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Increased circulating heparan sulfate level

MedGen UID:
1704813
•Concept ID:
C5139507
•
Finding
Synonyms: Increased blood heparan sulfate concentration; Increased blood heparan sulphate concentration; Increased circulating heparan sulphate level
 
HPO: HP:0410342

Definition

An abnormal increase in the concentration of heparan sulfate in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating heparan sulfate level

Recent clinical studies

Etiology

Ηeparan sulphate in infectious and non-infectious exacerbations of COPD.
Papakonstantinou E, Christopoulou ME, Karakioulaki M, Grize L, Tamm M, Stolz D
Respirology 2023 Aug;28(8):767-774. Epub 2023 Jun 13 doi: 10.1111/resp.14531. PMID: 37311657
Interleukin-8: An evolving chemokine.
Matsushima K, Yang D, Oppenheim JJ
Cytokine 2022 May;153:155828. Epub 2022 Mar 2 doi: 10.1016/j.cyto.2022.155828. PMID: 35247648
Effect of Heparanase and Heparan Sulfate Chains in Hemostasis.
Nadir Y
Semin Thromb Hemost 2021 Apr;47(3):254-260. Epub 2021 Apr 1 doi: 10.1055/s-0041-1725065. PMID: 33794550
Circulating heparan sulfate chains and body weight contribute to anti-Xa levels in cancer patients using the prophylactic dose of enoxaparin.
Maurice-Dror C, Litvak M, Keren-Politansky A, Ackerman S, Haim N, Nadir Y
J Thromb Thrombolysis 2020 Jul;50(1):112-122. doi: 10.1007/s11239-020-02128-1. PMID: 32377957
Bivalirudin, blood loss, and graft patency in coronary artery bypass surgery.
Merry AF
Semin Thromb Hemost 2004 Jun;30(3):337-46. doi: 10.1055/s-2004-831046. PMID: 15282656

Diagnosis

Biomarkers in HCV-related mixed cryoglobulinemia patients withnon-Hodgkin lymphoma.
Gulli F, Marino M, Napodano C, Pocino K, Pandolfi F, Gasbarrini A, Rapaccini GL, Basile U
Eur Rev Med Pharmacol Sci 2020 Aug;24(15):8067-8074. doi: 10.26355/eurrev_202008_22490. PMID: 32767333
Circulating syndecan-1 as a novel biomarker relates to lung function, systemic inflammation, and exacerbation in COPD.
Li D, Wu Y, Guo S, Qin J, Feng M, An Y, Zhang J, Li Y, Xiong S, Zhou H, Zeng Q, Chen L, Wen F
Int J Chron Obstruct Pulmon Dis 2019;14:1933-1941. Epub 2019 Aug 28 doi: 10.2147/COPD.S207855. PMID: 31695352Free PMC Article
Impairment of the endothelial glycocalyx in cardiogenic shock and its prognostic relevance.
Jung C, Fuernau G, Muench P, Desch S, Eitel I, Schuler G, Adams V, Figulla HR, Thiele H
Shock 2015 May;43(5):450-5. doi: 10.1097/SHK.0000000000000329. PMID: 25692257
Evaluation of glycosaminoglycans and heparanase in placentas of women with preeclampsia.
Famá EA, Souza RS, Melo CM, Melo Pompei L, Pinhal MA
Clin Chim Acta 2014 Nov 1;437:155-60. Epub 2014 Jul 30 doi: 10.1016/j.cca.2014.07.023. PMID: 25083812
Circulating glycosaminoglycan species in septic shock.
Nelson A, Berkestedt I, Bodelsson M
Acta Anaesthesiol Scand 2014 Jan;58(1):36-43. Epub 2013 Nov 7 doi: 10.1111/aas.12223. PMID: 24341693

