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Unresectable Esophageal Squamous Cell Carcinoma

MedGen UID:
1723894
•Concept ID:
C5419207
•
Neoplastic Process

Definition

Esophageal squamous cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Esophageal Squamous Cell Carcinoma

Professional guidelines

PubMed

Efficacy and survival of nivolumab treatment for recurrent/unresectable esophageal squamous-cell carcinoma: real-world clinical data from a large multi-institutional cohort.
Makino T, Nakai S, Momose K, Yamashita K, Tanaka K, Miyata H, Yamamoto S, Motoori M, Kimura Y, Ushimaru Y, Hirao M, Matsuyama J, Akamaru Y, Kurokawa Y, Eguchi H, Doki Y
Esophagus 2024 Jul;21(3):319-327. Epub 2024 May 8 doi: 10.1007/s10388-024-01056-w. PMID: 38717686Free PMC Article
Treatment patterns and survival in advanced unresectable esophageal squamous cell cancer: A population-based study.
Pape M, Vissers PAJ, de Vos-Geelen J, Hulshof MCCM, Gisbertz SS, Jeene PM, van Laarhoven HWM, Verhoeven RHA
Cancer Sci 2022 Mar;113(3):1038-1046. Epub 2022 Jan 25 doi: 10.1111/cas.15262. PMID: 34986523Free PMC Article
Comparison of the clinical efficacy between single-agent and dual-agent concurrent chemoradiotherapy in the treatment of unresectable esophageal squamous cell carcinoma: a multicenter retrospective analysis.
Li J, Gong Y, Diao P, Huang Q, Wen Y, Lin B, Cai H, Tian H, He B, Ji L, Guo P, Miao J, Du X
Radiat Oncol 2018 Jan 22;13(1):12. doi: 10.1186/s13014-018-0958-5. PMID: 29357883Free PMC Article

Recent clinical studies

Etiology

Nomogram Based on Monocyte-to-Lymphocyte Ratio to Predict Survival of Unresectable Esophageal Squamous Cell Carcinoma Who Receive First-Line PD-1/PD-L1 Inhibitors Combined with Chemotherapy.
Ma X, Ding Y, Qian J, Wan M, Li N, Mao C, Xiao C, Jiang H, Zheng Y, Wu L, Chen X, Xu N
Curr Oncol 2022 Nov 18;29(11):8937-8954. doi: 10.3390/curroncol29110702. PMID: 36421355Free PMC Article
Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Tsuchiya N, Kunisaki C, Sato S, Tanaka Y, Sato K, Watanabe J, Takeda K, Kosaka T, Akiyama H, Endo I
Langenbecks Arch Surg 2022 Aug;407(5):1911-1921. Epub 2022 Mar 1 doi: 10.1007/s00423-022-02445-4. PMID: 35230525
Treatment patterns and survival in advanced unresectable esophageal squamous cell cancer: A population-based study.
Pape M, Vissers PAJ, de Vos-Geelen J, Hulshof MCCM, Gisbertz SS, Jeene PM, van Laarhoven HWM, Verhoeven RHA
Cancer Sci 2022 Mar;113(3):1038-1046. Epub 2022 Jan 25 doi: 10.1111/cas.15262. PMID: 34986523Free PMC Article
Feasibility of conversion thoracoscopic esophagectomy after induction therapy for locally advanced unresectable esophageal squamous cell carcinoma.
Kubo K, Kanematsu K, Kurita D, Ishiyama K, Oguma J, Itami J, Daiko H
Jpn J Clin Oncol 2021 Aug 1;51(8):1225-1231. doi: 10.1093/jjco/hyab085. PMID: 34109411
Chemoradiotherapy for esophageal squamous cell cancer.
Sasaki Y, Kato K
Jpn J Clin Oncol 2016 Sep;46(9):805-10. Epub 2016 Jul 5 doi: 10.1093/jjco/hyw082. PMID: 27380810

