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Recurrent Acute Megakaryoblastic Leukemia

MedGen UID:
1718677
Concept ID:
C2367455
Neoplastic Process
Synonym: Relapsed Acute Megakaryoblastic Leukemia

Definition

The reemergence of acute megakaryoblastic leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Megakaryoblastic Leukemia

Professional guidelines

PubMed

Barwe SP, Kolb EA, Gopalakrishnapillai A
Blood Rev 2024 Mar;64:101154. Epub 2023 Nov 25 doi: 10.1016/j.blre.2023.101154. PMID: 38016838
De Marchi F, Araki M, Komatsu N
Expert Rev Hematol 2019 May;12(5):285-293. Epub 2019 Apr 27 doi: 10.1080/17474086.2019.1609351. PMID: 30991862
Bae E, Park CJ, Cho YU, Seo EJ, Chi HS, Jang S, Lee KH, Lee JH, Lee JH, Suh JJ, Im HJ
Int J Lab Hematol 2013 Dec;35(6):629-36. Epub 2013 May 22 doi: 10.1111/ijlh.12101. PMID: 23693053

Recent clinical studies

Etiology

Pastore F, Gittinger H, Raab S, Tschuri S, Ksienzyk B, Konstandin NP, Schneider S, Rothenberg-Thurley M, Horny HP, Werner M, Sauerland MC, Amler S, Görlich D, Berdel WE, Wörmann B, Braess J, Hiddemann W, Tischer J, Herold T, Metzeler KH, Spiekermann K
Br J Haematol 2023 Sep;202(6):1165-1177. Epub 2023 Jul 16 doi: 10.1111/bjh.18982. PMID: 37455345
Lalonde E, Rentas S, Wertheim G, Cao K, Surrey LF, Lin F, Zhao X, Obstfeld A, Aplenc R, Luo M, Li MM
Cold Spring Harb Mol Case Stud 2021 Apr;7(2) Epub 2021 Apr 8 doi: 10.1101/mcs.a005975. PMID: 33832921Free PMC Article
Panda D, Chatterjee G, Sardana R, Khanka T, Ghogale S, Deshpande N, Badrinath Y, Shetty D, Narula G, Banavali S, Patkar NV, Gujral S, Subramanian PG, Tembhare PR
Cytometry B Clin Cytom 2021 Mar;100(2):206-217. Epub 2020 Aug 31 doi: 10.1002/cyto.b.21943. PMID: 32865882
Hara Y, Shiba N, Ohki K, Tabuchi K, Yamato G, Park MJ, Tomizawa D, Kinoshita A, Shimada A, Arakawa H, Saito AM, Kiyokawa N, Tawa A, Horibe K, Taga T, Adachi S, Taki T, Hayashi Y
Genes Chromosomes Cancer 2017 May;56(5):394-404. Epub 2017 Feb 14 doi: 10.1002/gcc.22444. PMID: 28063190
Ishiyama K, Yamaguchi T, Eto T, Ohashi K, Uchida N, Kanamori H, Fukuda T, Miyamura K, Inoue Y, Taguchi J, Mori T, Iwato K, Morishima Y, Nagamura-Inoue T, Atsuta Y, Sakamaki H, Takami A
Leuk Res 2016 Aug;47:47-53. Epub 2016 May 12 doi: 10.1016/j.leukres.2016.04.017. PMID: 27244257

Diagnosis

Kerbs P, Vosberg S, Krebs S, Graf A, Blum H, Swoboda A, Batcha AMN, Mansmann U, Metzler D, Heckman CA, Herold T, Greif PA
Haematologica 2022 Jan 1;107(1):100-111. doi: 10.3324/haematol.2021.278436. PMID: 34134471Free PMC Article
Lalonde E, Rentas S, Wertheim G, Cao K, Surrey LF, Lin F, Zhao X, Obstfeld A, Aplenc R, Luo M, Li MM
Cold Spring Harb Mol Case Stud 2021 Apr;7(2) Epub 2021 Apr 8 doi: 10.1101/mcs.a005975. PMID: 33832921Free PMC Article
Qi H, Mao Y, Cao Q, Sun X, Kuai W, Song J, Ma L, Hong Z, Hu J, Zhou G
Med Sci Monit 2020 Jun 13;26:e922662. doi: 10.12659/MSM.922662. PMID: 32532951Free PMC Article
De Marchi F, Araki M, Komatsu N
Expert Rev Hematol 2019 May;12(5):285-293. Epub 2019 Apr 27 doi: 10.1080/17474086.2019.1609351. PMID: 30991862
Lopez CK, Malinge S, Gaudry M, Bernard OA, Mercher T
Trends Cancer 2017 Sep;3(9):631-642. Epub 2017 Aug 18 doi: 10.1016/j.trecan.2017.07.003. PMID: 28867167

