free PMC Article
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
Urinary Tract Large Cell Neuroendocrine Carcinoma: Diagnostic, Prognostic and Therapeutic Issues.
Sanguedolce F, Calò B, Chirico M, Tortorella S, Carrieri G, Cormio L
Anticancer Res 2020 May;40(5):2439-2447. doi: 10.21873/anticanres.14213. PMID: 32366387
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Large cell neuroendocrine carcinoma of the urinary bladder. Bibliographic review.
Martín IJ, Vilar DG, Aguado JM, Perelló CG, Aliaga MR, Argente VG, Ferreres LA, Gómez JG
Arch Esp Urol 2011 Mar;64(2):105-13. PMID: 21399243

Clinical prediction guides

Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior : Description of a case and review of the pertinent literature.
Pini GM, Uccella S, Corinti M, Colecchia M, Pelosi G, Patriarca C
Virchows Arch 2021 Jul;479(1):69-78. Epub 2021 Jan 17 doi: 10.1007/s00428-021-03023-7. PMID: 33454836Free PMC Article
Neuroendocrine Carcinoma of the Urinary Bladder: A Large, Retrospective Study From the French Genito-Urinary Tumor Group.
Sroussi M, Elaidi R, Fléchon A, Lorcet M, Borchiellini D, Tardy MP, Gravis G, Guérin M, Laguerre B, Estrade F, Delva R, Barthélémy P, Loriot Y, Lavaud P, Lebret T, Neuzillet Y, Penel N, Houede N, Pouessel D, Rousseau B, Mussat E, Gross-Goupil M, Culine S, Gauthier H, Gobert A, Roupret M, Huillard O, Tartas S, Radulescu C, Allory Y, Oudard S
Clin Genitourin Cancer 2020 Aug;18(4):295-303.e3. Epub 2019 Dec 5 doi: 10.1016/j.clgc.2019.11.014. PMID: 31882335
Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases.
Wang G, Xiao L, Zhang M, Kamat AM, Siefker-Radtke A, Dinney CP, Czerniak B, Guo CC
Hum Pathol 2018 Sep;79:57-65. Epub 2018 May 12 doi: 10.1016/j.humpath.2018.05.005. PMID: 29763719Free PMC Article
Updates in the Pathologic Diagnosis and Classification of Epithelial Neoplasms of Urachal Origin.
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813
Urachal carcinomas of the nonglandular type: salient features and considerations in pathologic diagnosis.
Paner GP, Barkan GA, Mehta V, Sirintrapun SJ, Tsuzuki T, Sebo TJ, Jimenez RE
Am J Surg Pathol 2012 Mar;36(3):432-42. doi: 10.1097/PAS.0b013e31823fe49c. PMID: 22301493

Recent systematic reviews

What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522
Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...