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Penile Melanoma

MedGen UID:
1697024
•Concept ID:
C1403753
•
Neoplastic Process
Synonym: Melanoma of the Penis

Definition

A melanoma that arises from the penis. It may be cutaneous or mucosal. The most common site of involvement is glans penis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPenile Melanoma

Professional guidelines

PubMed

Clinical features, molecular characteristics and surgical management of primary penile mucosal melanoma based on the European Association of Urology Penile Cancer Guidelines.
Cakir OO, Pozzi E, Castiglione F, Freeman A, Haider A, Rees R, Alnajjar HM, Bunker C, Muneer A
Melanoma Res 2022 Feb 1;32(1):27-34. doi: 10.1097/CMR.0000000000000788. PMID: 34840322
Ano-uro-genital mucosal melanoma UK national guidelines.
Smith HG, Bagwan I, Board RE, Capper S, Coupland SE, Glen J, Lalondrelle S, Mayberry A, Muneer A, Nugent K, Pathiraja P, Payne M, Peach H, Smith J, Westwell S, Wilson E, Rodwell S, Gore M, Turnbull N, Smith MJF
Eur J Cancer 2020 Aug;135:22-30. Epub 2020 Jun 9 doi: 10.1016/j.ejca.2020.04.030. PMID: 32531566
Surgical Management of Primary Scrotal Cancer.
Huang JH, Broggi M, Osunkoya AO, Master VA
Urol Clin North Am 2016 Nov;43(4):531-544. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.014. PMID: 27717439

Recent clinical studies

Etiology

A population-level analysis of nonsquamous penile cancer: The importance of histology.
Bhambhvani HP, Greenberg DR, Parham MJ, Eisenberg ML
Urol Oncol 2021 Feb;39(2):136.e1-136.e10. Epub 2020 Nov 27 doi: 10.1016/j.urolonc.2020.11.025. PMID: 33257222
Penile Melanoma In Situ: Long Term Follow Up.
Krughoff K, Kilchevksy A, Stadelmann W, Gorman T, Madden-Fuentes R
Urology 2020 Jul;141:e51-e52. Epub 2020 Apr 11 doi: 10.1016/j.urology.2020.03.027. PMID: 32289363
A clinical, histologic, and follow-up study of genital melanosis in men and women.
Haugh AM, Merkel EA, Zhang B, Bubley JA, Verzì AE, Lee CY, Gerami P
J Am Acad Dermatol 2017 May;76(5):836-840. Epub 2016 Dec 13 doi: 10.1016/j.jaad.2016.11.003. PMID: 27986395
Penile primary melanoma: analysis of 6 patients treated at Brazilian National Cancer Institute in the last eight years.
Bechara GR, Schwindt AB, Ornellas AA, Silva DE, Lott FM, Campos FS
Int Braz J Urol 2013 Nov-Dec;39(6):823-31. doi: 10.1590/S1677-5538.IBJU.2013.06.08. PMID: 24456774
Prognosis of primary mucosal penile melanoma: a series of 19 Dutch patients and 47 patients from the literature.
van Geel AN, den Bakker MA, Kirkels W, Horenblas S, Kroon BB, de Wilt JH, Eggermont AM, Mooi WJ, van der Aa MN
Urology 2007 Jul;70(1):143-7. doi: 10.1016/j.urology.2007.03.039. PMID: 17656225

