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Refractory Pancreatic Ductal Adenocarcinoma

MedGen UID:
1712889
Concept ID:
C5237191
Neoplastic Process

Definition

Pancreatic ductal adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Pancreatic Ductal Adenocarcinoma

Professional guidelines

PubMed

Sonbol MB, Firwana B, Wang Z, Almader-Douglas D, Borad MJ, Makhoul I, Ramanathan RK, Ahn DH, Bekaii-Saab T
Cancer 2017 Dec 1;123(23):4680-4686. Epub 2017 Aug 17 doi: 10.1002/cncr.30927. PMID: 28817187

Recent clinical studies

Etiology

Chung C, Galvin R, Achenbach E, Dziadkowiec O, Sen S
Oncology (Williston Park) 2021 Dec 23;35(12):794-803. doi: 10.46883/2021.25920931. PMID: 35089001
Park SJ, Kim H, Shin K, Hong TH, Suh JH, Lee MA
BMC Cancer 2021 Nov 3;21(1):1176. doi: 10.1186/s12885-021-08887-1. PMID: 34732161Free PMC Article
Hajda J, Leuchs B, Angelova AL, Frehtman V, Rommelaere J, Mertens M, Pilz M, Kieser M, Krebs O, Dahm M, Huber B, Engeland CE, Mavratzas A, Hohmann N, Schreiber J, Jäger D, Halama N, Sedlaczek O, Gaida MM, Daniel V, Springfeld C, Ungerechts G
Clin Cancer Res 2021 Oct 15;27(20):5546-5556. Epub 2021 Aug 23 doi: 10.1158/1078-0432.CCR-21-1020. PMID: 34426438
Sadozai H, Acharjee A, Eppenberger-Castori S, Gloor B, Gruber T, Schenk M, Karamitopoulou E
Front Immunol 2021;12:643529. Epub 2021 Feb 19 doi: 10.3389/fimmu.2021.643529. PMID: 33679807Free PMC Article
Kim JH, Lee SC, Oh SY, Song SY, Lee N, Nam EM, Lee S, Hwang IG, Lee HR, Lee KT, Bae SB, Kim HJ, Jang JS, Lim DH, Lee HW, Kang SY, Kang JH
Cancer Commun (Lond) 2018 Jun 4;38(1):32. doi: 10.1186/s40880-018-0304-1. PMID: 29866170Free PMC Article

Diagnosis

Sato H, Sasaki K, Hara T, Tsuji Y, Arao Y, Otsuka C, Hamano Y, Ogita M, Kobayashi S, di Luccio E, Hirotsu T, Doki Y, Eguchi H, Satoh T, Uchida S, Ishii H
Biomolecules 2022 Oct 17;12(10) doi: 10.3390/biom12101503. PMID: 36291712Free PMC Article
Lumibao JC, Tremblay JR, Hsu J, Engle DD
J Exp Med 2022 Jun 6;219(6) Epub 2022 May 6 doi: 10.1084/jem.20211505. PMID: 35522218Free PMC Article
Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, Farabaugh CS, Moon E, Levine BL, Melenhorst JJ, Plesa G, June CH, Albelda SM, Beatty GL
Mol Ther 2019 Nov 6;27(11):1919-1929. Epub 2019 Jul 30 doi: 10.1016/j.ymthe.2019.07.015. PMID: 31420241Free PMC Article
McDonald PC, Chafe SC, Brown WS, Saberi S, Swayampakula M, Venkateswaran G, Nemirovsky O, Gillespie JA, Karasinska JM, Kalloger SE, Supuran CT, Schaeffer DF, Bashashati A, Shah SP, Topham JT, Yapp DT, Li J, Renouf DJ, Stanger BZ, Dedhar S
Gastroenterology 2019 Sep;157(3):823-837. Epub 2019 May 9 doi: 10.1053/j.gastro.2019.05.004. PMID: 31078621
Longo V, Brunetti O, Gnoni A, Cascinu S, Gasparini G, Lorusso V, Ribatti D, Silvestris N
Oncotarget 2016 Sep 6;7(36):58649-58658. doi: 10.18632/oncotarget.10765. PMID: 27462915Free PMC Article

