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Adnexal Secretory Carcinoma

MedGen UID:
1711807
•Concept ID:
C5238497
•
Neoplastic Process
Synonyms: Mammary-Type Secretory Carcinoma of the Skin; Primary Cutaneous Mammary Analogue Secretory Carcinoma

Definition

A rare adnexal carcinoma that is histopathologically identical to homologous lesions in the salivary gland and breast. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdnexal Secretory Carcinoma

Recent clinical studies

Etiology

Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Secretory Carcinoma of the Skin: Report of 6 Cases, Including a Case With a Novel NFIX-PKN1 Translocation.
Kastnerova L, Luzar B, Goto K, Grishakov V, Gatalica Z, Kamarachev J, Martinek P, Hájková V, Grossmann P, Imai H, Fukui H, Michal M, Kazakov DV
Am J Surg Pathol 2019 Aug;43(8):1092-1098. doi: 10.1097/PAS.0000000000001261. PMID: 31045890
Serum HE4 as a useful biomarker in discriminating ovarian cancer from benign pelvic disease.
Zheng H, Gao Y
Int J Gynecol Cancer 2012 Jul;22(6):1000-5. doi: 10.1097/IGC.0b013e318249bee7. PMID: 22426406
HE4 and epithelial ovarian cancer: comparison and clinical evaluation of two immunoassays and a combination algorithm.
Ruggeri G, Bandiera E, Zanotti L, Belloli S, Ravaggi A, Romani C, Bignotti E, Tassi RA, Tognon G, Galli C, Caimi L, Pecorelli S
Clin Chim Acta 2011 Jul 15;412(15-16):1447-53. Epub 2011 Apr 30 doi: 10.1016/j.cca.2011.04.028. PMID: 21557935
The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass.
Moore RG, Brown AK, Miller MC, Skates S, Allard WJ, Verch T, Steinhoff M, Messerlian G, DiSilvestro P, Granai CO, Bast RC Jr
Gynecol Oncol 2008 Feb;108(2):402-8. Epub 2007 Dec 3 doi: 10.1016/j.ygyno.2007.10.017. PMID: 18061248

Diagnosis

Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Secretory Carcinoma of the Eyelid Arising in an Adnexal Gland.
Armijos PO, Uhlenhake E, Milman T
Ophthalmology 2022 Oct;129(10):1218. Epub 2022 Jun 23 doi: 10.1016/j.ophtha.2022.02.024. PMID: 35753863
Malignant Sweat Gland Tumors.
Ahn CS, Sangüeza OP
Hematol Oncol Clin North Am 2019 Feb;33(1):53-71. doi: 10.1016/j.hoc.2018.09.002. PMID: 30497677
Primary cutaneous cribriform apocrine carcinoma: Case report and literature review.
Wu JD, Changchien CH, Liao KS
Indian J Dermatol Venereol Leprol 2018 Sep-Oct;84(5):569-572. doi: 10.4103/ijdvl.IJDVL_830_16. PMID: 29735815
Sox10 and DOG1 Expression in Primary Adnexal Tumors of the Skin.
Lezcano C, Ho J, Seethala RR
Am J Dermatopathol 2017 Dec;39(12):896-902. doi: 10.1097/DAD.0000000000000872. PMID: 28394798

Prognosis

Primary Cutaneous Mammary Analog Secretory Carcinoma With ETV6-NTRK3 Translocation.
Amin SM, Beattie A, Ling X, Jennings LJ, Guitart J
Am J Dermatopathol 2016 Nov;38(11):842-845. doi: 10.1097/DAD.0000000000000590. PMID: 27763904
Accuracy of endometrial sampling compared to conventional dilatation and curettage in women with abnormal uterine bleeding.
Abdelazim IA, Abdelrazak KM, Elbiaa AA, Al-Kadi M, Yehia AH
Arch Gynecol Obstet 2015 May;291(5):1121-6. Epub 2014 Nov 4 doi: 10.1007/s00404-014-3523-y. PMID: 25367600
Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma.
Miyamoto T, Asaka R, Suzuki A, Takatsu A, Kashima H, Shiozawa T
Exp Mol Pathol 2011 Oct;91(2):563-8. Epub 2011 Jul 8 doi: 10.1016/j.yexmp.2011.06.002. PMID: 21763306
The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass.
Moore RG, Brown AK, Miller MC, Skates S, Allard WJ, Verch T, Steinhoff M, Messerlian G, DiSilvestro P, Granai CO, Bast RC Jr
Gynecol Oncol 2008 Feb;108(2):402-8. Epub 2007 Dec 3 doi: 10.1016/j.ygyno.2007.10.017. PMID: 18061248
Microvessel density (MVD) as a prognosticator in endometrial carcinoma.
Ozalp S, Yalcin OT, Acikalin M, Tanir HM, Oner U, Akkoyunlu A
Eur J Gynaecol Oncol 2003;24(3-4):305-8. PMID: 12807245

Clinical prediction guides

Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Primary Cutaneous Mammary Analog Secretory Carcinoma With ETV6-NTRK3 Translocation.
Amin SM, Beattie A, Ling X, Jennings LJ, Guitart J
Am J Dermatopathol 2016 Nov;38(11):842-845. doi: 10.1097/DAD.0000000000000590. PMID: 27763904
Laminin C1 expression by uterine carcinoma cells is associated with tumor progression.
Kashima H, Wu RC, Wang Y, Sinno AK, Miyamoto T, Shiozawa T, Wang TL, Fader AN, Shih IeM
Gynecol Oncol 2015 Nov;139(2):338-44. Epub 2015 Sep 3 doi: 10.1016/j.ygyno.2015.08.025. PMID: 26343160Free PMC Article
The expression of CD23 in cutaneous non-lymphoid neoplasms.
Carvalho J, Fullen D, Lowe L, Su L, Ma L
J Cutan Pathol 2007 Sep;34(9):693-8. doi: 10.1111/j.1600-0560.2006.00685.x. PMID: 17696916
Ber-EP4 immunoreactivity in normal skin and cutaneous neoplasms.
Jimenez FJ, Burchette JL Jr, Grichnik JM, Hitchcock MG
Mod Pathol 1995 Oct;8(8):854-8. PMID: 8552575

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