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Kidney Paraganglioma

MedGen UID:
1686753
•Concept ID:
C5204273
•
Neoplastic Process
Synonym: Renal Paraganglioma

Definition

An extremely rare paraganglioma that arises from the renal hilum. Paragangliomas that arise from the perihilar sympathetic ganglia are not included in this category. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKidney Paraganglioma

Professional guidelines

PubMed

Clarifying the Cause and Treatment of Paroxysmal Hypertension (Pseudopheochromocytoma).
Mann SJ, Solanki KV
Curr Hypertens Rep 2022 Sep;24(9):353-359. Epub 2022 Jun 6 doi: 10.1007/s11906-022-01198-1. PMID: 35666406
Management recommendations for pancreatic manifestations of von Hippel-Lindau disease.
Laks S, van Leeuwaarde R, Patel D, Keutgen XM, Hammel P, Nilubol N, Links TP, Halfdanarson TR, Daniels AB, Tirosh A; Pancreatic Manifestations Recommendations Development Subcommittee of the VHL Alliance
Cancer 2022 Feb 1;128(3):435-446. Epub 2021 Nov 4 doi: 10.1002/cncr.33978. PMID: 34735022
Resistant Hypertension: Diagnosis and Management.
Nagarajan N, Jalal D
Adv Chronic Kidney Dis 2019 Mar;26(2):99-109. doi: 10.1053/j.ackd.2019.03.002. PMID: 31023454

Recent clinical studies

Etiology

Von Hippel-Lindau disease: insights into oxygen sensing, protein degradation, and cancer.
Kaelin WG Jr
J Clin Invest 2022 Sep 15;132(18) doi: 10.1172/JCI162480. PMID: 36106637Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
VHL disease.
Barontini M, Dahia PL
Best Pract Res Clin Endocrinol Metab 2010 Jun;24(3):401-13. doi: 10.1016/j.beem.2010.01.002. PMID: 20833332
Von Hippel-Lindau disease.
Kaelin WG
Annu Rev Pathol 2007;2:145-73. doi: 10.1146/annurev.pathol.2.010506.092049. PMID: 18039096
Adrenal autotransplantation.
Srougi M, Gittes RF
Urol Surv 1978 Apr;28(2):41-8. PMID: 209598

Diagnosis

Adrenal cysts: an emerging condition.
Calissendorff J, Juhlin CC, Sundin A, Bancos I, Falhammar H
Nat Rev Endocrinol 2023 Jul;19(7):398-406. Epub 2023 Apr 24 doi: 10.1038/s41574-023-00835-2. PMID: 37095252
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia.
Toledo RA, Jimenez C, Armaiz-Pena G, Arenillas C, Capdevila J, Dahia PLM
Endocr Rev 2023 Mar 4;44(2):312-322. doi: 10.1210/endrev/bnac025. PMID: 36301191Free PMC Article
Resistant Hypertension: Diagnosis and Management.
Nagarajan N, Jalal D
Adv Chronic Kidney Dis 2019 Mar;26(2):99-109. doi: 10.1053/j.ackd.2019.03.002. PMID: 31023454
von Hippel-Lindau syndrome.
Chou A, Toon C, Pickett J, Gill AJ
Front Horm Res 2013;41:30-49. Epub 2013 Mar 19 doi: 10.1159/000345668. PMID: 23652669
Adrenal autotransplantation.
Srougi M, Gittes RF
Urol Surv 1978 Apr;28(2):41-8. PMID: 209598

Therapy

Belzutifan: First Approval.
Deeks ED
Drugs 2021 Nov;81(16):1921-1927. doi: 10.1007/s40265-021-01606-x. PMID: 34613603
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Resistant Hypertension: Diagnosis and Management.
Nagarajan N, Jalal D
Adv Chronic Kidney Dis 2019 Mar;26(2):99-109. doi: 10.1053/j.ackd.2019.03.002. PMID: 31023454
Catecholamine excess: pseudopheochromocytoma and beyond.
Garcha AS, Cohen DL
Adv Chronic Kidney Dis 2015 May;22(3):218-23. doi: 10.1053/j.ackd.2014.11.002. PMID: 25908471
Adrenal autotransplantation.
Srougi M, Gittes RF
Urol Surv 1978 Apr;28(2):41-8. PMID: 209598

Prognosis

Hereditary succinate dehydrogenase-deficient renal cell carcinoma.
Rogala J, Zhou M
Semin Diagn Pathol 2024 Jan;41(1):32-41. Epub 2023 Nov 8 doi: 10.1053/j.semdp.2023.11.001. PMID: 37981479
Extracellular Vesicles and Hypertension.
Tang H, Hu Y, Deng J
Adv Exp Med Biol 2023;1418:69-80. doi: 10.1007/978-981-99-1443-2_5. PMID: 37603273
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Succinate Dehydrogenase-Deficient Renal Cell Carcinoma.
Tsai TH, Lee WY
Arch Pathol Lab Med 2019 May;143(5):643-647. Epub 2018 Dec 21 doi: 10.5858/arpa.2018-0024-RS. PMID: 31026220
Pheochromocytoma-induced aggression?
Altiner S, Dodell G, Abed J, Blackford L, Colt E
Endocr Pract 2011 Sep-Oct;17(5):e126-9. doi: 10.4158/EP10336.CR. PMID: 21803721

Clinical prediction guides

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Hemangioblastomas and Other Vascular Origating Tumors of Brain or Spinal Cord.
Vetrano IG, Gioppo A, Faragò G, Pinzi V, Pollo B, Broggi M, Schiariti M, Ferroli P, Acerbi F
Adv Exp Med Biol 2023;1405:377-403. doi: 10.1007/978-3-031-23705-8_14. PMID: 37452946
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia.
Toledo RA, Jimenez C, Armaiz-Pena G, Arenillas C, Capdevila J, Dahia PLM
Endocr Rev 2023 Mar 4;44(2):312-322. doi: 10.1210/endrev/bnac025. PMID: 36301191Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Intrarenal hemodynamics and kidney function in pheochromocytoma and paraganglioma before and after surgical treatment.
Januszewicz M, Dobrowolski P, Januszewicz A, Warchoł-Celińska E, Jóźwik-Plebanek K, Motyl D, Kabat M, Pęczkowska M, Michałowska I, Ambroziak U, Toutounchi S, Gałązka Z, Courcelles L, Pappaccogli M, Eisenhofer G, Persu A, Lenders JWM, Kądziela J, Prejbisz A
Blood Press 2021 Jun;30(3):172-179. Epub 2021 Feb 15 doi: 10.1080/08037051.2020.1851590. PMID: 33586556

Recent systematic reviews

Pheochromocytoma Turned Malignant During Pregnancy in a Patient With Neurofibromatosis Type I - A Case Report and Systematic Review of the Current Literature.
Zeitler C, Fuderer L, Schmitz K, Arora R, Dammerer D
Anticancer Res 2022 Sep;42(9):4647-4656. doi: 10.21873/anticanres.15969. PMID: 36039448
Pheochromocytoma as a frequent false-positive in adrenal washout CT: A systematic review and meta-analysis.
Woo S, Suh CH, Kim SY, Cho JY, Kim SH
Eur Radiol 2018 Mar;28(3):1027-1036. Epub 2017 Oct 12 doi: 10.1007/s00330-017-5076-5. PMID: 29026974
Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children.
Gómez FM, Patel PA, Stuart S, Roebuck DJ
Pediatr Radiol 2014 Oct;44(10):1281-9. Epub 2014 May 13 doi: 10.1007/s00247-014-3001-5. PMID: 24821394

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