U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Disseminated cutaneous warts

MedGen UID:
1708110
Concept ID:
C5139200
Neoplastic Process
HPO: HP:0032215

Definition

Multiple skin warts located in multiple parts of the body, e.g., neck, trunks, and extremities. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisseminated cutaneous warts

Conditions with this feature

Epidermodysplasia verruciformis, susceptibility to, 4
MedGen UID:
1648396
Concept ID:
C4749042
Finding
Epidermodysplasia verruciformis-4 is an autosomal recessive immunologic disorder characterized by increased susceptibility to certain human papilloma viruses (HPV) that cause warts and skin lesions. Affected individuals present in childhood with disseminated flat warts and psoriatic-like lesions that do not respond to treatment. Immunologic workup shows defects in T-cell development and signaling (summary by Crequer et al., 2012). For a discussion of genetic heterogeneity of susceptibility to epidermodysplasia verruciformis, see EV1 (226400).
Immunodeficiency 79
MedGen UID:
1783683
Concept ID:
C5543220
Disease or Syndrome
Immunodeficiency-79 (IMD79) is an autosomal recessive disorder characterized by childhood onset of recurrent and recalcitrant skin warts due to uncontrolled viral infection with human papillomavirus (HPV). Some patients may also have recurrent respiratory infections beginning in childhood, but the phenotype overall is mild compared to other primary immunodeficiencies. Patients may not come to attention until adulthood. Laboratory studies show absence of the CD4 antigen on T cells, monocytes, and dendritic cells, with variable secondary abnormalities in B cells and NK cells due to lack of CD4+ T cells (summary by Lisco et al., 2021).

Professional guidelines

Recent clinical studies

Etiology

Nunes EM, Talpe-Nunes V, Sichero L
Clinics (Sao Paulo) 2018 Aug 20;73(suppl 1):e489s. doi: 10.6061/clinics/2018/e489s. PMID: 30133564Free PMC Article
Diadie S, Diatta BA, Ndiaye M, Seck NB, Diallo S, Niang SO, Dieng MT
Med Sante Trop 2018 Feb 1;28(1):106-108. doi: 10.1684/mst.2017.0722. PMID: 29226827
Badavanis G, Pasmatzi E, Monastirli A, Georgiou S, Tsambaos D
Acta Dermatovenerol Croat 2017 Jul;25(2):164-166. PMID: 28871935
Piaserico S, Sandini E, Peserico A, Alaibac M
G Ital Dermatol Venereol 2014 Aug;149(4):409-15. PMID: 25068228
Kreuter A, Hochdorfer B, Brockmeyer NH, Altmeyer P, Pfister H, Wieland U; Competence Network HIV/AIDS
Arch Dermatol 2008 Mar;144(3):366-72. doi: 10.1001/archderm.144.3.366. PMID: 18347293

Diagnosis

Chandler DJ, Walker SL
Clin Dermatol 2024 Mar-Apr;42(2):155-168. Epub 2023 Dec 22 doi: 10.1016/j.clindermatol.2023.12.005. PMID: 38142787
Oliveira VF, Funari AP, Taborda M, Magri ASGK, Levin AS, Magri MMC
Rev Inst Med Trop Sao Paulo 2023;65:e60. Epub 2023 Dec 4 doi: 10.1590/S1678-9946202365060. PMID: 38055378Free PMC Article
Béziat V
Hum Genet 2020 Jun;139(6-7):919-939. Epub 2020 May 20 doi: 10.1007/s00439-020-02183-x. PMID: 32435828Free PMC Article
Diadie S, Diatta BA, Ndiaye M, Seck NB, Diallo S, Niang SO, Dieng MT
Med Sante Trop 2018 Feb 1;28(1):106-108. doi: 10.1684/mst.2017.0722. PMID: 29226827
Kreuter A, Hochdorfer B, Brockmeyer NH, Altmeyer P, Pfister H, Wieland U; Competence Network HIV/AIDS
Arch Dermatol 2008 Mar;144(3):366-72. doi: 10.1001/archderm.144.3.366. PMID: 18347293

Therapy

Oliveira VF, Funari AP, Taborda M, Magri ASGK, Levin AS, Magri MMC
Rev Inst Med Trop Sao Paulo 2023;65:e60. Epub 2023 Dec 4 doi: 10.1590/S1678-9946202365060. PMID: 38055378Free PMC Article
de Jong SJ, Créquer A, Matos I, Hum D, Gunasekharan V, Lorenzo L, Jabot-Hanin F, Imahorn E, Arias AA, Vahidnezhad H, Youssefian L, Markle JG, Patin E, D'Amico A, Wang CQF, Full F, Ensser A, Leisner TM, Parise LV, Bouaziz M, Maya NP, Cadena XR, Saka B, Saeidian AH, Aghazadeh N, Zeinali S, Itin P, Krueger JG, Laimins L, Abel L, Fuchs E, Uitto J, Franco JL, Burger B, Orth G, Jouanguy E, Casanova JL
J Exp Med 2018 Sep 3;215(9):2289-2310. Epub 2018 Aug 1 doi: 10.1084/jem.20170308. PMID: 30068544Free PMC Article
Badavanis G, Pasmatzi E, Monastirli A, Georgiou S, Tsambaos D
Acta Dermatovenerol Croat 2017 Jul;25(2):164-166. PMID: 28871935
Piaserico S, Sandini E, Peserico A, Alaibac M
G Ital Dermatol Venereol 2014 Aug;149(4):409-15. PMID: 25068228
Aghaei S
Dermatol Online J 2006 Feb 28;12(2):10. PMID: 16638403

Prognosis

Chandler DJ, Walker SL
Clin Dermatol 2024 Mar-Apr;42(2):155-168. Epub 2023 Dec 22 doi: 10.1016/j.clindermatol.2023.12.005. PMID: 38142787
Béziat V
Hum Genet 2020 Jun;139(6-7):919-939. Epub 2020 May 20 doi: 10.1007/s00439-020-02183-x. PMID: 32435828Free PMC Article
Badavanis G, Pasmatzi E, Monastirli A, Georgiou S, Tsambaos D
Acta Dermatovenerol Croat 2017 Jul;25(2):164-166. PMID: 28871935
Piaserico S, Sandini E, Peserico A, Alaibac M
G Ital Dermatol Venereol 2014 Aug;149(4):409-15. PMID: 25068228

Clinical prediction guides

Filipović N, Tomas D, Buljan M
Acta Dermatovenerol Croat 2023 Nov;31(2):112-114. PMID: 38006375
Diadie S, Diatta BA, Ndiaye M, Seck NB, Diallo S, Niang SO, Dieng MT
Med Sante Trop 2018 Feb 1;28(1):106-108. doi: 10.1684/mst.2017.0722. PMID: 29226827
Badavanis G, Pasmatzi E, Monastirli A, Georgiou S, Tsambaos D
Acta Dermatovenerol Croat 2017 Jul;25(2):164-166. PMID: 28871935
Piaserico S, Sandini E, Peserico A, Alaibac M
G Ital Dermatol Venereol 2014 Aug;149(4):409-15. PMID: 25068228
Kreuter A, Hochdorfer B, Brockmeyer NH, Altmeyer P, Pfister H, Wieland U; Competence Network HIV/AIDS
Arch Dermatol 2008 Mar;144(3):366-72. doi: 10.1001/archderm.144.3.366. PMID: 18347293

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...