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Advanced Esophageal Carcinoma

MedGen UID:
1705531
•Concept ID:
C5205387
•
Neoplastic Process

Definition

Esophageal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline.
Shah MA, Kennedy EB, Catenacci DV, Deighton DC, Goodman KA, Malhotra NK, Willett C, Stiles B, Sharma P, Tang L, Wijnhoven BPL, Hofstetter WL
J Clin Oncol 2020 Aug 10;38(23):2677-2694. Epub 2020 Jun 22 doi: 10.1200/JCO.20.00866. PMID: 32568633
Neoadjuvant Treatment for Locally Invasive Esophageal Cancer.
Iams WT, Villaflor VM
World J Surg 2017 Jul;41(7):1719-1725. doi: 10.1007/s00268-017-3959-x. PMID: 28271259
Preoperative treatment of locally advanced esophageal carcinoma (Review).
Orditura M, Galizia G, Fabozzi A, Lieto E, Gambardella V, Morgillo F, Del Genio GM, Fei L, Di Martino N, Renda A, Ciardiello F, De Vita F
Int J Oncol 2013 Dec;43(6):1745-53. Epub 2013 Oct 2 doi: 10.3892/ijo.2013.2118. PMID: 24100679

Recent clinical studies

Etiology

Safety and Antitumor Activity of the Anti-Programmed Death-1 Antibody Pembrolizumab in Patients With Advanced Esophageal Carcinoma.
Doi T, Piha-Paul SA, Jalal SI, Saraf S, Lunceford J, Koshiji M, Bennouna J
J Clin Oncol 2018 Jan 1;36(1):61-67. Epub 2017 Nov 8 doi: 10.1200/JCO.2017.74.9846. PMID: 29116900
Treatment utilization and outcomes in elderly patients with locally advanced esophageal carcinoma: a review of the National Cancer Database.
Vlacich G, Samson PP, Perkins SM, Roach MC, Parikh PJ, Bradley JD, Lockhart AC, Puri V, Meyers BF, Kozower B, Robinson CG
Cancer Med 2017 Dec;6(12):2886-2896. Epub 2017 Nov 15 doi: 10.1002/cam4.1250. PMID: 29139215Free PMC Article
Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma.
Wang Y, Xu G, Wang J, Li XH, Sun P, Zhang W, Li JX, Wu CY
Anticancer Res 2017 Aug;37(8):4643-4647. doi: 10.21873/anticanres.11866. PMID: 28739765
Locally advanced esophageal carcinoma: is there still a role of surgery alone without neoadjuvant treatment?
Reeh M, Nentwich MF, Asani S, Uzunoglu FG, Bockhorn M, Sauter G, Rösch T, Izbicki JR, Bogoevski D
J Gastrointest Surg 2015 Apr;19(4):587-93. Epub 2015 Feb 5 doi: 10.1007/s11605-015-2762-y. PMID: 25652343
Advanced esophageal carcinoma.
Lerut TE, de Leyn P, Coosemans W, Van Raemdonck D, Cuypers P, Van Cleynenbreughel B
World J Surg 1994 May-Jun;18(3):379-87. doi: 10.1007/BF00316818. PMID: 8091779

