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Basaloid (Undifferentiated) Penile Intraepithelial Neoplasia

MedGen UID:
1702220
•Concept ID:
C5206636
•
Neoplastic Process
Synonyms: Basaloid (Undifferentiated) PeIN; Basaloid PeIN; Basaloid Penile Intraepithelial Neoplasia

Definition

Intraepithelial neoplasia of the penis characterized by full-thickness replacement of the squamous epithelium by immature, small, monotonous, basophilic cells. The cells have round to oval nuclei, inconspicuous nucleoli, and scant cytoplasm. Apoptosis and mitotic figures are prominent. (WHO 2016) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasaloid (Undifferentiated) Penile Intraepithelial Neoplasia

Recent clinical studies

Etiology

Histologic and immunohistochemical assessment of penile carcinomas in a North American population.
Mentrikoski MJ, Stelow EB, Culp S, Frierson HF Jr, Cathro HP
Am J Surg Pathol 2014 Oct;38(10):1340-8. doi: 10.1097/PAS.0000000000000124. PMID: 25210933
Identification and genotyping of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: correlation with pathologic subtypes, p16(INK4a) expression, and prognosis.
Ferrándiz-Pulido C, Masferrer E, de Torres I, Lloveras B, Hernandez-Losa J, Mojal S, Salvador C, Morote J, Ramon y Cajal S, Pujol RM, Garcia-Patos V, Toll A
J Am Acad Dermatol 2013 Jan;68(1):73-82. Epub 2012 Aug 3 doi: 10.1016/j.jaad.2012.05.029. PMID: 22863066
Histologic classification of penile intraepithelial neoplasia.
Velazquez EF, Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):96-102. doi: 10.1053/j.semdp.2011.08.009. PMID: 22641959
Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients.
Chaux A, Velazquez EF, Amin A, Soskin A, Pfannl R, Rodríguez IM, Barreto JE, Lezcano C, Ayala G, Netto GJ, Cubilla AL
Hum Pathol 2012 Jul;43(7):1020-7. Epub 2011 Dec 12 doi: 10.1016/j.humpath.2011.07.025. PMID: 22169255
Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Mar;34(3):385-92. doi: 10.1097/PAS.0b013e3181cdad23. PMID: 20139761

Diagnosis

Penile Analogue of Stratified Mucin-Producing Intraepithelial Lesion of the Cervix: The First Described Case. A Diagnostic Pitfall.
Michal M, Michal M, Miesbauerova M, Hercogova J, Skopalikova B, Kazakov DV
Am J Dermatopathol 2016 May;38(5):e64-7. doi: 10.1097/DAD.0000000000000462. PMID: 27097242
Histologic and immunohistochemical assessment of penile carcinomas in a North American population.
Mentrikoski MJ, Stelow EB, Culp S, Frierson HF Jr, Cathro HP
Am J Surg Pathol 2014 Oct;38(10):1340-8. doi: 10.1097/PAS.0000000000000124. PMID: 25210933
Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Mar;34(3):385-92. doi: 10.1097/PAS.0b013e3181cdad23. PMID: 20139761

Prognosis

Penile Analogue of Stratified Mucin-Producing Intraepithelial Lesion of the Cervix: The First Described Case. A Diagnostic Pitfall.
Michal M, Michal M, Miesbauerova M, Hercogova J, Skopalikova B, Kazakov DV
Am J Dermatopathol 2016 May;38(5):e64-7. doi: 10.1097/DAD.0000000000000462. PMID: 27097242
Clinicopathological features of carcinoma of the distal penile urethra.
Corbishley CM, Rajab RM, Watkin NA
Semin Diagn Pathol 2015 May;32(3):238-44. Epub 2014 Dec 25 doi: 10.1053/j.semdp.2014.12.015. PMID: 25656527
Histologic and immunohistochemical assessment of penile carcinomas in a North American population.
Mentrikoski MJ, Stelow EB, Culp S, Frierson HF Jr, Cathro HP
Am J Surg Pathol 2014 Oct;38(10):1340-8. doi: 10.1097/PAS.0000000000000124. PMID: 25210933
Identification and genotyping of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: correlation with pathologic subtypes, p16(INK4a) expression, and prognosis.
Ferrándiz-Pulido C, Masferrer E, de Torres I, Lloveras B, Hernandez-Losa J, Mojal S, Salvador C, Morote J, Ramon y Cajal S, Pujol RM, Garcia-Patos V, Toll A
J Am Acad Dermatol 2013 Jan;68(1):73-82. Epub 2012 Aug 3 doi: 10.1016/j.jaad.2012.05.029. PMID: 22863066
Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Mar;34(3):385-92. doi: 10.1097/PAS.0b013e3181cdad23. PMID: 20139761

Clinical prediction guides

Penile Analogue of Stratified Mucin-Producing Intraepithelial Lesion of the Cervix: The First Described Case. A Diagnostic Pitfall.
Michal M, Michal M, Miesbauerova M, Hercogova J, Skopalikova B, Kazakov DV
Am J Dermatopathol 2016 May;38(5):e64-7. doi: 10.1097/DAD.0000000000000462. PMID: 27097242
Histologic and immunohistochemical assessment of penile carcinomas in a North American population.
Mentrikoski MJ, Stelow EB, Culp S, Frierson HF Jr, Cathro HP
Am J Surg Pathol 2014 Oct;38(10):1340-8. doi: 10.1097/PAS.0000000000000124. PMID: 25210933
Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Mar;34(3):385-92. doi: 10.1097/PAS.0b013e3181cdad23. PMID: 20139761
Analysis of alterations adjacent to invasive squamous cell carcinoma of the penis and their relationship with associated carcinoma.
Renaud-Vilmer C, Cavelier-Balloy B, Verola O, Morel P, Servant JM, Desgrandchamps F, Dubertret L
J Am Acad Dermatol 2010 Feb;62(2):284-90. doi: 10.1016/j.jaad.2009.06.087. PMID: 20115951

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