Therapy

The Effect of Preoperative Methylprednisolone on Postoperative Delirium in Older Patients Undergoing Gastrointestinal Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial.
Xiang XB, Chen H, Wu YL, Wang K, Yue X, Cheng XQ
J Gerontol A Biol Sci Med Sci 2022 Mar 3;77(3):517-523. doi: 10.1093/gerona/glab248. PMID: 34423832
Circulating heparan sulfate chains and body weight contribute to anti-Xa levels in cancer patients using the prophylactic dose of enoxaparin.
Maurice-Dror C, Litvak M, Keren-Politansky A, Ackerman S, Haim N, Nadir Y
J Thromb Thrombolysis 2020 Jul;50(1):112-122. doi: 10.1007/s11239-020-02128-1. PMID: 32377957
Impairment of the endothelial glycocalyx in cardiogenic shock and its prognostic relevance.
Jung C, Fuernau G, Muench P, Desch S, Eitel I, Schuler G, Adams V, Figulla HR, Thiele H
Shock 2015 May;43(5):450-5. doi: 10.1097/SHK.0000000000000329. PMID: 25692257
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.
Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM
Nature 2014 Sep 18;513(7518):436-9. Epub 2014 Jul 16 doi: 10.1038/nature13540. PMID: 25043058Free PMC Article
Bivalirudin, blood loss, and graft patency in coronary artery bypass surgery.
Merry AF
Semin Thromb Hemost 2004 Jun;30(3):337-46. doi: 10.1055/s-2004-831046. PMID: 15282656

Prognosis

Circulating glycocalyx shedding products as biomarkers for evaluating prognosis of patients with out-of-hospital cardiac arrest after return of spontaneous circulation.
Li J, Qi Z, Sun C, Zhang Y, Gong L, Li Y, Dong H, Jia W, Zhong L, Yang J
Sci Rep 2024 Jul 30;14(1):17582. doi: 10.1038/s41598-024-68738-4. PMID: 39079959Free PMC Article
Syndecan-1 in liver pathophysiology.
Reszegi A, Tátrai P, Regős E, Kovalszky I, Baghy K
Am J Physiol Cell Physiol 2022 Aug 1;323(2):C289-C294. Epub 2022 Jun 15 doi: 10.1152/ajpcell.00039.2022. PMID: 35704700
Biomarkers in HCV-related mixed cryoglobulinemia patients withnon-Hodgkin lymphoma.
Gulli F, Marino M, Napodano C, Pocino K, Pandolfi F, Gasbarrini A, Rapaccini GL, Basile U
Eur Rev Med Pharmacol Sci 2020 Aug;24(15):8067-8074. doi: 10.26355/eurrev_202008_22490. PMID: 32767333
Postoperative microcirculatory perfusion and endothelial glycocalyx shedding following cardiac surgery with cardiopulmonary bypass.
Dekker NAM, Veerhoek D, Koning NJ, van Leeuwen ALI, Elbers PWG, van den Brom CE, Vonk ABA, Boer C
Anaesthesia 2019 May;74(5):609-618. Epub 2019 Jan 27 doi: 10.1111/anae.14577. PMID: 30687934Free PMC Article
Impairment of the endothelial glycocalyx in cardiogenic shock and its prognostic relevance.
Jung C, Fuernau G, Muench P, Desch S, Eitel I, Schuler G, Adams V, Figulla HR, Thiele H
Shock 2015 May;43(5):450-5. doi: 10.1097/SHK.0000000000000329. PMID: 25692257

Clinical prediction guides

Syndecan-1 in liver pathophysiology.
Reszegi A, Tátrai P, Regős E, Kovalszky I, Baghy K
Am J Physiol Cell Physiol 2022 Aug 1;323(2):C289-C294. Epub 2022 Jun 15 doi: 10.1152/ajpcell.00039.2022. PMID: 35704700
Interleukin-8: An evolving chemokine.
Matsushima K, Yang D, Oppenheim JJ
Cytokine 2022 May;153:155828. Epub 2022 Mar 2 doi: 10.1016/j.cyto.2022.155828. PMID: 35247648
VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.
Hawinkels LJ, Zuidwijk K, Verspaget HW, de Jonge-Muller ES, van Duijn W, Ferreira V, Fontijn RD, David G, Hommes DW, Lamers CB, Sier CF
Eur J Cancer 2008 Sep;44(13):1904-13. Epub 2008 Aug 6 doi: 10.1016/j.ejca.2008.06.031. PMID: 18691882
Inhibitors of the hyaluronidases.
Mio K, Stern R
Matrix Biol 2002 Jan;21(1):31-7. doi: 10.1016/s0945-053x(01)00185-8. PMID: 11827790
Heparin-endothelial cell interactions.
D'Amore PA
Haemostasis 1990;20 Suppl 1:159-65. doi: 10.1159/000216175. PMID: 2083869

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