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11q Translocation

MedGen UID:
1612372
•Concept ID:
C4524825
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that refers to any translocation involving the long arm of chromosome 11. [from NCI]

Professional guidelines

PubMed

Immunoglobulin heavy chain (IGH@) translocations negatively impact treatment-free survival for chronic lymphocytic leukemia patients who have an isolated deletion 13q abnormality.
Gerrie AS, Bruyere H, Chan MJ, Dalal CB, Ramadan KM, Huang SJ, Toze CL, Gillan TL
Cancer Genet 2012 Oct;205(10):523-7. Epub 2012 Aug 29 doi: 10.1016/j.cancergen.2012.05.011. PMID: 22939229
Unusual segregation for 11q;22q parental translocation in a triplet pregnancy: prenatal diagnosis in chorionic villi and amniotic fluid.
Soler A, Carrio A, Perez-Vidal MT, Borrell A, Fortuny A
Prenat Diagn 1993 Feb;13(2):137-41. doi: 10.1002/pd.1970130209. PMID: 8464833

Recent clinical studies

Etiology

Developmental retardation due to paternal 5q/11q translocation in a Chinese infant: clinical, chromosomal and microarray characterization.
Zhao X, Xu H, Zhao C, Li L
J Genet 2019 Sep;98 PMID: 31544782

Diagnosis

CGH Array and Karyotype as Complementary Tools in Prenatal Diagnosis: Prenatal Diagnosis of a 4q Derivative Chromosome from Maternal 4q;11q Translocation.
Gonzalez C, Serrano MG, Barbancho Lopez C, Garcia-Riaño T, Barea Calero V, Moreno Perea R, Rodriguez Mogollón B, Queipo Rojas A, Climent AG, Cava Valenciano F
Fetal Pediatr Pathol 2018 Jun;37(3):184-190. Epub 2018 May 17 doi: 10.1080/15513815.2018.1467518. PMID: 29771170
Clinical and hematologic characteristics in acute leukemia with 11q23 translocations.
Kaneko Y, Maseki N, Takasaki N, Sakurai M, Hayashi Y, Nakazawa S, Mori T, Sakurai M, Takeda T, Shikano T
Blood 1986 Feb;67(2):484-91. PMID: 3942833

Clinical prediction guides

Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites.
Kalsi G, Mankoo BS, Curtis D, Brynjolfsson J, Read T, Sharma T, Murphy P, Petursson H, Gurling HM
Psychol Med 1995 May;25(3):531-7. doi: 10.1017/s0033291700033456. PMID: 7480434
Clinical and hematologic characteristics in acute leukemia with 11q23 translocations.
Kaneko Y, Maseki N, Takasaki N, Sakurai M, Hayashi Y, Nakazawa S, Mori T, Sakurai M, Takeda T, Shikano T
Blood 1986 Feb;67(2):484-91. PMID: 3942833

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