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Urethra transitional cell carcinoma

MedGen UID:
167840
•Concept ID:
C0863015
•
Neoplastic Process
Synonyms: Transitional Cell Carcinoma of the Urethra; transitional cell carcinoma of the urethra; Transitional Cell Carcinoma of Urethra; transitional cell carcinoma of urethra; UCU; Urethra Transitional Cell Carcinoma; urethra transitional cell carcinoma; Urethral Transitional Cell Carcinoma; urethral transitional cell carcinoma; urethral urothelial cancer; Urethral Urothelial Carcinoma; urethral urothelial carcinoma
 
Monarch Initiative: MONDO:0002836

Definition

A urothelial carcinoma that arises from the male or female urethra. [from NCI]

Professional guidelines

PubMed

Current Disease Management of Primary Urethral Carcinoma.
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949
Treatment and Outcomes of Primary Urethra Cancer.
Eng TY, Chen TW, Patel AJ, Vincent JN, Ha CS
Am J Clin Oncol 2018 Sep;41(9):905-908. doi: 10.1097/COC.0000000000000391. PMID: 28537991
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415

Recent clinical studies

Etiology

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
Orthotopic neobladder after cystectomy for bladder cancer.
Kakizoe T
Proc Jpn Acad Ser B Phys Biol Sci 2020;96(7):255-265. doi: 10.2183/pjab.96.019. PMID: 32788549Free PMC Article
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415
Indications for urethrectomy.
Elmajian DA
Semin Urol Oncol 2001 Feb;19(1):37-44. PMID: 11246732

Diagnosis

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
NCCN Guidelines® Insights: Bladder Cancer, Version 2.2022.
Flaig TW, Spiess PE, Abern M, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Chan K, Chang S, Friedlander T, Greenberg RE, Guru KA, Herr HW, Hoffman-Censits J, Kishan A, Kundu S, Lele SM, Mamtani R, Margulis V, Mian OY, Michalski J, Montgomery JS, Nandagopal L, Pagliaro LC, Parikh M, Patterson A, Plimack ER, Pohar KS, Preston MA, Richards K, Sexton WJ, Siefker-Radtke AO, Tollefson M, Tward J, Wright JL, Dwyer MA, Cassara CJ, Gurski LA
J Natl Compr Canc Netw 2022 Aug;20(8):866-878. doi: 10.6004/jnccn.2022.0041. PMID: 35948037
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415

Therapy

Tailored immunotherapy approach with nivolumab with or without ipilimumab in patients with advanced transitional cell carcinoma after platinum-based chemotherapy (TITAN-TCC): a multicentre, single-arm, phase 2 trial.
Grimm MO, Grün CB, Niegisch G, Pichler M, Roghmann F, Schmitz-Dräger B, Baretton G, Schmitz M, Bolenz C, Foller S, Leucht K, Schumacher U, Schostak M, Meran J, Loidl W, Zengerling F
Lancet Oncol 2023 Apr;24(4):347-359. Epub 2023 Feb 28 doi: 10.1016/S1470-2045(23)00053-0. PMID: 36868252
Orthotopic neobladder after cystectomy for bladder cancer.
Kakizoe T
Proc Jpn Acad Ser B Phys Biol Sci 2020;96(7):255-265. doi: 10.2183/pjab.96.019. PMID: 32788549Free PMC Article
The microbiome of the urinary tract--a role beyond infection.
Whiteside SA, Razvi H, Dave S, Reid G, Burton JP
Nat Rev Urol 2015 Feb;12(2):81-90. Epub 2015 Jan 20 doi: 10.1038/nrurol.2014.361. PMID: 25600098
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415
Urothelial carcinoma in the prostatic urethra and prostate: current controversies.
Liedberg F, Chebil G, Månsson W
Expert Rev Anticancer Ther 2007 Mar;7(3):383-90. doi: 10.1586/14737140.7.3.383. PMID: 17338657

