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Localized Malignant Pancreatic Neoplasm

MedGen UID:
1711226
•Concept ID:
C5237325
•
Neoplastic Process

Definition

A malignant neoplasm that arises from the pancreas and has not spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Malignant Pancreatic Neoplasm

Professional guidelines

PubMed

Venous thromboembolism in cancer patients: ESMO Clinical Practice Guideline.
Falanga A, Ay C, Di Nisio M, Gerotziafas G, Jara-Palomares L, Langer F, Lecumberri R, Mandala M, Maraveyas A, Pabinger I, Sinn M, Syrigos K, Young A, Jordan K; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 May;34(5):452-467. Epub 2023 Jan 10 doi: 10.1016/j.annonc.2022.12.014. PMID: 36638869
Pancreatic Cancer: A Review of Current Treatment and Novel Therapies.
Kolbeinsson HM, Chandana S, Wright GP, Chung M
J Invest Surg 2023 Dec 31;36(1):2129884. Epub 2022 Oct 3 doi: 10.1080/08941939.2022.2129884. PMID: 36191926
Diagnosis and management of insulinoma.
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article

Recent clinical studies

Etiology

ESTRO ACROP guidelines for target volume definition in pancreatic cancer.
Brunner TB, Haustermans K, Huguet F, Morganti AG, Mukherjee S, Belka C, Krempien R, Hawkins MA, Valentini V, Roeder F
Radiother Oncol 2021 Jan;154:60-69. Epub 2020 Aug 28 doi: 10.1016/j.radonc.2020.07.052. PMID: 32861703
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer.
Liang C, Shi S, Qin Y, Meng Q, Hua J, Hu Q, Ji S, Zhang B, Xu J, Yu XJ
Gut 2020 May;69(5):888-900. Epub 2019 Oct 14 doi: 10.1136/gutjnl-2018-317163. PMID: 31611300
Chemotherapy for pancreatic cancer.
Springfeld C, Jäger D, Büchler MW, Strobel O, Hackert T, Palmer DH, Neoptolemos JP
Presse Med 2019 Mar;48(3 Pt 2):e159-e174. Epub 2019 Mar 15 doi: 10.1016/j.lpm.2019.02.025. PMID: 30879894
Pancreatic cancer.
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Diagnosis

Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
IPMN: surgical treatment.
Käppeli RM, Müller SA, Hummel B, Kruse C, Müller P, Fornaro J, Wilhelm A, Zadnikar M, Schmied BM, Tarantino I
Langenbecks Arch Surg 2013 Dec;398(8):1029-37. Epub 2013 Sep 3 doi: 10.1007/s00423-013-1106-1. PMID: 23999775
Diagnosis and management of insulinoma.
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article

Therapy

Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Treatment landscape of metastatic pancreatic cancer.
De Dosso S, Siebenhüner AR, Winder T, Meisel A, Fritsch R, Astaras C, Szturz P, Borner M
Cancer Treat Rev 2021 May;96:102180. Epub 2021 Mar 17 doi: 10.1016/j.ctrv.2021.102180. PMID: 33812339
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Chemotherapy for pancreatic cancer.
Springfeld C, Jäger D, Büchler MW, Strobel O, Hackert T, Palmer DH, Neoptolemos JP
Presse Med 2019 Mar;48(3 Pt 2):e159-e174. Epub 2019 Mar 15 doi: 10.1016/j.lpm.2019.02.025. PMID: 30879894
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Prognosis

Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer.
Liang C, Shi S, Qin Y, Meng Q, Hua J, Hu Q, Ji S, Zhang B, Xu J, Yu XJ
Gut 2020 May;69(5):888-900. Epub 2019 Oct 14 doi: 10.1136/gutjnl-2018-317163. PMID: 31611300
Prognostic and predictive factors on overall survival and surgical outcomes in pancreatic neuroendocrine tumors: recent advances and controversies.
Lee L, Ito T, Jensen RT
Expert Rev Anticancer Ther 2019 Dec;19(12):1029-1050. Epub 2019 Nov 27 doi: 10.1080/14737140.2019.1693893. PMID: 31738624Free PMC Article
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159

Clinical prediction guides

Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer.
Liang C, Shi S, Qin Y, Meng Q, Hua J, Hu Q, Ji S, Zhang B, Xu J, Yu XJ
Gut 2020 May;69(5):888-900. Epub 2019 Oct 14 doi: 10.1136/gutjnl-2018-317163. PMID: 31611300
Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy.
Ge L, Pan B, Song F, Ma J, Zeraatkar D, Zhou J, Tian J
BMJ Open 2017 Dec 26;7(12):e018175. doi: 10.1136/bmjopen-2017-018175. PMID: 29282264Free PMC Article
Diagnosis and management of insulinoma.
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article

Recent systematic reviews

FOLFIRINOX or Gemcitabine-based Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: A Multi-institutional, Patient-Level, Meta-analysis and Systematic Review.
Eshmuminov D, Aminjonov B, Palm RF, Malleo G, Schmocker RK, Abdallah R, Yoo C, Shaib WL, Schneider MA, Rangelova E, Choi YJ, Kim H, Rose JB, Patel S, Wilson GC, Maloney S, Timmermann L, Sahora K, Rössler F, Lopez-Lopez V, Boyer E, Maggino L, Malinka T, Park JY, Katz MHG, Prakash L, Ahmad SA, Helton S, Jang JY, Hoffe SE, Salvia R, Taieb J, He J, Clavien PA, Held U, Lehmann K
Ann Surg Oncol 2023 Jul;30(7):4417-4428. Epub 2023 Apr 5 doi: 10.1245/s10434-023-13353-2. PMID: 37020094Free PMC Article
Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review.
Ruze R, Song J, Yin X, Chen Y, Xu R, Wang C, Zhao Y
Signal Transduct Target Ther 2023 Mar 24;8(1):139. doi: 10.1038/s41392-023-01376-w. PMID: 36964133Free PMC Article
Arterial resections in pancreatic cancer - Systematic review and meta-analysis.
Małczak P, Sierżęga M, Stefura T, Kacprzyk A, Droś J, Skomarovska O, Krzysztofik M, Major P, Pędziwiatr M
HPB (Oxford) 2020 Jul;22(7):961-968. Epub 2020 Apr 30 doi: 10.1016/j.hpb.2020.04.005. PMID: 32360186
FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis.
Suker M, Beumer BR, Sadot E, Marthey L, Faris JE, Mellon EA, El-Rayes BF, Wang-Gillam A, Lacy J, Hosein PJ, Moorcraft SY, Conroy T, Hohla F, Allen P, Taieb J, Hong TS, Shridhar R, Chau I, van Eijck CH, Koerkamp BG
Lancet Oncol 2016 Jun;17(6):801-810. Epub 2016 May 6 doi: 10.1016/S1470-2045(16)00172-8. PMID: 27160474Free PMC Article
Pancreatic cancer.
Kocher HM, Alrawashdeh W
BMJ Clin Evid 2010 May 19;2010 PMID: 21729338Free PMC Article

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