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Advanced Adrenal Gland Pheochromocytoma

MedGen UID:
1689108
•Concept ID:
C5205608
•
Neoplastic Process

Definition

An adrenal gland pheochromocytoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Adrenal Gland Pheochromocytoma

Professional guidelines

PubMed

European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Multidisciplinary practice guidelines for the diagnosis, genetic counseling and treatment of pheochromocytomas and paragangliomas.
Garcia-Carbonero R, Matute Teresa F, Mercader-Cidoncha E, Mitjavila-Casanovas M, Robledo M, Tena I, Alvarez-Escola C, Arístegui M, Bella-Cueto MR, Ferrer-Albiach C, Hanzu FA
Clin Transl Oncol 2021 Oct;23(10):1995-2019. Epub 2021 May 6 doi: 10.1007/s12094-021-02622-9. PMID: 33959901Free PMC Article

Recent clinical studies

Etiology

Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Advances in Endocrine Surgery.
Lui MS, Shirali AS, Huang BL, Fisher SB, Perrier ND
Surg Oncol Clin N Am 2023 Jan;32(1):199-220. Epub 2022 Nov 3 doi: 10.1016/j.soc.2022.08.004. PMID: 36410918
Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Fassnacht M, Assie G, Baudin E, Eisenhofer G, de la Fouchardiere C, Haak HR, de Krijger R, Porpiglia F, Terzolo M, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2020 Nov;31(11):1476-1490. Epub 2020 Aug 27 doi: 10.1016/j.annonc.2020.08.2099. PMID: 32861807
VHL disease.
Barontini M, Dahia PL
Best Pract Res Clin Endocrinol Metab 2010 Jun;24(3):401-13. doi: 10.1016/j.beem.2010.01.002. PMID: 20833332

Diagnosis

European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Pheochromocytomas and paragangliomas.
Yen K, Lodish M
Curr Opin Pediatr 2021 Aug 1;33(4):430-435. doi: 10.1097/MOP.0000000000001029. PMID: 34039901Free PMC Article
Advances in adrenal tumors 2018.
Crona J, Beuschlein F, Pacak K, Skogseid B
Endocr Relat Cancer 2018 Jul;25(7):R405-R420. doi: 10.1530/ERC-18-0138. PMID: 29794126Free PMC Article
Metastatic paraganglioma.
Fliedner SM, Lehnert H, Pacak K
Semin Oncol 2010 Dec;37(6):627-37. doi: 10.1053/j.seminoncol.2010.10.017. PMID: 21167381Free PMC Article
Pheochromocytoma.
Eigelberger MS, Duh QY
Curr Treat Options Oncol 2001 Aug;2(4):321-9. doi: 10.1007/s11864-001-0025-5. PMID: 12057112

Therapy

Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
Targeted Therapies in Pheochromocytoma and Paraganglioma.
Wang K, Crona J, Beuschlein F, Grossman AB, Pacak K, Nölting S
J Clin Endocrinol Metab 2022 Nov 23;107(11):2963-2972. doi: 10.1210/clinem/dgac471. PMID: 35973976Free PMC Article
Genetic and molecular aspects of hypertension.
Padmanabhan S, Caulfield M, Dominiczak AF
Circ Res 2015 Mar 13;116(6):937-59. doi: 10.1161/CIRCRESAHA.116.303647. PMID: 25767282
Pheochromocytoma and functional paraganglioma.
Roman S
Curr Opin Oncol 2004 Jan;16(1):8-12. doi: 10.1097/00001622-200401000-00003. PMID: 14685086
Pheochromocytoma.
Eigelberger MS, Duh QY
Curr Treat Options Oncol 2001 Aug;2(4):321-9. doi: 10.1007/s11864-001-0025-5. PMID: 12057112

Prognosis

Hot Trends in Pheochromocytoma and Paraganglioma: Are We Getting Closer to Personalized Dynamic Prognostication?
Juhlin CC, Mete O
Turk Patoloji Derg 2024;40(3):143-148. doi: 10.5146/tjpath.2024.13681. PMID: 39171856Free PMC Article
Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Fassnacht M, Assie G, Baudin E, Eisenhofer G, de la Fouchardiere C, Haak HR, de Krijger R, Porpiglia F, Terzolo M, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2020 Nov;31(11):1476-1490. Epub 2020 Aug 27 doi: 10.1016/j.annonc.2020.08.2099. PMID: 32861807
Pheochromocytoma: When to search a germline defect?
Buffet A, Burnichon N, Amar L, Gimenez-Roqueplo AP
Presse Med 2018 Jul-Aug;47(7-8 Pt 2):e109-e118. Epub 2018 Aug 9 doi: 10.1016/j.lpm.2018.07.003. PMID: 30100270
The genetic basis of pheochromocytoma and paraganglioma: implications for management.
Shuch B, Ricketts CJ, Metwalli AR, Pacak K, Linehan WM
Urology 2014 Jun;83(6):1225-32. Epub 2014 Mar 15 doi: 10.1016/j.urology.2014.01.007. PMID: 24642075Free PMC Article

Clinical prediction guides

Immunotherapy for endocrine tumours: a clinician's perspective.
Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Recent advances in the management of pheochromocytoma and paraganglioma.
Tanabe A, Naruse M
Hypertens Res 2020 Nov;43(11):1141-1151. Epub 2020 Aug 11 doi: 10.1038/s41440-020-0531-0. PMID: 32778780
Pheochromocytoma: When to search a germline defect?
Buffet A, Burnichon N, Amar L, Gimenez-Roqueplo AP
Presse Med 2018 Jul-Aug;47(7-8 Pt 2):e109-e118. Epub 2018 Aug 9 doi: 10.1016/j.lpm.2018.07.003. PMID: 30100270
Recent advances in the diagnosis and treatment of pheochromocytoma.
Widimský J Jr
Kidney Blood Press Res 2006;29(5):321-6. Epub 2006 Nov 21 doi: 10.1159/000097262. PMID: 17119341

Recent systematic reviews

Safety and efficacy of peptide receptor radionuclide therapy in patients with advanced pheochromocytoma and paraganglioma: A single-institution experience and review of the literature.
Tang CYL, Chua WM, Huang HL, Lam WW, Loh LM, Tai D, Ong SYK, Yan SX, Loke KSH, Ng DC, Tham WY
J Neuroendocrinol 2023 Dec;35(12):e13349. Epub 2023 Nov 8 doi: 10.1111/jne.13349. PMID: 37937484
Adrenal incidentalomas -- a continuing management dilemma.
Nawar R, Aron D
Endocr Relat Cancer 2005 Sep;12(3):585-98. doi: 10.1677/erc.1.00951. PMID: 16172193

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