Diagnosis

Xiaoaiping injection as adjunct therapy for patients with advanced esophageal carcinoma: A protocol for a systematic review and meta-analysis.
Liu Z, Dong Y, Zhu M, Mu Y, Chen L
Medicine (Baltimore) 2020 Jun 26;99(26):e20984. doi: 10.1097/MD.0000000000020984. PMID: 32590810Free PMC Article
Treatment utilization and outcomes in elderly patients with locally advanced esophageal carcinoma: a review of the National Cancer Database.
Vlacich G, Samson PP, Perkins SM, Roach MC, Parikh PJ, Bradley JD, Lockhart AC, Puri V, Meyers BF, Kozower B, Robinson CG
Cancer Med 2017 Dec;6(12):2886-2896. Epub 2017 Nov 15 doi: 10.1002/cam4.1250. PMID: 29139215Free PMC Article
Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma.
Wang Y, Xu G, Wang J, Li XH, Sun P, Zhang W, Li JX, Wu CY
Anticancer Res 2017 Aug;37(8):4643-4647. doi: 10.21873/anticanres.11866. PMID: 28739765
Neoadjuvant Treatment for Locally Invasive Esophageal Cancer.
Iams WT, Villaflor VM
World J Surg 2017 Jul;41(7):1719-1725. doi: 10.1007/s00268-017-3959-x. PMID: 28271259
Early esophageal cancer.
Levine MS, Dillon EC, Saul SH, Laufer I
AJR Am J Roentgenol 1986 Mar;146(3):507-12. doi: 10.2214/ajr.146.3.507. PMID: 3484867

Therapy

Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline.
Shah MA, Kennedy EB, Catenacci DV, Deighton DC, Goodman KA, Malhotra NK, Willett C, Stiles B, Sharma P, Tang L, Wijnhoven BPL, Hofstetter WL
J Clin Oncol 2020 Aug 10;38(23):2677-2694. Epub 2020 Jun 22 doi: 10.1200/JCO.20.00866. PMID: 32568633
Immune Checkpoint Inhibitors in Esophageal Cancers: are we Finally Finding the Right Path in the Mist?
Vivaldi C, Catanese S, Massa V, Pecora I, Salani F, Santi S, Lencioni M, Vasile E, Falcone A, Fornaro L
Int J Mol Sci 2020 Feb 28;21(5) doi: 10.3390/ijms21051658. PMID: 32121290Free PMC Article
Safety and Antitumor Activity of the Anti-Programmed Death-1 Antibody Pembrolizumab in Patients With Advanced Esophageal Carcinoma.
Doi T, Piha-Paul SA, Jalal SI, Saraf S, Lunceford J, Koshiji M, Bennouna J
J Clin Oncol 2018 Jan 1;36(1):61-67. Epub 2017 Nov 8 doi: 10.1200/JCO.2017.74.9846. PMID: 29116900
Neoadjuvant Treatment for Locally Invasive Esophageal Cancer.
Iams WT, Villaflor VM
World J Surg 2017 Jul;41(7):1719-1725. doi: 10.1007/s00268-017-3959-x. PMID: 28271259
Docetaxel, nedaplatin, and S-1 (DGS) chemotherapy for advanced esophageal carcinoma: a phase I dose-escalation study.
Tanaka Y, Yoshida K, Osada S, Yamaguchi K, Takahashi T
Anticancer Res 2011 Dec;31(12):4589-97. PMID: 22199335

Prognosis

Immune Checkpoint Inhibitors in Esophageal Cancers: are we Finally Finding the Right Path in the Mist?
Vivaldi C, Catanese S, Massa V, Pecora I, Salani F, Santi S, Lencioni M, Vasile E, Falcone A, Fornaro L
Int J Mol Sci 2020 Feb 28;21(5) doi: 10.3390/ijms21051658. PMID: 32121290Free PMC Article
Neoadjuvant Treatment for Locally Invasive Esophageal Cancer.
Iams WT, Villaflor VM
World J Surg 2017 Jul;41(7):1719-1725. doi: 10.1007/s00268-017-3959-x. PMID: 28271259
Preoperative treatment of locally advanced esophageal carcinoma (Review).
Orditura M, Galizia G, Fabozzi A, Lieto E, Gambardella V, Morgillo F, Del Genio GM, Fei L, Di Martino N, Renda A, Ciardiello F, De Vita F
Int J Oncol 2013 Dec;43(6):1745-53. Epub 2013 Oct 2 doi: 10.3892/ijo.2013.2118. PMID: 24100679
Advanced esophageal carcinoma.
Lerut TE, de Leyn P, Coosemans W, Van Raemdonck D, Cuypers P, Van Cleynenbreughel B
World J Surg 1994 May-Jun;18(3):379-87. doi: 10.1007/BF00316818. PMID: 8091779
Early esophageal cancer.
Levine MS, Dillon EC, Saul SH, Laufer I
AJR Am J Roentgenol 1986 Mar;146(3):507-12. doi: 10.2214/ajr.146.3.507. PMID: 3484867