Diagnosis

Prognostic factors for esophageal respiratory fistula in unresectable esophageal squamous cell carcinoma treated with radiotherapy.
Qi JC, Zhi L, Li H, Huang Y, Ye Y, Li H, Wang T, Lin L, Zhuang Y
Sci Rep 2024 Jul 26;14(1):17144. doi: 10.1038/s41598-024-67859-0. PMID: 39060397Free PMC Article
Induction immunotherapy plus chemotherapy followed by definitive chemoradiation therapy in locally advanced esophageal squamous cell carcinoma: a propensity-score matched study.
Lian HM, Wu JL, Liufu WJ, Yu TT, Niu SQ, Bao Y, Peng F
Cancer Immunol Immunother 2024 Feb 16;73(3):55. doi: 10.1007/s00262-024-03649-x. PMID: 38366287Free PMC Article
Treatment patterns and survival in advanced unresectable esophageal squamous cell cancer: A population-based study.
Pape M, Vissers PAJ, de Vos-Geelen J, Hulshof MCCM, Gisbertz SS, Jeene PM, van Laarhoven HWM, Verhoeven RHA
Cancer Sci 2022 Mar;113(3):1038-1046. Epub 2022 Jan 25 doi: 10.1111/cas.15262. PMID: 34986523Free PMC Article
Prognostic impact of eosinophils in peripheral blood and tumor site in patients with esophageal squamous cell carcinoma treated with concurrent chemoradiotherapy.
Yang X, Wang L, Du H, Lin B, Yi J, Wen X, Geng L, Du X
Medicine (Baltimore) 2021 Jan 22;100(3):e24328. doi: 10.1097/MD.0000000000024328. PMID: 33546064Free PMC Article
Involved-field irradiation in definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma.
Zhang X, Li M, Meng X, Kong L, Zhang Y, Wei G, Zhang X, Shi F, Hu M, Zhang G, Yu J
Radiat Oncol 2014 Feb 26;9:64. doi: 10.1186/1748-717X-9-64. PMID: 24571804Free PMC Article

Therapy

Efficacy and survival of nivolumab treatment for recurrent/unresectable esophageal squamous-cell carcinoma: real-world clinical data from a large multi-institutional cohort.
Makino T, Nakai S, Momose K, Yamashita K, Tanaka K, Miyata H, Yamamoto S, Motoori M, Kimura Y, Ushimaru Y, Hirao M, Matsuyama J, Akamaru Y, Kurokawa Y, Eguchi H, Doki Y
Esophagus 2024 Jul;21(3):319-327. Epub 2024 May 8 doi: 10.1007/s10388-024-01056-w. PMID: 38717686Free PMC Article
Benefits of camrelizumab plus carboplatin and albumin paclitaxel as induction therapy for locally advanced borderline resectable or unresectable esophageal squamous cell carcinoma.
Chao L, Liu J, Chen Y, Fan Y, Guo S, Zhang S
Thorac Cancer 2024 Mar;15(8):622-629. Epub 2024 Feb 5 doi: 10.1111/1759-7714.15232. PMID: 38316630Free PMC Article
Docetaxel, Cisplatin, and 5-FU Triplet Therapy as Conversion Therapy for Locoregionally Advanced Unresectable Esophageal Squamous Cell Carcinoma.
Chan WL, Choi CW, Wong IY, Tsang TH, Lam AT, Tse RP, Chan KK, Wong C, Law BT, Cheung EE, Chan SY, Lam KO, Kwong D, Law S
Ann Surg Oncol 2023 Feb;30(2):861-870. Epub 2022 Oct 28 doi: 10.1245/s10434-022-12694-8. PMID: 36307666
Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Tsuchiya N, Kunisaki C, Sato S, Tanaka Y, Sato K, Watanabe J, Takeda K, Kosaka T, Akiyama H, Endo I
Langenbecks Arch Surg 2022 Aug;407(5):1911-1921. Epub 2022 Mar 1 doi: 10.1007/s00423-022-02445-4. PMID: 35230525
Chemoradiotherapy for esophageal squamous cell cancer.
Sasaki Y, Kato K
Jpn J Clin Oncol 2016 Sep;46(9):805-10. Epub 2016 Jul 5 doi: 10.1093/jjco/hyw082. PMID: 27380810

