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Sinonasal Adenocarcinoma, Salivary-Type

MedGen UID:
1685449
•Concept ID:
C5205717
•
Neoplastic Process
Synonym: Nasal Cavity and Paranasal Sinus Adenocarcinoma, Salivary-Type

Definition

Adenocarcinomas that arise from the seromucinous glands and surface epithelium of the nasal cavity and paranasal sinuses. These adenocarcinomas morphologically resemble the adenocarcinomas that arise from the major and minor salivary glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinonasal Adenocarcinoma, Salivary-Type

Recent clinical studies

Etiology

ETV6 Gene Rearrangements Characterize a Morphologically Distinct Subset of Sinonasal Low-grade Non-intestinal-type Adenocarcinoma: A Novel Translocation-associated Carcinoma Restricted to the Sinonasal Tract.
Andreasen S, Skálová A, Agaimy A, Bishop JA, Laco J, Leivo I, Franchi A, Larsen SR, Erentaite D, Ulhøi BP, von Buchwald C, Melchior LC, Michal M, Kiss K
Am J Surg Pathol 2017 Nov;41(11):1552-1560. doi: 10.1097/PAS.0000000000000912. PMID: 28719468
Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.
Tilson MP, Gallia GL, Bishop JA
Head Neck Pathol 2014 Mar;8(1):59-65. Epub 2013 Jul 12 doi: 10.1007/s12105-013-0475-7. PMID: 23846317Free PMC Article

Diagnosis

Sinonasal Adenocarcinoma: Update on Classification, Immunophenotype and Molecular Features.
Leivo I
Head Neck Pathol 2016 Mar;10(1):68-74. Epub 2016 Feb 1 doi: 10.1007/s12105-016-0694-9. PMID: 26830399Free PMC Article
Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.
Tilson MP, Gallia GL, Bishop JA
Head Neck Pathol 2014 Mar;8(1):59-65. Epub 2013 Jul 12 doi: 10.1007/s12105-013-0475-7. PMID: 23846317Free PMC Article

Prognosis

Signet-ring cell adenocarcinoma of sinonasal tract: an immunohistochemical study of the mucins profile.
Castillo C, Buob D, Mortuaire G, Chevalier D, Aubert S, Copin MC, Leroy X
Arch Pathol Lab Med 2007 Jun;131(6):961-4. doi: 10.5858/2007-131-961-SCAOST. PMID: 17550327

Clinical prediction guides

Primary and Secondary/ Metastatic Salivary Duct Carcinoma Presenting within the Sinonasal Tract.
Agaimy A, Mueller SK, Bishop JA, Chiosea SI
Head Neck Pathol 2021 Sep;15(3):769-779. Epub 2021 Jan 11 doi: 10.1007/s12105-020-01271-8. PMID: 33428064Free PMC Article
Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.
Tilson MP, Gallia GL, Bishop JA
Head Neck Pathol 2014 Mar;8(1):59-65. Epub 2013 Jul 12 doi: 10.1007/s12105-013-0475-7. PMID: 23846317Free PMC Article

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