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Focal impaired awareness cognitive seizure

MedGen UID:
1711758
•Concept ID:
C5397766
•
Disease or Syndrome
Synonyms: Focal onset impaired awareness cognitive epileptic seizure; Focal onset impaired awareness cognitive seizure; Focal-onset impaired awareness cognitive epileptic seizure
SNOMED CT: Focal onset impaired awareness cognitive seizure (1281834001); Focal onset impaired awareness cognitive epileptic seizure (1281834001); Focal impaired awareness cognitive seizure (1281834001); Focal-onset impaired awareness cognitive epileptic seizure (1281834001)
 
HPO: HP:0032756

Definition

A focal cognitive seizure in which awareness is partially or fully impaired at some point during the seizure. [from HPO]

Professional guidelines

PubMed

Diagnosis, treatment, and follow-up of patients with cerebral amyloid angiopathy-related inflammation.
Cancelloni V, Rufa A, Battisti C, De Stefano N, Mastrocinque E, Garosi G, Venezia D, Chiarotti I, Cerase A
Neurol Sci 2022 Nov;43(11):6381-6387. Epub 2022 Aug 5 doi: 10.1007/s10072-022-06299-y. PMID: 35930182Free PMC Article
Clinical characteristics and treatment experience of individuals with SCN8A developmental and epileptic encephalopathy (SCN8A-DEE): Findings from an online caregiver survey.
Cutts A, Savoie H, Hammer MF, Schreiber J, Grayson C, Luzon C, Butterfield N, Pimstone SN, Aycardi E, Harden C, Yonan C, Jen E, Nguyen T, Carmack T, Haubenberger D
Seizure 2022 Apr;97:50-57. Epub 2022 Mar 10 doi: 10.1016/j.seizure.2022.03.008. PMID: 35325842
Genotype/phenotype of 6 Chinese cases with Niemann-Pick disease type C.
Xiong H, Higaki K, Wei CJ, Bao XH, Zhang YH, Fu N, Qin J, Adachi K, Kumura Y, Ninomiya H, Nanba E, Wu XR
Gene 2012 May 1;498(2):332-5. Epub 2012 Feb 4 doi: 10.1016/j.gene.2012.01.026. PMID: 22326530

Recent clinical studies

Etiology

Posterior Cingulate Epilepsy: A Systematic Review.
Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing.
Contreras Ramirez V, Patedakis Litvinov B, Gunawardane NA, Zhao CW, Yotter C, Quraishi IH, Blumenfeld H
Epileptic Disord 2022 Oct 1;24(5):899-905. doi: 10.1684/epd.2022.1472. PMID: 35904040Free PMC Article
Social cognition and psychopathology in childhood and adolescence.
Besag FMC, Vasey MJ
Epilepsy Behav 2019 Nov;100(Pt B):106210. Epub 2019 Jun 10 doi: 10.1016/j.yebeh.2019.03.015. PMID: 31196824
Neurostimulation to improve level of consciousness in patients with epilepsy.
Gummadavelli A, Kundishora AJ, Willie JT, Andrews JP, Gerrard JL, Spencer DD, Blumenfeld H
Neurosurg Focus 2015 Jun;38(6):E10. doi: 10.3171/2015.3.FOCUS1535. PMID: 26030698Free PMC Article
Consciousness of seizures and consciousness during seizures: are they related?
Detyniecki K, Blumenfeld H
Epilepsy Behav 2014 Jan;30:6-9. Epub 2013 Oct 12 doi: 10.1016/j.yebeh.2013.09.018. PMID: 24126026Free PMC Article

Diagnosis

Posterior Cingulate Epilepsy: A Systematic Review.
Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing.
Contreras Ramirez V, Patedakis Litvinov B, Gunawardane NA, Zhao CW, Yotter C, Quraishi IH, Blumenfeld H
Epileptic Disord 2022 Oct 1;24(5):899-905. doi: 10.1684/epd.2022.1472. PMID: 35904040Free PMC Article
CASPR2-IgG-associated autoimmune seizures.
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
A systematic review of adults with Dravet syndrome.
Selvarajah A, Zulfiqar-Ali Q, Marques P, Rong M, Andrade DM
Seizure 2021 Apr;87:39-45. Epub 2021 Feb 22 doi: 10.1016/j.seizure.2021.02.025. PMID: 33677403
Social cognition and psychopathology in childhood and adolescence.
Besag FMC, Vasey MJ
Epilepsy Behav 2019 Nov;100(Pt B):106210. Epub 2019 Jun 10 doi: 10.1016/j.yebeh.2019.03.015. PMID: 31196824

