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Microinvasive Anal Carcinoma

MedGen UID:
1714727
•Concept ID:
C5238485
•
Neoplastic Process

Definition

Anal carcinoma with minimal stromal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicroinvasive Anal Carcinoma

Professional guidelines

PubMed

Five year experience of the treatment of squamous cell carcinoma of the anus.
Leo CA, Santorelli C, Hodgkinson JD, Bidovaneta O, Baldelli F, Cantarella F, Cavazzoni E
G Chir 2017 Jul-Aug;38(4):176-180. doi: 10.11138/gchir/2017.38.4.176. PMID: 29182899Free PMC Article

Recent clinical studies

Etiology

Five year experience of the treatment of squamous cell carcinoma of the anus.
Leo CA, Santorelli C, Hodgkinson JD, Bidovaneta O, Baldelli F, Cantarella F, Cavazzoni E
G Chir 2017 Jul-Aug;38(4):176-180. doi: 10.11138/gchir/2017.38.4.176. PMID: 29182899Free PMC Article
Establishing an anal dysplasia clinic for HIV-infected men: initial experience.
Siekas LL, Aboulafia DM
AIDS Read 2009 May;19(5):178-86. PMID: 19554736
Histological features of human papilloma virus 16 and its association with the development and progression of anal squamous cell carcinoma.
Kagawa R, Yamaguchi T, Furuta R
Surg Today 2006;36(10):885-91. doi: 10.1007/s00595-006-3266-x. PMID: 16998682
AgNOR analysis of atypical ductal hyperplasia and intraductal carcinoma of the breast.
Guski H, Hufnagl P, Kaufmann O, Krause M, Winzer KJ
Anal Quant Cytol Histol 2000 Jun;22(3):206-12. PMID: 10872036
Proliferative epidermal lesions associated with anogenital Paget's disease.
Brainard JA, Hart WR
Am J Surg Pathol 2000 Apr;24(4):543-52. doi: 10.1097/00000478-200004000-00008. PMID: 10757401

Diagnosis

Five year experience of the treatment of squamous cell carcinoma of the anus.
Leo CA, Santorelli C, Hodgkinson JD, Bidovaneta O, Baldelli F, Cantarella F, Cavazzoni E
G Chir 2017 Jul-Aug;38(4):176-180. doi: 10.11138/gchir/2017.38.4.176. PMID: 29182899Free PMC Article
Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report.
Nahas SC, Nahas CS, Silva Filho EV, Levi JE, Atui FC, Marques CF
Sao Paulo Med J 2007 Sep 6;125(5):292-4. doi: 10.1590/s1516-31802007000500009. PMID: 18094898
Correlation of immunochemical detection of HPV L1 capsid protein in pap smears with regression of high-risk HPV positive mild/moderate dysplasia.
Griesser H, Sander H, Hilfrich R, Moser B, Schenck U
Anal Quant Cytol Histol 2004 Oct;26(5):241-5. PMID: 15560527
AgNOR analysis of atypical ductal hyperplasia and intraductal carcinoma of the breast.
Guski H, Hufnagl P, Kaufmann O, Krause M, Winzer KJ
Anal Quant Cytol Histol 2000 Jun;22(3):206-12. PMID: 10872036
Proliferative epidermal lesions associated with anogenital Paget's disease.
Brainard JA, Hart WR
Am J Surg Pathol 2000 Apr;24(4):543-52. doi: 10.1097/00000478-200004000-00008. PMID: 10757401

Therapy

Involved-field, low-dose chemoradiotherapy for early-stage anal carcinoma.
Hatfield P, Cooper R, Sebag-Montefiore D
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):419-24. Epub 2007 Oct 24 doi: 10.1016/j.ijrobp.2007.06.072. PMID: 17919842
Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report.
Nahas SC, Nahas CS, Silva Filho EV, Levi JE, Atui FC, Marques CF
Sao Paulo Med J 2007 Sep 6;125(5):292-4. doi: 10.1590/s1516-31802007000500009. PMID: 18094898
Topical 5-fluorouracil in the management of extensive anal Bowen's disease: a preferred approach.
Graham BD, Jetmore AB, Foote JE, Arnold LK
Dis Colon Rectum 2005 Mar;48(3):444-50. doi: 10.1007/s10350-004-0901-8. PMID: 15747068
Chromatin texture in high grade prostatic intraepithelial neoplasia and early invasive carcinoma.
da Silva VD, Montironi R, Thompson D, Bartels HG, Vaught L, Hamilton PW, Bartels PH
Anal Quant Cytol Histol 1999 Apr;21(2):113-20. PMID: 10560478

Prognosis

Establishing an anal dysplasia clinic for HIV-infected men: initial experience.
Siekas LL, Aboulafia DM
AIDS Read 2009 May;19(5):178-86. PMID: 19554736
Involved-field, low-dose chemoradiotherapy for early-stage anal carcinoma.
Hatfield P, Cooper R, Sebag-Montefiore D
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):419-24. Epub 2007 Oct 24 doi: 10.1016/j.ijrobp.2007.06.072. PMID: 17919842
Histological features of human papilloma virus 16 and its association with the development and progression of anal squamous cell carcinoma.
Kagawa R, Yamaguchi T, Furuta R
Surg Today 2006;36(10):885-91. doi: 10.1007/s00595-006-3266-x. PMID: 16998682
AgNOR analysis of atypical ductal hyperplasia and intraductal carcinoma of the breast.
Guski H, Hufnagl P, Kaufmann O, Krause M, Winzer KJ
Anal Quant Cytol Histol 2000 Jun;22(3):206-12. PMID: 10872036
Preservation of anal function after total excision of the anal mucosa for Bowen's disease.
Reynolds VH, Madden JJ, Franklin JD, Burnett LS, Jones HW 3rd, Lynch JB
Ann Surg 1984 May;199(5):563-8. doi: 10.1097/00000658-198405000-00011. PMID: 6372711Free PMC Article

Clinical prediction guides

Values of 5mC, 5hmC, and TET2 for identifying the presence and progression of breast precancerous lesion.
Zhang Z, Jin Y, Zhang W, Chu C, Zhang K, Gao X, Zhou J, Zou L, Tang F, Wang H, Zou Q
J Clin Lab Anal 2020 May;34(5):e23162. Epub 2019 Dec 22 doi: 10.1002/jcla.23162. PMID: 31867779Free PMC Article
Adenocarcinoma in a hemorrhoidectomy specimen: case report and review of the literature.
Timaran CH, Sangwan YP, Solla JA
Am Surg 2000 Aug;66(8):789-92. PMID: 10966042
Intraepithelial neoplasia of the anal canal in hemorrhoidal tissue: a study of 19 cases.
Foust RL, Dean PJ, Stoler MH, Moinuddin SM
Hum Pathol 1991 Jun;22(6):528-34. doi: 10.1016/0046-8177(91)90228-h. PMID: 1650751
DNA profiles in dysplasia and carcinoma of the human esophagus.
Rubio CA, Auer GU, Kato Y, Liu FS
Anal Quant Cytol Histol 1988 Jun;10(3):207-10. PMID: 3408547
Preservation of anal function after total excision of the anal mucosa for Bowen's disease.
Reynolds VH, Madden JJ, Franklin JD, Burnett LS, Jones HW 3rd, Lynch JB
Ann Surg 1984 May;199(5):563-8. doi: 10.1097/00000658-198405000-00011. PMID: 6372711Free PMC Article

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