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Elevated circulating vitamin B6 concentration

MedGen UID:
1694849
•Concept ID:
C5139369
•
Finding
Synonym: Elevated circulating vitamin B6 level
 
HPO: HP:0032477

Definition

An abnormally increased concentration of vitamin B6 in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating vitamin B6 concentration

Professional guidelines

PubMed

Hypophosphatasia - aetiology, nosology, pathogenesis, diagnosis and treatment.
Whyte MP
Nat Rev Endocrinol 2016 Apr;12(4):233-46. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.14. PMID: 26893260
Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
Christensen MH, Pedersen EK, Nordbø Y, Varhaug JE, Midttun Ø, Ueland PM, Nygård OK, Mellgren G, Lien EA
J Intern Med 2012 Dec;272(6):583-91. Epub 2012 Aug 5 doi: 10.1111/j.1365-2796.2012.02570.x. PMID: 22757621

Recent clinical studies

Etiology

Micronutrients and Allergic Diseases: A Mendelian Randomization Study.
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W
Int Arch Allergy Immunol 2025;186(1):41-51. Epub 2024 Aug 6 doi: 10.1159/000540376. PMID: 39106841
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Hypophosphatasia - aetiology, nosology, pathogenesis, diagnosis and treatment.
Whyte MP
Nat Rev Endocrinol 2016 Apr;12(4):233-46. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.14. PMID: 26893260
Homocysteine and coronary atherosclerosis.
Mayer EL, Jacobsen DW, Robinson K
J Am Coll Cardiol 1996 Mar 1;27(3):517-27. doi: 10.1016/0735-1097(95)00508-0. PMID: 8606260

Diagnosis

Micronutrients and Allergic Diseases: A Mendelian Randomization Study.
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W
Int Arch Allergy Immunol 2025;186(1):41-51. Epub 2024 Aug 6 doi: 10.1159/000540376. PMID: 39106841
Hypophosphatasia: Vitamin B(6) status of affected children and adults.
Whyte MP, Zhang F, Wenkert D, Mack KE, Bijanki VN, Ericson KL, Coburn SP
Bone 2022 Jan;154:116204. Epub 2021 Sep 20 doi: 10.1016/j.bone.2021.116204. PMID: 34547524
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Hypophosphatasia - aetiology, nosology, pathogenesis, diagnosis and treatment.
Whyte MP
Nat Rev Endocrinol 2016 Apr;12(4):233-46. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.14. PMID: 26893260

Therapy

Micronutrients and Allergic Diseases: A Mendelian Randomization Study.
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W
Int Arch Allergy Immunol 2025;186(1):41-51. Epub 2024 Aug 6 doi: 10.1159/000540376. PMID: 39106841
Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris.
Bråtveit M, Van Parys A, Olsen T, Strand E, Marienborg I, Laupsa-Borge J, Haugsgjerd TR, McCann A, Dhar I, Ueland PM, Dierkes J, Dankel SN, Nygård OK, Lysne V
Br J Nutr 2024 May 28;131(10):1678-1690. Epub 2024 Feb 16 doi: 10.1017/S0007114524000473. PMID: 38361451Free PMC Article
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Homocysteine and renal disease.
van Guldener C, Robinson K
Semin Thromb Hemost 2000;26(3):313-24. doi: 10.1055/s-2000-8407. PMID: 11011849
Homocysteine and coronary atherosclerosis.
Mayer EL, Jacobsen DW, Robinson K
J Am Coll Cardiol 1996 Mar 1;27(3):517-27. doi: 10.1016/0735-1097(95)00508-0. PMID: 8606260

Prognosis

Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris.
Bråtveit M, Van Parys A, Olsen T, Strand E, Marienborg I, Laupsa-Borge J, Haugsgjerd TR, McCann A, Dhar I, Ueland PM, Dierkes J, Dankel SN, Nygård OK, Lysne V
Br J Nutr 2024 May 28;131(10):1678-1690. Epub 2024 Feb 16 doi: 10.1017/S0007114524000473. PMID: 38361451Free PMC Article
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Homocysteine is associated with severity of microvasculopathy in sickle cell disease patients.
Samarron SL, Miller JW, Cheung AT, Chen PC, Lin X, Zwerdling T, Wun T, Green R
Br J Haematol 2020 Aug;190(3):450-457. Epub 2020 Apr 19 doi: 10.1111/bjh.16618. PMID: 32307711Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Homocysteine and renal disease.
van Guldener C, Robinson K
Semin Thromb Hemost 2000;26(3):313-24. doi: 10.1055/s-2000-8407. PMID: 11011849

Clinical prediction guides

Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Homocysteine is associated with severity of microvasculopathy in sickle cell disease patients.
Samarron SL, Miller JW, Cheung AT, Chen PC, Lin X, Zwerdling T, Wun T, Green R
Br J Haematol 2020 Aug;190(3):450-457. Epub 2020 Apr 19 doi: 10.1111/bjh.16618. PMID: 32307711Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
Christensen MH, Pedersen EK, Nordbø Y, Varhaug JE, Midttun Ø, Ueland PM, Nygård OK, Mellgren G, Lien EA
J Intern Med 2012 Dec;272(6):583-91. Epub 2012 Aug 5 doi: 10.1111/j.1365-2796.2012.02570.x. PMID: 22757621
Folate, vitamin B₁₂ and total homocysteine levels in Arab adolescent subjects: reference ranges and potential determinants.
Akanji AO, Thalib L, Al-Isa AN
Nutr Metab Cardiovasc Dis 2012 Oct;22(10):900-6. Epub 2010 Dec 30 doi: 10.1016/j.numecd.2010.10.020. PMID: 21194911

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