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Acute graft versus host disease

MedGen UID:
208987
Concept ID:
C0856825
Disease or Syndrome
Synonym: Acute graft vs. host disease
SNOMED CT: Acute graft-versus-host disease (402355000); Acute graft versus host disease (402355000)
 
Monarch Initiative: MONDO:0020546
Orphanet: ORPHA99920

Definition

A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, usually affecting the skin, liver, and GI tract. The onset is usually within one hundred days of transplantation or immunologic manipulation. [from NCI]

Professional guidelines

PubMed

Jamy O, Zeiser R, Chen YB
Blood 2023 Sep 21;142(12):1037-1046. doi: 10.1182/blood.2023020073. PMID: 37471585
Del Bufalo F, Becilli M, Rosignoli C, De Angelis B, Algeri M, Hanssens L, Gunetti M, Iacovelli S, Li Pira G, Girolami E, Leone G, Lazzaro S, Bertaina V, Sinibaldi M, Di Cecca S, Iaffaldano L, Künkele A, Boccieri E, Del Baldo G, Pagliara D, Merli P, Carta R, Quintarelli C, Locatelli F
Blood 2023 Jul 13;142(2):146-157. doi: 10.1182/blood.2023020023. PMID: 37172203
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article

Recent clinical studies

Etiology

Liu J, Fan Z, Xu N, Ye J, Chen Y, Shao R, Sun Y, Wu Q, Liu Q, Jin H
Ann Hematol 2023 Oct;102(10):2865-2877. Epub 2023 Jul 20 doi: 10.1007/s00277-023-05361-9. PMID: 37474631
Patel DA, Crain M, Pusic I, Schroeder MA
Drugs 2023 Jul;83(10):893-907. Epub 2023 May 29 doi: 10.1007/s40265-023-01889-2. PMID: 37247105
Su Y, Sun X, Liu X, Qu Q, Yang L, Chen Q, Liu F, Li Y, Wang Q, Huang B, Huang XJ, Zhang XH
J Hematol Oncol 2022 Jul 21;15(1):99. doi: 10.1186/s13045-022-01315-2. PMID: 35864538Free PMC Article
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
Hill GR, Koyama M
Blood 2020 Jul 23;136(4):418-428. doi: 10.1182/blood.2019000952. PMID: 32526028Free PMC Article

Diagnosis

Bayraktar E, Graf T, Ayuk FA, Beutel G, Penack O, Luft T, Brueder N, Castellani G, Reinhardt HC, Kröger N, Beelen DW, Turki AT
Nat Commun 2023 Nov 28;14(1):7799. doi: 10.1038/s41467-023-43372-2. PMID: 38017035Free PMC Article
Malard F, Holler E, Sandmaier BM, Huang H, Mohty M
Nat Rev Dis Primers 2023 Jun 8;9(1):27. doi: 10.1038/s41572-023-00438-1. PMID: 37291149
Aladağ E, Kelkitli E, Göker H
Turk J Haematol 2020 Feb 20;37(1):1-4. Epub 2019 Sep 2 doi: 10.4274/tjh.galenos.2019.2019.0157. PMID: 31475512Free PMC Article
Naymagon S, Naymagon L, Wong SY, Ko HM, Renteria A, Levine J, Colombel JF, Ferrara J
Nat Rev Gastroenterol Hepatol 2017 Dec;14(12):711-726. Epub 2017 Sep 27 doi: 10.1038/nrgastro.2017.126. PMID: 28951581Free PMC Article
Mistrik M, Bojtarova E, Sopko L, Masakova L, Roziakova L, Martinka J, Batorova A
Bratisl Lek Listy 2016;117(7):388-96. doi: 10.4149/bll_2016_077. PMID: 27546540

Therapy

Khandelwal P, Langenberg L, Luebbering N, Lake KE, Butcher A, Bota K, Ramos KN, Taggart C, Choe H, Vasu S, Teusink-Cross A, Koo J, Wallace G, Romick-Rosendale L, Watanabe-Chailland M, Haslam DB, Lane A, Davies SM
Blood 2024 Mar 21;143(12):1181-1192. doi: 10.1182/blood.2023022865. PMID: 38227933
Jamy O, Zeiser R, Chen YB
Blood 2023 Sep 21;142(12):1037-1046. doi: 10.1182/blood.2023020073. PMID: 37471585
Malard F, Holler E, Sandmaier BM, Huang H, Mohty M
Nat Rev Dis Primers 2023 Jun 8;9(1):27. doi: 10.1038/s41572-023-00438-1. PMID: 37291149
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
Zeiser R, von Bubnoff N, Butler J, Mohty M, Niederwieser D, Or R, Szer J, Wagner EM, Zuckerman T, Mahuzier B, Xu J, Wilke C, Gandhi KK, Socié G; REACH2 Trial Group
N Engl J Med 2020 May 7;382(19):1800-1810. Epub 2020 Apr 22 doi: 10.1056/NEJMoa1917635. PMID: 32320566

