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Abnormal circulating heparan sulfate level

MedGen UID:
1686747
•Concept ID:
C5139506
•
Finding
Synonyms: Abnormal circulating heparan sulphate level; Abnormality of the concentration of heparan sulfate in the blood; Abnormality of the concentration of heparan sulphate in the blood
 
HPO: HP:0410341

Definition

An abnormal level of heparan sulfate in the blood. [from HPO]

Recent clinical studies

Diagnosis

Structural characterization and functional effects of a circulating heparan sulfate in a patient with hepatocellular carcinoma.
Wages DS, Staprans I, Hambleton J, Bass NM, Corash L
Am J Hematol 1998 Aug;58(4):285-92. doi: 10.1002/(sici)1096-8652(199808)58:4<285::aid-ajh6>3.0.co;2-m. PMID: 9692391

Therapy

Intra-articular enzyme replacement therapy with rhIDUA is safe, well-tolerated, and reduces articular GAG storage in the canine model of mucopolysaccharidosis type I.
Wang RY, Aminian A, McEntee MF, Kan SH, Simonaro CM, Lamanna WC, Lawrence R, Ellinwood NM, Guerra C, Le SQ, Dickson PI, Esko JD
Mol Genet Metab 2014 Aug;112(4):286-93. Epub 2014 Jun 6 doi: 10.1016/j.ymgme.2014.05.015. PMID: 24951454Free PMC Article
Cardiopulmonary bypass in patients with heparin-induced thrombocytopenia using Org 10172.
Wilhelm MJ, Schmid C, Kececioglu D, Möllhoff T, Ostermann H, Scheld HH
Ann Thorac Surg 1996 Mar;61(3):920-4. doi: 10.1016/0003-4975(95)01172-2. PMID: 8619718

Clinical prediction guides

Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation.
Biasin V, Wygrecka M, Bärnthaler T, Jandl K, Jain PP, Bálint Z, Kovacs G, Leitinger G, Kolb-Lenz D, Kornmueller K, Peters F, Sinn K, Klepetko W, Heinemann A, Olschewski A, Becker-Pauly C, Kwapiszewska G
Thromb Haemost 2018 Oct;118(10):1790-1802. Epub 2018 Sep 20 doi: 10.1055/s-0038-1670657. PMID: 30235485

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