Therapy

Pastore F, Gittinger H, Raab S, Tschuri S, Ksienzyk B, Konstandin NP, Schneider S, Rothenberg-Thurley M, Horny HP, Werner M, Sauerland MC, Amler S, Görlich D, Berdel WE, Wörmann B, Braess J, Hiddemann W, Tischer J, Herold T, Metzeler KH, Spiekermann K
Br J Haematol 2023 Sep;202(6):1165-1177. Epub 2023 Jul 16 doi: 10.1111/bjh.18982. PMID: 37455345
Qi H, Mao Y, Cao Q, Sun X, Kuai W, Song J, Ma L, Hong Z, Hu J, Zhou G
Med Sci Monit 2020 Jun 13;26:e922662. doi: 10.12659/MSM.922662. PMID: 32532951Free PMC Article
Janjetovic S, Bacher U, Haalck T, Janning M, Bokemeyer C, Fiedler W
Acta Haematol 2013;129(2):121-5. Epub 2012 Nov 28 doi: 10.1159/000342897. PMID: 23207728
Yeasmin S, Nakayama K, Ishibashi M, Oride A, Katagiri A, Purwana IN, Iida K, Nakayama N, Ishikura H, Miyazaki K
Int J Gynecol Cancer 2008 Nov-Dec;18(6):1371-6. Epub 2008 Jan 23 doi: 10.1111/j.1525-1438.2007.01185.x. PMID: 18217963
Zipursky A, Peeters M, Poon A
Pediatr Hematol Oncol 1987;4(3):211-30. doi: 10.3109/08880018709141272. PMID: 2978961

Prognosis

Barwe SP, Kolb EA, Gopalakrishnapillai A
Blood Rev 2024 Mar;64:101154. Epub 2023 Nov 25 doi: 10.1016/j.blre.2023.101154. PMID: 38016838
Pastore F, Gittinger H, Raab S, Tschuri S, Ksienzyk B, Konstandin NP, Schneider S, Rothenberg-Thurley M, Horny HP, Werner M, Sauerland MC, Amler S, Görlich D, Berdel WE, Wörmann B, Braess J, Hiddemann W, Tischer J, Herold T, Metzeler KH, Spiekermann K
Br J Haematol 2023 Sep;202(6):1165-1177. Epub 2023 Jul 16 doi: 10.1111/bjh.18982. PMID: 37455345
Qi H, Mao Y, Cao Q, Sun X, Kuai W, Song J, Ma L, Hong Z, Hu J, Zhou G
Med Sci Monit 2020 Jun 13;26:e922662. doi: 10.12659/MSM.922662. PMID: 32532951Free PMC Article
De Marchi F, Araki M, Komatsu N
Expert Rev Hematol 2019 May;12(5):285-293. Epub 2019 Apr 27 doi: 10.1080/17474086.2019.1609351. PMID: 30991862
Lopez CK, Malinge S, Gaudry M, Bernard OA, Mercher T
Trends Cancer 2017 Sep;3(9):631-642. Epub 2017 Aug 18 doi: 10.1016/j.trecan.2017.07.003. PMID: 28867167

Clinical prediction guides

Ishiyama K, Yamaguchi T, Eto T, Ohashi K, Uchida N, Kanamori H, Fukuda T, Miyamura K, Inoue Y, Taguchi J, Mori T, Iwato K, Morishima Y, Nagamura-Inoue T, Atsuta Y, Sakamaki H, Takami A
Leuk Res 2016 Aug;47:47-53. Epub 2016 May 12 doi: 10.1016/j.leukres.2016.04.017. PMID: 27244257
de Rooij JD, Masetti R, van den Heuvel-Eibrink MM, Cayuela JM, Trka J, Reinhardt D, Rasche M, Sonneveld E, Alonzo TA, Fornerod M, Zimmermann M, Pigazzi M, Pieters R, Meshinchi S, Zwaan CM, Locatelli F
Blood 2016 Jun 30;127(26):3424-30. Epub 2016 Apr 25 doi: 10.1182/blood-2016-01-695551. PMID: 27114462Free PMC Article
Malinge S, Ragu C, Della-Valle V, Pisani D, Constantinescu SN, Perez C, Villeval JL, Reinhardt D, Landman-Parker J, Michaux L, Dastugue N, Baruchel A, Vainchenker W, Bourquin JP, Penard-Lacronique V, Bernard OA
Blood 2008 Nov 15;112(10):4220-6. Epub 2008 Aug 28 doi: 10.1182/blood-2008-01-136366. PMID: 18755984
Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA
Proc Natl Acad Sci U S A 2001 May 8;98(10):5776-9. doi: 10.1073/pnas.101001498. PMID: 11344311Free PMC Article
Zipursky A, Peeters M, Poon A
Pediatr Hematol Oncol 1987;4(3):211-30. doi: 10.3109/08880018709141272. PMID: 2978961

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