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Penile Cutaneous Melanoma

MedGen UID:
1791543
•Concept ID:
C5555102
•
Neoplastic Process

Definition

A melanoma that arises from the skin of the penis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPenile Cutaneous Melanoma

Professional guidelines

PubMed

Clinical features, molecular characteristics and surgical management of primary penile mucosal melanoma based on the European Association of Urology Penile Cancer Guidelines.
Cakir OO, Pozzi E, Castiglione F, Freeman A, Haider A, Rees R, Alnajjar HM, Bunker C, Muneer A
Melanoma Res 2022 Feb 1;32(1):27-34. doi: 10.1097/CMR.0000000000000788. PMID: 34840322
Ano-uro-genital mucosal melanoma UK national guidelines.
Smith HG, Bagwan I, Board RE, Capper S, Coupland SE, Glen J, Lalondrelle S, Mayberry A, Muneer A, Nugent K, Pathiraja P, Payne M, Peach H, Smith J, Westwell S, Wilson E, Rodwell S, Gore M, Turnbull N, Smith MJF
Eur J Cancer 2020 Aug;135:22-30. Epub 2020 Jun 9 doi: 10.1016/j.ejca.2020.04.030. PMID: 32531566
Surgical Management of Primary Scrotal Cancer.
Huang JH, Broggi M, Osunkoya AO, Master VA
Urol Clin North Am 2016 Nov;43(4):531-544. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.014. PMID: 27717439

Recent clinical studies

Etiology

Urologic conditions associated with malignancy.
Lo EM, Hotaling JM, Pastuszak AW
Urol Oncol 2020 Jan;38(1):23-30. Epub 2019 Jan 2 doi: 10.1016/j.urolonc.2018.12.018. PMID: 30611645Free PMC Article
Sentinel Lymph Node Biopsy Procedures.
Moncayo VM, Alazraki AL, Alazraki NP, Aarsvold JN
Semin Nucl Med 2017 Nov;47(6):595-617. Epub 2017 Sep 6 doi: 10.1053/j.semnuclmed.2017.06.004. PMID: 28969759
Pigmented penile macules.
Mahto M, Woolley PD, Ashworth J
Int J STD AIDS 2004 Nov;15(11):717-9. doi: 10.1258/0956462042395276. PMID: 15537454
Penile melanosis.
Revuz J, Clerici T
J Am Acad Dermatol 1989 Apr;20(4):567-70. doi: 10.1016/s0190-9622(89)70064-5. PMID: 2715403
Chemosurgery.
Mohs FE
Clin Plast Surg 1980 Jul;7(3):349-60. PMID: 7438703

Diagnosis

Preputial melanoma.
Tchernev G, Temelkova I
Wien Med Wochenschr 2021 Feb;171(1-2):41-42. Epub 2020 May 7 doi: 10.1007/s10354-020-00751-4. PMID: 32382854
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Primary penile melanoma.
Andrei R, Cioplea M, Mageriu V, Chuaibi A, Cauni V, Zurac S, Staniceanu F
Rom J Intern Med 2014 Apr-Jun;52(2):121-5. PMID: 25338349
Pigmented penile macules.
Mahto M, Woolley PD, Ashworth J
Int J STD AIDS 2004 Nov;15(11):717-9. doi: 10.1258/0956462042395276. PMID: 15537454
Penile melanosis.
Revuz J, Clerici T
J Am Acad Dermatol 1989 Apr;20(4):567-70. doi: 10.1016/s0190-9622(89)70064-5. PMID: 2715403

Therapy

Assessment and Reporting of Perioperative Adverse Events and Complications in Patients Undergoing Inguinal Lymphadenectomy for Melanoma, Vulvar Cancer, and Penile Cancer: A Systematic Review and Meta-analysis.
Cacciamani GE, Medina LG, Sayegh AS, La Riva A, Perez LC, Eppler MB, Gill I, Sotelo R; Complications and Adverse Events in Lymphadenectomy of the Inguinal Area (CALI) project, the International Consensus Panel on Complications in Urology (ICPCU), and the Intraoperative Complications assessment and reporting with Universal Standards (ICARUS) Global Surgical Collaboration
World J Surg 2023 Apr;47(4):962-974. Epub 2023 Jan 28 doi: 10.1007/s00268-022-06882-6. PMID: 36709215
Identification of fusions with potential clinical significance in melanoma.
Moran JMT, Le LP, Nardi V, Golas J, Farahani AA, Signorelli S, Onozato ML, Foreman RK, Duncan LM, Lawrence DP, Lennerz JK, Dias-Santagata D, Hoang MP
Mod Pathol 2022 Dec;35(12):1837-1847. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01138-z. PMID: 35871080
The Role of PDE5 Inhibitors and the NO/cGMP Pathway in Cancer.
Peak TC, Richman A, Gur S, Yafi FA, Hellstrom WJ
Sex Med Rev 2016 Jan;4(1):74-84. Epub 2016 Jan 8 doi: 10.1016/j.sxmr.2015.10.004. PMID: 27872007
Carcinogenic risks of psoralen UV-A therapy and narrowband UV-B therapy in chronic plaque psoriasis: a systematic literature review.
Archier E, Devaux S, Castela E, Gallini A, Aubin F, Le Maître M, Aractingi S, Bachelez H, Cribier B, Joly P, Jullien D, Misery L, Paul C, Ortonne JP, Richard MA
J Eur Acad Dermatol Venereol 2012 May;26 Suppl 3:22-31. doi: 10.1111/j.1468-3083.2012.04520.x. PMID: 22512677
Chemosurgery.
Mohs FE
Clin Plast Surg 1980 Jul;7(3):349-60. PMID: 7438703

