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Endocrine Mucin-Producing Sweat Gland Carcinoma

MedGen UID:
1690224
Concept ID:
C5231080
Neoplastic Process
Synonym: Endocrine mucin-producing sweat gland carcinoma
SNOMED CT: Endocrine mucin-producing sweat gland carcinoma (822967009); Endocrine mucin-producing sweat gland carcinoma (1293109007)

Definition

A rare, low-grade sweat gland carcinoma with neuroendocrine differentiation. It usually arises on the eyelids and periorbital skin. It affects mostly older individuals. Women are affected more frequently than men. Morphologically, it is characterized by well-demarcated nodules with cystic, papillary, or cribriform architectural patterns. The neoplastic cells are small to intermediate polygonal to round cells. Small amounts of intracellular or extracellular mucin are present. In some cases, this carcinoma is a precursor of mucinous carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndocrine Mucin-Producing Sweat Gland Carcinoma

Professional guidelines

PubMed

Flux K, Brenn T
Clin Lab Med 2017 Sep;37(3):587-601. Epub 2017 Jun 9 doi: 10.1016/j.cll.2017.05.006. PMID: 28802502

Recent clinical studies

Etiology

Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Ansari AN, Bobos M, Shih S, Chen MC, Ardakani NM, Rosales CM, Chen CJ, Savage C, Bracey T, McKee PH, Cerruto CA
Am J Dermatopathol 2019 Aug;41(8):571-577. doi: 10.1097/DAD.0000000000001370. PMID: 31335409
Baker MS, Yin VT, Ivan D, Allen RC, Carter KD, Esmaeli B, Shriver EM
Ophthalmic Plast Reconstr Surg 2017 Mar/Apr;33(2):101-105. doi: 10.1097/IOP.0000000000000658. PMID: 26974419
Shon W, Salomão DR
Int J Dermatol 2014 Oct;53(10):1228-34. doi: 10.1111/ijd.12470. PMID: 25219513
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370

Diagnosis

Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Ansari AN, Bobos M, Shih S, Chen MC, Ardakani NM, Rosales CM, Chen CJ, Savage C, Bracey T, McKee PH, Cerruto CA
Am J Dermatopathol 2019 Aug;41(8):571-577. doi: 10.1097/DAD.0000000000001370. PMID: 31335409
Cardoso JC, Calonje E
Histopathology 2015 Nov;67(5):589-606. Epub 2015 Jul 21 doi: 10.1111/his.12767. PMID: 26114606
Rongioletti F, Ferreli C, Pinna AL, Atzori L
G Ital Dermatol Venereol 2015 Aug;150(4):407-17. PMID: 26086411
Shimizu I, Dufresne R, Robinson-Bostom L
Cutis 2014 Jan;93(1):47-9. PMID: 24505585

Prognosis

Au RTM, Bundele MM
J Cutan Pathol 2021 Sep;48(9):1156-1165. Epub 2021 Mar 5 doi: 10.1111/cup.13983. PMID: 33590507
Ansari AN, Bobos M, Shih S, Chen MC, Ardakani NM, Rosales CM, Chen CJ, Savage C, Bracey T, McKee PH, Cerruto CA
Am J Dermatopathol 2019 Aug;41(8):571-577. doi: 10.1097/DAD.0000000000001370. PMID: 31335409
Baker MS, Yin VT, Ivan D, Allen RC, Carter KD, Esmaeli B, Shriver EM
Ophthalmic Plast Reconstr Surg 2017 Mar/Apr;33(2):101-105. doi: 10.1097/IOP.0000000000000658. PMID: 26974419
Rongioletti F, Ferreli C, Pinna AL, Atzori L
G Ital Dermatol Venereol 2015 Aug;150(4):407-17. PMID: 26086411
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370

Clinical prediction guides

Ravi PY, Walsh NM, Archibald C, Pasternak S
Am J Dermatopathol 2022 May 1;44(5):321-326. doi: 10.1097/DAD.0000000000002132. PMID: 35170475
Bakrin IH, Rajaintharan PS, Tawil Z, Mahayidin H
Malays J Pathol 2020 Apr;42(1):111-114. PMID: 32342939
Ansari AN, Bobos M, Shih S, Chen MC, Ardakani NM, Rosales CM, Chen CJ, Savage C, Bracey T, McKee PH, Cerruto CA
Am J Dermatopathol 2019 Aug;41(8):571-577. doi: 10.1097/DAD.0000000000001370. PMID: 31335409
Shon W, Salomão DR
Int J Dermatol 2014 Oct;53(10):1228-34. doi: 10.1111/ijd.12470. PMID: 25219513
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370

Recent systematic reviews

Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370

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