Prognosis

Duan H, Ru Y, Chen J
Expert Opin Ther Targets 2024 Sep;28(9):807-824. Epub 2024 Sep 19 doi: 10.1080/14728222.2024.2405091. PMID: 39300696
Lafarge A, Dupont T, Canet E, Moreau AS, Picard M, Mokart D, Platon L, Mayaux J, Wallet F, Issa N, Raphalen JH, Pène F, Renault A, Peffault de la Tour R, Récher C, Chevallier P, Zafrani L, Darmon M, Bigé N, Azoulay E
Am J Respir Crit Care Med 2024 Oct 15;210(8):1017-1024. doi: 10.1164/rccm.202401-0135OC. PMID: 39018219
Akahoshi Y, Spyrou N, Hogan WJ, Ayuk F, DeFilipp Z, Weber D, Choe HK, Hexner EO, Rösler W, Etra AM, Sandhu K, Yanik GA, Chanswangphuwana C, Kitko CL, Reshef R, Kraus S, Wölfl M, Eder M, Bertrand H, Qayed M, Merli P, Grupp SA, Aguayo-Hiraldo P, Schechter T, Ullrich E, Baez J, Beheshti R, Gleich S, Kowalyk S, Morales G, Young R, Kwon D, Nakamura R, Levine JE, Ferrara JLM, Chen YB
Blood Adv 2023 Aug 22;7(16):4479-4491. doi: 10.1182/bloodadvances.2023009885. PMID: 37315175Free PMC Article
Mistrik M, Bojtarova E, Sopko L, Masakova L, Roziakova L, Martinka J, Batorova A
Bratisl Lek Listy 2016;117(7):388-96. doi: 10.4149/bll_2016_077. PMID: 27546540
Kanda J
Int J Hematol 2013 Sep;98(3):300-8. Epub 2013 Jul 28 doi: 10.1007/s12185-013-1405-x. PMID: 23893313

Clinical prediction guides

Lin Y, Gu Q, Lu S, Pan Z, Yang Z, Li Y, Yang S, Lv Y, Zheng Z, Sun G, Gou F, Xu C, Zhao X, Wang F, Wang C, Yuan S, Xie X, Cao Y, Liu Y, Gu W, Cheng T, Cheng H, Hu X
J Clin Invest 2023 Aug 1;133(15) doi: 10.1172/JCI162201. PMID: 37338986Free PMC Article
Patel DA, Crain M, Pusic I, Schroeder MA
Drugs 2023 Jul;83(10):893-907. Epub 2023 May 29 doi: 10.1007/s40265-023-01889-2. PMID: 37247105
Su Y, Sun X, Liu X, Qu Q, Yang L, Chen Q, Liu F, Li Y, Wang Q, Huang B, Huang XJ, Zhang XH
J Hematol Oncol 2022 Jul 21;15(1):99. doi: 10.1186/s13045-022-01315-2. PMID: 35864538Free PMC Article
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
Srinagesh HK, Ferrara JLM
Best Pract Res Clin Haematol 2019 Dec;32(4):101111. Epub 2019 Oct 18 doi: 10.1016/j.beha.2019.101111. PMID: 31779977Free PMC Article

Recent systematic reviews

Bhattarai A, Shah S, Yadav R, Dhakal G, Neupane R, Paudel S, Bhandari P, Abu Serhan H, Sah R, Sah S, Barboza JJ
Hematology 2024 Dec;29(1):2293497. Epub 2023 Dec 19 doi: 10.1080/16078454.2023.2293497. PMID: 38112182
Li AC, Dong C, Tay ST, Ananthakrishnan A, Ma KS
Front Immunol 2022;13:1025350. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1025350. PMID: 36439135Free PMC Article
Fan S, Huo WX, Yang Y, Shen MZ, Mo XD
Front Immunol 2022;13:954268. Epub 2022 Aug 4 doi: 10.3389/fimmu.2022.954268. PMID: 35990629Free PMC Article
Friend BD, Schiller GJ
Blood Rev 2022 Mar;52:100886. Epub 2021 Sep 2 doi: 10.1016/j.blre.2021.100886. PMID: 34509319
Hashmi S, Ahmed M, Murad MH, Litzow MR, Adams RH, Ball LM, Prasad VK, Kebriaei P, Ringden O
Lancet Haematol 2016 Jan;3(1):e45-52. Epub 2015 Nov 27 doi: 10.1016/S2352-3026(15)00224-0. PMID: 26765648

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