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Unresectable Uveal Melanoma

MedGen UID:
1726417
Concept ID:
C5419539
Neoplastic Process

Definition

Uveal melanoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Uveal Melanoma

Professional guidelines

PubMed

Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
Wang Z, Xie Y, Wang JQ, Cheng Y, Fleishman J, Chen ZS, Chen Y
Drugs Today (Barc) 2023 Mar;59(3):179-193. doi: 10.1358/dot.2023.59.3.3542417. PMID: 36847626
Chen LN, Carvajal RD
Expert Rev Anticancer Ther 2022 Oct;22(10):1017-1027. Epub 2022 Sep 19 doi: 10.1080/14737140.2022.2124971. PMID: 36102132Free PMC Article

Recent clinical studies

Etiology

Hassel JC, Piperno-Neumann S, Rutkowski P, Baurain JF, Schlaak M, Butler MO, Sullivan RJ, Dummer R, Kirkwood JM, Orloff M, Sacco JJ, Ochsenreither S, Joshua AM, Gastaud L, Curti B, Piulats JM, Salama AKS, Shoushtari AN, Demidov L, Milhem M, Chmielowski B, Kim KB, Carvajal RD, Hamid O, Collins L, Ranade K, Holland C, Pfeiffer C, Nathan P
N Engl J Med 2023 Dec 14;389(24):2256-2266. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2304753. PMID: 37870955
Dummer R, Corrie P, Gutzmer R, Meniawy TM, Del Vecchio M, Lebbé C, Guida M, Dutriaux C, Dreno B, Meyer N, Ferrucci PF, Dalle S, Khattak MA, Grob JJ, Briscoe K, Larkin J, Mansard S, Lesimple T, Guidoboni M, Sabatini S, Richtig E, Herbst R, Lobo M, Askelson M, Ascierto PA, Maio M
J Clin Oncol 2023 Aug 10;41(23):3917-3929. Epub 2023 Jun 12 doi: 10.1200/JCO.22.02199. PMID: 37307514
Tong TML, Samim M, Kapiteijn E, Meijer TS, Speetjens FM, Brüning R, Schroeder TH, El-Sanosy S, Maschke H, Wacker FK, Vogel A, Dewald CLA, Goeman JJ, Burgmans MC
Cardiovasc Intervent Radiol 2022 Sep;45(9):1304-1313. Epub 2022 Aug 3 doi: 10.1007/s00270-022-03225-9. PMID: 35922562Free PMC Article
Steeb T, Wessely A, Ruzicka T, Heppt MV, Berking C
Eur J Cancer 2018 Nov;103:41-51. Epub 2018 Sep 8 doi: 10.1016/j.ejca.2018.08.005. PMID: 30205280
Karydis I, Gangi A, Wheater MJ, Choi J, Wilson I, Thomas K, Pearce N, Takhar A, Gupta S, Hardman D, Sileno S, Stedman B, Zager JS, Ottensmeier C
J Surg Oncol 2018 May;117(6):1170-1178. Epub 2017 Dec 28 doi: 10.1002/jso.24956. PMID: 29284076Free PMC Article

Diagnosis

Nomura M, Oze I, Masuishi T, Yokota T, Satake H, Iwasawa S, Kato K, Andoh M
Int J Clin Oncol 2020 May;25(5):972-977. Epub 2020 Jan 14 doi: 10.1007/s10147-020-01618-9. PMID: 31938955
Zhuo H, Zhou L
Pharmazie 2016 Oct 1;71(10):555-561. doi: 10.1691/ph.2016.6683. PMID: 29441921
de Leede EM, Burgmans MC, Kapiteijn E, Luyten GP, Jager MJ, Tijl FG, Hartgrink HH, Grünhagen DJ, Rothbarth J, van de Velde CJ, Verhoef C, Vahrmeijer AL
Melanoma Res 2016 Dec;26(6):588-594. doi: 10.1097/CMR.0000000000000286. PMID: 27513071
Kottschade LA, McWilliams RR, Markovic SN, Block MS, Villasboas Bisneto J, Pham AQ, Esplin BL, Dronca RS
Melanoma Res 2016 Jun;26(3):300-3. doi: 10.1097/CMR.0000000000000242. PMID: 26848796
Eldredge-Hindy H, Ohri N, Anne PR, Eschelman D, Gonsalves C, Intenzo C, Bar-Ad V, Dicker A, Doyle L, Li J, Sato T
Am J Clin Oncol 2016 Apr;39(2):189-95. doi: 10.1097/COC.0000000000000033. PMID: 24441583Free PMC Article

Therapy

Hassel JC, Piperno-Neumann S, Rutkowski P, Baurain JF, Schlaak M, Butler MO, Sullivan RJ, Dummer R, Kirkwood JM, Orloff M, Sacco JJ, Ochsenreither S, Joshua AM, Gastaud L, Curti B, Piulats JM, Salama AKS, Shoushtari AN, Demidov L, Milhem M, Chmielowski B, Kim KB, Carvajal RD, Hamid O, Collins L, Ranade K, Holland C, Pfeiffer C, Nathan P
N Engl J Med 2023 Dec 14;389(24):2256-2266. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2304753. PMID: 37870955
Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
van de Donk NWCJ, Zweegman S
Lancet 2023 Jul 8;402(10396):142-158. Epub 2023 Jun 1 doi: 10.1016/S0140-6736(23)00521-4. PMID: 37271153
Chen LN, Carvajal RD
Expert Rev Anticancer Ther 2022 Oct;22(10):1017-1027. Epub 2022 Sep 19 doi: 10.1080/14737140.2022.2124971. PMID: 36102132Free PMC Article
Dhillon S
Drugs 2022 Apr;82(6):703-710. doi: 10.1007/s40265-022-01704-4. PMID: 35364798

