Abnormal circulating heparan sulfate level

MedGen UID:: 1686747
•Concept ID:: C5139506
•: Finding

Synonyms:	Abnormal circulating heparan sulphate level; Abnormality of the concentration of heparan sulfate in the blood; Abnormality of the concentration of heparan sulphate in the blood

HPO:	HP:0410341

Definition

An abnormal level of heparan sulfate in the blood. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal circulating heparan sulfate level

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal circulating metabolite concentration
    - Abnormal circulating organic compound concentration
      - Abnormal circulating carbohydrate concentration
        Abnormal circulating heparan sulfate level
        Decreased circulating heparan sulfate level
        Increased circulating heparan sulfate level

Recent clinical studies

Diagnosis

Structural characterization and functional effects of a circulating heparan sulfate in a patient with hepatocellular carcinoma.

Wages DS, Staprans I, Hambleton J, Bass NM, Corash L
Am J Hematol 1998 Aug;58(4):285-92. doi: 10.1002/(sici)1096-8652(199808)58:4<285::aid-ajh6>3.0.co;2-m. PMID: 9692391

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Therapy

Intra-articular enzyme replacement therapy with rhIDUA is safe, well-tolerated, and reduces articular GAG storage in the canine model of mucopolysaccharidosis type I.

Wang RY, Aminian A, McEntee MF, Kan SH, Simonaro CM, Lamanna WC, Lawrence R, Ellinwood NM, Guerra C, Le SQ, Dickson PI, Esko JD
Mol Genet Metab 2014 Aug;112(4):286-93. Epub 2014 Jun 6 doi: 10.1016/j.ymgme.2014.05.015. PMID: 24951454 Free PMC Article

Cardiopulmonary bypass in patients with heparin-induced thrombocytopenia using Org 10172.

Wilhelm MJ, Schmid C, Kececioglu D, Möllhoff T, Ostermann H, Scheld HH
Ann Thorac Surg 1996 Mar;61(3):920-4. doi: 10.1016/0003-4975(95)01172-2. PMID: 8619718

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Clinical prediction guides

Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation.

Biasin V, Wygrecka M, Bärnthaler T, Jandl K, Jain PP, Bálint Z, Kovacs G, Leitinger G, Kolb-Lenz D, Kornmueller K, Peters F, Sinn K, Klepetko W, Heinemann A, Olschewski A, Becker-Pauly C, Kwapiszewska G
Thromb Haemost 2018 Oct;118(10):1790-1802. Epub 2018 Sep 20 doi: 10.1055/s-0038-1670657. PMID: 30235485

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Abnormal circulating heparan sulfate level

Definition

Term Hierarchy

Recent clinical studies

Diagnosis

Therapy

Clinical prediction guides

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Table of contents

Clinical resources

Consumer resources

Reviews

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