Therapy

Clinical characteristics and treatment experience of individuals with SCN8A developmental and epileptic encephalopathy (SCN8A-DEE): Findings from an online caregiver survey.
Cutts A, Savoie H, Hammer MF, Schreiber J, Grayson C, Luzon C, Butterfield N, Pimstone SN, Aycardi E, Harden C, Yonan C, Jen E, Nguyen T, Carmack T, Haubenberger D
Seizure 2022 Apr;97:50-57. Epub 2022 Mar 10 doi: 10.1016/j.seizure.2022.03.008. PMID: 35325842
CASPR2-IgG-associated autoimmune seizures.
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
Methylprednisolone pulse therapy in 31 patients with refractory epilepsy: A single-center retrospective analysis.
Kimizu T, Takahashi Y, Oboshi T, Horino A, Omatsu H, Koike T, Yoshitomi S, Yamaguchi T, Otani H, Ikeda H, Imai K, Shigematsu H
Epilepsy Behav 2020 Aug;109:107116. Epub 2020 May 6 doi: 10.1016/j.yebeh.2020.107116. PMID: 32388139
Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
Utility of the electroencephalogram in attention deficit hyperactivity disorder.
Millichap JG, Millichap JJ, Stack CV
Clin EEG Neurosci 2011 Jul;42(3):180-4. doi: 10.1177/155005941104200307. PMID: 21870470

Prognosis

Diagnosis, treatment, and follow-up of patients with cerebral amyloid angiopathy-related inflammation.
Cancelloni V, Rufa A, Battisti C, De Stefano N, Mastrocinque E, Garosi G, Venezia D, Chiarotti I, Cerase A
Neurol Sci 2022 Nov;43(11):6381-6387. Epub 2022 Aug 5 doi: 10.1007/s10072-022-06299-y. PMID: 35930182Free PMC Article
CASPR2-IgG-associated autoimmune seizures.
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
Epilepsy and EEG Abnormalities in Children with Autism Spectrum Disorders.
Sharma V, Saini AG, Malhi P, Singhi P
Indian J Pediatr 2022 Oct;89(10):975-982. Epub 2021 Nov 29 doi: 10.1007/s12098-021-03928-w. PMID: 34843062
Impaired awareness in mesial temporal lobe epilepsy: Network analysis of foramen ovale and scalp EEG.
Varotto G, Burini A, Didato G, Deleo F, Pastori C, Dominese A, Tringali G, Panzica F, de Curtis M, Di Giacomo R
Clin Neurophysiol 2021 Dec;132(12):3084-3094. Epub 2021 Oct 11 doi: 10.1016/j.clinph.2021.09.011. PMID: 34717226
Circulating miR-146a and miR-134 in predicting drug-resistant epilepsy in patients with focal impaired awareness seizures.
Leontariti M, Avgeris M, Katsarou MS, Drakoulis N, Siatouni A, Verentzioti A, Alexoudi A, Fytraki A, Patrikelis P, Vassilacopoulou D, Gatzonis S, Sideris DC
Epilepsia 2020 May;61(5):959-970. Epub 2020 Apr 21 doi: 10.1111/epi.16502. PMID: 32314378

Clinical prediction guides

Posterior Cingulate Epilepsy: A Systematic Review.
Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
Epilepsy and EEG Abnormalities in Children with Autism Spectrum Disorders.
Sharma V, Saini AG, Malhi P, Singhi P
Indian J Pediatr 2022 Oct;89(10):975-982. Epub 2021 Nov 29 doi: 10.1007/s12098-021-03928-w. PMID: 34843062
Impaired awareness in mesial temporal lobe epilepsy: Network analysis of foramen ovale and scalp EEG.
Varotto G, Burini A, Didato G, Deleo F, Pastori C, Dominese A, Tringali G, Panzica F, de Curtis M, Di Giacomo R
Clin Neurophysiol 2021 Dec;132(12):3084-3094. Epub 2021 Oct 11 doi: 10.1016/j.clinph.2021.09.011. PMID: 34717226
Circulating miR-146a and miR-134 in predicting drug-resistant epilepsy in patients with focal impaired awareness seizures.
Leontariti M, Avgeris M, Katsarou MS, Drakoulis N, Siatouni A, Verentzioti A, Alexoudi A, Fytraki A, Patrikelis P, Vassilacopoulou D, Gatzonis S, Sideris DC
Epilepsia 2020 May;61(5):959-970. Epub 2020 Apr 21 doi: 10.1111/epi.16502. PMID: 32314378
Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659

Recent systematic reviews

Posterior Cingulate Epilepsy: A Systematic Review.
Pepin C, Brochu K, Lessard-Bonaventure P, Nguyen DK, Martineau L
J Clin Neurophysiol 2023 Sep 1;40(6):507-515. Epub 2023 Mar 15 doi: 10.1097/WNP.0000000000000975. PMID: 36930208
A systematic review of adults with Dravet syndrome.
Selvarajah A, Zulfiqar-Ali Q, Marques P, Rong M, Andrade DM
Seizure 2021 Apr;87:39-45. Epub 2021 Feb 22 doi: 10.1016/j.seizure.2021.02.025. PMID: 33677403

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