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Focal impaired awareness seizure with dissociation at onset

MedGen UID:
1720563
•Concept ID:
C5397884
•
Disease or Syndrome
HPO: HP:0032879

Definition

A focal cognitive epileptic seizure with dissociation at the onset of the seizure and with impairment of awareness at at some point during the seizure. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal impaired awareness seizure with dissociation at onset

Professional guidelines

PubMed

A review of the treatment of functional neurological disorder with intensive short-term dynamic psychotherapy.
Russell L, Abbass A, Allder S
Epilepsy Behav 2022 May;130:108657. Epub 2022 Apr 4 doi: 10.1016/j.yebeh.2022.108657. PMID: 35390566
A descriptive study of patients diagnosed with psychogenic nonepileptic seizures at a tertiary epilepsy center in the Czech Republic: One-year follow-up.
Krámská L, Myers L, Hrešková L, Jerie M, Vojtěch Z
Epilepsy Behav 2021 May;118:107922. Epub 2021 Mar 19 doi: 10.1016/j.yebeh.2021.107922. PMID: 33752043
Psychogenic seizures: A review and description of pitfalls in their acute diagnosis and management in the emergency department.
Siket MS, Merchant RC
Emerg Med Clin North Am 2011 Feb;29(1):73-81. doi: 10.1016/j.emc.2010.08.007. PMID: 21109104

Recent clinical studies

Etiology

The clinical characteristics of childhood-onset and late-onset functional seizures: How do they differ?
Asadi-Pooya AA, Mishra M, Farazdaghi M, Fox J
Epilepsy Behav 2023 Aug;145:109336. Epub 2023 Jun 27 doi: 10.1016/j.yebeh.2023.109336. PMID: 37385121
New-onset functional seizures during the COVID-19 pandemic.
Asadi-Pooya AA, Farazdaghi M
Clin Neurol Neurosurg 2022 Aug;219:107310. Epub 2022 May 28 doi: 10.1016/j.clineuro.2022.107310. PMID: 35660168Free PMC Article
Semantic and episodic memory in adults with temporal lobe epilepsy.
Barrett Jones S, A Miller L, Kleitman S, Nikpour A, Lah S
Appl Neuropsychol Adult 2022 Nov-Dec;29(6):1352-1361. Epub 2021 Feb 17 doi: 10.1080/23279095.2021.1876692. PMID: 33595395
Depression and anxiety in patients from Lebanon with new onset functional seizures.
Nawfal O, Nasreddine W, Hmaimess G, Dassouki M, Beydoun A, Toufaili H, Wazne J, Dirani M, Beydoun A
Seizure 2021 May;88:22-28. Epub 2021 Mar 16 doi: 10.1016/j.seizure.2021.03.014. PMID: 33799136
Psychopathology in epilepsy.
Perrine KR
Semin Neurol 1991 Jun;11(2):175-81. doi: 10.1055/s-2008-1041219. PMID: 1925133

Diagnosis

The clinical characteristics of childhood-onset and late-onset functional seizures: How do they differ?
Asadi-Pooya AA, Mishra M, Farazdaghi M, Fox J
Epilepsy Behav 2023 Aug;145:109336. Epub 2023 Jun 27 doi: 10.1016/j.yebeh.2023.109336. PMID: 37385121
New-onset functional seizures during the COVID-19 pandemic.
Asadi-Pooya AA, Farazdaghi M
Clin Neurol Neurosurg 2022 Aug;219:107310. Epub 2022 May 28 doi: 10.1016/j.clineuro.2022.107310. PMID: 35660168Free PMC Article
Depression and anxiety in patients from Lebanon with new onset functional seizures.
Nawfal O, Nasreddine W, Hmaimess G, Dassouki M, Beydoun A, Toufaili H, Wazne J, Dirani M, Beydoun A
Seizure 2021 May;88:22-28. Epub 2021 Mar 16 doi: 10.1016/j.seizure.2021.03.014. PMID: 33799136
Electroencephalography in neonatal epilepsies.
Okumura A
Pediatr Int 2020 Sep;62(9):1019-1028. doi: 10.1111/ped.14227. PMID: 32153072
Epileptic amnesic syndrome.
Gallassi R, Morreale A, Di Sarro R, Lugaresi E
Epilepsia 1992;33 Suppl 6:S21-5. PMID: 1486832

