Abnormal core 1 O-glycan level

MedGen UID:: 1706968
•Concept ID:: C5139524
•: Finding

Synonym:	Abnormal concentration of T-antigen

HPO:	HP:0410359

Definition

An abnormal in the concentration of core 1 O-glycans on glycoproteins. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal core 1 O-glycan level

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal metabolism
    - Abnormal glycosylation
      - Abnormal protein glycosylation
        Abnormal protein O-linked glycosylation
        Abnormal core 1 O-glycan level
        Decreased core 1 O-glycan level
        Increased core 1 O-glycan level

Recent clinical studies

Diagnosis

Cosmc transfection decreases malignant behavior of Tn(+) cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure.

Ding R, Hu X, Hu W, Du Z, Huang P, Wang M, Sheng J, Ma Y, Wang A, Luan X, Dong M, Cao Q, Zou Y, Hu T
Aging (Albany NY) 2021 Oct 13;13(19):23393-23406. doi: 10.18632/aging.203633. PMID: 34644263 Free PMC Article

See all (1)

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