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Increased blood folate concentration

MedGen UID:
1704255
Concept ID:
C5139164
Finding
HPO: HP:0032164

Definition

An elevated circulating concentration of folic acid, which is also known as vitamin B9. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased blood folate concentration

Professional guidelines

PubMed

Frank J, Kisters K, Stirban OA, Obeid R, Lorkowski S, Wallert M, Egert S, Podszun MC, Eckert GP, Pettersen JA, Venturelli S, Classen HG, Golombek J
Biofactors 2021 Jul;47(4):522-550. Epub 2021 Mar 26 doi: 10.1002/biof.1728. PMID: 33772908
Rainero I, Vacca A, Roveta F, Govone F, Gai A, Rubino E
Expert Opin Ther Targets 2019 Jan;23(1):29-37. Epub 2018 Nov 28 doi: 10.1080/14728222.2019.1549544. PMID: 30451038
Reilly R, McNulty H, Pentieva K, Strain JJ, Ward M
Proc Nutr Soc 2014 Feb;73(1):47-56. Epub 2013 Oct 17 doi: 10.1017/S0029665113003613. PMID: 24131523

Recent clinical studies

Etiology

Xu J, Zhu X, Guan G, Zhang Y, Hui R, Xing Y, Wang J, Zhu L
Hypertens Res 2023 Jun;46(6):1504-1515. Epub 2023 Mar 10 doi: 10.1038/s41440-023-01249-3. PMID: 36899181
Liao WZ, Zhou ZY, Mao JH, Wang ZX, Hu YM, Lou YF, Zheng QR, Guo XG
BMC Infect Dis 2023 Jan 23;23(1):48. doi: 10.1186/s12879-022-07950-x. PMID: 36690944Free PMC Article
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B
Cells 2021 Aug 3;10(8) doi: 10.3390/cells10081976. PMID: 34440744Free PMC Article
Pietrzik K, Bailey L, Shane B
Clin Pharmacokinet 2010 Aug;49(8):535-48. doi: 10.2165/11532990-000000000-00000. PMID: 20608755
Bailey LB
J Nutr 1990 Nov;120 Suppl 11:1508-11. doi: 10.1093/jn/120.suppl_11.1508. PMID: 2243297

Diagnosis

Zhang Y, Mustieles V, Wang YX, Sun Y, Agudelo J, Bibi Z, Torres N, Oulhote Y, Slitt A, Messerlian C
Lancet Planet Health 2023 Jun;7(6):e449-e458. doi: 10.1016/S2542-5196(23)00088-8. PMID: 37286242Free PMC Article
Liao WZ, Zhou ZY, Mao JH, Wang ZX, Hu YM, Lou YF, Zheng QR, Guo XG
BMC Infect Dis 2023 Jan 23;23(1):48. doi: 10.1186/s12879-022-07950-x. PMID: 36690944Free PMC Article
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B
Cells 2021 Aug 3;10(8) doi: 10.3390/cells10081976. PMID: 34440744Free PMC Article
Lamarca A, Palmer DH, Wasan HS, Ross PJ, Ma YT, Arora A, Falk S, Gillmore R, Wadsley J, Patel K, Anthoney A, Maraveyas A, Iveson T, Waters JS, Hobbs C, Barber S, Ryder WD, Ramage J, Davies LM, Bridgewater JA, Valle JW; Advanced Biliary Cancer Working Group
Lancet Oncol 2021 May;22(5):690-701. Epub 2021 Mar 30 doi: 10.1016/S1470-2045(21)00027-9. PMID: 33798493Free PMC Article
Kruse JA
Intensive Care Med 1992;18(7):391-7. doi: 10.1007/BF01694340. PMID: 1469176

