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Unresectable Esophageal Squamous Cell Carcinoma

MedGen UID:
1723894
•Concept ID:
C5419207
•
Neoplastic Process

Definition

Esophageal squamous cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Esophageal Squamous Cell Carcinoma

Professional guidelines

PubMed

Treatment patterns and survival in advanced unresectable esophageal squamous cell cancer: A population-based study.
Pape M, Vissers PAJ, de Vos-Geelen J, Hulshof MCCM, Gisbertz SS, Jeene PM, van Laarhoven HWM, Verhoeven RHA
Cancer Sci 2022 Mar;113(3):1038-1046. Epub 2022 Jan 25 doi: 10.1111/cas.15262. PMID: 34986523Free PMC Article
Comparison of the clinical efficacy between single-agent and dual-agent concurrent chemoradiotherapy in the treatment of unresectable esophageal squamous cell carcinoma: a multicenter retrospective analysis.
Li J, Gong Y, Diao P, Huang Q, Wen Y, Lin B, Cai H, Tian H, He B, Ji L, Guo P, Miao J, Du X
Radiat Oncol 2018 Jan 22;13(1):12. doi: 10.1186/s13014-018-0958-5. PMID: 29357883Free PMC Article

Recent clinical studies

Etiology

Nomogram Based on Monocyte-to-Lymphocyte Ratio to Predict Survival of Unresectable Esophageal Squamous Cell Carcinoma Who Receive First-Line PD-1/PD-L1 Inhibitors Combined with Chemotherapy.
Ma X, Ding Y, Qian J, Wan M, Li N, Mao C, Xiao C, Jiang H, Zheng Y, Wu L, Chen X, Xu N
Curr Oncol 2022 Nov 18;29(11):8937-8954. doi: 10.3390/curroncol29110702. PMID: 36421355Free PMC Article
Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Tsuchiya N, Kunisaki C, Sato S, Tanaka Y, Sato K, Watanabe J, Takeda K, Kosaka T, Akiyama H, Endo I
Langenbecks Arch Surg 2022 Aug;407(5):1911-1921. Epub 2022 Mar 1 doi: 10.1007/s00423-022-02445-4. PMID: 35230525
Treatment patterns and survival in advanced unresectable esophageal squamous cell cancer: A population-based study.
Pape M, Vissers PAJ, de Vos-Geelen J, Hulshof MCCM, Gisbertz SS, Jeene PM, van Laarhoven HWM, Verhoeven RHA
Cancer Sci 2022 Mar;113(3):1038-1046. Epub 2022 Jan 25 doi: 10.1111/cas.15262. PMID: 34986523Free PMC Article
Feasibility of conversion thoracoscopic esophagectomy after induction therapy for locally advanced unresectable esophageal squamous cell carcinoma.
Kubo K, Kanematsu K, Kurita D, Ishiyama K, Oguma J, Itami J, Daiko H
Jpn J Clin Oncol 2021 Aug 1;51(8):1225-1231. doi: 10.1093/jjco/hyab085. PMID: 34109411
Chemoradiotherapy for esophageal squamous cell cancer.
Sasaki Y, Kato K
Jpn J Clin Oncol 2016 Sep;46(9):805-10. Epub 2016 Jul 5 doi: 10.1093/jjco/hyw082. PMID: 27380810