Therapy

Sato H, Sasaki K, Hara T, Tsuji Y, Arao Y, Otsuka C, Hamano Y, Ogita M, Kobayashi S, di Luccio E, Hirotsu T, Doki Y, Eguchi H, Satoh T, Uchida S, Ishii H
Biomolecules 2022 Oct 17;12(10) doi: 10.3390/biom12101503. PMID: 36291712Free PMC Article
Bardia A, Messersmith WA, Kio EA, Berlin JD, Vahdat L, Masters GA, Moroose R, Santin AD, Kalinsky K, Picozzi V, O'Shaughnessy J, Gray JE, Komiya T, Lang JM, Chang JC, Starodub A, Goldenberg DM, Sharkey RM, Maliakal P, Hong Q, Wegener WA, Goswami T, Ocean AJ
Ann Oncol 2021 Jun;32(6):746-756. Epub 2021 Mar 16 doi: 10.1016/j.annonc.2021.03.005. PMID: 33741442
Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, Farabaugh CS, Moon E, Levine BL, Melenhorst JJ, Plesa G, June CH, Albelda SM, Beatty GL
Mol Ther 2019 Nov 6;27(11):1919-1929. Epub 2019 Jul 30 doi: 10.1016/j.ymthe.2019.07.015. PMID: 31420241Free PMC Article
Beatty GL, O'Hara MH, Lacey SF, Torigian DA, Nazimuddin F, Chen F, Kulikovskaya IM, Soulen MC, McGarvey M, Nelson AM, Gladney WL, Levine BL, Melenhorst JJ, Plesa G, June CH
Gastroenterology 2018 Jul;155(1):29-32. Epub 2018 Mar 20 doi: 10.1053/j.gastro.2018.03.029. PMID: 29567081Free PMC Article
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA
Science 2009 Jun 12;324(5933):1457-61. Epub 2009 May 21 doi: 10.1126/science.1171362. PMID: 19460966Free PMC Article

Prognosis

Yamamoto Y, Kasashima H, Fukui Y, Tsujio G, Yashiro M, Maeda K
Cancer Sci 2023 Jan;114(1):16-24. Epub 2022 Oct 19 doi: 10.1111/cas.15609. PMID: 36197901Free PMC Article
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Nat Genet 2022 Aug;54(8):1178-1191. Epub 2022 Jul 28 doi: 10.1038/s41588-022-01134-8. PMID: 35902743Free PMC Article
Lumibao JC, Tremblay JR, Hsu J, Engle DD
J Exp Med 2022 Jun 6;219(6) Epub 2022 May 6 doi: 10.1084/jem.20211505. PMID: 35522218Free PMC Article
Li J, Yuan S, Norgard RJ, Yan F, Sun YH, Kim IK, Merrell AJ, Sela Y, Jiang Y, Bhanu NV, Garcia BA, Vonderheide RH, Blanco A, Stanger BZ
Cancer Discov 2021 Mar;11(3):736-753. Epub 2020 Nov 6 doi: 10.1158/2159-8290.CD-20-0519. PMID: 33158848Free PMC Article
Beatty GL, O'Hara MH, Lacey SF, Torigian DA, Nazimuddin F, Chen F, Kulikovskaya IM, Soulen MC, McGarvey M, Nelson AM, Gladney WL, Levine BL, Melenhorst JJ, Plesa G, June CH
Gastroenterology 2018 Jul;155(1):29-32. Epub 2018 Mar 20 doi: 10.1053/j.gastro.2018.03.029. PMID: 29567081Free PMC Article

Clinical prediction guides

Kong W, Liu Z, Sun M, Liu H, Kong C, Ma J, Wang R, Qian F
Cancer Lett 2022 Jul 28;539:215718. Epub 2022 May 5 doi: 10.1016/j.canlet.2022.215718. PMID: 35526650
Zhang Y, Liu Q, Cui M, Wang M, Hua S, Gao J, Liao Q
Front Immunol 2021;12:774435. Epub 2022 Jan 3 doi: 10.3389/fimmu.2021.774435. PMID: 35046938Free PMC Article
Fraunhoffer NA, Abuelafia AM, Teyssedou C, Chuluyan E, Bigonnet M, Palazzo L, Gayet O, Nicolle R, Cros J, Iovanna J, Dusetti N
Eur J Cancer 2021 Sep;155:42-53. Epub 2021 Aug 1 doi: 10.1016/j.ejca.2021.06.038. PMID: 34348180
Li R, He Y, Zhang H, Wang J, Liu X, Liu H, Wu H, Liang Z
Front Immunol 2021;12:690056. Epub 2021 Jul 15 doi: 10.3389/fimmu.2021.690056. PMID: 34335594Free PMC Article
Liudahl SM, Betts CB, Sivagnanam S, Morales-Oyarvide V, da Silva A, Yuan C, Hwang S, Grossblatt-Wait A, Leis KR, Larson W, Lavoie MB, Robinson P, Dias Costa A, Väyrynen SA, Clancy TE, Rubinson DA, Link J, Keith D, Horton W, Tempero MA, Vonderheide RH, Jaffee EM, Sheppard B, Goecks J, Sears RC, Park BS, Mori M, Nowak JA, Wolpin BM, Coussens LM
Cancer Discov 2021 Aug;11(8):2014-2031. Epub 2021 Mar 16 doi: 10.1158/2159-8290.CD-20-0841. PMID: 33727309Free PMC Article

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