Prognosis

Dummer R, Corrie P, Gutzmer R, Meniawy TM, Del Vecchio M, Lebbé C, Guida M, Dutriaux C, Dreno B, Meyer N, Ferrucci PF, Dalle S, Khattak MA, Grob JJ, Briscoe K, Larkin J, Mansard S, Lesimple T, Guidoboni M, Sabatini S, Richtig E, Herbst R, Lobo M, Askelson M, Ascierto PA, Maio M
J Clin Oncol 2023 Aug 10;41(23):3917-3929. Epub 2023 Jun 12 doi: 10.1200/JCO.22.02199. PMID: 37307514
Wang Z, Xie Y, Wang JQ, Cheng Y, Fleishman J, Chen ZS, Chen Y
Drugs Today (Barc) 2023 Mar;59(3):179-193. doi: 10.1358/dot.2023.59.3.3542417. PMID: 36847626
Chen LN, Carvajal RD
Expert Rev Anticancer Ther 2022 Oct;22(10):1017-1027. Epub 2022 Sep 19 doi: 10.1080/14737140.2022.2124971. PMID: 36102132Free PMC Article
Tong TML, Samim M, Kapiteijn E, Meijer TS, Speetjens FM, Brüning R, Schroeder TH, El-Sanosy S, Maschke H, Wacker FK, Vogel A, Dewald CLA, Goeman JJ, Burgmans MC
Cardiovasc Intervent Radiol 2022 Sep;45(9):1304-1313. Epub 2022 Aug 3 doi: 10.1007/s00270-022-03225-9. PMID: 35922562Free PMC Article
Zhuo H, Zhou L
Pharmazie 2016 Oct 1;71(10):555-561. doi: 10.1691/ph.2016.6683. PMID: 29441921

Clinical prediction guides

Hassel JC, Piperno-Neumann S, Rutkowski P, Baurain JF, Schlaak M, Butler MO, Sullivan RJ, Dummer R, Kirkwood JM, Orloff M, Sacco JJ, Ochsenreither S, Joshua AM, Gastaud L, Curti B, Piulats JM, Salama AKS, Shoushtari AN, Demidov L, Milhem M, Chmielowski B, Kim KB, Carvajal RD, Hamid O, Collins L, Ranade K, Holland C, Pfeiffer C, Nathan P
N Engl J Med 2023 Dec 14;389(24):2256-2266. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2304753. PMID: 37870955
Dummer R, Corrie P, Gutzmer R, Meniawy TM, Del Vecchio M, Lebbé C, Guida M, Dutriaux C, Dreno B, Meyer N, Ferrucci PF, Dalle S, Khattak MA, Grob JJ, Briscoe K, Larkin J, Mansard S, Lesimple T, Guidoboni M, Sabatini S, Richtig E, Herbst R, Lobo M, Askelson M, Ascierto PA, Maio M
J Clin Oncol 2023 Aug 10;41(23):3917-3929. Epub 2023 Jun 12 doi: 10.1200/JCO.22.02199. PMID: 37307514
Tong TML, Samim M, Kapiteijn E, Meijer TS, Speetjens FM, Brüning R, Schroeder TH, El-Sanosy S, Maschke H, Wacker FK, Vogel A, Dewald CLA, Goeman JJ, Burgmans MC
Cardiovasc Intervent Radiol 2022 Sep;45(9):1304-1313. Epub 2022 Aug 3 doi: 10.1007/s00270-022-03225-9. PMID: 35922562Free PMC Article
Steeb T, Wessely A, Ruzicka T, Heppt MV, Berking C
Eur J Cancer 2018 Nov;103:41-51. Epub 2018 Sep 8 doi: 10.1016/j.ejca.2018.08.005. PMID: 30205280
Heppt MV, Steeb T, Schlager JG, Rosumeck S, Dressler C, Ruzicka T, Nast A, Berking C
Cancer Treat Rev 2017 Nov;60:44-52. Epub 2017 Aug 24 doi: 10.1016/j.ctrv.2017.08.009. PMID: 28881222

Recent systematic reviews

Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
Alexander H, Wen D, Chu M, Han C, Hadden P, Thomas R, Bartlett A
Br J Radiol 2022 Jan 1;95(1129):20210200. Epub 2021 Nov 10 doi: 10.1259/bjr.20210200. PMID: 34757824Free PMC Article
Seth R, Messersmith H, Kaur V, Kirkwood JM, Kudchadkar R, McQuade JL, Provenzano A, Swami U, Weber J, Alluri KC, Agarwala S, Ascierto PA, Atkins MB, Davis N, Ernstoff MS, Faries MB, Gold JS, Guild S, Gyorki DE, Khushalani NI, Meyers MO, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Tsai KK, van Akkooi A, Funchain P
J Clin Oncol 2020 Nov 20;38(33):3947-3970. Epub 2020 Mar 31 doi: 10.1200/JCO.20.00198. PMID: 32228358
Steeb T, Wessely A, Ruzicka T, Heppt MV, Berking C
Eur J Cancer 2018 Nov;103:41-51. Epub 2018 Sep 8 doi: 10.1016/j.ejca.2018.08.005. PMID: 30205280
Heppt MV, Steeb T, Schlager JG, Rosumeck S, Dressler C, Ruzicka T, Nast A, Berking C
Cancer Treat Rev 2017 Nov;60:44-52. Epub 2017 Aug 24 doi: 10.1016/j.ctrv.2017.08.009. PMID: 28881222

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