Therapy

Ferraro S, Biganzoli G, Gringeri M, Radice S, Rizzuto AS, Carnovale C, Biganzoli EM, Clementi E
Clin Nutr 2022 Feb;41(2):374-383. Epub 2021 Dec 10 doi: 10.1016/j.clnu.2021.12.012. PMID: 34999332
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B
Cells 2021 Aug 3;10(8) doi: 10.3390/cells10081976. PMID: 34440744Free PMC Article
Hoek J, Steegers-Theunissen RPM, Willemsen SP, Schoenmakers S
Mol Nutr Food Res 2020 May;64(9):e1900696. Epub 2020 Feb 20 doi: 10.1002/mnfr.201900696. PMID: 32032459Free PMC Article
Pietrzik K, Bailey L, Shane B
Clin Pharmacokinet 2010 Aug;49(8):535-48. doi: 10.2165/11532990-000000000-00000. PMID: 20608755
Bailey LB
J Nutr 1990 Nov;120 Suppl 11:1508-11. doi: 10.1093/jn/120.suppl_11.1508. PMID: 2243297

Prognosis

Lamarca A, Palmer DH, Wasan HS, Ross PJ, Ma YT, Arora A, Falk S, Gillmore R, Wadsley J, Patel K, Anthoney A, Maraveyas A, Iveson T, Waters JS, Hobbs C, Barber S, Ryder WD, Ramage J, Davies LM, Bridgewater JA, Valle JW; Advanced Biliary Cancer Working Group
Lancet Oncol 2021 May;22(5):690-701. Epub 2021 Mar 30 doi: 10.1016/S1470-2045(21)00027-9. PMID: 33798493Free PMC Article
Del Bo' C, Riso P, Gardana C, Brusamolino A, Battezzati A, Ciappellano S
Clin Nutr 2019 Apr;38(2):575-583. Epub 2018 Feb 15 doi: 10.1016/j.clnu.2018.02.008. PMID: 29499976
Hankey GJ
Stroke Vasc Neurol 2018 Jun;3(2):51-58. Epub 2018 Jun 6 doi: 10.1136/svn-2018-000156. PMID: 30022794Free PMC Article
Howard SC, McCormick J, Pui CH, Buddington RK, Harvey RD
Oncologist 2016 Dec;21(12):1471-1482. Epub 2016 Aug 5 doi: 10.1634/theoncologist.2015-0164. PMID: 27496039Free PMC Article
Kruse JA
Intensive Care Med 1992;18(7):391-7. doi: 10.1007/BF01694340. PMID: 1469176

Clinical prediction guides

Xu R, Liu S, Zhong Z, Guo Y, Xia T, Chen Y, Ding L
Nutrients 2023 Jun 16;15(12) doi: 10.3390/nu15122766. PMID: 37375669Free PMC Article
Liao WZ, Zhou ZY, Mao JH, Wang ZX, Hu YM, Lou YF, Zheng QR, Guo XG
BMC Infect Dis 2023 Jan 23;23(1):48. doi: 10.1186/s12879-022-07950-x. PMID: 36690944Free PMC Article
Tian Y, Luan M, Zhang J, Yang H, Wang Y, Chen H
Chemosphere 2022 Nov;307(Pt 3):135995. Epub 2022 Aug 15 doi: 10.1016/j.chemosphere.2022.135995. PMID: 35981617
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B
Cells 2021 Aug 3;10(8) doi: 10.3390/cells10081976. PMID: 34440744Free PMC Article
Collin SM
Adv Clin Chem 2013;60:1-63. doi: 10.1016/b978-0-12-407681-5.00001-5. PMID: 23724740

Recent systematic reviews

Xu R, Liu S, Zhong Z, Guo Y, Xia T, Chen Y, Ding L
Nutrients 2023 Jun 16;15(12) doi: 10.3390/nu15122766. PMID: 37375669Free PMC Article
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B
Cells 2021 Aug 3;10(8) doi: 10.3390/cells10081976. PMID: 34440744Free PMC Article
Hoek J, Steegers-Theunissen RPM, Willemsen SP, Schoenmakers S
Mol Nutr Food Res 2020 May;64(9):e1900696. Epub 2020 Feb 20 doi: 10.1002/mnfr.201900696. PMID: 32032459Free PMC Article
Low MS, Speedy J, Styles CE, De-Regil LM, Pasricha SR
Cochrane Database Syst Rev 2016 Apr 18;4(4):CD009747. doi: 10.1002/14651858.CD009747.pub2. PMID: 27087396Free PMC Article

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