Prognosis

Docetaxel, Cisplatin, and 5-FU Triplet Therapy as Conversion Therapy for Locoregionally Advanced Unresectable Esophageal Squamous Cell Carcinoma.
Chan WL, Choi CW, Wong IY, Tsang TH, Lam AT, Tse RP, Chan KK, Wong C, Law BT, Cheung EE, Chan SY, Lam KO, Kwong D, Law S
Ann Surg Oncol 2023 Feb;30(2):861-870. Epub 2022 Oct 28 doi: 10.1245/s10434-022-12694-8. PMID: 36307666
Nomogram Based on Monocyte-to-Lymphocyte Ratio to Predict Survival of Unresectable Esophageal Squamous Cell Carcinoma Who Receive First-Line PD-1/PD-L1 Inhibitors Combined with Chemotherapy.
Ma X, Ding Y, Qian J, Wan M, Li N, Mao C, Xiao C, Jiang H, Zheng Y, Wu L, Chen X, Xu N
Curr Oncol 2022 Nov 18;29(11):8937-8954. doi: 10.3390/curroncol29110702. PMID: 36421355Free PMC Article
Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Tsuchiya N, Kunisaki C, Sato S, Tanaka Y, Sato K, Watanabe J, Takeda K, Kosaka T, Akiyama H, Endo I
Langenbecks Arch Surg 2022 Aug;407(5):1911-1921. Epub 2022 Mar 1 doi: 10.1007/s00423-022-02445-4. PMID: 35230525
Treatment patterns and survival in advanced unresectable esophageal squamous cell cancer: A population-based study.
Pape M, Vissers PAJ, de Vos-Geelen J, Hulshof MCCM, Gisbertz SS, Jeene PM, van Laarhoven HWM, Verhoeven RHA
Cancer Sci 2022 Mar;113(3):1038-1046. Epub 2022 Jan 25 doi: 10.1111/cas.15262. PMID: 34986523Free PMC Article
Chemoradiotherapy for esophageal squamous cell cancer.
Sasaki Y, Kato K
Jpn J Clin Oncol 2016 Sep;46(9):805-10. Epub 2016 Jul 5 doi: 10.1093/jjco/hyw082. PMID: 27380810

Clinical prediction guides

Prognostic factors for esophageal respiratory fistula in unresectable esophageal squamous cell carcinoma treated with radiotherapy.
Qi JC, Zhi L, Li H, Huang Y, Ye Y, Li H, Wang T, Lin L, Zhuang Y
Sci Rep 2024 Jul 26;14(1):17144. doi: 10.1038/s41598-024-67859-0. PMID: 39060397Free PMC Article
Efficacy and survival of nivolumab treatment for recurrent/unresectable esophageal squamous-cell carcinoma: real-world clinical data from a large multi-institutional cohort.
Makino T, Nakai S, Momose K, Yamashita K, Tanaka K, Miyata H, Yamamoto S, Motoori M, Kimura Y, Ushimaru Y, Hirao M, Matsuyama J, Akamaru Y, Kurokawa Y, Eguchi H, Doki Y
Esophagus 2024 Jul;21(3):319-327. Epub 2024 May 8 doi: 10.1007/s10388-024-01056-w. PMID: 38717686Free PMC Article
Benefits of camrelizumab plus carboplatin and albumin paclitaxel as induction therapy for locally advanced borderline resectable or unresectable esophageal squamous cell carcinoma.
Chao L, Liu J, Chen Y, Fan Y, Guo S, Zhang S
Thorac Cancer 2024 Mar;15(8):622-629. Epub 2024 Feb 5 doi: 10.1111/1759-7714.15232. PMID: 38316630Free PMC Article
Nomogram Based on Monocyte-to-Lymphocyte Ratio to Predict Survival of Unresectable Esophageal Squamous Cell Carcinoma Who Receive First-Line PD-1/PD-L1 Inhibitors Combined with Chemotherapy.
Ma X, Ding Y, Qian J, Wan M, Li N, Mao C, Xiao C, Jiang H, Zheng Y, Wu L, Chen X, Xu N
Curr Oncol 2022 Nov 18;29(11):8937-8954. doi: 10.3390/curroncol29110702. PMID: 36421355Free PMC Article
Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Tsuchiya N, Kunisaki C, Sato S, Tanaka Y, Sato K, Watanabe J, Takeda K, Kosaka T, Akiyama H, Endo I
Langenbecks Arch Surg 2022 Aug;407(5):1911-1921. Epub 2022 Mar 1 doi: 10.1007/s00423-022-02445-4. PMID: 35230525

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