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Usual Prostate Adenocarcinoma with Neuroendocrine Differentiation

MedGen UID:
1690336
•Concept ID:
C5203858
•
Neoplastic Process
Synonym: Usual Prostate Adenocarcinoma with Neuroendocrine Cells

Definition

Acinar adenocarcinoma of the prostate gland characterized by the presence of scattered neuroendocrine cells by immunohistochemistry. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUsual Prostate Adenocarcinoma with Neuroendocrine Differentiation

Professional guidelines

PubMed

Variants and unusual patterns of prostate cancer: clinicopathologic and differential diagnostic considerations.
Fine SW
Adv Anat Pathol 2012 Jul;19(4):204-16. doi: 10.1097/PAP.0b013e31825c6b92. PMID: 22692283

Recent clinical studies

Etiology

Neuroendocrine differentiation in usual-type prostatic adenocarcinoma: Molecular characterization and clinical significance.
Kaur H, Samarska I, Lu J, Faisal F, Maughan BL, Murali S, Asrani K, Alshalalfa M, Antonarakis ES, Epstein JI, Joshu CE, Schaeffer EM, Mosquera JM, Lotan TL
Prostate 2020 Sep;80(12):1012-1023. Epub 2020 Jul 10 doi: 10.1002/pros.24035. PMID: 32649013Free PMC Article
Significance of Paneth cell-like differentiation in prostatic adenocarcinoma: a retrospective cohort study of 80 cases.
Salles DC, Mata DA, Epstein JI
Hum Pathol 2020 Aug;102:7-12. Epub 2020 May 20 doi: 10.1016/j.humpath.2020.05.003. PMID: 32445653
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447

Diagnosis

Primary Prostatic Carcinoma With De Novo Diffuse Neuroendocrine Differentiation.
Galea LA, Mow C, Fine SW, Manohar P
Int J Surg Pathol 2022 Apr;30(2):232-236. Epub 2021 Aug 2 doi: 10.1177/10668969211035844. PMID: 34338584Free PMC Article
Proposed morphologic classification of prostate cancer with neuroendocrine differentiation.
Epstein JI, Amin MB, Beltran H, Lotan TL, Mosquera JM, Reuter VE, Robinson BD, Troncoso P, Rubin MA
Am J Surg Pathol 2014 Jun;38(6):756-67. doi: 10.1097/PAS.0000000000000208. PMID: 24705311Free PMC Article
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
Variants and unusual patterns of prostate cancer: clinicopathologic and differential diagnostic considerations.
Fine SW
Adv Anat Pathol 2012 Jul;19(4):204-16. doi: 10.1097/PAP.0b013e31825c6b92. PMID: 22692283
Prostate carcinoma with neuroendocrine differentiation: case report and literature review.
Fernandes RC, Matsushita MM, Mauad T, Nascimento Saldiva PH
Rev Hosp Clin Fac Med Sao Paulo 2001 Sep-Oct;56(5):153-8. doi: 10.1590/s0041-87812001000500005. PMID: 11781596

Therapy

Primary Prostatic Carcinoma With De Novo Diffuse Neuroendocrine Differentiation.
Galea LA, Mow C, Fine SW, Manohar P
Int J Surg Pathol 2022 Apr;30(2):232-236. Epub 2021 Aug 2 doi: 10.1177/10668969211035844. PMID: 34338584Free PMC Article

Prognosis

Neuroendocrine differentiation in usual-type prostatic adenocarcinoma: Molecular characterization and clinical significance.
Kaur H, Samarska I, Lu J, Faisal F, Maughan BL, Murali S, Asrani K, Alshalalfa M, Antonarakis ES, Epstein JI, Joshu CE, Schaeffer EM, Mosquera JM, Lotan TL
Prostate 2020 Sep;80(12):1012-1023. Epub 2020 Jul 10 doi: 10.1002/pros.24035. PMID: 32649013Free PMC Article
Significance of Paneth cell-like differentiation in prostatic adenocarcinoma: a retrospective cohort study of 80 cases.
Salles DC, Mata DA, Epstein JI
Hum Pathol 2020 Aug;102:7-12. Epub 2020 May 20 doi: 10.1016/j.humpath.2020.05.003. PMID: 32445653
Expression of neuroendocrine differentiation markers in lethal metastatic castration-resistant prostate cancer.
Sainio M, Visakorpi T, Tolonen T, Ilvesaro J, Bova GS
Pathol Res Pract 2018 Jun;214(6):848-856. Epub 2018 Apr 26 doi: 10.1016/j.prp.2018.04.015. PMID: 29728311
Proposed morphologic classification of prostate cancer with neuroendocrine differentiation.
Epstein JI, Amin MB, Beltran H, Lotan TL, Mosquera JM, Reuter VE, Robinson BD, Troncoso P, Rubin MA
Am J Surg Pathol 2014 Jun;38(6):756-67. doi: 10.1097/PAS.0000000000000208. PMID: 24705311Free PMC Article
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447

Clinical prediction guides

Neuroendocrine differentiation in usual-type prostatic adenocarcinoma: Molecular characterization and clinical significance.
Kaur H, Samarska I, Lu J, Faisal F, Maughan BL, Murali S, Asrani K, Alshalalfa M, Antonarakis ES, Epstein JI, Joshu CE, Schaeffer EM, Mosquera JM, Lotan TL
Prostate 2020 Sep;80(12):1012-1023. Epub 2020 Jul 10 doi: 10.1002/pros.24035. PMID: 32649013Free PMC Article
Proposed morphologic classification of prostate cancer with neuroendocrine differentiation.
Epstein JI, Amin MB, Beltran H, Lotan TL, Mosquera JM, Reuter VE, Robinson BD, Troncoso P, Rubin MA
Am J Surg Pathol 2014 Jun;38(6):756-67. doi: 10.1097/PAS.0000000000000208. PMID: 24705311Free PMC Article
Variants and unusual patterns of prostate cancer: clinicopathologic and differential diagnostic considerations.
Fine SW
Adv Anat Pathol 2012 Jul;19(4):204-16. doi: 10.1097/PAP.0b013e31825c6b92. PMID: 22692283
Small cell carcinoma of the prostate. A morphologic and immunohistochemical study of 95 cases.
Wang W, Epstein JI
Am J Surg Pathol 2008 Jan;32(1):65-71. doi: 10.1097/PAS.0b013e318058a96b. PMID: 18162772

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