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Abnormal circulating glycine concentration

MedGen UID:
1684773
•Concept ID:
C5139043
•
Finding
Synonym: Abnormality of glycine metabolism
 
HPO: HP:0010895

Definition

Any deviation from the normal concentration of glycine in the blood circulation. [from HPO]

Conditions with this feature

Cysteine Peptiduria
MedGen UID:
346587
•Concept ID:
C1857438
•
Disease or Syndrome
See: Condition Record
Cysteine Peptiduria

Professional guidelines

PubMed

Liver involvement in human schistosomiasis mansoni. Regression of immunological and biochemical disease markers after specific treatment.
Zwingenberger K, Harms G, Feldmeier H, Müller O, Steiner A, Bienzle U
Acta Trop 1988 Sep;45(3):263-75. PMID: 2903628

Recent clinical studies

Etiology

Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR).
Chavira-Suárez E, Rosel-Pech C, Polo-Oteyza E, Ancira-Moreno M, Ibarra-González I, Vela-Amieva M, Meraz-Cruz N, Aguilar-Salinas C, Vadillo-Ortega F
PLoS One 2020;15(8):e0237917. Epub 2020 Aug 24 doi: 10.1371/journal.pone.0237917. PMID: 32834003Free PMC Article
Increased circulating conjugated primary bile acids are associated with hyperandrogenism in women with polycystic ovary syndrome.
Zhang B, Shen S, Gu T, Hong T, Liu J, Sun J, Wang H, Bi Y, Zhu D
J Steroid Biochem Mol Biol 2019 May;189:171-175. Epub 2019 Mar 5 doi: 10.1016/j.jsbmb.2019.03.005. PMID: 30849463
L-cysteine, N-acetyl-L-cysteine, and glutathione protect Xenopus laevis embryos against acrylamide-induced malformations and mortality in the frog embryo teratogenesis assay.
Rayburn JR, Friedman M
J Agric Food Chem 2010 Oct 27;58(20):11172-8. Epub 2010 Sep 28 doi: 10.1021/jf1023998. PMID: 20873821
Renal impairment in chronic cigarette smokers.
Gambaro G, Verlato F, Budakovic A, Casara D, Saladini G, Del Prete D, Bertaglia G, Masiero M, Checchetto S, Baggio B
J Am Soc Nephrol 1998 Apr;9(4):562-7. doi: 10.1681/ASN.V94562. PMID: 9555657
Free amino acid concentrations in normal and abnormal third trimester placental villi.
Morris NH, Burston D, Ramsay B, Sooranna SR
Eur J Clin Invest 1995 Oct;25(10):796-8. doi: 10.1111/j.1365-2362.1995.tb01960.x. PMID: 8557068

Diagnosis

Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models.
Moestue SA, Borgan E, Huuse EM, Lindholm EM, Sitter B, Børresen-Dale AL, Engebraaten O, Maelandsmo GM, Gribbestad IS
BMC Cancer 2010 Aug 17;10:433. doi: 10.1186/1471-2407-10-433. PMID: 20716336Free PMC Article
Human ACTH hypersensitivity syndrome associated with abnormalities of the ACTH receptor gene.
Hiroi N, Yakushiji F, Shimojo M, Watanabe S, Sugano S, Yamaguchi N, Miyachi Y
Clin Endocrinol (Oxf) 1998 Feb;48(2):129-34. doi: 10.1046/j.1365-2265.1998.3971187.x. PMID: 9579221

Therapy

L-cysteine, N-acetyl-L-cysteine, and glutathione protect Xenopus laevis embryos against acrylamide-induced malformations and mortality in the frog embryo teratogenesis assay.
Rayburn JR, Friedman M
J Agric Food Chem 2010 Oct 27;58(20):11172-8. Epub 2010 Sep 28 doi: 10.1021/jf1023998. PMID: 20873821
The continuing importance of bile acids in liver and intestinal disease.
Hofmann AF
Arch Intern Med 1999 Dec 13-27;159(22):2647-58. doi: 10.1001/archinte.159.22.2647. PMID: 10597755
Human ACTH hypersensitivity syndrome associated with abnormalities of the ACTH receptor gene.
Hiroi N, Yakushiji F, Shimojo M, Watanabe S, Sugano S, Yamaguchi N, Miyachi Y
Clin Endocrinol (Oxf) 1998 Feb;48(2):129-34. doi: 10.1046/j.1365-2265.1998.3971187.x. PMID: 9579221
Renal impairment in chronic cigarette smokers.
Gambaro G, Verlato F, Budakovic A, Casara D, Saladini G, Del Prete D, Bertaglia G, Masiero M, Checchetto S, Baggio B
J Am Soc Nephrol 1998 Apr;9(4):562-7. doi: 10.1681/ASN.V94562. PMID: 9555657
Liver involvement in human schistosomiasis mansoni. Regression of immunological and biochemical disease markers after specific treatment.
Zwingenberger K, Harms G, Feldmeier H, Müller O, Steiner A, Bienzle U
Acta Trop 1988 Sep;45(3):263-75. PMID: 2903628

Prognosis

Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models.
Moestue SA, Borgan E, Huuse EM, Lindholm EM, Sitter B, Børresen-Dale AL, Engebraaten O, Maelandsmo GM, Gribbestad IS
BMC Cancer 2010 Aug 17;10:433. doi: 10.1186/1471-2407-10-433. PMID: 20716336Free PMC Article
Renal impairment in chronic cigarette smokers.
Gambaro G, Verlato F, Budakovic A, Casara D, Saladini G, Del Prete D, Bertaglia G, Masiero M, Checchetto S, Baggio B
J Am Soc Nephrol 1998 Apr;9(4):562-7. doi: 10.1681/ASN.V94562. PMID: 9555657
Defective bile acid amidation: predicted features of a new inborn error of metabolism.
Hofmann AF, Strandvik B
Lancet 1988 Aug 6;2(8606):311-3. doi: 10.1016/s0140-6736(88)92359-8. PMID: 2899723

Clinical prediction guides

Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models.
Moestue SA, Borgan E, Huuse EM, Lindholm EM, Sitter B, Børresen-Dale AL, Engebraaten O, Maelandsmo GM, Gribbestad IS
BMC Cancer 2010 Aug 17;10:433. doi: 10.1186/1471-2407-10-433. PMID: 20716336Free PMC Article
Defective bile acid amidation: predicted features of a new inborn error of metabolism.
Hofmann AF, Strandvik B
Lancet 1988 Aug 6;2(8606):311-3. doi: 10.1016/s0140-6736(88)92359-8. PMID: 2899723
Cross-linking of fibrinogen and fibrin by fibrin-stablizing factor (factor XIIIa).
Kanaide H, Shainoff JR
J Lab Clin Med 1975 Apr;85(4):574-97. PMID: 1168234

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