Diagnosis

Treatment patterns and survival in advanced unresectable esophageal squamous cell cancer: A population-based study.
Pape M, Vissers PAJ, de Vos-Geelen J, Hulshof MCCM, Gisbertz SS, Jeene PM, van Laarhoven HWM, Verhoeven RHA
Cancer Sci 2022 Mar;113(3):1038-1046. Epub 2022 Jan 25 doi: 10.1111/cas.15262. PMID: 34986523Free PMC Article
Prognostic impact of eosinophils in peripheral blood and tumor site in patients with esophageal squamous cell carcinoma treated with concurrent chemoradiotherapy.
Yang X, Wang L, Du H, Lin B, Yi J, Wen X, Geng L, Du X
Medicine (Baltimore) 2021 Jan 22;100(3):e24328. doi: 10.1097/MD.0000000000024328. PMID: 33546064Free PMC Article
Prognostic value of lymph node to primary tumor standardized uptake value ratio in unresectable esophageal cancer.
Chen PJ, Yap WK, Chang YC, Tseng CK, Chao YK, Hsieh JC, Pai PC, Lee CH, Yang CK, Ho AT, Hung TM
BMC Cancer 2020 Jun 10;20(1):545. doi: 10.1186/s12885-020-07044-4. PMID: 32522275Free PMC Article
Concurrent cisplatin and 5-fluorouracil versus concurrent cisplatin and docetaxel with radiotherapy for esophageal squamous cell carcinoma: a propensity score-matched analysis.
Zhang P, Xi M, Li QQ, Hu YH, Guo X, Zhao L, Liu H, Liu SL, Luo LL, Liu Q, Liu MZ
Oncotarget 2016 Jul 12;7(28):44686-44694. doi: 10.18632/oncotarget.9301. PMID: 27183916Free PMC Article
Involved-field irradiation in definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma.
Zhang X, Li M, Meng X, Kong L, Zhang Y, Wei G, Zhang X, Shi F, Hu M, Zhang G, Yu J
Radiat Oncol 2014 Feb 26;9:64. doi: 10.1186/1748-717X-9-64. PMID: 24571804Free PMC Article

Therapy

Benefits of camrelizumab plus carboplatin and albumin paclitaxel as induction therapy for locally advanced borderline resectable or unresectable esophageal squamous cell carcinoma.
Chao L, Liu J, Chen Y, Fan Y, Guo S, Zhang S
Thorac Cancer 2024 Mar;15(8):622-629. Epub 2024 Feb 5 doi: 10.1111/1759-7714.15232. PMID: 38316630Free PMC Article
Docetaxel, Cisplatin, and 5-FU Triplet Therapy as Conversion Therapy for Locoregionally Advanced Unresectable Esophageal Squamous Cell Carcinoma.
Chan WL, Choi CW, Wong IY, Tsang TH, Lam AT, Tse RP, Chan KK, Wong C, Law BT, Cheung EE, Chan SY, Lam KO, Kwong D, Law S
Ann Surg Oncol 2023 Feb;30(2):861-870. Epub 2022 Oct 28 doi: 10.1245/s10434-022-12694-8. PMID: 36307666
Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Tsuchiya N, Kunisaki C, Sato S, Tanaka Y, Sato K, Watanabe J, Takeda K, Kosaka T, Akiyama H, Endo I
Langenbecks Arch Surg 2022 Aug;407(5):1911-1921. Epub 2022 Mar 1 doi: 10.1007/s00423-022-02445-4. PMID: 35230525
Safety of thoracoscopic esophagectomy after induction chemotherapy for locally advanced unresectable esophageal squamous cell carcinoma.
Akiyama Y, Iwaya T, Endo F, Nikai H, Baba S, Chiba T, Kimura T, Takahara T, Otsuka K, Nitta H, Mizuno M, Kimura Y, Koeda K, Sasaki A
Asian J Endosc Surg 2020 Apr;13(2):152-159. Epub 2019 Jul 16 doi: 10.1111/ases.12731. PMID: 31313511
Chemoradiotherapy for esophageal squamous cell cancer.
Sasaki Y, Kato K
Jpn J Clin Oncol 2016 Sep;46(9):805-10. Epub 2016 Jul 5 doi: 10.1093/jjco/hyw082. PMID: 27380810