Prognosis

Preputial melanoma.
Tchernev G, Temelkova I
Wien Med Wochenschr 2021 Feb;171(1-2):41-42. Epub 2020 May 7 doi: 10.1007/s10354-020-00751-4. PMID: 32382854
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Primary penile melanoma.
Andrei R, Cioplea M, Mageriu V, Chuaibi A, Cauni V, Zurac S, Staniceanu F
Rom J Intern Med 2014 Apr-Jun;52(2):121-5. PMID: 25338349
Penile tumours: a review.
Wollina U, Steinbach F, Verma S, Tchernev G
J Eur Acad Dermatol Venereol 2014 Oct;28(10):1267-76. Epub 2014 Mar 31 doi: 10.1111/jdv.12491. PMID: 24684236
Penile melanosis.
Revuz J, Clerici T
J Am Acad Dermatol 1989 Apr;20(4):567-70. doi: 10.1016/s0190-9622(89)70064-5. PMID: 2715403

Clinical prediction guides

Malaysian and Chinese King Cobra Venom Cytotoxicity in Melanoma and Neonatal Foreskin Fibroblasts Is Mediated by Age and Geography.
Op den Brouw B, Fernandez-Rojo MA, Charlton T, Fry BG, Ikonomopoulou MP
Toxins (Basel) 2023 Sep 4;15(9) doi: 10.3390/toxins15090549. PMID: 37755975
Assessment and Reporting of Perioperative Adverse Events and Complications in Patients Undergoing Inguinal Lymphadenectomy for Melanoma, Vulvar Cancer, and Penile Cancer: A Systematic Review and Meta-analysis.
Cacciamani GE, Medina LG, Sayegh AS, La Riva A, Perez LC, Eppler MB, Gill I, Sotelo R; Complications and Adverse Events in Lymphadenectomy of the Inguinal Area (CALI) project, the International Consensus Panel on Complications in Urology (ICPCU), and the Intraoperative Complications assessment and reporting with Universal Standards (ICARUS) Global Surgical Collaboration
World J Surg 2023 Apr;47(4):962-974. Epub 2023 Jan 28 doi: 10.1007/s00268-022-06882-6. PMID: 36709215
A population-level analysis of nonsquamous penile cancer: The importance of histology.
Bhambhvani HP, Greenberg DR, Parham MJ, Eisenberg ML
Urol Oncol 2021 Feb;39(2):136.e1-136.e10. Epub 2020 Nov 27 doi: 10.1016/j.urolonc.2020.11.025. PMID: 33257222
Neuroendocrine factors: The missing link in non‑melanoma skin cancer (Review).
Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, Drakoulis N, Mamoulakis C, Tzanakakis G, Neagu M, Spandidos DA, Izotov BN, Tsatsakis AM
Oncol Rep 2017 Sep;38(3):1327-1340. Epub 2017 Jul 13 doi: 10.3892/or.2017.5817. PMID: 28713981Free PMC Article
Penile melanosis.
Revuz J, Clerici T
J Am Acad Dermatol 1989 Apr;20(4):567-70. doi: 10.1016/s0190-9622(89)70064-5. PMID: 2715403

Recent systematic reviews

Assessment and Reporting of Perioperative Adverse Events and Complications in Patients Undergoing Inguinal Lymphadenectomy for Melanoma, Vulvar Cancer, and Penile Cancer: A Systematic Review and Meta-analysis.
Cacciamani GE, Medina LG, Sayegh AS, La Riva A, Perez LC, Eppler MB, Gill I, Sotelo R; Complications and Adverse Events in Lymphadenectomy of the Inguinal Area (CALI) project, the International Consensus Panel on Complications in Urology (ICPCU), and the Intraoperative Complications assessment and reporting with Universal Standards (ICARUS) Global Surgical Collaboration
World J Surg 2023 Apr;47(4):962-974. Epub 2023 Jan 28 doi: 10.1007/s00268-022-06882-6. PMID: 36709215
Mutational Characteristics of Primary Mucosal Melanoma: A Systematic Review.
Beaudoux O, Oudart JB, Riffaud L, Visseaux L, Marchal A, Lebre AS, Grange F
Mol Diagn Ther 2022 Mar;26(2):189-202. Epub 2022 Feb 23 doi: 10.1007/s40291-021-00572-0. PMID: 35195858
Systematic Review of Surgical Treatment and Outcomes After Local Surgery of Primary Cutaneous Melanomas of the Penis and Scrotum.
Bittar JM, Bittar PG, Wan MT, Kovell RC, Guzzo TJ, Shin TM, Etzkorn JR, Sobanko JF, Miller CJ
Dermatol Surg 2018 Sep;44(9):1159-1169. doi: 10.1097/DSS.0000000000001579. PMID: 29985865
Wound drainage following groin dissection for malignant disease in adults.
Thomson DR, Sadideen H, Furniss D
Cochrane Database Syst Rev 2014 Nov 11;(11):CD010933. doi: 10.1002/14651858.CD010933.pub2. PMID: 25387103
A comparison of fibrin sealant versus standard closure in the reduction of postoperative morbidity after groin dissection: A systematic review and meta-analysis.
Weldrick C, Bashar K, O'Sullivan TA, Gillis E, Clarke Moloney M, Tang TY, Walsh SR
Eur J Surg Oncol 2014 Nov;40(11):1391-8. Epub 2014 Jul 27 doi: 10.1016/j.ejso.2014.07.034. PMID: 25125341

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