Clinical prediction guides

Immune Checkpoint Inhibitors in Esophageal Cancers: are we Finally Finding the Right Path in the Mist?
Vivaldi C, Catanese S, Massa V, Pecora I, Salani F, Santi S, Lencioni M, Vasile E, Falcone A, Fornaro L
Int J Mol Sci 2020 Feb 28;21(5) doi: 10.3390/ijms21051658. PMID: 32121290Free PMC Article
Safety and Antitumor Activity of the Anti-Programmed Death-1 Antibody Pembrolizumab in Patients With Advanced Esophageal Carcinoma.
Doi T, Piha-Paul SA, Jalal SI, Saraf S, Lunceford J, Koshiji M, Bennouna J
J Clin Oncol 2018 Jan 1;36(1):61-67. Epub 2017 Nov 8 doi: 10.1200/JCO.2017.74.9846. PMID: 29116900
Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma.
Wang Y, Xu G, Wang J, Li XH, Sun P, Zhang W, Li JX, Wu CY
Anticancer Res 2017 Aug;37(8):4643-4647. doi: 10.21873/anticanres.11866. PMID: 28739765
Preoperative treatment of locally advanced esophageal carcinoma (Review).
Orditura M, Galizia G, Fabozzi A, Lieto E, Gambardella V, Morgillo F, Del Genio GM, Fei L, Di Martino N, Renda A, Ciardiello F, De Vita F
Int J Oncol 2013 Dec;43(6):1745-53. Epub 2013 Oct 2 doi: 10.3892/ijo.2013.2118. PMID: 24100679
Prediction of major postoperative complications and survival for locally advanced esophageal carcinoma patients.
Sunpaweravong S, Ruangsin S, Laohawiriyakamol S, Mahattanobon S, Geater A
Asian J Surg 2012 Jul;35(3):104-9. Epub 2012 Jun 6 doi: 10.1016/j.asjsur.2012.04.029. PMID: 22884266

Recent systematic reviews

Liver Injury in Patients With Distal Esophageal Carcinoma After Precision Radiation Therapy: Systematic Review of FDG-PET/CT Patterns.
Betancourt Cuellar SL, Benveniste MF, Truong M, Nguyen QN, Atiyah A, Hofstetter WL, Erasmus JJ
Am J Clin Oncol 2023 Jan 1;46(1):25-30. Epub 2022 Nov 16 doi: 10.1097/COC.0000000000000960. PMID: 36562692
The impact of radiation dose on the efficacy of definitive chemoradiotherapy in patients with locally advanced esophageal carcinoma: a systematic review and meta-analysis.
Luo D, Zhong Q, Zhu X
Cancer Biol Ther 2023 Dec 31;24(1):1-10. doi: 10.1080/15384047.2022.2156246. PMID: 36519807Free PMC Article
Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline.
Shah MA, Kennedy EB, Catenacci DV, Deighton DC, Goodman KA, Malhotra NK, Willett C, Stiles B, Sharma P, Tang L, Wijnhoven BPL, Hofstetter WL
J Clin Oncol 2020 Aug 10;38(23):2677-2694. Epub 2020 Jun 22 doi: 10.1200/JCO.20.00866. PMID: 32568633
Clinical complete response after chemoradiotherapy for carcinoma of thoracic esophagus: Is esophagectomy always necessary? A systematic review and meta-analysis.
Wang J, Qin J, Jing S, Liu Q, Cheng Y, Wang Y, Cao F
Thorac Cancer 2018 Dec;9(12):1638-1647. Epub 2018 Oct 1 doi: 10.1111/1759-7714.12874. PMID: 30277016Free PMC Article

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