Therapy

Moderators of cognitive behavioural therapy treatment effects and predictors of outcome in the CODES randomised controlled trial for adults with dissociative seizures.
Goldstein LH, Robinson EJ, Chalder T, Stone J, Reuber M, Medford N, Carson A, Moore M, Landau S
J Psychosom Res 2022 Jul;158:110921. Epub 2022 Apr 19 doi: 10.1016/j.jpsychores.2022.110921. PMID: 35617911
Functional seizures: Cluster analysis may predict the associated risk factors.
Asadi-Pooya AA, Farazdaghi M
Epilepsy Behav 2022 Jan;126:108485. Epub 2021 Dec 15 doi: 10.1016/j.yebeh.2021.108485. PMID: 34922327
Psychological and demographic characteristics of 368 patients with dissociative seizures: data from the CODES cohort.
Goldstein LH, Robinson EJ, Mellers JDC, Stone J, Carson A, Chalder T, Reuber M, Eastwood C, Landau S, McCrone P, Moore M, Mosweu I, Murray J, Perdue I, Pilecka I, Richardson MP, Medford N; CODES Study Group
Psychol Med 2021 Oct;51(14):2433-2445. Epub 2020 May 11 doi: 10.1017/S0033291720001051. PMID: 32389147Free PMC Article
Characteristics of 698 patients with dissociative seizures: A UK multicenter study.
Goldstein LH, Robinson EJ, Reuber M, Chalder T, Callaghan H, Eastwood C, Landau S, McCrone P, Medford N, Mellers JDC, Moore M, Mosweu I, Murray J, Perdue I, Pilecka I, Richardson MP, Carson A, Stone J; CODES Study Group
Epilepsia 2019 Nov;60(11):2182-2193. Epub 2019 Oct 13 doi: 10.1111/epi.16350. PMID: 31608436Free PMC Article
Review of Intranasally Administered Medications for Use in the Emergency Department.
Bailey AM, Baum RA, Horn K, Lewis T, Morizio K, Schultz A, Weant K, Justice SN
J Emerg Med 2017 Jul;53(1):38-48. Epub 2017 Mar 1 doi: 10.1016/j.jemermed.2017.01.020. PMID: 28259526

Prognosis

The effect of attachment style on long-term outcomes in psychogenic nonepileptic seizures: Results from a prospective study.
Villagrán A, Lund C, Duncan R, Lossius MI
Epilepsy Behav 2022 Oct;135:108890. Epub 2022 Aug 28 doi: 10.1016/j.yebeh.2022.108890. PMID: 36037581
Functional seizures: Cluster analysis may predict the associated risk factors.
Asadi-Pooya AA, Farazdaghi M
Epilepsy Behav 2022 Jan;126:108485. Epub 2021 Dec 15 doi: 10.1016/j.yebeh.2021.108485. PMID: 34922327
Psychiatric Disorders in Children and Adolescents With Psychogenic Nonepileptic Seizures.
Hansen AS, Rask CU, Christensen AE, Rodrigo-Domingo M, Christensen J, Nielsen RE
Neurology 2021 Aug 3;97(5):e464-e475. Epub 2021 May 24 doi: 10.1212/WNL.0000000000012270. PMID: 34031196
Nonepileptic attack disorder and functional movement disorder: A clinical continuum?
Rather MA, Cavanna AE
Epilepsy Behav 2020 May;106:107028. Epub 2020 Mar 20 doi: 10.1016/j.yebeh.2020.107028. PMID: 32203928
Psychological long-term outcome in patients with psychogenic nonepileptic seizures.
Walther K, Volbers B, Erdmann L, Dogan Onugoren M, Gollwitzer S, Kasper BS, Kurzbuch K, Lang J, Schwab S, Schwarz M, Hamer HM
Epilepsia 2019 Apr;60(4):669-678. Epub 2019 Mar 5 doi: 10.1111/epi.14682. PMID: 30838655

Clinical prediction guides

Functional seizures: Cluster analysis may predict the associated risk factors.
Asadi-Pooya AA, Farazdaghi M
Epilepsy Behav 2022 Jan;126:108485. Epub 2021 Dec 15 doi: 10.1016/j.yebeh.2021.108485. PMID: 34922327
Depression and anxiety in patients from Lebanon with new onset functional seizures.
Nawfal O, Nasreddine W, Hmaimess G, Dassouki M, Beydoun A, Toufaili H, Wazne J, Dirani M, Beydoun A
Seizure 2021 May;88:22-28. Epub 2021 Mar 16 doi: 10.1016/j.seizure.2021.03.014. PMID: 33799136
Dissociation and other clinical phenomena in youth with psychogenic non-epileptic seizures (PNES) compared to youth with epilepsy.
Myers L, Trobliger R, Bortnik K, Zeng R, Segal E, Lancman M
Seizure 2019 Aug;70:49-55. Epub 2019 Jun 24 doi: 10.1016/j.seizure.2019.06.028. PMID: 31255873
The role of OPRM1 polymorphism in the etiology of alcoholism.
Samochowiec A, Samochowiec J, Pełka-Wysiecka J, Kucharska-Mazur J, Grochans E, Jabłoński M, Bieńkowski P, Murawiec S, Małecka I, Mak M, Kołodziej Ł, Heitzman J, Grzywacz A
Adv Clin Exp Med 2019 Feb;28(2):199-202. doi: 10.17219/acem/78592. PMID: 30085428
Dissociative experiences in patients with epilepsy.
Özdemir O, Cilingir V, Özdemir PG, Milanlioglu A, Hamamci M, Yilmaz E
Arq Neuropsiquiatr 2016 Mar;74(3):189-94. doi: 10.1590/0004-282X20160045. PMID: 27050846

Recent systematic reviews

Alcohol and Sedative-Hypnotic Withdrawal Catatonia: Two Case Reports, Systematic Literature Review, and Suggestion of a Potential Relationship With Alcohol Withdrawal Delirium.
Oldham MA, Desan PH
Psychosomatics 2016 May-Jun;57(3):246-55. Epub 2015 Dec 22 doi: 10.1016/j.psym.2015.12.007. PMID: 26949118

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