Prognosis

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
Incidence, mortality and survival of transitional cell carcinoma in the urinary system: A population-based analysis.
Tang X, Zhan X, Chen X
Medicine (Baltimore) 2023 Nov 17;102(46):e36063. doi: 10.1097/MD.0000000000036063. PMID: 37986351Free PMC Article
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721
Prostatic biology, histologic patterns and clinical consequences of transitional cell carcinoma.
Lerner SP, Colen J, Shen S
Curr Opin Urol 2008 Sep;18(5):508-12. doi: 10.1097/MOU.0b013e32830b86f9. PMID: 18670276

Clinical prediction guides

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
Tailored immunotherapy approach with nivolumab with or without ipilimumab in patients with advanced transitional cell carcinoma after platinum-based chemotherapy (TITAN-TCC): a multicentre, single-arm, phase 2 trial.
Grimm MO, Grün CB, Niegisch G, Pichler M, Roghmann F, Schmitz-Dräger B, Baretton G, Schmitz M, Bolenz C, Foller S, Leucht K, Schumacher U, Schostak M, Meran J, Loidl W, Zengerling F
Lancet Oncol 2023 Apr;24(4):347-359. Epub 2023 Feb 28 doi: 10.1016/S1470-2045(23)00053-0. PMID: 36868252
Synchronous Penile Squamous Cell Carcinoma, Bladder Urothelial Carcinoma and Prostate Adenocarcinoma Diagnosed in One Procedure.
Deng F, Kong MX, Lai J
Anticancer Res 2022 Jul;42(7):3601-3605. doi: 10.21873/anticanres.15847. PMID: 35790255
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721
The microbiome of the urinary tract--a role beyond infection.
Whiteside SA, Razvi H, Dave S, Reid G, Burton JP
Nat Rev Urol 2015 Feb;12(2):81-90. Epub 2015 Jan 20 doi: 10.1038/nrurol.2014.361. PMID: 25600098

Recent systematic reviews

Oncologic and Safety Outcomes for Endoscopic Surgery Versus Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: An Updated Systematic Review and Meta-analysis.
Kawada T, Laukhtina E, Quhal F, Yanagisawa T, Rajwa P, Pallauf M, von Deimling M, Bianchi A, Pradere B, Fajkovic H, Enikeev D, Gontero P, Rouprêt M, Seisen T, Araki M, Shariat SF
Eur Urol Focus 2023 Mar;9(2):236-240. Epub 2022 Nov 30 doi: 10.1016/j.euf.2022.11.016. PMID: 36463089
Follow-up of the Urethra and Management of Urethral Recurrence After Radical Cystectomy: A Systematic Review and Proposal of Management Algorithm by the European Association of Urology-Young Academic Urologists: Urothelial Carcinoma Working Group.
Laukhtina E, Moschini M, Soria F, Andrea DD, Teoh JY, Mori K, Albisinni S, Mari A, Krajewski W, Cimadamore A, Abufaraj M, Enikeev D, Neuzillet Y, Giannarini G, Xylinas E, Kamat AM, Roupret M, Babjuk M, Witjes JA, Shariat SF, Pradere B; European Association of Urology; Young Academic Urologists EAU-YAU: Urothelial Carcinoma Working Group; European Association of Urology Section of Oncological Urology ESOU
Eur Urol Focus 2022 Nov;8(6):1635-1642. Epub 2022 Mar 23 doi: 10.1016/j.euf.2022.03.004. PMID: 35337773
Ureteral and urethral recurrence after radical cystectomy: a systematic review.
Carando R, Shariat SF, Moschini M, D'Andrea D
Curr Opin Urol 2020 May;30(3):441-448. doi: 10.1097/MOU.0000000000000752. PMID: 32235282
Urethral recurrence after radical cystectomy for urothelial carcinoma: A systematic review and meta-analysis.
Fahmy O, Khairul-Asri MG, Schubert T, Renninger M, Kübler H, Stenzl A, Gakis G
Urol Oncol 2018 Feb;36(2):54-59. Epub 2017 Nov 28 doi: 10.1016/j.urolonc.2017.11.007. PMID: 29196179
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article

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