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Nasal Cavity Exophytic Papilloma

MedGen UID:
1708509
•Concept ID:
C5239392
•
Neoplastic Process
Synonym: Nasal Cavity Exophytic Schneiderian Papilloma

Definition

A benign nasal cavity exophytic papillary neoplasm with fibrovascular cores lined by epithelial cells. It arises from the lower anterior nasal septum. Clinical manifestations include nasal obstruction, epistaxis, and the presence of a mass. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasal Cavity Exophytic Papilloma

Recent clinical studies

Etiology

Evaluation of the incidence of inflammatory and tumor pathology of nose and nasal sinus region.
Nassrallah S, Neagoş CM, Mocan SL, Neagoş A
Rom J Morphol Embryol 2020 Oct-Dec;61(4):1295-1300. doi: 10.47162/RJME.61.4.30. PMID: 34171077Free PMC Article
Human Papilloma Virus (HPV) in Sinonasal Papillomas and Squamous Cell Carcinomas: A PCR-based Study of 60 cases.
Beigh A, Rashi R, Junaid S, Khuroo MS, Farook S
Gulf J Oncolog 2018 Jan;1(26):37-42. PMID: 29607821
Exophytic sinonasal papillomas and nasal florid papillomatosis: A retrospective study.
Glâtre R, De Kermadec H, Alsamad IA, Badoual C, Gauthier A, Brugel L, Parra C, Coste A, Prulière-Escabasse V, Bequignon E
Head Neck 2018 Apr;40(4):740-746. Epub 2018 Jan 17 doi: 10.1002/hed.25042. PMID: 29341451
Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review.
Re M, Gioacchini FM, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, Bertini A, Magliulo G, Pasquini E
Eur Arch Otorhinolaryngol 2017 Aug;274(8):2991-3000. Epub 2017 Apr 21 doi: 10.1007/s00405-017-4571-2. PMID: 28432463
Inflammation and the pathogenesis of inverted papilloma.
Roh HJ, Procop GW, Batra PS, Citardi MJ, Lanza DC
Am J Rhinol 2004 Mar-Apr;18(2):65-74. PMID: 15152870

Diagnosis

Low-grade papillary Schneiderian carcinoma with TP53 mutation: a case report and review of the literature.
Yuzawa S, Michizuka T, Kakisaka R, Ono Y, Hayashi M, Takahara M, Katada A, Mizukami Y, Tanino M
Diagn Pathol 2023 Apr 11;18(1):44. doi: 10.1186/s13000-023-01334-8. PMID: 37041626Free PMC Article
Evaluation of the incidence of inflammatory and tumor pathology of nose and nasal sinus region.
Nassrallah S, Neagoş CM, Mocan SL, Neagoş A
Rom J Morphol Embryol 2020 Oct-Dec;61(4):1295-1300. doi: 10.47162/RJME.61.4.30. PMID: 34171077Free PMC Article
Malignant transformation of exophytic Schneiderian papilloma of the nasal cavity.
Terada T
Pathol Int 2012 Mar;62(3):199-203. Epub 2012 Feb 14 doi: 10.1111/j.1440-1827.2012.02795.x. PMID: 22360508
Sialadenoma papilliferum of nasal cavity: case report.
Ozel HE, Ergul G, Gur OE, Kulacoglu S, Ozdem C
J Laryngol Otol 2008 Sep;122(9):e21. Epub 2008 Jul 29 doi: 10.1017/S0022215108003253. PMID: 18662434
Inflammation and the pathogenesis of inverted papilloma.
Roh HJ, Procop GW, Batra PS, Citardi MJ, Lanza DC
Am J Rhinol 2004 Mar-Apr;18(2):65-74. PMID: 15152870

Therapy

Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma.
Chatelet F, Vinciguerra A, Marc M, Herman P, Verillaud B
Int Forum Allergy Rhinol 2024 Nov;14(11):1834-1837. Epub 2024 Jun 27 doi: 10.1002/alr.23399. PMID: 38934682

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Evaluation of the incidence of inflammatory and tumor pathology of nose and nasal sinus region.
Nassrallah S, Neagoş CM, Mocan SL, Neagoş A
Rom J Morphol Embryol 2020 Oct-Dec;61(4):1295-1300. doi: 10.47162/RJME.61.4.30. PMID: 34171077Free PMC Article
Human Papilloma Virus (HPV) in Sinonasal Papillomas and Squamous Cell Carcinomas: A PCR-based Study of 60 cases.
Beigh A, Rashi R, Junaid S, Khuroo MS, Farook S
Gulf J Oncolog 2018 Jan;1(26):37-42. PMID: 29607821
Exophytic sinonasal papillomas and nasal florid papillomatosis: A retrospective study.
Glâtre R, De Kermadec H, Alsamad IA, Badoual C, Gauthier A, Brugel L, Parra C, Coste A, Prulière-Escabasse V, Bequignon E
Head Neck 2018 Apr;40(4):740-746. Epub 2018 Jan 17 doi: 10.1002/hed.25042. PMID: 29341451
Inflammation and the pathogenesis of inverted papilloma.
Roh HJ, Procop GW, Batra PS, Citardi MJ, Lanza DC
Am J Rhinol 2004 Mar-Apr;18(2):65-74. PMID: 15152870

Clinical prediction guides

Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma.
Chatelet F, Vinciguerra A, Marc M, Herman P, Verillaud B
Int Forum Allergy Rhinol 2024 Nov;14(11):1834-1837. Epub 2024 Jun 27 doi: 10.1002/alr.23399. PMID: 38934682
Human Papilloma Virus (HPV) in Sinonasal Papillomas and Squamous Cell Carcinomas: A PCR-based Study of 60 cases.
Beigh A, Rashi R, Junaid S, Khuroo MS, Farook S
Gulf J Oncolog 2018 Jan;1(26):37-42. PMID: 29607821
Inflammation and the pathogenesis of inverted papilloma.
Roh HJ, Procop GW, Batra PS, Citardi MJ, Lanza DC
Am J Rhinol 2004 Mar-Apr;18(2):65-74. PMID: 15152870

Recent systematic reviews

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review.
Re M, Gioacchini FM, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, Bertini A, Magliulo G, Pasquini E
Eur Arch Otorhinolaryngol 2017 Aug;274(8):2991-3000. Epub 2017 Apr 21 doi: 10.1007/s00405-017-4571-2. PMID: 28432463

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