Diagnosis

A population-level analysis of nonsquamous penile cancer: The importance of histology.
Bhambhvani HP, Greenberg DR, Parham MJ, Eisenberg ML
Urol Oncol 2021 Feb;39(2):136.e1-136.e10. Epub 2020 Nov 27 doi: 10.1016/j.urolonc.2020.11.025. PMID: 33257222
Preputial melanoma.
Tchernev G, Temelkova I
Wien Med Wochenschr 2021 Feb;171(1-2):41-42. Epub 2020 May 7 doi: 10.1007/s10354-020-00751-4. PMID: 32382854
Primary penile melanoma.
Andrei R, Cioplea M, Mageriu V, Chuaibi A, Cauni V, Zurac S, Staniceanu F
Rom J Intern Med 2014 Apr-Jun;52(2):121-5. PMID: 25338349
Penile primary melanoma: analysis of 6 patients treated at Brazilian National Cancer Institute in the last eight years.
Bechara GR, Schwindt AB, Ornellas AA, Silva DE, Lott FM, Campos FS
Int Braz J Urol 2013 Nov-Dec;39(6):823-31. doi: 10.1590/S1677-5538.IBJU.2013.06.08. PMID: 24456774
Prognosis of primary mucosal penile melanoma: a series of 19 Dutch patients and 47 patients from the literature.
van Geel AN, den Bakker MA, Kirkels W, Horenblas S, Kroon BB, de Wilt JH, Eggermont AM, Mooi WJ, van der Aa MN
Urology 2007 Jul;70(1):143-7. doi: 10.1016/j.urology.2007.03.039. PMID: 17656225

Therapy

Response to Imatinib in a Patient with Double-mutant KIT Metastatic Penile Melanoma.
Beaudoux O, Ehret M, Criquet E, Franceschi J, Durlach A, Oudart JB, Visseaux L, Grange F
Acta Derm Venereol 2021 Apr 12;101(4):adv00426. doi: 10.2340/00015555-3715. PMID: 33283249Free PMC Article
Lymphoscintigraphy for sentinel node mapping using a hybrid SPECT/CT system.
Even-Sapir E, Lerman H, Lievshitz G, Khafif A, Fliss DM, Schwartz A, Gur E, Skornick Y, Schneebaum S
J Nucl Med 2003 Sep;44(9):1413-20. PMID: 12960185

Prognosis

A population-level analysis of nonsquamous penile cancer: The importance of histology.
Bhambhvani HP, Greenberg DR, Parham MJ, Eisenberg ML
Urol Oncol 2021 Feb;39(2):136.e1-136.e10. Epub 2020 Nov 27 doi: 10.1016/j.urolonc.2020.11.025. PMID: 33257222
Preputial melanoma.
Tchernev G, Temelkova I
Wien Med Wochenschr 2021 Feb;171(1-2):41-42. Epub 2020 May 7 doi: 10.1007/s10354-020-00751-4. PMID: 32382854
Primary penile melanoma.
Andrei R, Cioplea M, Mageriu V, Chuaibi A, Cauni V, Zurac S, Staniceanu F
Rom J Intern Med 2014 Apr-Jun;52(2):121-5. PMID: 25338349
Clinicopathological and molecular study of penile melanoma.
Oxley JD, Corbishley C, Down L, Watkin N, Dickerson D, Wong NA
J Clin Pathol 2012 Mar;65(3):228-31. Epub 2011 Oct 19 doi: 10.1136/jclinpath-2011-200344. PMID: 22011445
Prognosis of primary mucosal penile melanoma: a series of 19 Dutch patients and 47 patients from the literature.
van Geel AN, den Bakker MA, Kirkels W, Horenblas S, Kroon BB, de Wilt JH, Eggermont AM, Mooi WJ, van der Aa MN
Urology 2007 Jul;70(1):143-7. doi: 10.1016/j.urology.2007.03.039. PMID: 17656225

Clinical prediction guides

Penile melanoma: a pathological report of two cases.
Pósfai B, Szentkereszty M, Sánta F, Bajory Z, Simon A, Kozéki Z, Csányi I, Akgul M, Kuthi L
Diagn Pathol 2023 Oct 28;18(1):117. doi: 10.1186/s13000-023-01404-x. PMID: 37898793Free PMC Article
A population-level analysis of nonsquamous penile cancer: The importance of histology.
Bhambhvani HP, Greenberg DR, Parham MJ, Eisenberg ML
Urol Oncol 2021 Feb;39(2):136.e1-136.e10. Epub 2020 Nov 27 doi: 10.1016/j.urolonc.2020.11.025. PMID: 33257222

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