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Gastrointestinal Tract Acute Graft Versus Host Disease

MedGen UID:
1709313
•Concept ID:
C5238928
•
Disease or Syndrome

Definition

Acute graft versus host disease occurring in the gastrointestinal tract. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastrointestinal Tract Acute Graft Versus Host Disease

Professional guidelines

PubMed

Oral beclomethasone dipropionate as an initial treatment for stages 1-2 gastrointestinal tract acute graft-versus-host disease following unrelated cord blood transplantation.
Yamamoto H, Uchida N, Uchida Y, Nishida A, Ota H, Kageyama K, Nasu I, Wada S, Kaji D, Ishiwata K, Takagi S, Tsuji M, Asano-Mori Y, Matsuno N, Yamamoto G, Masuoka K, Izutsu K, Wake A, Yoneyama A, Makino S, Ito T, Hayashi M, Taniguchi S
Ann Hematol 2015 Dec;94(12):2073-5. Epub 2015 Sep 16 doi: 10.1007/s00277-015-2483-z. PMID: 26374433

Recent clinical studies

Therapy

Acute graft-versus-host disease.
Malard F, Holler E, Sandmaier BM, Huang H, Mohty M
Nat Rev Dis Primers 2023 Jun 8;9(1):27. doi: 10.1038/s41572-023-00438-1. PMID: 37291149
Allogeneic hematopoietic cell transplantation, the microbiome, and graft-versus-host disease.
van Lier YF, Vos J, Blom B, Hazenberg MD
Gut Microbes 2023 Jan-Dec;15(1):2178805. doi: 10.1080/19490976.2023.2178805. PMID: 36794370Free PMC Article
Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.
Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte RF, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socié G, Solano C, Vrhovac R, Zeiser R, Kröger N, Basak GW
Lancet Haematol 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485
Acute graft-versus-host disease of the gut: considerations for the gastroenterologist.
Naymagon S, Naymagon L, Wong SY, Ko HM, Renteria A, Levine J, Colombel JF, Ferrara J
Nat Rev Gastroenterol Hepatol 2017 Dec;14(12):711-726. Epub 2017 Sep 27 doi: 10.1038/nrgastro.2017.126. PMID: 28951581Free PMC Article
Graft-versus-host disease.
Ferrara JL, Levine JE, Reddy P, Holler E
Lancet 2009 May 2;373(9674):1550-61. Epub 2009 Mar 11 doi: 10.1016/S0140-6736(09)60237-3. PMID: 19282026Free PMC Article

Prognosis

New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD).
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial.
Jagasia M, Perales MA, Schroeder MA, Ali H, Shah NN, Chen YB, Fazal S, Dawkins FW, Arbushites MC, Tian C, Connelly-Smith L, Howell MD, Khoury HJ
Blood 2020 May 14;135(20):1739-1749. doi: 10.1182/blood.2020004823. PMID: 32160294Free PMC Article
GVHD: biology matters.
Ferrara JLM, Chaudhry MS
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):221-227. doi: 10.1182/asheducation-2018.1.221. PMID: 30504314Free PMC Article
GVHD: biology matters.
Ferrara JLM, Chaudhry MS
Blood Adv 2018 Nov 27;2(22):3411-3417. doi: 10.1182/bloodadvances.2018020214. PMID: 30482771Free PMC Article
Acute graft-versus-host disease of the gut: considerations for the gastroenterologist.
Naymagon S, Naymagon L, Wong SY, Ko HM, Renteria A, Levine J, Colombel JF, Ferrara J
Nat Rev Gastroenterol Hepatol 2017 Dec;14(12):711-726. Epub 2017 Sep 27 doi: 10.1038/nrgastro.2017.126. PMID: 28951581Free PMC Article

Clinical prediction guides

New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD).
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial.
Jagasia M, Perales MA, Schroeder MA, Ali H, Shah NN, Chen YB, Fazal S, Dawkins FW, Arbushites MC, Tian C, Connelly-Smith L, Howell MD, Khoury HJ
Blood 2020 May 14;135(20):1739-1749. doi: 10.1182/blood.2020004823. PMID: 32160294Free PMC Article
GVHD: biology matters.
Ferrara JLM, Chaudhry MS
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):221-227. doi: 10.1182/asheducation-2018.1.221. PMID: 30504314Free PMC Article
GVHD: biology matters.
Ferrara JLM, Chaudhry MS
Blood Adv 2018 Nov 27;2(22):3411-3417. doi: 10.1182/bloodadvances.2018020214. PMID: 30482771Free PMC Article
An overview of infectious complications after allogeneic hematopoietic stem cell transplantation.
Sahin U, Toprak SK, Atilla PA, Atilla E, Demirer T
J Infect Chemother 2016 Aug;22(8):505-14. Epub 2016 Jun 22 doi: 10.1016/j.jiac.2016.05.006. PMID: 27344206

Recent systematic reviews

Diagnostic and prognostic role of elafin in skin acute graft versus host disease: a systematic review.
Bhattarai A, Shah S, Yadav R, Dhakal G, Neupane R, Paudel S, Bhandari P, Abu Serhan H, Sah R, Sah S, Barboza JJ
Hematology 2024 Dec;29(1):2293497. Epub 2023 Dec 19 doi: 10.1080/16078454.2023.2293497. PMID: 38112182
Chronic graft-versus-host disease presenting as acute polymyositis: A case series and systematic review.
Shahzad M, Chaudhary SG, Basit A, Thellman C, Rodriguez L, Abhyankar SH, McGuirk JP, Mushtaq MU
Transpl Immunol 2022 Feb;70:101520. Epub 2021 Dec 22 doi: 10.1016/j.trim.2021.101520. PMID: 34952168
Extracorporeal photopheresis in steroid-refractory acute or chronic graft-versus-host disease: results of a systematic review of prospective studies.
Abu-Dalle I, Reljic T, Nishihori T, Antar A, Bazarbachi A, Djulbegovic B, Kumar A, Kharfan-Dabaja MA
Biol Blood Marrow Transplant 2014 Nov;20(11):1677-86. Epub 2014 May 24 doi: 10.1016/j.bbmt.2014.05.017. PMID: 24867779

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