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t(11;19)(q23;p13)

MedGen UID:
1712574
•Concept ID:
C5239098
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that refers to the translocation of the long arm (q23) of chromosome 11 and the short arm (p13) of chromosome 19. It is associated with KMT2A (MLL) fusions, including those with MLLT1 (ENL) and ELL, and acute myeloid leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(11;19)(q23;p13)

Recent clinical studies

Etiology

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation.
Rubnitz JE, Camitta BM, Mahmoud H, Raimondi SC, Carroll AJ, Borowitz MJ, Shuster JJ, Link MP, Pullen DJ, Downing JR, Behm FG, Pui CH
J Clin Oncol 1999 Jan;17(1):191-6. doi: 10.1200/JCO.1999.17.1.191. PMID: 10458233
The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients. European 11q23 Workshop participants.
Moorman AV, Hagemeijer A, Charrin C, Rieder H, Secker-Walker LM
Leukemia 1998 May;12(5):805-10. doi: 10.1038/sj.leu.2401016. PMID: 9593285
Acute myeloid leukemia with 11q23 translocations: myelomonocytic immunophenotype by multiparameter flow cytometry.
Baer MR, Stewart CC, Lawrence D, Arthur DC, Mrózek K, Strout MP, Davey FR, Schiffer CA, Bloomfield CD
Leukemia 1998 Mar;12(3):317-25. doi: 10.1038/sj.leu.2400933. PMID: 9529125

Diagnosis

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
Rare KMT2A-ELL and Novel ZNF56-KMT2A Fusion Genes in Pediatric T-cell Acute Lymphoblastic Leukemia.
Panagopoulos I, Andersen K, Eilert-Olsen M, Rognlien AG, Munthe-Kaas MC, Micci F, Heim S
Cancer Genomics Proteomics 2021 Mar-Apr;18(2):121-131. doi: 10.21873/cgp.20247. PMID: 33608309Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation.
Rubnitz JE, Camitta BM, Mahmoud H, Raimondi SC, Carroll AJ, Borowitz MJ, Shuster JJ, Link MP, Pullen DJ, Downing JR, Behm FG, Pui CH
J Clin Oncol 1999 Jan;17(1):191-6. doi: 10.1200/JCO.1999.17.1.191. PMID: 10458233
Heterogeneity in the breakpoints of chromosome 19 among acute leukemic patients with the t(11;19)(q23;p13) translocation.
Mitani K, Sato Y, Kobayashi Y, Shibasaki Y, Kasuga M, Inaba T, Hayashi Y, Miura Y, Miyazono K, Hirai
Am J Hematol 1989 Aug;31(4):253-7. doi: 10.1002/ajh.2830310407. PMID: 2741924

Therapy

Therapy-induced secondary acute myeloid leukemia with t(11;19)(q23;p13.1) in a pediatric patient with relapsed acute promyelocytic leukemia.
Dang DN, Morris HD, Feusner JH, Koduru P, Wilson K, Timmons CF, Cavalier M, Luu HS
J Pediatr Hematol Oncol 2014 Nov;36(8):e546-8. doi: 10.1097/MPH.0000000000000183. PMID: 24942021
A case of therapy-related acute lymphoblastic leukemia with t(11;19)(q23;p13.3) and MLL/MLLT1 gene rearrangement.
Yoo BJ, Nam MH, Sung HJ, Lim CS, Lee CK, Cho YJ, Lee KN, Yoon SY
Korean J Lab Med 2011 Jan;31(1):13-7. doi: 10.3343/kjlm.2011.31.1.13. PMID: 21239865Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities.
Hunger SP, Tkachuk DC, Amylon MD, Link MP, Carroll AJ, Welborn JL, Willman CL, Cleary ML
Blood 1993 Jun 15;81(12):3197-203. PMID: 8389614
Translocation t(11;19) (q23;p13) in a child with myelomonocytic leukemia following 2 years after chemotherapy for pneumoblastoma.
Rialland X, Pein F, Saint-Andre JP, Flamant F
Med Pediatr Oncol 1993;21(2):146-9. doi: 10.1002/mpo.2950210213. PMID: 7679464

Prognosis

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
KMT2A-MLLT1 and the Novel SEC16A-KMT2A in a Cryptic 3-Way Translocation t(9;11;19) Present in an Infant With Acute Lymphoblastic Leukemia.
de Matos RRC, Ferreira GM, Meyer C, Marschalek R, Larghero P, Ribeiro RC, Liehr T, Othman M, Bizarro MTSM, Sobral da Costa E, Land MGP, Abdelhay E, Binato R, Silva MLM
J Pediatr Hematol Oncol 2022 Apr 1;44(3):e719-e722. doi: 10.1097/MPH.0000000000002386. PMID: 34966090
Rare KMT2A-ELL and Novel ZNF56-KMT2A Fusion Genes in Pediatric T-cell Acute Lymphoblastic Leukemia.
Panagopoulos I, Andersen K, Eilert-Olsen M, Rognlien AG, Munthe-Kaas MC, Micci F, Heim S
Cancer Genomics Proteomics 2021 Mar-Apr;18(2):121-131. doi: 10.21873/cgp.20247. PMID: 33608309Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation.
Rubnitz JE, Camitta BM, Mahmoud H, Raimondi SC, Carroll AJ, Borowitz MJ, Shuster JJ, Link MP, Pullen DJ, Downing JR, Behm FG, Pui CH
J Clin Oncol 1999 Jan;17(1):191-6. doi: 10.1200/JCO.1999.17.1.191. PMID: 10458233

Clinical prediction guides

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
Reemergence of translocation t(11;19)(q23;p13.1) in the absence of clinically overt leukemia.
Uemura S, Tamura A, Saito A, Hasegawa D, Nino N, Yokoi T, Tahara T, Kozaki A, Kishimoto K, Ishida T, Kawasaki K, Mori T, Nishimura N, Ishimae M, Eguchi M, Kosaka Y
Int J Hematol 2017 Dec;106(6):847-851. Epub 2017 Jul 1 doi: 10.1007/s12185-017-2289-y. PMID: 28669059
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Translocation (8;12)(q13;p13) during disease progression in acute myelomonocytic leukemia with t(11;19)(q23;p13.1).
Yamamoto K, Nagata K, Tsurukubo Y, Inagaki K, Ono R, Taki T, Hayashi Y, Hamaguchi H
Cancer Genet Cytogenet 2002 Aug;137(1):64-7. doi: 10.1016/s0165-4608(02)00555-1. PMID: 12377416
Clinical and hematologic characteristics in acute leukemia with 11q23 translocations.
Kaneko Y, Maseki N, Takasaki N, Sakurai M, Hayashi Y, Nakazawa S, Mori T, Sakurai M, Takeda T, Shikano T
Blood 1986 Feb;67(2):484-91. PMID: 3942833

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