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Increased core 1 O-glycan level

MedGen UID:
1698367
•Concept ID:
C5139525
•
Finding
Synonym: Increased T-antigen concentration
 
HPO: HP:0410360

Definition

An abnormal increase in the concentration of core 1 O-glycans on glycoproteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased core 1 O-glycan level

Recent clinical studies

Etiology

Serum O-glycosylated hepatitis B surface antigen levels in patients with chronic hepatitis B during nucleos(t)ide analog therapy.
Murata A, Angata K, Sogabe M, Sato S, Ichida T, Narimatsu H, Genda T
BMC Gastroenterol 2022 May 31;22(1):270. doi: 10.1186/s12876-022-02352-4. PMID: 35641912Free PMC Article
The Association of rs1047763 and rs1008898 of C1GALT1 with IgA Nephropathy Risk: A Global Meta-Analysis.
Nie R, Cheng G, Zhang J, Dong Y, Wang C, Liu J, Qin X
Monoclon Antib Immunodiagn Immunother 2017 Jun;36(3):95-103. doi: 10.1089/mab.2016.0050. PMID: 28636500
Alterations of O-glycan biosynthesis in human colon cancer tissues.
Yang JM, Byrd JC, Siddiki BB, Chung YS, Okuno M, Sowa M, Kim YS, Matta KL, Brockhausen I
Glycobiology 1994 Dec;4(6):873-84. doi: 10.1093/glycob/4.6.873. PMID: 7734850
Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Gal beta 3 GalNAc alpha-R (GlcNAc to GalNAc) beta(1-6)-N-acetylglucosaminyltransferase in leukemic cells.
Brockhausen I, Kuhns W, Schachter H, Matta KL, Sutherland DR, Baker MA
Cancer Res 1991 Feb 15;51(4):1257-63. PMID: 1997166
Glycosyltransferase changes upon differentiation of CaCo-2 human colonic adenocarcinoma cells.
Brockhausen I, Romero PA, Herscovics A
Cancer Res 1991 Jun 15;51(12):3136-42. PMID: 1904002

Diagnosis

Production of CA125 with Tn antigens using a glycosylphosphatidylinositol anchoring system.
Tang YH, Leng JX, Yang G, Gao XD, Liu YS, Fujita M
J Biochem 2024 Jul 1;176(1):23-34. doi: 10.1093/jb/mvae019. PMID: 38382634
Functional analysis of GCNT3 for cell migration and EMT of castration-resistant prostate cancer cells.
Yamamoto D, Sasaki K, Kosaka T, Oya M, Sato T
Glycobiology 2022 Sep 19;32(10):897-908. doi: 10.1093/glycob/cwac044. PMID: 35867813
Cosmc transfection decreases malignant behavior of Tn(+) cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure.
Ding R, Hu X, Hu W, Du Z, Huang P, Wang M, Sheng J, Ma Y, Wang A, Luan X, Dong M, Cao Q, Zou Y, Hu T
Aging (Albany NY) 2021 Oct 13;13(19):23393-23406. doi: 10.18632/aging.203633. PMID: 34644263Free PMC Article
Selected reaction monitoring to differentiate and relatively quantitate isomers of sulfated and unsulfated core 1 O-glycans from salivary MUC7 protein in rheumatoid arthritis.
Flowers SA, Ali L, Lane CS, Olin M, Karlsson NG
Mol Cell Proteomics 2013 Apr;12(4):921-31. Epub 2013 Mar 1 doi: 10.1074/mcp.M113.028878. PMID: 23457413Free PMC Article

Therapy

Functional analysis of GCNT3 for cell migration and EMT of castration-resistant prostate cancer cells.
Yamamoto D, Sasaki K, Kosaka T, Oya M, Sato T
Glycobiology 2022 Sep 19;32(10):897-908. doi: 10.1093/glycob/cwac044. PMID: 35867813

Prognosis

Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Ye J, Wei X, Shang Y, Pan Q, Yang M, Tian Y, He Y, Peng Z, Chen L, Chen W, Wang R
Oncogene 2017 Nov 16;36(46):6391-6407. Epub 2017 Jul 24 doi: 10.1038/onc.2017.241. PMID: 28745318

Clinical prediction guides

Functional analysis of GCNT3 for cell migration and EMT of castration-resistant prostate cancer cells.
Yamamoto D, Sasaki K, Kosaka T, Oya M, Sato T
Glycobiology 2022 Sep 19;32(10):897-908. doi: 10.1093/glycob/cwac044. PMID: 35867813
Manganese ion concentration affects production of human core 3 O-glycan in Saccharomyces cerevisiae.
Saito F, Sakamoto I, Kanatani A, Chiba Y
Biochim Biophys Acta 2016 Sep;1860(9):1809-20. Epub 2016 May 31 doi: 10.1016/j.bbagen.2016.05.038. PMID: 27259834
Glycosylation characteristics of colorectal cancer.
Holst S, Wuhrer M, Rombouts Y
Adv Cancer Res 2015;126:203-56. Epub 2015 Feb 7 doi: 10.1016/bs.acr.2014.11.004. PMID: 25727149
New mutations in C1GALT1C1 in individuals with Tn positive phenotype.
Crew VK, Singleton BK, Green C, Parsons SF, Daniels G, Anstee DJ
Br J Haematol 2008 Aug;142(4):657-67. Epub 2008 Jun 5 doi: 10.1111/j.1365-2141.2008.07215.x. PMID: 18537974
Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Gal beta 3 GalNAc alpha-R (GlcNAc to GalNAc) beta(1-6)-N-acetylglucosaminyltransferase in leukemic cells.
Brockhausen I, Kuhns W, Schachter H, Matta KL, Sutherland DR, Baker MA
Cancer Res 1991 Feb 15;51(4):1257-63. PMID: 1997166

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