Prognosis

Docetaxel, Cisplatin, and 5-FU Triplet Therapy as Conversion Therapy for Locoregionally Advanced Unresectable Esophageal Squamous Cell Carcinoma.
Chan WL, Choi CW, Wong IY, Tsang TH, Lam AT, Tse RP, Chan KK, Wong C, Law BT, Cheung EE, Chan SY, Lam KO, Kwong D, Law S
Ann Surg Oncol 2023 Feb;30(2):861-870. Epub 2022 Oct 28 doi: 10.1245/s10434-022-12694-8. PMID: 36307666
Nomogram Based on Monocyte-to-Lymphocyte Ratio to Predict Survival of Unresectable Esophageal Squamous Cell Carcinoma Who Receive First-Line PD-1/PD-L1 Inhibitors Combined with Chemotherapy.
Ma X, Ding Y, Qian J, Wan M, Li N, Mao C, Xiao C, Jiang H, Zheng Y, Wu L, Chen X, Xu N
Curr Oncol 2022 Nov 18;29(11):8937-8954. doi: 10.3390/curroncol29110702. PMID: 36421355Free PMC Article
Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Tsuchiya N, Kunisaki C, Sato S, Tanaka Y, Sato K, Watanabe J, Takeda K, Kosaka T, Akiyama H, Endo I
Langenbecks Arch Surg 2022 Aug;407(5):1911-1921. Epub 2022 Mar 1 doi: 10.1007/s00423-022-02445-4. PMID: 35230525
Treatment patterns and survival in advanced unresectable esophageal squamous cell cancer: A population-based study.
Pape M, Vissers PAJ, de Vos-Geelen J, Hulshof MCCM, Gisbertz SS, Jeene PM, van Laarhoven HWM, Verhoeven RHA
Cancer Sci 2022 Mar;113(3):1038-1046. Epub 2022 Jan 25 doi: 10.1111/cas.15262. PMID: 34986523Free PMC Article
Chemoradiotherapy for esophageal squamous cell cancer.
Sasaki Y, Kato K
Jpn J Clin Oncol 2016 Sep;46(9):805-10. Epub 2016 Jul 5 doi: 10.1093/jjco/hyw082. PMID: 27380810

Clinical prediction guides

Nomogram Based on Monocyte-to-Lymphocyte Ratio to Predict Survival of Unresectable Esophageal Squamous Cell Carcinoma Who Receive First-Line PD-1/PD-L1 Inhibitors Combined with Chemotherapy.
Ma X, Ding Y, Qian J, Wan M, Li N, Mao C, Xiao C, Jiang H, Zheng Y, Wu L, Chen X, Xu N
Curr Oncol 2022 Nov 18;29(11):8937-8954. doi: 10.3390/curroncol29110702. PMID: 36421355Free PMC Article
Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Tsuchiya N, Kunisaki C, Sato S, Tanaka Y, Sato K, Watanabe J, Takeda K, Kosaka T, Akiyama H, Endo I
Langenbecks Arch Surg 2022 Aug;407(5):1911-1921. Epub 2022 Mar 1 doi: 10.1007/s00423-022-02445-4. PMID: 35230525
Prognostic impact of eosinophils in peripheral blood and tumor site in patients with esophageal squamous cell carcinoma treated with concurrent chemoradiotherapy.
Yang X, Wang L, Du H, Lin B, Yi J, Wen X, Geng L, Du X
Medicine (Baltimore) 2021 Jan 22;100(3):e24328. doi: 10.1097/MD.0000000000024328. PMID: 33546064Free PMC Article
Icotinib With Concurrent Radiotherapy vs Radiotherapy Alone in Older Adults With Unresectable Esophageal Squamous Cell Carcinoma: A Phase II Randomized Clinical Trial.
Luo H, Jiang W, Ma L, Chen P, Fang M, Ding L, Hua Y, Du D, Jing Z, Xie R, Song Y, Wang J, Zhou R, Tian Z, Wu S
JAMA Netw Open 2020 Oct 1;3(10):e2019440. doi: 10.1001/jamanetworkopen.2020.19440. PMID: 33026449Free PMC Article
Risk factors for esophageal fistula in thoracic esophageal squamous cell carcinoma invading adjacent organs treated with definitive chemoradiotherapy: a monocentric case-control study.
Kawakami T, Tsushima T, Omae K, Ogawa H, Shirasu H, Kito Y, Yoshida Y, Hamauchi S, Todaka A, Machida N, Yokota T, Yamazaki K, Fukutomi A, Onozawa Y, Yasui H
BMC Cancer 2018 May 18;18(1):573. doi: 10.1186/s12885-018-4486-3. PMID: 29776344Free PMC Article

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